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Expert Opinion on Drug Discovery Volume 10, 2015 - Issue 5
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Review

Designing drugs that combat kidney damage

Adrián M RamosInstituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Laboratory of Renal and Vascular Pathology and Diabetes, Av. Reyes Católicos 2, 28040, Madrid, [email protected];Instituto de Salud Carlos III, Red de Investigación Renal (REDINREN), Av. Reyes Católicos 2, 28040, Madrid, Spain;Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), School of Medicine, Av. Reyes Católicos 2, 28040, Madrid;Fundación Renal Iñigo Álvarez de Toledo IRSIN C/José Abascal, 42, 1° izda, 28003, Madrid, Spain
, PhD,
Cristian González-GuerreroInstituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Laboratory of Renal and Vascular Pathology and Diabetes, Av. Reyes Católicos 2, 28040, Madrid, [email protected]
, BsC,
Ana SanzInstituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Laboratory of Renal and Vascular Pathology and Diabetes, Av. Reyes Católicos 2, 28040, Madrid, [email protected]
, PhD,
María Dolores Sanchez-NiñoNephrology Laboratory, IDIPAZ, P° de la Castellana, 261, 28046, Madrid, Spain
, PhD,
Laura Rodríguez-OsorioInstituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Department of Nephrology, Av. Reyes Católicos 2, 28040, Madrid, Spain
, MD,
Catalina Martín-ClearyInstituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Department of Nephrology, Av. Reyes Católicos 2, 28040, Madrid, Spain
, MD,
Beatriz Fernández-FernándezInstituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Department of Nephrology, Av. Reyes Católicos 2, 28040, Madrid, Spain
, MD,
Marta Ruiz-OrtegaInstituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), Laboratory of Renal and Vascular Pathology and Diabetes, Av. Reyes Católicos 2, 28040, Madrid, [email protected];Instituto de Salud Carlos III, Red de Investigación Renal (REDINREN), Av. Reyes Católicos 2, 28040, Madrid, Spain;Universidad Autónoma de Madrid, Cellular Biology in Renal Diseases Laboratory, Av. Reyes Católicos 2, 28040, Madrid, Spain
, PhD &
Alberto OrtizInstituto de Salud Carlos III, Red de Investigación Renal (REDINREN), Av. Reyes Católicos 2, 28040, Madrid, Spain;Universidad Autónoma de Madrid, Instituto de Investigación Sanitaria-Fundación Jiménez Díaz (IIS-FJD), School of Medicine, Av. Reyes Católicos 2, 28040, Madrid;Fundación Renal Iñigo Álvarez de Toledo IRSIN C/José Abascal, 42, 1° izda, 28003, Madrid, Spain
, MD PhD (Professor) show all
Pages 541-556 | Published online: 03 Apr 2015

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Laura Devlin, Praveen Dhondurao Sudhindar & John A. Sayer. (2023) Renal ciliopathies: promising drug targets and prospects for clinical trials. Expert Opinion on Therapeutic Targets 27:4-5, pages 325-346.
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Yali Xu, Ping Zou & Xiaojing Cao. (2022) Advances in pharmacotherapy for acute kidney injury. Expert Opinion on Pharmacotherapy 23:6, pages 713-726.
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Kevin M. Gallagher, Stephen O’neill, Ewen M Harrison, James A Ross, Stephen J Wigmore & Jeremy Hughes. (2017) Recent early clinical drug development for acute kidney injury. Expert Opinion on Investigational Drugs 26:2, pages 141-154.
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Mariam Hashim, Huma Mujahid, Samina Hassan, Shanila Bukhari, Iram Anjum, Christophe Hano, Bilal Haider Abbasi & Sumaira Anjum. (2022) Implication of Nanoparticles to Combat Chronic Liver and Kidney Diseases: Progress and Perspectives. Biomolecules 12:10, pages 1337.
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J. P. Jose Merlin & Xiaogang Li. (2022) Role of Nanotechnology and Their Perspectives in the Treatment of Kidney Diseases. Frontiers in Genetics 12.
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Zhong Chen, Haisheng Peng & Changmei Zhang. (2020) Advances in kidney-targeted drug delivery systems. International Journal of Pharmaceutics 587, pages 119679.
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Peipei Zhao, Xiaojing Chen, Qiaoling Wang, Hanbing Zou, Yuexia Xie, Hongmei Liu, Yan Zhou, Peifeng Liu & Huili Dai. (2020) Differential toxicity mechanism of gold nanoparticles in HK-2 renal proximal tubular cells and 786-0 carcinoma cells. Nanomedicine 15:11, pages 1079-1096.
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Pavan K. Bhatraju, Leila R. Zelnick, Vernon M. Chinchilli, Dennis G. Moledina, Steve G. Coca, Chirag R. Parikh, Amit X. Garg, Chi-yuan Hsu, Alan S. Go, Kathleen D. Liu, T. Alp Ikizler, Edward D. Siew, James S. Kaufman, Paul L. Kimmel, Jonathan Himmelfarb & Mark M. Wurfel. (2020) Association Between Early Recovery of Kidney Function After Acute Kidney Injury and Long-term Clinical Outcomes. JAMA Network Open 3:4, pages e202682.
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Qin Zhou, Wei Chen & Xue‐Qing Yu. (2019) Long non‐coding RNAs as novel diagnostic and therapeutic targets in kidney disease. Chronic Diseases and Translational Medicine 5:4, pages 252-257.
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Angelo Moreno, George A. Pitoc, Nancy J. Ganson, Juliana M. Layzer, Michael S. Hershfield, Alice F. Tarantal & Bruce A. Sullenger. (2019) Anti-PEG Antibodies Inhibit the Anticoagulant Activity of PEGylated Aptamers. Cell Chemical Biology 26:5, pages 634-644.e3.
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M. Laura Soriano, Alberto Rodríguez-Benot & Miguel Valcárcel. (2018) Nanotechnological foundations of a “new” Nephrology. Nefrología (English Edition) 38:4, pages 362-372.
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Diego Martin-Sanchez, Jonay Poveda, Miguel Fontecha-Barriuso, Olga Ruiz-Andres, María Dolores Sanchez-Niño, Marta Ruiz-Ortega, Alberto Ortiz & Ana Belén Sanz. (2018) Targeting of regulated necrosis in kidney disease. Nefrología (English Edition) 38:2, pages 125-135.
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Diego Martin-Sanchez, Jonay Poveda, Miguel Fontecha-Barriuso, Olga Ruiz-Andres, María Dolores Sanchez-Niño, Marta Ruiz-Ortega, Alberto Ortiz & Ana Belén Sanz. (2018) Targeting of regulated necrosis in kidney disease. Nefrología 38:2, pages 125-135.
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Seiji Itano, Minoru Satoh, Hiroyuki Kadoya, Yuji Sogawa, Atsushi Uchida, Tamaki Sasaki & Naoki Kashihara. (2017) Colchicine attenuates renal fibrosis in a murine unilateral ureteral obstruction model. Molecular Medicine Reports.
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Zhong Li & Wei Zhang. (2017) Protective effect of berberine on renal fibrosis caused by diabetic nephropathy. Molecular Medicine Reports 16:2, pages 1055-1062.
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Jonathan Wang, Jacqueline J. Masehi-Lano & Eun Ji Chung. (2017) Peptide and antibody ligands for renal targeting: nanomedicine strategies for kidney disease. Biomaterials Science 5:8, pages 1450-1459.
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Nazila Kamaly, John C. He, Dennis A. Ausiello & Omid C. Farokhzad. (2016) Nanomedicines for renal disease: current status and future applications. Nature Reviews Nephrology 12:12, pages 738-753.
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Chongxiang Xiong, Monica V. Masucci, Xiaoxu Zhou, Na Liu, Xiujuan Zang, Evelyn Tolbert, Ting C. Zhao & Shougang Zhuang. (2016) Pharmacological targeting of BET proteins inhibits renal fibroblast activation and alleviates renal fibrosis. Oncotarget 7:43, pages 69291-69308.
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Jehrod Brenneman, Jon Hill & Steve Pullen. (2016) Emerging therapeutics for the treatment of diabetic nephropathy. Bioorganic & Medicinal Chemistry Letters 26:18, pages 4394-4402.
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