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Review

DNA vaccines for biodefense

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Pages 1739-1754 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

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Hamid Reza Jahantigh, Behzad Shahbazi, Hamed Gouklai, Hans Van der Weken, Zahra Gharibi, Zahra Rezaei, Mehri Habibi & Khadijeh Ahmadi. (2023) Design peptide and multi-epitope protein vaccine candidates against monkeypox virus using reverse vaccinology approach: an in-silico study. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-21.
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Kathleen A. Cashman, Eric R. Wilkinson, Suzanne E. Wollen, Joshua D. Shamblin, Justine M. Zelko, Jeremy J. Bearss, Xiankun Zeng, Kate E. Broderick & Connie S. Schmaljohn. (2017) DNA vaccines elicit durable protective immunity against individual or simultaneous infections with Lassa and Ebola viruses in guinea pigs. Human Vaccines & Immunotherapeutics 13:12, pages 3010-3019.
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Kathleen A. Cashman, Eric R. Wilkinson, Carl I. Shaia, Paul R. Facemire, Todd M. Bell, Jeremy J. Bearss, Joshua D. Shamblin, Suzanne E. Wollen, Kate E. Broderick, Niranjan Y. Sardesai & Connie S. Schmaljohn. (2017) A DNA vaccine delivered by dermal electroporation fully protects cynomolgus macaques against Lassa fever. Human Vaccines & Immunotherapeutics 13:12, pages 2902-2911.
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Peter Pushko, Igor S. Lukashevich, Scott C. Weaver & Irina Tretyakova. (2016) DNA-launched live-attenuated vaccines for biodefense applications. Expert Review of Vaccines 15:9, pages 1223-1234.
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Kate E Broderick & Laurent M Humeau. (2015) Electroporation-enhanced delivery of nucleic acid vaccines. Expert Review of Vaccines 14:2, pages 195-204.
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Karl Ljungberg & Peter Liljeström. (2015) Self-replicating alphavirus RNA vaccines. Expert Review of Vaccines 14:2, pages 177-194.
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Kai Zhao, Yang Zhang, Xiaoyan Zhang, Wei Li, Ci Shi, Chen Guo, Chunxiao Dai, Qian Chen, Zheng Jin, Yan Zhao, Hongyu Cui & Yunfeng Wang. (2014) Preparation and efficacy of Newcastle disease virus DNA vaccine encapsulated in chitosan nanoparticles. International Journal of Nanomedicine 9, pages 389-402.
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Joseph W Golden & Jay W Hooper. (2011) The strategic use of novel smallpox vaccines in the post-eradication world. Expert Review of Vaccines 10:7, pages 1021-1035.
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Articles from other publishers (18)

Min Hoon Lee, Hong Seok Choi, Na Young Kim, Euni Sim, Jun Young Choi, Sungyoul Hong, Young Kee Shin, Chi Ho Yu, Se Hun Gu, Dong Hyun Song, Gyueng Haeng Hur & Sungho Shin. (2023) Post-Vaccination Delivery of CpG ODNs Enhances the Th2-Associated Protective Immunity of the Smallpox DNA Vaccine. Molecular Biotechnology.
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Katarzyna Rakoczy, Monika Kisielewska, Mikołaj Sędzik, Laura Jonderko, Julia Celińska, Natalia Sauer, Wojciech Szlasa, Jolanta Saczko, Vitalij Novickij & Julita Kulbacka. (2022) Electroporation in Clinical Applications—The Potential of Gene Electrotransfer and Electrochemotherapy. Applied Sciences 12:21, pages 10821.
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Na Young Kim, Won Rak Son, Min Hoon Lee, Hong Seok Choi, Jun Young Choi, Young Jo Song, Chi Ho Yu, Dong Hyun Song, Gyeung Haeng Hur, Seong Tae Jeong, Sung Youl Hong, Young Kee Shin & Sungho Shin. (2022) A multipathogen DNA vaccine elicits protective immune responses against two class A bioterrorism agents, anthrax and botulism. Applied Microbiology and Biotechnology 106:4, pages 1531-1542.
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Maryam Shafaati, Massoud Saidijam, Meysam Soleimani, Fereshte Hazrati, Rasoul Mirzaei, Bagher Amirheidari, Hamid Tanzadehpanah, Sajad Karampoor, Sima Kazemi, Bahram Yavari, Hanie Mahaki, Mohsen Safaei, Fatemeh Rahbarizadeh, Pouria Samadi & Yaghoub Ahmadyousefi. (2022) A brief review on DNA vaccines in the era of COVID-19. Future Virology 17:1, pages 49-66.
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Manish Pandey, Divya Ojha, Sakshi Bansal, Ambadas B. Rode & Geetanjali Chawla. (2021) From bench side to clinic: Potential and challenges of RNA vaccines and therapeutics in infectious diseases. Molecular Aspects of Medicine 81, pages 101003.
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Allen J. Duplantier, Amy C. Shurtleff, Cheryl Miller, Chih-Yuan Chiang, Rekha G. Panchal & Melek Sunay. 2020. Drug Discovery Targeting Drug-Resistant Bacteria. Drug Discovery Targeting Drug-Resistant Bacteria 171 222 .
Sung-Youl Ko, Wataru AkahataEun Sung YangWing-Pui KongCrystal W. BurkeShelley P. HonnoldDonald K. NicholsYan-Jang S. Huang, Gretchen L. Schieber, Kevin Carlton, Luis DaSilva, Vicki Traina-Dorge, Dana L. VanlandinghamYaroslav TsybovskyTyler StephensUlrich BaxaStephen Higgs, Chad J. Roy, Pamela J. Glass, John R. Mascola, Gary J. Nabel & Srinivas S. Rao. (2019) A virus-like particle vaccine prevents equine encephalitis virus infection in nonhuman primates. Science Translational Medicine 11:492.
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T. E. Sizikova, V. N. Lebedev, S. I. Syromyatnikova & S. V. Borisevich. (2018) The Current State of Vaccine Development for Specific Prophylactics of Arenaviral Hemorrhagic Fevers. Problems of Particularly Dangerous Infections:2, pages 30-36.
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Lesley C. Dupuy, Michelle J. Richards, Brian D. Livingston, Drew Hannaman & Connie S. Schmaljohn. (2018) A Multiagent Alphavirus DNA Vaccine Delivered by Intramuscular Electroporation Elicits Robust and Durable Virus-Specific Immune Responses in Mice and Rabbits and Completely Protects Mice against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenges. Journal of Immunology Research 2018, pages 1-15.
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Drew Hannaman, Lesley C. Dupuy, Barry Ellefsen & Connie S. Schmaljohn. (2016) A Phase 1 clinical trial of a DNA vaccine for Venezuelan equine encephalitis delivered by intramuscular or intradermal electroporation. Vaccine 34:31, pages 3607-3612.
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Na Young Kim, Dong Suk Chang, Yeonsu Kim, Chang Hwan Kim, Gyeung Haeng Hur, Jai Myung Yang & Sungho Shin. (2015) Enhanced Immune Response to DNA Vaccine Encoding Bacillus anthracis PA-D4 Protects Mice against Anthrax Spore Challenge. PLOS ONE 10:10, pages e0139671.
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Les P NagataJonathan P Wong, Wei-gang Hu & Josh Q Wu. (2013) Vaccines and therapeutics for the encephalitic alphaviruses. Future Virology 8:7, pages 661-674.
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Irina Tretyakova, Igor S. Lukashevich, Pamela Glass, Eryu Wang, Scott Weaver & Peter Pushko. (2013) Novel vaccine against Venezuelan equine encephalitis combines advantages of DNA immunization and a live attenuated vaccine. Vaccine 31:7, pages 1019-1025.
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Wu Ou, Josie Delisle, Jerome Jacques, Joanna Shih, Graeme Price, Jens H Kuhn, Vivian Wang, Daniela Verthelyi, Gerardo Kaplan & Carolyn A Wilson. (2012) Induction of ebolavirus cross-species immunity using retrovirus-like particles bearing the Ebola virus glycoprotein lacking the mucin-like domain. Virology Journal 9:1.
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C.V. Badger, J.D. Richardson, R.L. DaSilva, M.J. Richards, M.D. Josleyn, L.C. Dupuy, J.W. Hooper & C.S. Schmaljohn. (2011) Development and application of a flow cytometric potency assay for DNA vaccines. Vaccine 29:39, pages 6728-6735.
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Lesley C. Dupuy, Michelle J. Richards, Barry Ellefsen, Lillian Chau, Alain Luxembourg, Drew Hannaman, Brian D. Livingston & Connie S. Schmaljohn. (2011) A DNA Vaccine for Venezuelan Equine Encephalitis Virus Delivered by Intramuscular Electroporation Elicits High Levels of Neutralizing Antibodies in Multiple Animal Models and Provides Protective Immunity to Mice and Nonhuman Primates. Clinical and Vaccine Immunology 18:5, pages 707-716.
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Dan Li, Shucheng Hua, Yanqiu Fan, Shufen Xu, Xiumei Duan, Lihua Liu, Yuanyuan Che, Shulei Li & Yan Tan. (2011) DNA vaccine expressing repeated carcinoembryonic antigen (CEA)625–667 induces strong immunity in mice. Immunology Letters 135:1-2, pages 124-128.
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Lesley C. Dupuy, Michelle J. Richards, Douglas S. Reed & Connie S. Schmaljohn. (2010) Immunogenicity and protective efficacy of a DNA vaccine against Venezuelan equine encephalitis virus aerosol challenge in nonhuman primates. Vaccine 28:46, pages 7345-7350.
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