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Review

Immunization strategies for Clostridium difficile infections

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Pages 469-479 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (6)

Melina Kachrimanidou, Theopisti Sarmourli, Lemonia Skoura, Symeon Metallidis & Nikolaos Malisiovas. (2016) Clostridium difficile infection: New insights into therapeutic options. Critical Reviews in Microbiology 42:5, pages 773-779.
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Enrico D'Amelio, Simonetta Salemi & Raffaele D'Amelio. (2016) Anti-Infectious Human Vaccination in Historical Perspective. International Reviews of Immunology 35:3, pages 260-290.
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Yuan-Kai Wang, Ya-Xian Yan, Hyeun Bum Kim, Xianghong Ju, Song Zhao, Keshan Zhang, Saul Tzipori & Xingmin Sun. (2015) A chimeric protein comprising the glucosyltransferase and cysteine proteinase domains of toxin B and the receptor binding domain of toxin A induces protective immunity against Clostridium difficile infection in mice and hamsters. Human Vaccines & Immunotherapeutics 11:9, pages 2215-2222.
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Song Zhao, Chandrabali Ghose-Paul, Keshan Zhang, Saul Tzipori & Xingmin Sun. (2014) Immune-based treatment and prevention of Clostridium difficile infection. Human Vaccines & Immunotherapeutics 10:12, pages 3522-3530.
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Marie-Paule Gustin, Marine Giard, Thomas Bénet & Philippe Vanhems. (2014) Use of surveillance data to identify target populations for Staphylococcus aureus vaccines and prevent surgical site infections: A pilot study. Human Vaccines & Immunotherapeutics 10:12, pages 3517-3521.
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Mario A Monteiro, Zuchao Ma, Lisa Bertolo, Yuening Jiao, Luis Arroyo, Douglas Hodgins, Michael Mallozzi, Gayatri Vedantam, Martin Sagermann, John Sundsmo & Herbert Chow. (2013) Carbohydrate-based Clostridium difficile vaccines. Expert Review of Vaccines 12:4, pages 421-431.
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Articles from other publishers (21)

Shaohui Wang, Duolong Zhu & Xingmin Sun. (2022) Development of an Effective Nontoxigenic Clostridioides difficile–Based Oral Vaccine against C. difficile Infection. Microbiology Spectrum 10:3.
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Larry K Kociolek, Joseph P Zackular & Tor Savidge. (2021) Translational Aspects of the Immunology of Clostridioides difficile Infection: Implications for Pediatric Populations . Journal of the Pediatric Infectious Diseases Society 10:Supplement_3, pages S8-S15.
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Peter H. Seeberger. (2021) Discovery of Semi- and Fully-Synthetic Carbohydrate Vaccines Against Bacterial Infections Using a Medicinal Chemistry Approach. Chemical Reviews 121:7, pages 3598-3626.
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Maju Joe & Todd L. Lowary. 2021. Comprehensive Glycoscience. Comprehensive Glycoscience 168 179 .
Rodrigo Emanuel Hernández Del Pino, Angela María Barbero, Laureano Ángel Español, Lorenzo Sebastián Morro & Virginia Pasquinelli. (2021) The adaptive immune response to Clostridioides difficile : A tricky balance between immunoprotection and immunopathogenesis . Journal of Leukocyte Biology 109:1, pages 195-210.
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Yuanguo Wang, Shaohui Wang, Laurent Bouillaut, Chunhui Li, Zhibian Duan, Keshan Zhang, Xianghong Ju, Saul Tzipori, Abraham L. Sonenshein & Xingmin Sun. (2018) Oral Immunization with Nontoxigenic Clostridium difficile Strains Expressing Chimeric Fragments of TcdA and TcdB Elicits Protective Immunity against C. difficile Infection in Both Mice and Hamsters. Infection and Immunity 86:11.
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Cinzia Colombo, Olimpia Pitirollo & Luigi Lay. (2018) Recent Advances in the Synthesis of Glycoconjugates for Vaccine Development. Molecules 23:7, pages 1712.
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Mackenzie Henderson, Amanda Bragg, Germin Fahim, Monica Shah & Evelyn Hermes-DeSantis. (2017) A Review of the Safety and Efficacy of Vaccines as Prophylaxis for Clostridium difficile Infections. Vaccines 5:3, pages 25.
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Jing-Hui Tian, Gregory Glenn, David Flyer, Bin Zhou, Ye Liu, Eddie Sullivan, Hua Wu, James F. Cummings, Larry Elllingsworth & Gale Smith. (2017) Clostridium difficile chimeric toxin receptor binding domain vaccine induced protection against different strains in active and passive challenge models. Vaccine 35:33, pages 4079-4087.
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Kang Yu, Ningning Bi, Chenghe Xiong, Shuihong Cai, Zhongzhu Long, Zhongwu Guo & Guofeng Gu. (2017) Synthesis of Defined and Functionalized Glycans of Lipoteichoic Acid: A Cell Surface Polysaccharide from Clostridium difficile . Organic Letters 19:12, pages 3123-3126.
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Alexey Gribenko, Elena Severina, Maninder K. Sidhu, Kathrin U. Jansen, Bruce A. Green & Yury V. Matsuka. (2017) Development of a subunit vaccine for prevention of Clostridium difficile associated diseases: Biophysical characterization of toxoids A and B. Biochemistry and Biophysics Reports 9, pages 193-202.
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Felix Broecker, Jonas Hanske, Christopher E. Martin, Ju Yuel Baek, Annette Wahlbrink, Felix Wojcik, Laura Hartmann, Christoph Rademacher, Chakkumkal Anish & Peter H. Seeberger. (2016) Multivalent display of minimal Clostridium difficile glycan epitopes mimics antigenic properties of larger glycans. Nature Communications 7:1.
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Eric Sheldon, Nicholas Kitchin, Yahong Peng, Joseph Eiden, William Gruber, Erik Johnson, Kathrin U. Jansen, Michael W. Pride & Louise Pedneault. (2016) A phase 1, placebo-controlled, randomized study of the safety, tolerability, and immunogenicity of a Clostridium difficile vaccine administered with or without aluminum hydroxide in healthy adults. Vaccine 34:18, pages 2082-2091.
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Julia Hütter & Bernd Lepenies. 2015. Carbohydrate-Based Vaccines. Carbohydrate-Based Vaccines 1 10 .
Kathleen B. ToLena M. Napolitano. (2014) Clostridium difficile Infection: Update on Diagnosis, Epidemiology, and Treatment Strategies . Surgical Infections 15:5, pages 490-502.
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Chakkumkal Anish, Benjamin Schumann, Claney Lebev Pereira & Peter H. Seeberger. (2014) Chemical Biology Approaches to Designing Defined Carbohydrate Vaccines. Chemistry & Biology 21:1, pages 38-50.
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Glenn S Tillotson & Karl WeissGlenn S TillotsonKarl Weiss. 2013. Clostridium difficile : New Challenges for an Old Foe . Clostridium difficile : New Challenges for an Old Foe 126 139 .
Yuening Jiao, Zuchao Ma, Doug Hodgins, Brittany Pequegnat, Lisa Bertolo, Luis Arroyo & Mario A. Monteiro. (2013) Clostridium difficile PSI polysaccharide: synthesis of pentasaccharide repeating block, conjugation to exotoxin B subunit, and detection of natural anti-PSI IgG antibodies in horse serum. Carbohydrate Research 378, pages 15-25.
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Christopher E. Martin, Felix Broecker, Matthias A. Oberli, Julia Komor, Jochen Mattner, Chakkumkal Anish & Peter H. Seeberger. (2013) Immunological Evaluation of a Synthetic Clostridium difficile Oligosaccharide Conjugate Vaccine Candidate and Identification of a Minimal Epitope. Journal of the American Chemical Society 135:26, pages 9713-9722.
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J.D. Stanley, J.G. Bartlett, B.W. DartIVIV & J.H. Ashcraft. (2013) Clostridium difficile infection. Current Problems in Surgery 50:7, pages 302-337.
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Christopher E. Martin, Felix Broecker, Steffen Eller, Matthias A. Oberli, Chakkumkal Anish, Claney L. Pereira & Peter H. Seeberger. (2013) Glycan arrays containing synthetic Clostridium difficile lipoteichoic acid oligomers as tools toward a carbohydrate vaccine. Chemical Communications 49:64, pages 7159.
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