578
Views
42
CrossRef citations to date
0
Altmetric
Reviews

The Bcl-2/Bax and Ras/Raf/MEK/ERK signaling pathways: implications in pediatric leukemia pathogenesis and new prospects for therapeutic approaches

, , , , &
Pages 587-597 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Xinmei Yang, Xijun Wu, Xiaosen Wu, Lei Huang, Jingrui Song, Chunmao Yuan, Zhixu He & Yanmei Li. (2022) The Flavagline Compound 1-(2-(dimethylamino)acetyl)-Rocaglaol Induces Apoptosis in K562 Cells by Regulating the PI3K/Akt/mTOR, JAK2/STAT3, and MAPK Pathways. Drug Design, Development and Therapy 16, pages 2545-2557.
Read now
Paulina Wyrozumska, Justyna Meissner, Monika Toporkiewicz, Marta Szarawarska, Kazimierz Kuliczkowski, Maciej Ugorski, Marta A Walasek & Aleksander F Sikorski. (2015) Liposome-coated lipoplex–based carrier for antisense oligonucleotides. Cancer Biology & Therapy 16:1, pages 66-76.
Read now
Xiaosheng Lu, Jinmin Zhao, Tingyang Li, Meijing Huang, Jian Liang & Wen Wei. (2015) 5,7-Dihydroxy-4′-methoxyisoflavone induces apoptosis by inhibiting the ERK and Akt pathways in human osteosarcoma cells. Connective Tissue Research 56:1, pages 59-64.
Read now

Articles from other publishers (39)

Mohamed M. Saleh, Tarek El-Moselhy, Eman El-Bastawissy, Mahmoud A.A. Ibrahim, Shaban R.M. Sayed, Mohamed-Elamir F. Hegazy, Thomas Efferth, Laila A. Jaragh-Alhadad & Peter A. Sidhom. (2023) The mystery of titan hunter: Rationalized striking of the MAPK pathway via Newly synthesized 6‐Indolylpyridone‐3‐Carbonitrile derivatives. European Journal of Medicinal Chemistry 259, pages 115675.
Crossref
Prajya Arya, Mohona Munshi & Pradyuman Kumar. (2023) Diosgenin: Chemistry, extraction, quantification and health benefits. Food Chemistry Advances 2, pages 100170.
Crossref
Camille A. McAloney, Rawan Makkawi, Yogesh Budhathoki, Matthew V. Cannon, Emily M. Franz, Amy C. Gross, Maren Cam, Tatyana A. Vetter, Rebekka Duhen, Alexander E. Davies & Ryan D. Roberts. (2023) Host-derived growth factors drive ERK phosphorylation and MCL1 expression to promote osteosarcoma cell survival during metastatic lung colonization. Cellular Oncology.
Crossref
Sultan Ayesh Mohammed Saghir. (2023) A new insight updates in diagnosis and management of acute lymphoblastic leukemia, cytogenetics, immunophenotyping, and proteomic profile. Electronic Journal of General Medicine 20:5, pages em519.
Crossref
Xia Li, Joanna J Tibenda, Yi Nan, Shi-Cong Huang, Na Ning, Guo-Qing Chen, Yu-Hua Du, Ya-Ting Yang, Fan-Di Meng & Ling Yuan. (2023) MiR-204-3p overexpression inhibits gastric carcinoma cell proliferation by inhibiting the MAPK pathway and RIP1/MLK1 necroptosis pathway to promote apoptosis. World Journal of Gastroenterology 29:29, pages 4542-4556.
Crossref
Zohreh Gholizadeh Siahmazgi, Shiva Irani, Ali Ghiaseddin, Parviz Fallah & Vahid Haghpanah. (2023) Xanthohumol hinders invasion and cell cycle progression in cancer cells through targeting MMP2, MMP9, FAK and P53 genes in three-dimensional breast and lung cancer cells culture. Cancer Cell International 23:1.
Crossref
Ying Zheng, Qingyu Zhang, Lingyang Jing, Yifan Fei & Hongfeng Zhao. (2022) The Effects of Chronic Lead Exposure on Testicular Development of Japanese Quail (Coturnix japonica): Histopathological Damages, Oxidative Stress, Steroidogenesis Disturbance, and Hypothalamus-Pituitary-Testis Axis Disruption. Biological Trace Element Research 201:7, pages 3446-3460.
Crossref
Jeong Gong, Ji Kim, So Park, Su Lee, Yun Choi, Sun Choi, Young Choi, Hee Lee, Jin Hong & Dae Hwang. (2023) Anti‑tumor effects of an aqueous extract of Ecklonia cava in BALB/cKorl syngeneic mice using colon carcinoma CT26 cells . Oncology Reports 49:6.
Crossref
Yasmin A. Ebedy, Mohamed O. Elshazly, Neven H. Hassan, Marwa A. Ibrahim & Eman I. Hassanen. (2022) Novel insights into the potential mechanisms underlying carbendazim‐induced hepatorenal toxicity in rats. Journal of Biochemical and Molecular Toxicology 36:8.
Crossref
Eman I. Hassanen, Yasmin A. Ebedy, Marwa A. Ibrahim, Khaled Y. Farroh & M.O. Elshazly. (2022) Insights overview on the possible protective effect of chitosan nanoparticles encapsulation against neurotoxicity induced by carbendazim in rats. NeuroToxicology 91, pages 31-43.
Crossref
Tanya Trippett, Helen Toledano, Quentin Campbell Hewson, Arnauld Verschuur, Anne-Marie Langevin, Isabelle Aerts, Lisa Howell, Soledad Gallego, Claudia Rossig, Amy Smith, Darshak Patel, Leonardo R. Pereira, Sravanthi Cheeti, Luna Musib, Katherine E. Hutchinson, Clare Devlin, Ronald Bernardi & Birgit Geoerger. (2022) Cobimetinib in Pediatric and Young Adult Patients with Relapsed or Refractory Solid Tumors (iMATRIX-cobi): A Multicenter, Phase I/II Study. Targeted Oncology 17:3, pages 283-293.
Crossref
Qijun Jiang, Qiao Chen, Chengpeng Li, Zhigang Gong, Zhigang Li & Shifang Ding. (2022) ox-LDL-Induced Endothelial Progenitor Cell Oxidative Stress via p38/Keap1/Nrf2 Pathway. Stem Cells International 2022, pages 1-15.
Crossref
Jeong Eun Gong, Ji Eun Kim, Su Jin Lee, Yun Ju Choi, You Jeong Jin, Young Whan Choi, Sun Il Choi & Dae Youn Hwang. (2022) Anti-Cancer Effects of α-Cubebenoate Derived from Schisandra chinensis in CT26 Colon Cancer Cells. Molecules 27:3, pages 737.
Crossref
Monaj Kumar Sarkar, Amrita Kar, Adithyan Jayaraman, Santanu Kar Mahapatra & Vellingiri Vadivel. (2022) Vitexin isolated from Prosopis cineraria leaves induce apoptosis in K-562 leukemia cells via inhibition of the BCR-ABL-Ras-Raf pathway . Journal of Pharmacy and Pharmacology 74:1, pages 103-111.
Crossref
Monaj Kumar Sarkar, Amrita Kar, Adithyan Jayaraman, Santanu Kar Mahapatra & Vellingiri Vadivel. (2021) Pharmacokinetic properties and anti-proliferative mechanisms of vanillin against acute lymphoblastic leukemia (Jurkat) cells. South African Journal of Botany 142, pages 82-87.
Crossref
Mi Ju Kang, Ji Eun Kim, Ji Won Park, Hyun Jun Choi, Su Ji Bae, Sun Il Choi, Jin Tae Hong & Dae Youn Hwang. (2021) Effects of Gallotannin-Enriched Extract of Galla Rhois on the Activation of Apoptosis, Cell Cycle Arrest, and Inhibition of Migration Ability in LLC1 Cells and LLC1 Tumors. Pathology and Oncology Research 27.
Crossref
Piao-Piao Li, Yi Yan, Hai-Tao Zhang, Shi-he Cui, Cheng-Han Wang, Wei Wei, Hong-Gang Qian, Jian-Cheng Wang & Qiang Zhang. (2020) Biological activities of siRNA-loaded lanthanum phosphate nanoparticles on colorectal cancer. Journal of Controlled Release 328, pages 45-58.
Crossref
Simona D’Aguanno & Donatella Del Bufalo. (2020) Inhibition of Anti-Apoptotic Bcl-2 Proteins in Preclinical and Clinical Studies: Current Overview in Cancer. Cells 9:5, pages 1287.
Crossref
Tao Jiang, Guowei Zhang, Yaozhong Liang, Zhenbin Cai, Zhi Liang, Hongsheng Lin & Minghui Tan. (2020) PlexinA3 Interacts with CRMP2 to Mediate Sema3A Signalling During Dendritic Growth in Cultured Cerebellar Granule Neurons. Neuroscience 434, pages 83-92.
Crossref
Junshan Liu, Jun Zheng, Xiaochun Lin, Shuntong Bai, Qiudi Deng, Wanjiao Gao, Hongling Zhou & Li Tong. (2020) The Total Flavonoid Extract from Glycyrrhiza inflat Bat. Suppresses Atrophic Gastritis in Rats through the Akt/MAPK Pathway . Evidence-Based Complementary and Alternative Medicine 2020, pages 1-9.
Crossref
Choo, Loh & Chen. (2019) Destined to Die: Apoptosis and Pediatric Cancers. Cancers 11:11, pages 1623.
Crossref
Sukesh Kumar Gupta, Shishir Kumar Patel, Munendra Singh Tomar, Shio Kumar Singh, Manoj Kumar Mesharam & Sairam Krishnamurthy. (2019) Long-term exposure of 2450 MHz electromagnetic radiation induces stress and anxiety like behavior in rats. Neurochemistry International 128, pages 1-13.
Crossref
Jian‐Ping Wang, Xuan‐Yang Huang, Ke‐Ying Zhang, Xue‐Mei Ding, Qiu‐Feng Zeng, Shi‐Ping Bai, Pietro Celi, Lei Yan, Huan‐Wei Peng & Xiang‐Bing Mao. (2018) Involvement of P38 and ERK1/2 in mitochondrial pathways independent cell apoptosis in oviduct magnum epithelial cells of layers challenged with vanadium. Environmental Toxicology 33:12, pages 1312-1320.
Crossref
Tao Chen, Shu‑Jun Li, Bin Chen, Qiong Huang, Xiang‑Ying Kong, Chen Shen, Hai‑Tao Gu & Xiao‑Wei Wang. (2018) Akt3 is a target of miR-29c-3p and serves an important function in the pathogenesis of congenital heart disease. International Journal of Molecular Medicine.
Crossref
Yu Zhou, Chaolin Ma, Bao-Ming Li & Chong Sun. (2018) Polygala japonica Houtt. reverses depression-like behavior and restores reduced hippocampal neurogenesis in chronic stress mice. Biomedicine & Pharmacotherapy 99, pages 986-996.
Crossref
Shiwei Hu, Jinhui Wang, Jingfeng Wang, Huicheng Yang, Shijie Li, Wei Jiang, Yu Liu & Jialiang Li. (2018) Long-chain bases from sea cucumber inhibits renal fibrosis and apoptosis in type 2 diabetic mice. Journal of Functional Foods 40, pages 760-768.
Crossref
Lingdi Ma, Zhenyu Xu, Jian Wang, Zhichao Zhu, Guibin Lin, Lijia Jiang, Xuzhang Lu & Chang Zou. (2017) Matrine inhibits BCR/ABL mediated ERK/MAPK pathway in human leukemia cells. Oncotarget 8:65, pages 108880-108889.
Crossref
Andrea Nicolini, Paola Ferrari, Lucrezia Diodati & Angelo Carpi. (2017) Recent Advances in Comprehending the Signaling Pathways Involved in the Progression of Breast Cancer. International Journal of Molecular Sciences 18:11, pages 2321.
Crossref
Hui Zhang, Yueyue Li, Linqiang Li, Hua Liu, Liangkai Hu, Ying Dai, Jianqing Chen, Shuqi Xu, Weimin Chen, Xiaorong Xu & Xuanfu Xu. (2017) Propylene Glycol Alginate Sodium Sulfate Alleviates Cerulein‐Induced Acute Pancreatitis by Modulating the MEK/ERK Pathway in Mice. Marine Drugs 15:2, pages 45.
Crossref
Nan Zhang, Canrong Lu & Lin Chen. (2016) miR-217 regulates tumor growth and apoptosis by targeting the MAPK signaling pathway in colorectal cancer. Oncology Letters 12:6, pages 4589-4597.
Crossref
Quanquan Wang, Lili Zhang, Xiaodong Yuan, Ya Ou, Xuhong Zhu, Zanzan Cheng, Pingshu Zhang, Xiaoying Wu, Yan Meng & Liping Zhang. (2016) The Relationship between the Bcl-2/Bax Proteins and the Mitochondria-Mediated Apoptosis Pathway in the Differentiation of Adipose-Derived Stromal Cells into Neurons. PLOS ONE 11:10, pages e0163327.
Crossref
Zhongming Huang, Junhua Li, Shaohua Du, Yanghua Tang, Ligang Huang, Luwei Xiao & Peijian Tong. (2016) FKBP14 overexpression contributes to osteosarcoma carcinogenesis and indicates poor survival outcome. Oncotarget 7:26, pages 39872-39884.
Crossref
Minjie Gao, Gege Chen, Houcai Wang, Bingqian Xie, Liangning Hu, Yuanyuan Kong, Guang Yang, Yi Tao, Ying Han, Xiaosong Wu, Yiwen Zhang, Bojie Dai & Jumei Shi. (2016) Therapeutic potential and functional interaction of carfilzomib and vorinostat in T-cell leukemia/lymphoma. Oncotarget 7:20, pages 29102-29115.
Crossref
Xiaodong Yuan, Lili Zhang, Shujuan Wang, Ya Ou, Quanquan Wang, Wei Peng, Hongjie Luo, Zanzan Cheng & Xuhong Zhu. (2016) Mitochondrial apoptosis and autophagy in the process of adipose-derived stromal cell differentiation into astrocytes. Cell Biology International 40:2, pages 156-165.
Crossref
Ramzi M. Mohammad, Irfana Muqbil, Leroy Lowe, Clement Yedjou, Hsue-Yin Hsu, Liang-Tzung Lin, Markus David Siegelin, Carmela Fimognari, Nagi B. Kumar, Q. Ping Dou, Huanjie Yang, Abbas K. Samadi, Gian Luigi Russo, Carmela Spagnuolo, Swapan K. Ray, Mrinmay Chakrabarti, James D. Morre, Helen M. Coley, Kanya Honoki, Hiromasa Fujii, Alexandros G. Georgakilas, Amedeo Amedei, Elena Niccolai, Amr Amin, S. Salman Ashraf, William G. Helferich, Xujuan Yang, Chandra S. Boosani, Gunjan Guha, Dipita Bhakta, Maria Rosa Ciriolo, Katia Aquilano, Sophie Chen, Sulma I. Mohammed, W. Nicol Keith, Alan Bilsland, Dorota Halicka, Somaira Nowsheen & Asfar S. Azmi. (2015) Broad targeting of resistance to apoptosis in cancer. Seminars in Cancer Biology 35, pages S78-S103.
Crossref
Na-Na Wang, Zhi-Heng Li, He Zhao, Yan-Fang Tao, Li-Xiao Xu, Jun Lu, Lan Cao, Xiao-Juan Du, Li-Chao Sun, Wen-Li Zhao, Pei-Fang Xiao, Fang Fang, Guang-Hao Su, Yan-Hong Li, Gang Li, Yi-Ping Li, Yun-Yun Xu, Hui-Ting Zhou, Yi Wu, Mei-Fang Jin, Lin Liu, Jian Ni, Jian Wang, Shao-Yan Hu, Xue-Ming Zhu, Xing Feng & Jian Pan. (2015) Molecular Targeting of the Oncoprotein PLK1 in Pediatric Acute Myeloid Leukemia: RO3280, a Novel PLK1 Inhibitor, Induces Apoptosis in Leukemia Cells. International Journal of Molecular Sciences 16:1, pages 1266-1292.
Crossref
Tomasz Cierpicki & Jolanta Grembecka. (2014) Targeting protein–protein interactions in hematologic malignancies: still a challenge or a great opportunity for future therapies?. Immunological Reviews 263:1, pages 279-301.
Crossref
Elena López Villar, Duojiao Wu, William C. Cho, Luis Madero & Xiangdong Wang. (2014) Proteomics‐based discovery of biomarkers for paediatric acute lymphoblastic leukaemia: challenges and opportunities. Journal of Cellular and Molecular Medicine 18:7, pages 1239-1246.
Crossref
Jie Zheng, Wei Du, Lai-jun Song, Rui Zhang, Lai-guang Sun, Feng-guo Chen & Xin-ting Wei. (2014) Norcantharidin induces growth inhibition and apoptosis of glioma cells by blocking the Raf/MEK/ERK pathway. World Journal of Surgical Oncology 12:1, pages 207.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.