Advanced search
Publication Cover
Expert Opinion on Drug Discovery Volume 10, 2015 - Issue 4
Submit an article Journal homepage
356
Views
24
CrossRef citations to date
0
Altmetric
Review

Approaches for discovering anti-prion compounds: lessons learned and challenges ahead

Maria Laura BolognesiDepartment of Pharmacy and Biotechnology, Alma Mater Studiorum - University of Bologna, Via Belmeloro 6, 40126 Bologna, [email protected]
(Professor) &
Giuseppe LegnameDepartment of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Via Bonomea 265, 34136 Trieste, [email protected]
(Professor)
Pages 389-397 | Published online: 15 Feb 2015

Citations (24)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Fabio Moda, Maria Laura Bolognesi & Giuseppe Legname. (2019) Novel screening approaches for human prion diseases drug discovery. Expert Opinion on Drug Discovery 14:10, pages 983-993.
Read now

Articles from other publishers (23)

Yeong-Gon Choi, Byungki Jang, Jeong-Ho Park, Min-Woo Choi, Gong Yeal Lee, Dae Jin Cho, Hong Youp Kim, Hae Kyoung Lim, Won Jae Lee, Eun-Kyoung Choi & Yong-Sun Kim. (2023) Radotinib Decreases Prion Propagation and Prolongs Survival Times in Models of Prion Disease. International Journal of Molecular Sciences 24:15, pages 12241.
Crossref
Matteo Staderini, Silvia Vanni, Arianna Colini Baldeschi, Gabriele Giachin, Marco Zattoni, Luigi Celauro, Chiara Ferracin, Edoardo Bistaffa, Fabio Moda, Daniel I. Pérez, Ana Martínez, M. Antonia Martín, Olmo Martín-Cámara, Ángel Cores, Giulia Bianchini, Robert Kammerer, J. Carlos Menéndez, Giuseppe Legname & Maria Laura Bolognesi. (2023) Bifunctional carbazole derivatives for simultaneous therapy and fluorescence imaging in prion disease murine cell models. European Journal of Medicinal Chemistry 245, pages 114923.
Crossref
Ghulam Mustafa, Muhammad Zia-ur-Rehman, Sajjad Hussain Sumrra, Muhammad Ashfaq, Wardha Zafar & Maryam Ashfaq. (2022) A critical review on recent trends on pharmacological applications of pyrazolone endowed derivatives. Journal of Molecular Structure 1262, pages 133044.
Crossref
Wei Yang, Cao Chen, Jia Chen, Ying Xia, Chao Hu, Lin Wang, Yue-Zhang Wu, Qi Shi, Zhi-Bao Chen & Xiao-Ping Dong. (2022) PrPSc Inhibition and Cellular Protection of DBL on a Prion-Infected Cultured Cell via Multiple Pathways. Molecular Neurobiology 59:5, pages 3310-3321.
Crossref
Carlo Mustazza, Marco Sbriccoli, Paola Minosi & Carla Raggi. (2020) Small Molecules with Anti-Prion Activity. Current Medicinal Chemistry 27:33, pages 5446-5479.
Crossref
Ludovica Zaccagnini, Giulia Rossetti, Thanh Hoa Tran, Giulia Salzano, Annachiara Gandini, Arianna Colini Baldeschi, Maria Laura Bolognesi, Paolo Carloni & Giuseppe Legname. (2020) In silico/in vitro screening and hit evaluation identified new phenothiazine anti-prion derivatives. European Journal of Medicinal Chemistry 196, pages 112295.
Crossref
Óscar López-Pérez, Janne Markus Toivonen, Alicia Otero, Laura Solanas, Pilar Zaragoza, Juan José Badiola, Rosario Osta, Rosa Bolea & Inmaculada Martín-Burriel. (2020) Impairment of autophagy in scrapie-infected transgenic mice at the clinical stage. Laboratory Investigation 100:1, pages 52-63.
Crossref
Takao Ishikawa & Kamil Lisiecki. (2020) Anti-prion drug screening system in Saccharomyces cerevisiae based on an artificial [LEU2+] prion. Fungal Genetics and Biology 134, pages 103280.
Crossref
Zhiqiang Du, Stephanie Valtierra, Luzivette Robles Cardona, Sara Fernandez Dunne, Chi-Hao Luan & Liming Li. (2019) Identifying Anti-prion Chemical Compounds Using a Newly Established Yeast High-Throughput Screening System. Cell Chemical Biology 26:12, pages 1664-1680.e4.
Crossref
Erica Corda, Xiaotang Du, Su Yeon Shim, Antonia N. Klein, Jessica Siltberg-Liberles & Sabine Gilch. (2018) Interaction of Peptide Aptamers with Prion Protein Central Domain Promotes α-Cleavage of PrPC. Molecular Neurobiology 55:10, pages 7758-7774.
Crossref
Katharina Annick Wüsten, Pasham Parameshwar Reddy, Andrej Smiyakin, Maria Eugenia Bernis & Gültekin Tamgüney. (2018) A Bioluminescent Cell Assay to Quantify Prion Protein Dimerization. Scientific Reports 8:1.
Crossref
N. C. Ferreira, L. M. Ascari, A. G. Hughson, G. R. Cavalheiro, C. F. Góes, P. N. Fernandes, J. R. Hollister, R. A. da Conceição, D. S. Silva, A. M. T. Souza, M. L. C. Barbosa, F. A. Lara, R. A. P. Martins, B. Caughey & Y. Cordeiro. (2018) A Promising Antiprion Trimethoxychalcone Binds to the Globular Domain of the Cellular Prion Protein and Changes Its Cellular Location. Antimicrobial Agents and Chemotherapy 62:2.
Crossref
Basant A. Abdulrahman, Dalia Abdelaziz, Simrika Thapa, Li Lu, Shubha Jain, Sabine Gilch, Stefan Proniuk, Alexander Zukiwski & Hermann M. Schatzl. (2017) The celecoxib derivatives AR-12 and AR-14 induce autophagy and clear prion-infected cells from prions. Scientific Reports 7:1.
Crossref
Adriano Aguzzi & Yingjun Liu. (2017) A role for astroglia in prion diseases. Journal of Experimental Medicine 214:12, pages 3477-3479.
Crossref
S. Vanni, F. Moda, M. Zattoni, E. Bistaffa, E. De Cecco, M. Rossi, G. Giaccone, F. Tagliavini, S. Haïk, J. P. Deslys, G. Zanusso, J. W. Ironside, I. Ferrer, G. G. Kovacs & G. Legname. (2017) Differential overexpression of SERPINA3 in human prion diseases. Scientific Reports 7:1.
Crossref
Luise Linsenmeier, Hermann C. Altmeppen, Sebastian Wetzel, Behnam Mohammadi, Paul Saftig & Markus Glatzel. (2017) Diverse functions of the prion protein – Does proteolytic processing hold the key?. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research 1864:11, pages 2128-2137.
Crossref
Giuseppe Legname. (2017) Elucidating the function of the prion protein. PLOS Pathogens 13:8, pages e1006458.
Crossref
Ludovica Zaccagnini, Simone Brogi, Margherita Brindisi, Sandra Gemma, Giulia Chemi, Giuseppe Legname, Giuseppe Campiani & Stefania Butini. (2017) Identification of novel fluorescent probes preventing PrP Sc replication in prion diseases. European Journal of Medicinal Chemistry 127, pages 859-873.
Crossref
Annachiara Gandini & Maria Laura Bolognesi. 2017. Prion Protein. Prion Protein 433 453 .
M.L. Bolognesi. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 74 106 .
Elisa Uliassi, Federica Prati, Salvatore Bongarzone & Maria Laura Bolognesi. 2017. Design of Hybrid Molecules for Drug Development. Design of Hybrid Molecules for Drug Development 259 277 .
Kenta Teruya, Ayumi Oguma, Keiko Nishizawa, Maki Kawata, Yuji Sakasegawa, Hiroshi Kamitakahara & Katsumi Doh-ura. (2016) A Single Subcutaneous Injection of Cellulose Ethers Administered Long before Infection Confers Sustained Protection against Prion Diseases in Rodents. PLOS Pathogens 12:12, pages e1006045.
Crossref
Maria Laura Bolognesi, Salvatore Bongarzone, Suzana Aulic, Hoang Ngoc Ai Tran, Federica Prati, Paolo Carloni & Giuseppe Legname. (2015) Rational approach to an antiprion compound with a multiple mechanism of action. Future Medicinal Chemistry 7:16, pages 2113-2120.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.