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Review

Current understanding of hepatic and intestinal OATP-mediated drug–drug interactions

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Pages 729-742 | Published online: 10 Jan 2014

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Fengjiao Wen, Meizhi Shi, Jialin Bian, Hongjian Zhang & Chunshan Gui. (2016) Identification of natural products as modulators of OATP2B1 using LC-MS/MS to quantify OATP-mediated uptake. Pharmaceutical Biology 54:2, pages 293-302.
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Anima M. Schäfer, Pierrine M. Gilgen, Clara Spirgi, Olivier Potterat & Henriette E. Meyer zu Schwabedissen. (2021) Constituents of Passiflora incarnata, but Not of Valeriana officinalis, Interact with the Organic Anion Transporting Polypeptides (OATP)2B1 and OATP1A2. Planta Medica 88:02, pages 152-162.
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Janine Hussner, Annalise Foletti, Isabell Seibert, Anja Fuchs, Eveline Schuler, Vanessa Malagnino, Markus Grube & Henriette E. Meyer zu Schwabedissen. (2021) Differences in transport function of the human and rat orthologue of the Organic Anion Transporting Polypeptide 2B1 (OATP2B1). Drug Metabolism and Pharmacokinetics 41, pages 100418.
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Yasin Ahmadi, Neda Mahmoudi, Bahman Yousefi & Ansar Karimian. (2020) The effects of statins with a high hepatoselectivity rank on the extra-hepatic tissues; New functions for statins. Pharmacological Research 152, pages 104621.
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Rachael R. Schulte & Richard H. Ho. (2019) Organic Anion Transporting Polypeptides: Emerging Roles in Cancer Pharmacology. Molecular Pharmacology 95:5, pages 490-506.
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Keumhan Noh & K. Sandy Pang. (2019) Theoretical consideration of the properties of intestinal flow models on route‐dependent drug removal: Segregated Flow (SFM) vs. Traditional (TM). Biopharmaceutics & Drug Disposition 40:5-6, pages 195-213.
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Savannah J. McFeely, Lanxiang Wu, Tasha K. Ritchie & Jashvant Unadkat. (2019) Organic anion transporting polypeptide 2B1 – More than a glass-full of drug interactions. Pharmacology & Therapeutics 196, pages 204-215.
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Lucie Navrátilová, Lenka Applová, Pavel Horký, Přemysl Mladěnka, Petr Pávek & František Trejtnar. (2018) Interaction of soy isoflavones and their main metabolites with hOATP2B1 transporter. Naunyn-Schmiedeberg's Archives of Pharmacology 391:10, pages 1063-1071.
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Leonidas Georgiou, Jeffrey Penny, Glynis Nicholls, Neil Woodhouse, François-Xavier Blé, Josephine H. Naish & Penny L. Hubbard Cristinacce. (2018) Modeling Gadoxetate Liver Uptake and Efflux Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging Enables Preclinical Quantification of Transporter Drug-Drug Interactions. Investigative Radiology 53:9, pages 563-570.
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R.H. Ho & R.B. Kim. 2018. Comprehensive Toxicology. Comprehensive Toxicology 574 616 .
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Jingjing Yu, Zhu Zhou, Jessica Tay-Sontheimer, René H. Levy & Isabelle Ragueneau-Majlessi. (2017) Intestinal Drug Interactions Mediated by OATPs: A Systematic Review of Preclinical and Clinical Findings. Journal of Pharmaceutical Sciences 106:9, pages 2312-2325.
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S. Ayalasomayajula, Y. Han, T. Langenickel, K. Malcolm, W. Zhou, I. Hanna, N. Alexander, A. Natrillo, B. Goswami, M. Hinder & G. Sunkara. (2016) In vitro and clinical evaluation of OATP-mediated drug interaction potential of sacubitril/valsartan (LCZ696) . Journal of Clinical Pharmacy and Therapeutics 41:4, pages 424-431.
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Wei-Yu Hou, Shang-Fu Xu, Qiong-Ni Zhu, Yuan-Fu Lu, Xing-Guo Cheng & Jie Liu. (2014) Age- and sex-related differences of organic anion-transporting polypeptide gene expression in livers of rats. Toxicology and Applied Pharmacology 280:2, pages 370-377.
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Zuzana Matuskova, Eva Anzenbacherova, Rostislav Vecera, Helena Tlaskalova-Hogenova, Milan Kolar & Pavel Anzenbacher. (2014) Administration of a Probiotic Can Change Drug Pharmacokinetics: Effect of E. coli Nissle 1917 on Amidarone Absorption in Rats. PLoS ONE 9:2, pages e87150.
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Varun Khurana, Mukul Minocha, Dhananjay Pal & Ashim K. Mitra. (2014) Role of OATP-1B1 and/or OATP-1B3 in hepatic disposition of tyrosine kinase inhibitors. Drug Metabolism and Drug Interactions 29:3.
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Fei Xu, Zhen Li, Jian Zheng, Florence Shin Gee Cheung, Ting Chan, Ling Zhu, Hongxiang Zhuge & Fanfan Zhou. (2013) The Inhibitory Effects of the Bioactive Components Isolated from Scutellaria Baicalensis on the Cellular Uptake Mediated by the Essential Solute Carrier Transporters. Journal of Pharmaceutical Sciences 102:11, pages 4205-4211.
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Benoit Chauvin, Sylvain Drouot, Aurélie Barrail-Tran & Anne-Marie Taburet. (2013) Drug–Drug Interactions Between HMG-CoA Reductase Inhibitors (Statins) and Antiviral Protease Inhibitors. Clinical Pharmacokinetics 52:10, pages 815-831.
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Zhihao Liu & Kexin Liu. (2013) The transporters of intestinal tract and techniques applied to evaluate interactions between drugs and transporters. Asian Journal of Pharmaceutical Sciences 8:3, pages 151-158.
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Kathleen Köck, Ying Xie, Roy L. Hawke, Nicholas H. Oberlies & Kim L. R. Brouwer. (2013) Interaction of Silymarin Flavonolignans with Organic Anion-Transporting Polypeptides. Drug Metabolism and Disposition 41:5, pages 958-965.
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Masahiro Segawa, Jiro Ogura, Satoru Seki, Shirou Itagaki, Natsuko Takahashi, Masaki Kobayashi, Takeshi Hirano, Hiroaki Yamaguchi & Ken Iseki. (2013) Rapid Stimulating Effect of the Antiarrhythmic Agent Amiodarone on Absorption of Organic Anion Compounds. Drug Metabolism and Pharmacokinetics 28:3, pages 178-186.
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Nina Isoherranen, Justin D. Lutz, Sophie P. Chung, Houda Hachad, Rene H. Levy & Isabelle Ragueneau-Majlessi. (2012) Importance of Multi-P450 Inhibition in Drug–Drug Interactions: Evaluation of Incidence, Inhibition Magnitude, and Prediction from in Vitro Data. Chemical Research in Toxicology 25:11, pages 2285-2300.
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M J Dolton, B D Roufogalis & A J McLachlan. (2012) Fruit Juices as Perpetrators of Drug Interactions: The Role of Organic Anion–Transporting Polypeptides. Clinical Pharmacology & Therapeutics 92:5, pages 622-630.
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Anna Koenen, Kathleen Köck, Markus Keiser, Werner Siegmund, Heyo K. Kroemer & Markus Grube. (2012) Steroid hormones specifically modify the activity of organic anion transporting polypeptides. European Journal of Pharmaceutical Sciences 47:4, pages 774-780.
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Barbara Döring, Thomas Lütteke, Joachim Geyer & Ernst Petzinger. 2012. Co-Transport Systems. Co-Transport Systems 105 168 .

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