225
Views
45
CrossRef citations to date
0
Altmetric
Reviews

The use of inductively coupled plasma mass spectrometry as a detector in drug metabolism studies

, PhD, , PhD, , PhD & , MSc
Pages 1187-1207 | Published online: 24 Aug 2008

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Catherine Duckett, Michael McCullagh, Christopher Smith & Ian D Wilson. (2015) The metabolism of 4-bromoaniline in the bile-cannulated rat: application of ICPMS (79/81Br), HPLC-ICPMS & HPLC-oaTOFMS. Xenobiotica 45:8, pages 672-680.
Read now
Anne Baumann & Uwe Karst. (2010) Online electrochemistry/mass spectrometry in drug metabolism studies: principles and applications. Expert Opinion on Drug Metabolism & Toxicology 6:6, pages 715-731.
Read now

Articles from other publishers (42)

Yanwu Chu, Zhanjie Zhang, Qianyuan He, Feng Chen, Ziqian Sheng, Deng Zhang, Honglin Jin, Fagang Jiang & Lianbo Guo. (2020) Half-life determination of inorganic-organic hybrid nanomaterials in mice using laser-induced breakdown spectroscopy. Journal of Advanced Research 24, pages 353-361.
Crossref
Balázs Klencsár, Sanwang Li, Lieve Balcaen & Frank Vanhaecke. (2018) High-performance liquid chromatography coupled to inductively coupled plasma – Mass spectrometry (HPLC-ICP-MS) for quantitative metabolite profiling of non-metal drugs. TrAC Trends in Analytical Chemistry 104, pages 118-134.
Crossref
Balázs Klencsár, Carlos Sánchez, Lieve Balcaen, José Todolí, Frederic Lynen & Frank Vanhaecke. (2018) Comparative evaluation of ICP sample introduction systems to be used in the metabolite profiling of chlorine-containing pharmaceuticals via HPLC-ICP-MS. Journal of Pharmaceutical and Biomedical Analysis 153, pages 135-144.
Crossref
Sarah Theiner, Márkó Grabarics, Luis Galvez, Hristo P. Varbanov, Nadine S. Sommerfeld, Mathea S. Galanski, Bernhard K. Keppler & Gunda Koellensperger. (2018) The impact of whole human blood on the kinetic inertness of platinum( iv ) prodrugs – an HPLC-ICP-MS study . Dalton Transactions 47:15, pages 5252-5258.
Crossref
Sanwang Li, Balázs Klencsár, Lieve Balcaen, Filip Cuyckens, Frederic Lynen & Frank Vanhaecke. (2018) A pre-column derivatization method allowing quantitative metabolite profiling of carboxyl and phenolic hydroxyl group containing pharmaceuticals in human plasma via liquid chromatography-inductively coupled plasma-tandem mass spectrometry (LC-ICP-MS/MS) . Journal of Analytical Atomic Spectrometry 33:2, pages 274-282.
Crossref
W.M.A Niessen. 2017. Encyclopedia of Spectroscopy and Spectrometry. Encyclopedia of Spectroscopy and Spectrometry 174 180 .
Lars Weidolf & Ian D. Wilson. 2016. Metabolite Safety in Drug Development. Metabolite Safety in Drug Development 141 176 .
Barbara Crone, Michael Aschner, Tanja Schwerdtle, Uwe Karst & Julia Bornhorst. (2015) Elemental bioimaging of Cisplatin in Caenorhabditis elegans by LA-ICP-MS . Metallomics 7:7, pages 1189-1195.
Crossref
Dmitry S. Perekalin, Valentin V. Novikov, Alexander A. Pavlov, Igor A. Ivanov, Natalia Yu. Anisimova, Alexey N. Kopylov, Dmitry S. Volkov, Irina F. Seregina, Michail A. Bolshov & Alexander R. Kudinov. (2015) Selective Ruthenium Labeling of the Tryptophan Residue in the Bee Venom Peptide Melittin. Chemistry – A European Journal 21:13, pages 4923-4925.
Crossref
Heng-Keang Lim, Yuan Cao, Xi Qiu, Jose Silva & David C. Evans. (2015) A Nonradioactive Approach to Investigate the Metabolism of Therapeutic Peptides by Tagging with 127 I and Using Inductively-Coupled Plasma Mass Spectrometry Analysis . Drug Metabolism and Disposition 43:1, pages 17-26.
Crossref
Konstantin Ossipov, Yulia Y. Scaffidi-Domianello, Irina F. Seregina, Mathea S. Galanski, Bernhard K. Keppler, Andrei R. Timerbaev & Mikhail A. Bolshov. (2014) Inductively coupled plasma mass spectrometry for metallodrug development: Albumin binding and serum distribution of cytotoxic cis- and trans-isomeric platinum(II) complexes. Journal of Inorganic Biochemistry 137, pages 40-45.
Crossref
Bernhard Michalke. (2014) Anwendung der Platinspeziation zum Nachweis einer Aktivierung oder Inhibierung von Pt enthaltenden Krebsmedikamenten. Perspectives in Medicine 2:1-4, pages 79-90.
Crossref
Juliusz Bianga, Amina Bouslimani, Nicole Bec, Fran?ois Quenet, Sandra Mounicou, Joanna Szpunar, Brice Bouyssiere, Ryszard Lobinski & Christian Larroque. (2014) Complementarity of MALDI and LA ICP mass spectrometry for platinum anticancer imaging in human tumor. Metallomics 6:8, pages 1382-1386.
Crossref
Andrei R. Timerbaev. (2014) Recent progress of ICP-MS in the development of metal-based drugs and diagnostic agents. J. Anal. At. Spectrom. 29:6, pages 1058-1072.
Crossref
Tam T.T.N. Nguyen, Jesper Østergaard, Stefan Stürup & Bente Gammelgaard. (2013) Determination of platinum drug release and liposome stability in human plasma by CE-ICP-MS. International Journal of Pharmaceutics 449:1-2, pages 95-102.
Crossref
Konstantin Ossipov, Lidia S. Foteeva, Irina F. Seregina, Sergei A. Perevalov, Andrei R. Timerbaev & Mikhail A. Bolshov. (2013) Metallomics for drug development: Serum protein binding and analysis of an anticancer tris(8-quinolinolato)gallium(III) drug using inductively coupled plasma mass spectrometry. Analytica Chimica Acta 785, pages 22-26.
Crossref
Gérard Hopfgartner. 2013. Mass Spectrometry for Drug Discovery and Drug Development. Mass Spectrometry for Drug Discovery and Drug Development 1 35 .
Gerrit Hermann, Petra Heffeter, Thomas Falta, Walter Berger, Stephan Hann & Gunda Koellensperger. (2013) In vitro studies on cisplatin focusing on kinetic aspects of intracellular chemistry by LC-ICP-MS. Metallomics 5:6, pages 636.
Crossref
Caiming Tang, Chao Li, Caixing Tang, Wei Zhan, Hai Zheng & Xianzhi Peng. (2013) Quantitative determination of platinum derived from cisplatin in human plasma ultrafiltrate using derivatization with diethyldithiocarbamate and liquid chromatography coupled with electrospray ionization tandem mass spectrometry. Analytical Methods 5:24, pages 7117.
Crossref
Sandra Jahn & Uwe Karst. (2012) Electrochemistry coupled to (liquid chromatography/) mass spectrometry—Current state and future perspectives. Journal of Chromatography A 1259, pages 16-49.
Crossref
Fred van Heuveln, Henri Meijering & Jaap Wieling. (2012) Inductively coupled plasma-MS in drug development: bioanalytical aspects and applications. Bioanalysis 4:15, pages 1933-1965.
Crossref
Cristina Losada, Joan J. Albertí, Javier Saurina & Sonia Sentellas. (2012) Determination of S-containing drug metabolites from in vitro and in vivo metabolism studies by using LC-ICP/MS. Analytical and Bioanalytical Chemistry 404:2, pages 539-551.
Crossref
Björn Meermann & Michael Sperling. (2012) Hyphenated techniques as tools for speciation analysis of metal-based pharmaceuticals: developments and applications. Analytical and Bioanalytical Chemistry 403:6, pages 1501-1522.
Crossref
Björn Meermann, Anne Hulstaert, Aline Laenen, Cis Van Looveren, Maarten Vliegen, Filip Cuyckens & Frank Vanhaecke. (2012) HPLC/ICP-MS in Combination with “Reverse” Online Isotope Dilution in Drug Metabolism Studies. Analytical Chemistry 84:5, pages 2395-2401.
Crossref
Filip Cuyckens, Nadine Pauwels, Valerie Koppen & Laurent Leclercq. (2012) Use of relative 12 C/ 14 C isotope ratios to estimate metabolite concentrations in the absence of authentic standards . Bioanalysis 4:2, pages 143-156.
Crossref
Björn Meermann, Marc Bockx, Aline Laenen, Cis Van Looveren, Filip Cuyckens & Frank Vanhaecke. (2011) Speciation analysis of bromine-containing drug metabolites in feces samples from a human in vivo study by means of HPLC/ICP-MS combined with on-line isotope dilution. Analytical and Bioanalytical Chemistry 402:1, pages 439-448.
Crossref
A.R. Timerbaev, K. Pawlak, C. Gabbiani & L. Messori. (2011) Recent progress in the application of analytical techniques to anticancer metallodrug proteomics. TrAC Trends in Analytical Chemistry 30:7, pages 1120-1138.
Crossref
Jon S.B. de Vlieger, Mark J.N. Giezen, David Falck, Cornelis Tump, Fred van Heuveln, Martin Giera, Jeroen Kool, Henk Lingeman, Jaap Wieling, Maarten Honing, Hubertus Irth & Wilfried M.A. Niessen. (2011) High temperature liquid chromatography hyphenated with ESI-MS and ICP-MS detection for the structural characterization and quantification of halogen containing drug metabolites. Analytica Chimica Acta 698:1-2, pages 69-76.
Crossref
Darya G. Filatova, Irina F. Seregina, Lidia S. Foteeva, Vladimir V. Pukhov, Andrei R. Timerbaev & Mikhail A. Bolshov. (2011) Determination of gallium originated from a gallium-based anticancer drug in human urine using ICP-MS. Analytical and Bioanalytical Chemistry 400:3, pages 709-714.
Crossref
Gordon J Dear, Claire Beaumont, Andrew Roberts, Bianca Squillaci, Steve Thomas, Mike Nash & Donna Fraser. (2011) Approaches for the rapid identification of drug metabolites in early clinical studies. Bioanalysis 3:2, pages 197-213.
Crossref
T. Falta, P. Heffeter, A. Mohamed, W. Berger, S. Hann & G. Koellensperger. (2011) Quantitative determination of intact free cisplatin in cell models by LC-ICP-MS. J. Anal. At. Spectrom. 26:1, pages 109-115.
Crossref
Yongmei Li. 2010. Biotransformation and Metabolite Elucidation of Xenobiotics. Biotransformation and Metabolite Elucidation of Xenobiotics 79 123 .
Angus NR Nedderman & Pat Wright. (2010) Looking back through the MIST: a perspective of evolving strategies and key focus areas for metabolite safety analysis. Bioanalysis 2:7, pages 1235-1248.
Crossref
Sandra Mounicou, Joanna Szpunar & Ryszard Lobinski. (2010) Inductively-Coupled Plasma Mass Spectrometry in Proteomics, Metabolomics and Metallomics Studies. European Journal of Mass Spectrometry 16:3, pages 243-253.
Crossref
Bernhard Michalke. (2010) Platinum speciation used for elucidating activation or inhibition of Pt-containing anti-cancer drugs. Journal of Trace Elements in Medicine and Biology 24:2, pages 69-77.
Crossref
S. Hann, T. Falta, K. Boeck, M. Sulyok & G. Koellensperger. (2010) On-line fast column switching SEC × IC separation combined with ICP-MS detection for mapping metallodrug–biomolecule interaction. Journal of Analytical Atomic Spectrometry 25:6, pages 861.
Crossref
Kenny De Wolf, Lieve Balcaen, Elke Van De Walle, Filip Cuyckens & Frank Vanhaecke. (2010) A comparison between HPLC-dynamic reaction cell-ICP-MS and HPLC-sector field-ICP-MS for the detection of glutathione-trapped reactive drug metabolites using clozapine as a model compound. Journal of Analytical Atomic Spectrometry 25:3, pages 419.
Crossref
Pat WrightZhuang MiaoBarclay Shilliday. (2009) Metabolite quantitation: detector technology and MIST implications. Bioanalysis 1:4, pages 831-845.
Crossref
Laurent Leclercq, Filip Cuyckens, Geert S. J. Mannens, Ronald de Vries, Philip Timmerman & David C. Evans. (2009) Which Human Metabolites Have We MIST? Retrospective Analysis, Practical Aspects, and Perspectives For Metabolite Identification and Quantification in Pharmaceutical Development. Chemical Research in Toxicology 22:2, pages 280-293.
Crossref
Thomas Falta, Gunda Koellensperger, Alexander Standler, Wolfgang Buchberger, Robert M. Mader & Stephan Hann. (2009) Quantification of cisplatin, carboplatin and oxaliplatin in spiked human plasma samples by ICP-SFMS and hydrophilic interaction liquid chromatography (HILIC) combined with ICP-MS detection. Journal of Analytical Atomic Spectrometry 24:10, pages 1336.
Crossref
Andrew Taylor, Simon Branch, Martin P. Day, Marina Patriarca & Mark White. (2009) Atomic Spectrometry Update. Clinical and biological materials, foods and beverages. Journal of Analytical Atomic Spectrometry 24:4, pages 535.
Crossref
Charlotte Møller, Stefan Stürup, Helle Rüsz Hansen & Bente Gammelgaard. (2009) Comparison of two CE-ICP-MS interfaces and quantitative measurements of carboplatin in plasma samples using an internal standard. Journal of Analytical Atomic Spectrometry 24:9, pages 1208.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.