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Emerging formats for next-generation antibody drug conjugates

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Sajeli Ahil Begum & Ahmed Kamal. (2023) What are the challenges involved in the strategies for future antibody-drug conjugate discovery and development for oncology?. Expert Opinion on Drug Discovery 18:6, pages 591-596.
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Camille Martin, Claire Kizlik-Masson, André Pèlegrin, Hervé Watier, Marie-Claude Viaud-Massuard & Nicolas Joubert. (2018) Antibody-drug conjugates: Design and development for therapy and imaging in and beyond cancer, LabEx MAbImprove industrial workshop, July 27–28, 2017, Tours, France. mAbs 10:2, pages 210-221.
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Jared L. Spidel, Earl F. Albone, Xin Cheng, Benjamin Vaessen, Sara Jacob, Andrew Z. Milinichik, Arielle Verdi, J. Bradford Kline & Luigi Grasso. (2017) Engineering humanized antibody framework sequences for optimal site-specific conjugation of cytotoxins. mAbs 9:6, pages 907-915.
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Laia Montoliu-Gaya, Javier Murciano-Calles, Jose C. Martinez & Sandra Villegas. (2017) Towards the improvement in stability of an anti-Aβ single-chain variable fragment, scFv-h3D6, as a way to enhance its therapeutic potential. Amyloid 24:3, pages 167-175.
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Earl F. Albone, Jared L. Spidel, Xin Cheng, Young Chul Park, Sara Jacob, Andrew Z. Milinichik, Ben Vaessen, Janet Butler, J. Bradford Kline & Luigi Grasso. (2017) Generation of therapeutic immunoconjugates via Residue-Specific Conjugation Technology (RESPECT) utilizing a native cysteine in the light chain framework of Oryctolagus cuniculus. Cancer Biology & Therapy 18:5, pages 347-357.
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Sam Massa, Catarina Xavier, Serge Muyldermans & Nick Devoogdt. (2016) Emerging site-specific bioconjugation strategies for radioimmunotracer development. Expert Opinion on Drug Delivery 13:8, pages 1149-1163.
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Yong Wang, Jingming Zhang, Boyang Han, Linzhi Tan, Wenkang Cai, Yuxuan Li, Yeyu Su, Yutong Yu, Xin Wang, Xiaojiang Duan, Haoyu Wang, Xiaomeng Shi, Jing Wang, Xing Yang & Tao Liu. (2023) Noncanonical amino acids as doubly bio-orthogonal handles for one-pot preparation of protein multiconjugates. Nature Communications 14:1.
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Wenhui Liu & Shuqing Chen. 2023. Antibody-Drug Conjugates and Cellular Metabolic Dynamics. Antibody-Drug Conjugates and Cellular Metabolic Dynamics 55 68 .
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Hany E. Marei, Carlo Cenciarelli & Anwarul Hasan. (2022) Potential of antibody–drug conjugates (ADCs) for cancer therapy. Cancer Cell International 22:1.
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Chen-Fu Lo, Tai-Yu Chiu, Yu-Tzu Liu, Li-Rung Huang, Teng-Kuang Yeh, Kuan-Hsun Huang, Kuan-Liang Liu, Chia-Yu Hsu, Ming-Yu Fang, Yu-Chen Huang, Tsu-An Hsu, Chiung-Tong Chen & Lun Kelvin Tsou. (2022) Synthesis and Evaluation of Small Molecule Drug Conjugates Harnessing Thioester-Linked Maytansinoids. Pharmaceutics 14:7, pages 1316.
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