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Development of enterovirus 71 vaccines: from the lab bench to Phase III clinical trials

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Yang Zhou, Jing-Xin Li, Peng-Fei Jin, Yu-Xiao Wang & Feng-Cai Zhu. (2016) Enterovirus 71: a whole virion inactivated enterovirus 71 vaccine. Expert Review of Vaccines 15:7, pages 803-813.
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Wei Zhang, Yujia Kong, Zhiwei Jiang, Chanjuan Li, Ling Wang & Jielai Xia. (2016) Comprehensive safety assessment of a human inactivated diploid enterovirus 71 vaccine based on a phase III clinical trial. Human Vaccines & Immunotherapeutics 12:4, pages 922-930.
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Jing-Xin Li, Yu-Fei Song, Ling Wang, Xue-Feng Zhang, Yuan-Sheng Hu, Yue-Mei Hu, Jie-Lai Xia, Jing Li & Feng-Cai Zhu. (2016) Two-year efficacy and immunogenicity of Sinovac Enterovirus 71 vaccine against hand, foot and mouth disease in children. Expert Review of Vaccines 15:1, pages 129-137.
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Michel Klein & Pele Chong. (2015) Is a multivalent hand, foot, and mouth disease vaccine feasible?. Human Vaccines & Immunotherapeutics 11:11, pages 2688-2704.
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Shiyang Sun, Liping Jiang, Zhenglun Liang, Qunying Mao, Weiheng Su, Huafei Zhang, Xiaojun Li, Jun Jin, Lin Xu, Dandan Zhao, Peihu Fan, Dong An, Ping Yang, Jingcai Lu, Xiuping Lv, Bo Sun, Fei Xu, Wei Kong & Chunlai Jiang. (2014) Evaluation of monovalent and bivalent vaccines against lethal Enterovirus 71 and Coxsackievirus A16 infection in newborn mice. Human Vaccines & Immunotherapeutics 10:10, pages 2885-2895.
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Articles from other publishers (30)

Hamid Motamedi, Amirhoushang Alvandi, Matin Fathollahi, Marzie Mahdizade Ari, Sajad Moradi, Jale Moradi & Ramin Abiri. (2023) In silico designing and immunoinformatics analysis of a novel peptide vaccine against metallo-beta-lactamase (VIM and IMP) variants. PLOS ONE 18:7, pages e0275237.
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Kevin Messacar, Matthew R. Vogt, Edwin J. Asturias & Mark J. Abzug. 2023. Plotkin's Vaccines. Plotkin's Vaccines 330 340.e5 .
Subrat Kumar Swain, Ayushman Gadnayak, Jatindra Nath Mohanty, Rachita Sarangi & Jayashankar Das. (2022) Does enterovirus 71 urge for effective vaccine control strategies? Challenges and current opinion. Reviews in Medical Virology 32:4.
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Yu Li, Yonghong Zhou, Yibing Cheng, Peng Wu, Chongchen Zhou, Peng Cui, Chunlan Song, Lu Liang, Fang Wang, Qi Qiu, Chun Guo, Mengyao Zeng, Lu Long, Benjamin J Cowling & Hongjie Yu. (2019) Effectiveness of EV-A71 vaccination in prevention of paediatric hand, foot, and mouth disease associated with EV-A71 virus infection requiring hospitalisation in Henan, China, 2017–18: a test-negative case-control study. The Lancet Child & Adolescent Health 3:10, pages 697-704.
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Ye Tian, Kai Zhou, Jing Hu, Ming-Feng Shan, Hong-Jian Chen, Shan Cheng, Li-Fei Liu & Xiao-Li Mei. (2019) Scavenger receptor class a, member 3 is associated with severity of hand, foot, and mouth disease in a case-control study. Medicine 98:40, pages e17471.
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Yuying Ma, Chengyou Shang, Peng Yang, Linfeng Li, Yangyang Zhai, Zheng Yin, Binghe Wang & Luqing Shang. (2018) 4-Iminooxazolidin-2-one as a Bioisostere of the Cyanohydrin Moiety: Inhibitors of Enterovirus 71 3C Protease. Journal of Medicinal Chemistry 61:22, pages 10333-10339.
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Gillian Cooper, Qunying Mao, Laura Crawt, Yiping Wang, Thomas Dougall, Peter Rigsby, Zhenglun Liang, Miao Xu, Philip Minor, Junzhi Wang & Javier Martin. (2018) Establishment of the 1st WHO International Standard for anti-EV71 serum (Human). Biologicals 53, pages 39-50.
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Susanna Esposito & Nicola Principi. (2018) Hand, foot and mouth disease: current knowledge on clinical manifestations, epidemiology, aetiology and prevention. European Journal of Clinical Microbiology & Infectious Diseases 37:3, pages 391-398.
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Xiaoli Wang, Zhiqiang Ku, Xiang Zhang, Xiaohua Ye, Jinhuan Chen, Qingwei Liu, Wei Zhang, Chao Zhang, Zhenglin Fu, Xia Jin, Yao Cong & Zhong Huang. (2018) Structure, Immunogenicity, and Protective Mechanism of an Engineered Enterovirus 71-Like Particle Vaccine Mimicking 80S Empty Capsid. Journal of Virology 92:1.
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Pele Choi-Sing Chong & Michel Klein. 2018. Plotkin's Vaccines. Plotkin's Vaccines 288 294.e3 .
Li Shi, Xingxiao Yin, Ying Li, Fei Shen & Jingsi Yang. (2017) China-invented vaccines against vaccine-preventable diseases for Belt & Road countries. Global Health Journal 1:3, pages 11-19.
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Jie Song, Yajie Hu, Jiaqi Li, Huiwen Zheng, Jingjing Wang, Lei Guo, Ruotong Ning, Hongzhe Li, Zening Yang, Haitao Fan & Longding Liu. (2017) Different microRNA profiles reveal the diverse outcomes induced by EV71 and CA16 infection in human umbilical vein endothelial cells using high-throughput sequencing. PLOS ONE 12:5, pages e0177657.
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Yajie Hu, Jie Song, Longding Liu, Jing Li, Beibei Tang, Ying Zhang, Jingjing Wang, Lichun Wang, Shengtao Fan, Ming Feng & Qihan Li. (2017) Comparison analysis of microRNAs in response to EV71 and CA16 infection in human bronchial epithelial cells by high-throughput sequencing to reveal differential infective mechanisms. Virus Research 228, pages 90-101.
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Lei Yin Emily Ang, Horng Khit Issac Too, Eng Lee Tan, Tak-Kwong Vincent Chow, Pei-Chi Lynette Shek, Elizabeth Tham & Sylvie Alonso. (2016) Antiviral activity of Lactobacillus reuteri Protectis against Coxsackievirus A and Enterovirus 71 infection in human skeletal muscle and colon cell lines. Virology Journal 13:1.
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Yajie Hu, Jie Song, Longding Liu, Jing Li, Beibei Tang, Jingjing Wang, Xiaolong Zhang, Ying Zhang, Lichun Wang, Yun Liao, Zhanlong He & Qihan Li. (2016) Different microRNA alterations contribute to diverse outcomes following EV71 and CA16 infections: Insights from high-throughput sequencing in rhesus monkey peripheral blood mononuclear cells. The International Journal of Biochemistry & Cell Biology 81, pages 20-31.
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Ping-Chin Chang, Shou-Chien Chen & Kow-Tong Chen. (2016) The Current Status of the Disease Caused by Enterovirus 71 Infections: Epidemiology, Pathogenesis, Molecular Epidemiology, and Vaccine Development. International Journal of Environmental Research and Public Health 13:9, pages 890.
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Shih-Yeh Lin, Hsin-Yi Chiu, Bor-Luen Chiang & Yu-Chen Hu. (2015) Development of EV71 virus-like particle purification processes. Vaccine 33:44, pages 5966-5973.
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Margarita Pons-Salort, Edward P.K. Parker & Nicholas C. Grassly. (2015) The epidemiology of non-polio enteroviruses. Current Opinion in Infectious Diseases 28:5, pages 479-487.
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Y. Y. ZHAO, H. JIN, X. F. ZHANG & B. WANG. (2015) Case-fatality of hand, foot and mouth disease associated with EV71: a systematic review and meta-analysis. Epidemiology and Infection 143:14, pages 3094-3102.
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Ya-Qian Hu, Guang-Cheng Xie, Dan-Di Li, Li-Li Pang, Jing Xie, Peng Wang, Ying Chen, Jing Yang, Wei-Xia Cheng, Qing Zhang, Yu Jin & Zhao-Jun Duan. (2015) Prevalence of Coxsackievirus A6 and Enterovirus 71 in Hand, Foot and Mouth Disease in Nanjing, China in 2013. Pediatric Infectious Disease Journal 34:9, pages 951-957.
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Chia-Ying Wu, Yi-Wen Lin, Chia-Ho Kuo, Wan-Hsin Liu, Hsiu-Fen Tai, Chien-Hung Pan, Yung-Tsung Chen, Pei-Wen Hsiao, Chi-Hsien Chan, Ching-Chuan Chang, Chung-Cheng Liu, Yen-Hung Chow & Juine-Ruey Chen. (2015) Inactivated Enterovirus 71 Vaccine Produced by 200-L Scale Serum-Free Microcarrier Bioreactor System Provides Cross-Protective Efficacy in Human SCARB2 Transgenic Mouse. PLOS ONE 10:8, pages e0136420.
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Li Wei Ang, Joanne Tay, Meng Chee Phoon, Jung Pu Hsu, Jeffery Cutter, Lyn James, Kee Tai Goh & Vincent Tak-Kwong Chow. (2015) Seroepidemiology of Coxsackievirus A6, Coxsackievirus A16, and Enterovirus 71 Infections among Children and Adolescents in Singapore, 2008-2010. PLOS ONE 10:5, pages e0127999.
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P. Chong, C.-C. Liu, Y.-H. Chow, A.-H. Chou & M. Klein. (2014) Review of Enterovirus 71 Vaccines. Clinical Infectious Diseases 60:5, pages 797-803.
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Jae-Hyoung Song, Kwisung Park, Aeri Shim, Bo-Eun Kwon, Jae-Hee Ahn, Young Jin Choi, Jae Kyung Kim, Sang-Gu Yeo, Kyungah Yoon & Hyun-Jeong Ko. (2015) Complete Sequence Analysis and Antiviral Screening of Medicinal Plants for Human Coxsackievirus A16 Isolated in Korea. Osong Public Health and Research Perspectives 6:1, pages 52-58.
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Qingwei Liu, Xin Tong & Zhong Huang. (2015) Towards broadly protective polyvalent vaccines against hand, foot and mouth disease. Microbes and Infection 17:2, pages 155-162.
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Hui Zhao, Hao-Yang Li, Jian-Feng Han, Yong-Qiang Deng, Shun-Ya Zhu, Xiao-Feng Li, Hui-Qin Yang, Yue-Xiang Li, Yu Zhang, E-De Qin, Rong Chen & Cheng-Feng Qin. (2015) Novel recombinant chimeric virus-like particle is immunogenic and protective against both enterovirus 71 and coxsackievirus A16 in mice. Scientific Reports 5:1.
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Cheng-Lin Deng, Huimin Yeo, Han-Qing Ye, Si-Qing Liu, Bao-Di Shang, Peng Gong, Sylvie Alonso, Pei-Yong Shi & Bo Zhang. (2014) Inhibition of Enterovirus 71 by Adenosine Analog NITD008. Journal of Virology 88:20, pages 11915-11923.
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Chia-Chyi Liu, Yen-Hung Chow, Pele Chong & Michel Klein. (2014) Prospect and challenges for the development of multivalent vaccines against hand, foot and mouth diseases. Vaccine 32:47, pages 6177-6182.
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Jing-Xin Li & Feng-Cai Zhu. (2014) Clinical progress for enterovirus 71 vaccines: what does the future hold?. Clinical Investigation 4:8, pages 679-681.
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Jingjing Wang, Sudong Qi, Xiaolong Zhang, Ying Zhang, Longding Liu, Yanchun Che, Zhanlong He, Yuan Zhao, Shuaiyao Lu, Wenhai Yu & Qihan Li. (2014) Coxsackievirus A 16 infection does not interfere with the specific immune response induced by an enterovirus 71 inactivated vaccine in rhesus monkeys. Vaccine 32:35, pages 4436-4442.
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