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Review

mTOR in renal cell cancer: modulator of tumor biology and therapeutic target

Pages 231-241 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Sebastiano Buti, Alessandro Leonetti, Alice Dallatomasina & Melissa Bersanelli. (2016) Everolimus in the management of metastatic renal cell carcinoma: an evidence-based review of its place in therapy. Core Evidence 11, pages 23-36.
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Wan-Xiang Zheng, Fei Yan, Qin Xue, Guo-Jun Wu, Wei-Jun Qin, Fu-Li Wang, Jun Qin, Chun-Juan Tian & Jian-Lin Yuan. (2015) Heme oxygenase-1 is a predictive biomarker for therapeutic targeting of advanced clear cell renal cell carcinoma treated with sorafenib or sunitinib. OncoTargets and Therapy 8, pages 2081-2088.
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Linda Cerbone, Federica Recine & Cora N Sternberg. (2014) Pharmacotherapy options for advanced renal cell carcinoma. Expert Opinion on Orphan Drugs 2:7, pages 643-652.
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Camillo Porta, Roberto Sabbatini, Giuseppe Procopio, Chiara Paglino, Enzo Galligioni & Cinzia Ortega. (2012) Primary resistance to tyrosine kinase inhibitors in patients with advanced renal cell carcinoma: state-of-the-science. Expert Review of Anticancer Therapy 12:12, pages 1571-1577.
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Ramy F. Youssef, Nicholas G. Cost, Oussama M. Darwish & Vitaly Margulis. (2012) Prognostic markers in renal cell carcinoma: A focus on the ‘mammalian target of rapamycin’ pathway. Arab Journal of Urology 10:2, pages 110-117.
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Dylan T Jones & Adrian L Harris. (2012) Small-molecule inhibitors of the HIF pathway and synthetic lethal interactions. Expert Opinion on Therapeutic Targets 16:5, pages 463-480.
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Elaine Cristina Lima de Souza, Andrea Claudia Freitas Ferreira & Denise Pires de Carvalho. (2011) The mTOR protein as a target in thyroid cancer. Expert Opinion on Therapeutic Targets 15:9, pages 1099-1112.
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Piotr J Wysocki & Bogna Wierusz-Wysocka. (2010) Obesity, hyperinsulinemia and breast cancer: novel targets and a novel role for metformin. Expert Review of Molecular Diagnostics 10:4, pages 509-519.
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Wolfgang Eberhardt, Usman Nasrullah & Josef Pfeilschifter. (2018) Activation of renal profibrotic TGFβ controlled signaling cascades by calcineurin and mTOR inhibitors. Cellular Signalling 52, pages 1-11.
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Aaron L. Brown, Maurice B. Fluitt & Carolyn M. Ecelbarger. (2018) Mechanistic target of rapamycin: integrating growth factor and nutrient signaling in the collecting duct. American Journal of Physiology-Renal Physiology 315:3, pages F413-F416.
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Sheng-Wen Wu, Pei-Ni Chen, Chin-Yin Lin, Yih-Shou Hsieh & Horng-Rong Chang. (2017) Everolimus suppresses invasion and migration of renal cell carcinoma by inhibiting FAK activity and reversing epithelial to mesenchymal transition in vitro and in vivo. Environmental Toxicology 32:7, pages 1888-1898.
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Nan Wang, Ruijuan Wu, Xiaoheng Cheng, Jin Jin, Zongchao Jia & Jimin Zheng. (2014) New insights into mTOR structure and regulation. Chinese Science Bulletin 59:24, pages 2927-2935.
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