241
Views
23
CrossRef citations to date
0
Altmetric
Drug Profile

Linaclotide, a synthetic guanylate cyclase C agonist, for the treatment of functional gastrointestinal disorders associated with constipation

&
Pages 301-310 | Published online: 10 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Erik S. Blomain, Amanda M. Pattison & Scott A. Waldman. (2016) GUCY2C ligand replacement to prevent colorectal cancer. Cancer Biology & Therapy 17:7, pages 713-718.
Read now
Paula Mosińska, Maciej Salaga & Jakub Fichna. (2016) Novel investigational drugs for constipation-predominant irritable bowel syndrome: a review. Expert Opinion on Investigational Drugs 25:3, pages 275-286.
Read now
Maria Vazquez Roque & Ernest P Bouras. (2015) Epidemiology and management of chronic constipation in elderly patients. Clinical Interventions in Aging 10, pages 919-930.
Read now
Erik S Blomain, Jieru E Lin, Crystal L Kraft, Urszula T Trela, Justin M Rock, Amanda S Aing, Adam E Snook & Scott A Waldman. (2013) Translating colorectal cancer prevention through the guanylyl cyclase C signaling axis. Expert Review of Clinical Pharmacology 6:5, pages 557-564.
Read now
J. Fortea & M. Prior. (2013) Irritable bowel syndrome with constipation: a European-focused systematic literature review of disease burden. Journal of Medical Economics 16:3, pages 329-341.
Read now
Jeffrey M Johnston & Harvey A Schneier. (2012) Clarification of trial end points presented in a recent review of linaclotide. Expert Review of Gastroenterology & Hepatology 6:1, pages 13-14.
Read now

Articles from other publishers (17)

Heidi M. Staudacher, Christopher J. Black, Scott B. Teasdale, Antonina Mikocka-Walus & Laurie Keefer. (2023) Irritable bowel syndrome and mental health comorbidity — approach to multidisciplinary management. Nature Reviews Gastroenterology & Hepatology 20:9, pages 582-596.
Crossref
Huiya Zhang & Shiyu Chen. (2022) Cyclic peptide drugs approved in the last two decades (2001–2021). RSC Chemical Biology 3:1, pages 18-31.
Crossref
Nayara Braga Emidio, Hue N. T. Tran, Asa Andersson, Philip E. Dawson, Fernando Albericio, Irina Vetter & Markus Muttenthaler. (2021) Improving the Gastrointestinal Stability of Linaclotide. Journal of Medicinal Chemistry 64:12, pages 8384-8390.
Crossref
Mulusew Yemiru Tessema, Zewdu Birhanu Wubneh & Assefa Belay Asrie. (2020) Laxative Activities of 80% Methanolic Extract of the Leaves of Grewia ferruginea Hochst Ex A Rich in Mice . Journal of Evidence-Based Integrative Medicine 25, pages 2515690X2092692.
Crossref
Állan S. Pires, William F. Porto, Pryscilla O. Castro, Octavio L. Franco & Sérgio A. Alencar. (2017) Theoretical structural characterization of lymphoguanylin: A potential candidate for the development of drugs to treat gastrointestinal disorders. Journal of Theoretical Biology 419, pages 193-200.
Crossref
Andrée-Anne Poirier, Benoit Aubé, Mélissa Côté, Nicolas Morin, Thérèse Di Paolo & Denis Soulet. (2016) Gastrointestinal Dysfunctions in Parkinson’s Disease: Symptoms and Treatments. Parkinson's Disease 2016, pages 1-23.
Crossref
L. Ashley Blackshaw, Dmitry S. Bordin, Christina Brock, Anne Brokjaer, Asbjørn Mohr Drewes, Adam D. Farmer, Anne Lund Krarup, Christian Lottrup, Antonina A. Masharova, Fouad J. Moawad & Anne Estrup Olesen. (2014) Pharmacologic treatments for esophageal disorders. Annals of the New York Academy of Sciences 1325:1, pages 23-39.
Crossref
Christophe Faure. (2014) Lubiprostone in Pediatric Functional Constipation. Journal of Pediatric Gastroenterology & Nutrition 58:3, pages 275-277.
Crossref
Corrado Blandizzi & Carmelo Scarpignato. 2014. A worldwide yearly survey of new data in adverse drug reactions and interactions. A worldwide yearly survey of new data in adverse drug reactions and interactions 633 658 .
J. Fichna, A. Sibaev, M. Sałaga, M. Sobczak & M. Storr. (2013) The cannabinoid-1 receptor inverse agonist taranabant reduces abdominal pain and increases intestinal transit in mice. Neurogastroenterology & Motility 25:8, pages e550-e559.
Crossref
Eamonn M.M. Quigley. (2013) Enfermedades del piso pelviano y del esfínter anal: perspectiva de un gastroenterólogo. Revista Médica Clínica Las Condes 24:2, pages 299-304.
Crossref
Eamonn M.M. Quigley. (2013) Disorders of the pelvic floor and anal sphincters; a gastroenterologist’s perspective. Revista Médica Clínica Las Condes 24:2, pages 293-298.
Crossref
Maria I. Vazquez-Roque & Ernest P. Bouras. (2013) Linaclotide, Novel Therapy for the Treatment of Chronic Idiopathic Constipation and Constipation-Predominant Irritable Bowel Syndrome. Advances in Therapy 30:3, pages 203-211.
Crossref
Robert W. Busby, Marco M. Kessler, Wilmin P. Bartolini, Alexander P. Bryant, Gerhard Hannig, Carolyn S. Higgins, Robert M. Solinga, Jenny V. Tobin, James D. Wakefield, Caroline B. Kurtz & Mark G. Currie. (2013) Pharmacologic Properties, Metabolism, and Disposition of Linaclotide, a Novel Therapeutic Peptide Approved for the Treatment of Irritable Bowel Syndrome with Constipation and Chronic Idiopathic Constipation. Journal of Pharmacology and Experimental Therapeutics 344:1, pages 196-206.
Crossref
John Cuppoletti, Anthony T Blikslager, Jayati Chakrabarti, Prashant K Nighot & Danuta H Malinowska. (2012) Contrasting effects of linaclotide and lubiprostone on restitution of epithelial cell barrier properties and cellular homeostasis after exposure to cell stressors. BMC Pharmacology 12:1.
Crossref
Gregory S Sayuk. (2012) Editorial: Linaclotide: Promising IBS-C Efficacy in an Era of Provisional Study Endpoints. American Journal of Gastroenterology 107:11, pages 1726-1729.
Crossref
Lincoln R. Potter. (2011) Guanylyl cyclase structure, function and regulation. Cellular Signalling 23:12, pages 1921-1926.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.