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The PIM kinases in hematological cancers

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Pages 81-96 | Published online: 10 Jan 2014

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Dereje Berta, Mekonnen Girma, Mulugeta Melku, Tiruneh Adane, Bisrat Birke & Aregawi Yalew. (2023) Role of RNA Splicing Mutations in Diffuse Large B Cell Lymphoma. International Journal of General Medicine 16, pages 2469-2480.
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Gehad Hamed, Hisham M Omar, Abbas M Sarhan & Hossam E Salah. (2022) Proviral Integration of Moloney Virus-2 (PIM-2) Expression Level as a Prognostic Marker in Patients with Acute Myeloid Leukemia. International Journal of General Medicine 15, pages 4247-4258.
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Hongmei Luo, Ruixue Sun, Yuhuan Zheng, Jingcao Huang, Fangfang Wang, Dan Long & Yu Wu. (2020) PIM3 Promotes the Proliferation and Migration of Acute Myeloid Leukemia Cells. OncoTargets and Therapy 13, pages 6897-6905.
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Aziz ur Rehman Aziz, Sumbal Farid, Kairong Qin, Hanqin Wang & Bo Liu. (2020) Regulation of insulin resistance and glucose metabolism by interaction of PIM kinases and insulin receptor substrates. Archives of Physiology and Biochemistry 126:2, pages 129-138.
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Ran-ran Ding, Jian-ling Yuan, Ya-nan Jia, Xiao-min Liao, Si-si Wang, Zhong-ming Shao, Mu-yin Feng, Wei Jie & Zhi-hua Shen. (2019) Epstein-Barr virus-encoded LMP1 regulated Pim1 kinase expression promotes nasopharyngeal carcinoma cells proliferation. OncoTargets and Therapy 12, pages 1137-1146.
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Benedito A Carneiro, Jessica K Altman, Jason B Kaplan, Gert Ossenkoppele, Ronan Swords, Leonidas C Platanias & Francis J Giles. (2015) Targeted therapy of acute myeloid leukemia. Expert Review of Anticancer Therapy 15:4, pages 399-413.
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Articles from other publishers (51)

Komala Ingle, Joseph F. LaComb, Lee M. Graves, Antonio T. Baines & Agnieszka B. Bialkowska. (2023) AUM302, a novel triple kinase PIM/PI3K/mTOR inhibitor, is a potent in vitro pancreatic cancer growth inhibitor. PLOS ONE 18:11, pages e0294065.
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Min Jea Shin, Won Sik Eum, Gi Soo Youn, Jung Hwan Park, Hyeon Ji Yeo, Eun Ji Yeo, Hyun Jung Kwon, Eun Jeong Sohn, Lee Re Lee, Na Yeon Kim, Su Yeon Kwon, Su Min Kim, Hyo Young Jung, Duk-Soo Kim, Sung-Woo Cho, Oh-Shin Kwon, Dae Won Kim & Soo Young Choi. (2023) Protective effects of cell permeable Tat-PIM2 protein on oxidative stress induced dopaminergic neuronal cell death. Heliyon 9:5, pages e15945.
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Mădălina Boșoteanu, Miruna Cristian, Mariana Așchie, Mariana Deacu, Anca Florentina Mitroi, Costel Stelian Brînzan & Gabriela Izabela Bălțătescu. (2022) Proteomics and genomics of a monomorphic epitheliotropic intestinal T-cell lymphoma: An extremely rare case report and short review of literature. Medicine 101:47, pages e31951.
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Sutapa Mahata, Pranab K. Sahoo, Ranita Pal, Sinjini Sarkar, Tanuma Mistry, Sushmita Ghosh & Vilas D. Nasare. (2022) PIM1/STAT3 axis: a potential co-targeted therapeutic approach in triple-negative breast cancer. Medical Oncology 39:7.
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Marcia Bellon & Christophe Nicot. (2022) Feedback Loop Regulation between Pim Kinases and Tax Keeps Human T-Cell Leukemia Virus Type 1 Viral Replication in Check. Journal of Virology 96:3.
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Aanchal Rathi, Dhiraj Kumar, Gulam Mustafa Hasan, Mohammad Mahfuzul Haque & Md Imtaiyaz Hassan. (2021) Therapeutic targeting of PIM KINASE signaling in cancer therapy: Structural and clinical prospects. Biochimica et Biophysica Acta (BBA) - General Subjects 1865:11, pages 129995.
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Kanasap Kaewchim, Kittirat Glab-ampai, Kodchakorn Mahasongkram, Monrat Chulanetra, Watee Seesuay, Wanpen Chaicumpa & Nitat Sookrung. (2021) Engineered Fully Human Single-Chain Monoclonal Antibodies to PIM2 Kinase. Molecules 26:21, pages 6436.
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Yu Han, Huimin Zhang, Shuxiang Wang, Bo Li, Kun Xing, Yuntao Shi, Hongxue Cao, Jian Zhang, Tong Tong, Jie Zang, Lihong Guan, Xiaoxiao Gao, Yuetong Wang, Dan Liu, Min Huang, Yongkui Jing & Linxiang Zhao. (2021) Optimization of 4,6-Disubstituted Pyrido[3,2- d ]pyrimidines as Dual MNK/PIM Inhibitors to Inhibit Leukemia Cell Growth . Journal of Medicinal Chemistry 64:18, pages 13719-13735.
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Jeremiah J Bearss, Sathish KR Padi, Neha Singh, Marina Cardo‐Vila, Jin H Song, Ghassan Mouneimne, Nikita Fernandes, Yang Li, Matthew R Harter, Jaime MC Gard, Anne E Cress, Wolfgang Peti, Andrew DL Nelson, J Ross Buchan, Andrew S Kraft & Koichi Okumura. (2021) EDC3 phosphorylation regulates growth and invasion through controlling P‐body formation and dynamics. EMBO reports 22:4.
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Ewelina Motylewska, Marcin Braun & Henryk Stępień. (2020) High Expression of NEK2 and PIM1, but Not PIM3, Is Linked to an Aggressive Phenotype of Bronchopulmonary Neuroendocrine Neoplasms. Endocrine Pathology 31:3, pages 264-273.
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Nagesh Kishan Panchal & E.P. Sabina. (2020) A serine/threonine protein PIM kinase as a biomarker of cancer and a target for anti-tumor therapy. Life Sciences 255, pages 117866.
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Magda M. F. Ismail, Amel M. Farrag & Dalal Abou‐El‐Ela. (2020) Synthesis, anticancer screening, and in silico ADME prediction of novel 2‐pyridones as Pim inhibitors . Journal of Heterocyclic Chemistry.
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Asmaa M. AboulMagd, Hossam M. Hassan, Ahmed M. Sayed, Usama Ramadan Abdelmohsen & Hamdy M. Abdel-Rahman. (2020) Saccharomonosporine A inspiration; synthesis of potent analogues as potential PIM kinase inhibitors. RSC Advances 10:12, pages 6752-6762.
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Ronja Bjørnstad, Reidun Aesoy, Øystein Bruserud, Annette K. Brenner, Francis Giraud, Tara Helen Dowling, Gro Gausdal, Pascale Moreau, Stein Ove Døskeland, Fabrice Anizon & Lars Herfindal. (2019) A Kinase Inhibitor with Anti-Pim Kinase Activity is a Potent and Selective Cytotoxic Agent Toward Acute Myeloid Leukemia. Molecular Cancer Therapeutics 18:3, pages 567-578.
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Yaya Chu, Mitchell S. Cairo & Auke Beishuizen. 2019. Resistance to Targeted Therapies in Lymphomas. Resistance to Targeted Therapies in Lymphomas 111 153 .
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Jude Juventus Aweya, Wei Wang, Yueling Zhang, Defu Yao, Shengkang Li & Fan Wang. (2018) Identification and molecular characterization of the Pim1 serine/threonine kinase homolog in Litopenaeus vannamei. Fish & Shellfish Immunology 74, pages 491-500.
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Xin Zhu, Yunfang Yu, Xiuxiu Hou, Jiajie Xu, Zhuo Tan, Xilin Nie, Zhiqiang Ling & Minghua Ge. (2017) Expression of PIM‑1 in salivary gland adenoid cystic carcinoma: Association with tumor progression and patients' prognosis. Oncology Letters.
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Maciej Szydłowski, Monika Prochorec-SobieszekAnna Szumera-CiećkiewiczEdyta DerezińskaGrażyna HoserDanuta WasilewskaOlga Szymańska-GiemzaEwa Jabłońska, Emilia Białopiotrowicz, Tomasz Sewastianik, Anna Polak, Wojciech CzardybonMichał GałęzowskiRenata WindakJan Maciej Zaucha, Krzysztof Warzocha, Krzysztof BrzózkaPrzemysław Juszczyński. (2017) Expression of PIM kinases in Reed-Sternberg cells fosters immune privilege and tumor cell survival in Hodgkin lymphoma. Blood 130:12, pages 1418-1429.
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Wei Du, Tiantian Chen, Yingmeng Ni, Xiaoxia Hou, Youchao Yu, Qi Zhou, Fang Wu, Wei Tang & Guochao Shi. (2017) Role of PIM2 in allergic asthma. Molecular Medicine Reports 16:5, pages 7504-7512.
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Xiuxiu Hou, Yunfang Yu, Jianguo Feng, Jiafeng Wang, Chuanming Zheng, Zhiqiang Ling, Minghua Ge & Xin Zhu. (2017) Biochemical changes of salivary gland adenoid cystic carcinoma cells induced by SGI-1776. Experimental Cell Research 352:2, pages 403-411.
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Reem Karmali & Leo I. Gordon. (2017) Molecular Subtyping in Diffuse Large B Cell Lymphoma: Closer to an Approach of Precision Therapy. Current Treatment Options in Oncology 18:2.
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Hongtu Zhang. (2017) Upregulation of PIM2 by Underexpression of MicroRNA-135-5p Improves Survival Rates of Skin Allografts by Suppressing Apoptosis of Fibroblast Cells. Medical Science Monitor 23, pages 107-113.
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Shuai Mou, Guangbin Wang, Ding Ding, Dongdong Yu, Yi Pei, Songling Teng & Qin Fu. (2016) Expression and function of PIM kinases in osteosarcoma. International Journal of Oncology 49:5, pages 2116-2126.
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Arati A. Inamdar, Andre Goy, Nehad M. Ayoub, Christen Attia, Lucia Oton, Varun Taruvai, Mark Costales, Yu-Ting Lin, Andrew Pecora & K. Stephen Suh. (2016) Mantle cell lymphoma in the era of precision medicine-diagnosis, biomarkers and therapeutic agents. Oncotarget 7:30, pages 48692-48731.
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Yunfei Liao, Yong Feng, Jacson Shen, Yan Gao, Gregory Cote, Edwin Choy, David Harmon, Henry Mankin, Francis Hornicek & Zhenfeng Duan. (2016) Clinical and biological significance of PIM1 kinase in osteosarcoma. Journal of Orthopaedic Research 34:7, pages 1185-1194.
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Gisele A. Nishiguchi, Matthew T. Burger, Wooseok Han, Jiong Lan, Gordana Atallah, Victoriano Tamez, Mika Lindvall, Cornelia Bellamacina, Pablo Garcia, Paul Feucht, Tatiana Zavorotinskaya, Yumin Dai & Kent Wong. (2016) Design, synthesis and structure activity relationship of potent pan-PIM kinase inhibitors derived from the pyridyl carboxamide scaffold. Bioorganic & Medicinal Chemistry Letters 26:9, pages 2328-2332.
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Justin A. MacDonald, Cindy Sutherland, David A. Carlson, Sabreena Bhaidani, Abdulhameed Al-Ghabkari, Karl Swärd, Timothy A. J. Haystead & Michael P. Walsh. (2016) A Small Molecule Pyrazolo[3,4- d ]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle . Molecular Pharmacology 89:1, pages 105-117.
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Rosalba Camicia, Hans C. Winkler & Paul O. Hassa. (2015) Novel drug targets for personalized precision medicine in relapsed/refractory diffuse large B-cell lymphoma: a comprehensive review. Molecular Cancer 14:1.
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Kévin Adam, Mireille Lambert, Elsa Lestang, Gabriel Champenois, Isabelle Dusanter-Fourt, Jérôme Tamburini, Didier Bouscary, Catherine Lacombe, Yael Zermati & Patrick Mayeux. (2015) Control of Pim2 kinase stability and expression in transformed human haematopoietic cells. Bioscience Reports 35:6.
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Daniel J. Albertson, Robert L. Schmidt, Jared J. Bearss, Sheryl R. Tripp, David J. Bearss & Ting Liu. (2015) Patterns and Significance of PIM Kinases in Urothelial Carcinoma. Applied Immunohistochemistry & Molecular Morphology 23:10, pages 717-723.
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Min Wang, Reynaldo Tzintzun, Mingzhang Gao, Zhidong Xu & Qi-Huang Zheng. (2015) Synthesis of [11C]CX-6258 as a new PET tracer for imaging of Pim kinases in cancer. Bioorganic & Medicinal Chemistry Letters 25:18, pages 3831-3835.
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Guoping Deng, Yasuhiro Nagai, Yan Xiao, Zhiyuan Li, Shujia Dai, Takuya Ohtani, Alison Banham, Bin Li, Shiaw-Lin Wu, Wayne Hancock, Arabinda Samanta, Hongtao Zhang & Mark I. Greene. (2015) Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation. Journal of Biological Chemistry 290:33, pages 20211-20220.
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Miren Ettcheto, Felix Junyent, Luisa de Lemos, Merce Pallas, Jaume Folch, Carlos Beas-Zarate, Ester Verdaguer, Raquel Gómez-Sintes, José J. Lucas, Carme Auladell & Antoni Camins. (2014) Mice Lacking Functional Fas Death Receptors Are Protected from Kainic Acid-Induced Apoptosis in the Hippocampus. Molecular Neurobiology 52:1, pages 120-129.
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Hao Guo, Jiaqiang Dong, Sijun Hu, Xiqiang Cai, Guangbo Tang, Jianhua Dou, Miaomiao Tian, Fuchu He, Yongzhan Nie & Daiming Fan. (2015) Biased random walk model for the prioritization of drug resistance associated proteins. Scientific Reports 5:1.
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Bich Thuy Le, Malika Kumarasiri, Julian RJ Adams, Mingfeng Yu, Robert Milne, Matthew J Sykes & Shudong Wang. (2015) Targeting Pim kinases for cancer treatment: opportunities and challenges. Future Medicinal Chemistry 7:1, pages 35-53.
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Xin Zhu, Jia-jie Xu, Si-si Hu, Jian-guo Feng, Lie-hao Jiang, Xiu-xiu Hou, Jun Cao, Jing Han, Zhi-qiang Ling & Ming-hua Ge. (2014) Pim-1 acts as an oncogene in human salivary gland adenoid cystic carcinoma. Journal of Experimental & Clinical Cancer Research 33:1.
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Esperanza Martín-Sánchez, Lina Odqvist, Socorro M. Rodríguez-Pinilla, Margarita Sánchez-Beato, Giovanna Roncador, Beatriz Domínguez-González, Carmen Blanco-Aparicio, Ana M. García Collazo, Esther González Cantalapiedra, Joaquín Pastor Fernández, Soraya Curiel del Olmo, Helena Pisonero, Rebeca Madureira, Carmen Almaraz, Manuela Mollejo, F. Javier Alves, Javier Menárguez, Fernando González-Palacios, José Luis Rodríguez-Peralto, Pablo L. Ortiz-Romero, Francisco X. Real, Juan F. García, James R. Bischoff & Miguel A. Piris. (2014) PIM Kinases as Potential Therapeutic Targets in a Subset of Peripheral T Cell Lymphoma Cases. PLoS ONE 9:11, pages e112148.
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Kumar Saurabh, Michael T. Scherzer, Parag P. Shah, Alice S. Mims, William W. Lockwood, Andrew S. Kraft & Levi J. Beverly. (2014) The PIM family of oncoproteins: Small kinases with huge implications in myeloid leukemogenesis and as therapeutic targets. Oncotarget 5:18, pages 8503-8514.
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Zhiyuan Li, Fang Lin, Changhua Zhuo, Guoping Deng, Zuojia Chen, Shuying Yin, Zhimei Gao, Miranda Piccioni, Andy Tsun, Sanjun Cai, Song Guo Zheng, Yu Zhang & Bin Li. (2014) PIM1 Kinase Phosphorylates the Human Transcription Factor FOXP3 at Serine 422 to Negatively Regulate Its Activity under Inflammation. Journal of Biological Chemistry 289:39, pages 26872-26881.
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Jianwei Xu, Taiping Zhang, Tianxiao Wang, Lei You & Yupei Zhao. (2014) PIM kinases: an overview in tumors and recent advances in pancreatic cancer. Future Oncology 10:5, pages 865-876.
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Maja Narlik-Grassow, Carmen Blanco-Aparicio & Amancio Carnero. (2014) The PIM Family of Serine/Threonine Kinases in Cancer. Medicinal Research Reviews 34:1, pages 136-159.
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Francesco Casuscelli, Elena Ardini, Nilla Avanzi, Elena Casale, Giovanni Cervi, Matteo D’Anello, Daniele Donati, Daniela Faiardi, Ronald D. Ferguson, Gianpaolo Fogliatto, Arturo Galvani, Aurelio Marsiglio, Danilo G. Mirizzi, Marisa Montemartini, Christian Orrenius, Gianluca Papeo, Claudia Piutti, Barbara Salom & Eduard R. Felder. (2013) Discovery and optimization of pyrrolo[1,2-a]pyrazinones leads to novel and selective inhibitors of PIM kinases. Bioorganic & Medicinal Chemistry 21:23, pages 7364-7380.
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Ningfei An, Ying-Wei Lin, Sandeep Mahajan, Joshua N. Kellner, Yong Wang, Zihai Li, Andrew S. Kraft & Yubin Kang. (2013) Pim1 Serine/Threonine Kinase Regulates the Number and Functions of Murine Hematopoietic Stem Cells. Stem Cells 31:6, pages 1202-1212.
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ZHEN WANG, XING-MIN LI, KUN SHANG, PENG ZHANG, CHAO-FU WANG, YU-HU XIN, LU ZHOU & YING-YI LI. (2013) T-18, a stemonamide synthetic intermediate inhibits Pim kinase activity and induces cell apoptosis, acting as a potent anticancer drug. Oncology Reports 29:3, pages 1245-1251.
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Mattia Mori, Cristina Tintori, Robert Selwyne Arul Christopher, Marco Radi, Silvia Schenone, Francesca Musumeci, Chiara Brullo, Patrizia Sanità, Simona Delle Monache, Adriano Angelucci, Miroslava Kissova, Emmanuele Crespan, Giovanni Maga & Maurizio Botta. (2013) A Combination Strategy to Inhibit Pim-1: Synergism between Noncompetitive and ATP-Competitive Inhibitors. ChemMedChem 8:3, pages 484-496.
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Thomas Walpen, Ina Kalus, Jürg Schwaller, Martin A. Peier, Edouard J. Battegay & Rok Humar. (2012) Nuclear PIM1 confers resistance to rapamycin-impaired endothelial proliferation. Biochemical and Biophysical Research Communications 429:1-2, pages 24-30.
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Hongtao Liu, Chao Zhang, Ting Liang, Jing Song, Jing Hao & Guihua Hou. (2012) Inhibition of Pim2-prolonged skin allograft survival through the apoptosis regulation pathway. Cellular & Molecular Immunology 9:6, pages 503-510.
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