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CRAC inhibitors: identification and potential

, , & , PhD
Pages 787-800 | Published online: 23 Jun 2008

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Meng Zhu, Bingke Lv, Wenjing Ge, Zhenwen Cui, Kai Zhao, Yugong Feng & Xuejun Yang. (2020) Suppression of store-operated Ca2+ entry regulated by silencing Orai1 inhibits C6 glioma cell motility via decreasing Pyk2 activity and promoting focal adhesion. Cell Cycle 19:24, pages 3468-3479.
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Articles from other publishers (22)

Adéla Tiffner & Isabella Derler. (2021) Isoform-Specific Properties of Orai Homologues in Activation, Downstream Signaling, Physiology and Pathophysiology. International Journal of Molecular Sciences 22:15, pages 8020.
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Matthew J.E. Maksoud, Vasiliki Tellios, Yun-Yan Xiang & Wei-Yang Lu. (2021) Nitric oxide displays a biphasic effect on calcium dynamics in microglia. Nitric Oxide 108, pages 28-39.
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Adéla Tiffner, Lena Maltan, Sarah Weiß & Isabella Derler. (2021) The Orai Pore Opening Mechanism. International Journal of Molecular Sciences 22:2, pages 533.
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Adéla Tiffner & Isabella Derler. (2020) Molecular Choreography and Structure of Ca2+ Release-Activated Ca2+ (CRAC) and KCa2+ Channels and Their Relevance in Disease with Special Focus on Cancer. Membranes 10:12, pages 425.
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Linda Waldherr, Adela Tiffner, Deepti Mishra, Matthias Sallinger, Romana Schober, Irene Frischauf, Tony Schmidt, Verena Handl, Peter Sagmeister, Manuel Köckinger, Isabella Derler, Muammer Üçal, Daniel Bonhenry, Silke Patz & Rainer Schindl. (2020) Blockage of Store-Operated Ca2+ Influx by Synta66 is Mediated by Direct Inhibition of the Ca2+ Selective Orai1 Pore. Cancers 12:10, pages 2876.
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Jun Huo & Hao Dong. (2020) Gating and regulation of the calcium release‐activated calcium channel: Recent progress from experiments and molecular modeling. Biopolymers 111:10.
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Sendoa Tajada & Carlos Villalobos. (2020) Calcium Permeable Channels in Cancer Hallmarks. Frontiers in Pharmacology 11.
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Adéla Krizova, Lena Maltan & Isabella Derler. (2019) Critical parameters maintaining authentic CRAC channel hallmarks. European Biophysics Journal 48:5, pages 425-445.
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M. Bulla, G. Gyimesi, J.H. Kim, R. Bhardwaj, M.A. Hediger, M. Frieden & N. Demaurex. (2018) ORAI1 channel gating and selectivity is differentially altered by natural mutations in the first or third transmembrane domain. The Journal of Physiology 597:2, pages 561-582.
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Jing Wen, Ying-Cheng Huang, Huan-Huan Xiu, Zhi-Ming Shan & Kang-Qing Xu. (2016) Altered expression of stromal interaction molecule (STIM)-calcium release-activated calcium channel protein (ORAI) and inositol 1,4,5-trisphosphate receptors (IP3Rs) in cancer: will they become a new battlefield for oncotherapy?. Chinese Journal of Cancer 35:1.
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Xiaolan Xu, Sher Ali, Yufeng Li, Haijie Yu, Mingshu Zhang, Jingze Lu & Tao Xu. (2016) 2-Aminoethoxydiphenyl Borate Potentiates CRAC Current by Directly Dilating the Pore of Open Orai1. Scientific Reports 6:1.
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Murali Prakriya & Richard S. Lewis. (2015) Store-Operated Calcium Channels. Physiological Reviews 95:4, pages 1383-1436.
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Jill L. Thompson & Trevor J. Shuttleworth. (2015) Anchoring protein AKAP79-mediated PKA phosphorylation of STIM1 determines selective activation of the ARC channel, a store-independent Orai channel. The Journal of Physiology 593:3, pages 559-572.
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Isabella Derler, Rainer Schindl, Reinhard Fritsch, Peter Heftberger, Maria Christine Riedl, Malcolm Begg, David House & Christoph Romanin. (2013) The action of selective CRAC channel blockers is affected by the Orai pore geometry. Cell Calcium 53:2, pages 139-151.
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Tomasz Gwozdz, Joanna Dutko-Gwozdz, Claudia Schafer & Victoria M. Bolotina. (2012) Overexpression of Orai1 and STIM1 Proteins Alters Regulation of Store-operated Ca2+ Entry by Endogenous Mediators. Journal of Biological Chemistry 287:27, pages 22865-22872.
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Jun He, Tao Yu, Jingying Pan & He Li. (2012) Visualisation and Identification of the Interaction between STIM1s in Resting Cells. PLoS ONE 7:3, pages e33377.
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Isabella Derler, Josef Madl, Gerhard Schütz & Christoph Romanin. 2012. Calcium Signaling. Calcium Signaling 383 410 .
Olivier Dellis, Pierre Mercier & Christine Chomienne. (2011) The boron-oxygen core of borinate esters is responsible for the store-operated calcium entry potentiation ability. BMC Pharmacology 11:1.
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Kristen Park Hopson, Jessica Truelove, Jerold Chun, Yumei Wang & Christian Waeber. (2011) S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells. American Journal of Physiology-Cell Physiology 300:4, pages C919-C926.
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R. Schindl, M. Muik, M. Fahrner, I. Derler, R. Fritsch, J. Bergsmann & C. Romanin. (2009) Recent progress on STIM1 domains controlling Orai activation. Cell Calcium 46:4, pages 227-232.
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Marc Fahrner, Martin Muik, Isabella Derler, Rainer Schindl, Reinhard Fritsch, Irene Frischauf & Christoph Romanin. (2009) Mechanistic view on domains mediating STIM1-Orai coupling. Immunological Reviews 231:1, pages 99-112.
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Zachary K. Sweeney, Ana Minatti, Donald C. Button & Silvia Patrick. (2009) Small-Molecule Inhibitors of Store-Operated Calcium Entry. ChemMedChem 4:5, pages 706-718.
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