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Expert Review of Vaccines Volume 4, 2005 - Issue 6
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Review

Current status and future prospects for a vaccine against American trypanosomiasis

Nisha Garg Sealy Center for Vaccine Development, Department of Microbiology, Immunology and Pathology, University of Texas Medical Branch, Galveston TX 77555, USA. [email protected]
&
Vandanajay Bhatia Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX 77555-1070, USA. [email protected]
Pages 867-880 | Published online: 09 Jan 2014

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Herbert B Tanowitz, Fabiana S Machado, David C Spray, Joel M Friedman, Oren S Weiss, Jose N Lora, Jyothi Nagajyothi, Diego N Moraes, Nisha Jain Garg, Maria Carmo P Nunes & Antonio Luiz P Ribeiro. (2015) Developments in the management of Chagas cardiomyopathy. Expert Review of Cardiovascular Therapy 13:12, pages 1393-1409.
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Fernando J Sánchez-Valdéz, Cecilia Pérez Brandán, Arturo Ferreira & Miguel Ángel Basombrío. (2015) Gene-deleted live-attenuated Trypanosoma cruzi parasites as vaccines to protect against Chagas disease. Expert Review of Vaccines 14:5, pages 681-697.
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Anna Maria Spagnuolo, Meir Shillor, Lindsey Kingsland, Andrea Thatcher, Matthew Toeniskoetter & Benjamin Wood. (2012) A logistic delay differential equation model for Chagas disease with interrupted spraying schedules. Journal of Biological Dynamics 6:2, pages 377-394.
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Israel Quijano-Hernandez & Eric Dumonteil. (2011) Advances and challenges towards a vaccine against Chagas disease. Human Vaccines 7:11, pages 1184-1191.
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Anna Maria Spagnuolo, Meir Shillor & Gabrielle A. Stryker. (2011) A model for Chagas disease with controlled spraying. Journal of Biological Dynamics 5:4, pages 299-317.
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Silvia Inés Cazorla, Fernanda María Frank & Emilio Luis Malchiodi. (2009) Vaccination approaches against Trypanosoma cruzi infection. Expert Review of Vaccines 8:7, pages 921-935.
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Soodabeh Saeidnia, Ahmad Reza Gohari & Azita Haddadi. (2013) Biogenic trypanocidal sesquiterpenes: lead compounds to design future trypanocidal drugs - a mini review. DARU Journal of Pharmaceutical Sciences 21:1.
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Juan C. Vázquez-Chagoyán, Shivali Gupta & Nisha Jain Garg. 2011. Chagas Disease, Part A. Chagas Disease, Part A 121 146 .
Shivali Gupta & Nisha Jain Garg. (2010) Prophylactic Efficacy of TcVac2 against Trypanosoma cruzi in Mice. PLoS Neglected Tropical Diseases 4:8, pages e797.
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Iveth J. González, Michael A. Miles & Mark D. Perkins. 2010. Infectious Diseases. Infectious Diseases 1205 1212 .
Angel Marcelo Padilla, Cecilia Perez Brandan & Miguel Angel Basombrío. 2010. American Trypanosomiasis. American Trypanosomiasis 827 848 .
Eric Dumonteil. (2009) Vaccine development against Trypanosoma cruzi and Leishmania species in the post-genomic era. Infection, Genetics and Evolution 9:6, pages 1075-1082.
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Ernesto S. Nakayasu, Matthew R. Gaynor, Tiago J. P. Sobreira, Jeremy A. Ross & Igor C. Almeida. (2009) Phosphoproteomic analysis of the human pathogen Trypanosoma cruzi at the epimastigote stage . PROTEOMICS 9:13, pages 3489-3506.
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Enrique I. Ramos, Kristine M. Garza, R. L. Krauth-Siegel, Julia Bader, Luiz E. Martinez & Rosa A. Maldonado. (2009) 2,3-Diphenyl-1,4-Naphthoquinone: A Potential Chemotherapeutic Agent Against Trypanosoma cruzi. Journal of Parasitology 95:2, pages 461-466.
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Valeria Tekiel, Catalina D. Alba-Soto, Stella M. González Cappa, Miriam Postan & Daniel O. Sánchez. (2009) Identification of novel vaccine candidates for Chagas’ disease by immunization with sequential fractions of a trypomastigote cDNA expression library. Vaccine 27:9, pages 1323-1332.
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Vandanajay Bhatia & Nisha Jain Garg. (2008) Previously Unrecognized Vaccine Candidates Control Trypanosoma cruzi Infection and Immunopathology in Mice . Clinical and Vaccine Immunology 15:8, pages 1158-1164.
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Vanessa Migliaccio, Fabiana R. Santos, Pietro Ciancaglini & F. Juarez Ramalho-Pinto. (2008) Use of proteoliposome as a vaccine against Trypanosoma cruzi in mice. Chemistry and Physics of Lipids 152:2, pages 86-94.
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Daniel F. Hoft, Christopher S. Eickhoff, Olivia K. Giddings, José R. C. Vasconcelos & Maurício M. Rodrigues. (2007) Trans -Sialidase Recombinant Protein Mixed with CpG Motif-Containing Oligodeoxynucleotide Induces Protective Mucosal and Systemic Trypanosoma cruzi Immunity Involving CD8+ CTL and B Cell-Mediated Cross-Priming . The Journal of Immunology 179:10, pages 6889-6900.
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M. Nia Madison, Yuliya Y. Kleshchenko, Pius N. Nde, Kaneatra J. Simmons, Maria F. Lima & Fernando Villalta. (2007) Human Defensin α-1 Causes Trypanosoma cruzi Membrane Pore Formation and Induces DNA Fragmentation, Which Leads to Trypanosome Destruction . Infection and Immunity 75:10, pages 4780-4791.
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Gilma Sanchez-Burgos, R. Gabino Mezquita-Vega, Javier Escobedo-Ortegon, Maria Jesus Ramirez-Sierra, Arletty Arjona-Torres, Ali Ouaissi, Mauricio M. Rodrigues & Eric Dumonteil. (2007) Comparative evaluation of therapeutic DNA vaccines against Trypanosoma cruzi in mice . FEMS Immunology & Medical Microbiology 50:3, pages 333-341.
Crossref
Eric Dumonteil. (2007) DNA Vaccines against Protozoan Parasites: Advances and Challenges. Journal of Biomedicine and Biotechnology 2007, pages 1-11.
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