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The discovery and development of cyclooxygenase-2 inhibitors as potential anticancer therapies

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Wanyi Liu, Guicheng Kuang, Binbin Yang, Hanlin Liu, Yangping Lv, Yang Xiong & Yongqiu Zeng. (2023) Progress on the role and mechanism of ribosome assembly regulator PNO1 in tumor. All Life 16:1.
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Walaa M. El-Husseiny, Magda A.-A. El-Sayed, Adel S. El-Azab, Nawaf A. AlSaif, Mohammed M. Alanazi & Alaa A.-M. Abdel-Aziz. (2020) Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition. Journal of Enzyme Inhibition and Medicinal Chemistry 35:1, pages 744-758.
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Jennifer Bourn & Maria Cekanova. (2018) Cyclooxygenase inhibitors potentiate receptor tyrosine kinase therapies in bladder cancer cells in vitro. Drug Design, Development and Therapy 12, pages 1727-1742.
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Pingting Zhou, Yanyan Li, Bo Li, Meichao Zhang, Ci Xu, Furao Liu, Lei Bian, Yuanhua Liu, Yuan Yao & Dong Li. (2018) Autophagy inhibition enhances celecoxib-induced apoptosis in osteosarcoma. Cell Cycle 17:8, pages 997-1006.
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Miklos Gulyas, Johanna Sofia Margareta Mattsson, Andrea Lindgren, Lars Ek, Kristina Lamberg Lundström, Annelie Behndig, Erik Holmberg, Patrick Micke & Bengt Bergman. (2018) COX-2 expression and effects of celecoxib in addition to standard chemotherapy in advanced non-small cell lung cancer. Acta Oncologica 57:2, pages 244-250.
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Koh Miura, Masayuki Satoh, Makoto Kinouchi, Kuniharu Yamamoto, Yasuhiro Hasegawa, Yoichiro Kakugawa, Masaaki Kawai, Kiyoshi Uchimi, Hiroki Aizawa, Shinobu Ohnuma, Taiki Kajiwara, Hiroto Sakurai & Tsuneaki Fujiya. (2015) The use of natural products in colorectal cancer drug discovery. Expert Opinion on Drug Discovery 10:4, pages 411-426.
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Daniel Gonnermann, Hans-Heinrich Oberg, Christian Kellner, Matthias Peipp, Susanne Sebens, Dieter Kabelitz & Daniela Wesch. (2015) Resistance of cyclooxygenase-2 expressing pancreatic ductal adenocarcinoma cells against γδ T cell cytotoxicity. OncoImmunology 4:3.
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Xiao-Qiang Yan, Zhong-Chang Wang, Bo Zhang, Peng-Fei Qi, Gui-Gen Li & Hai-Liang Zhu. (2019) Dihydropyrazole Derivatives Containing Benzo Oxygen Heterocycle and Sulfonamide Moieties Selectively and Potently Inhibit COX-2: Design, Synthesis, and Anti-Colon Cancer Activity Evaluation. Molecules 24:9, pages 1685.
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Guanhua Zhang & Ye-Hua Gan. (2017) Synergistic antitumor effects of the combined treatment with an HDAC6 inhibitor and a COX-2 inhibitor through activation of PTEN. Oncology Reports 38:5, pages 2657-2666.
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Atul Bhardwaj, Jatinder Kaur, Melinda Wuest & Frank Wuest. (2017) In situ click chemistry generation of cyclooxygenase-2 inhibitors. Nature Communications 8:1.
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