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Review

Carbohydrate-based Clostridium difficile vaccines

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Pages 421-431 | Published online: 09 Jan 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (7)

Mark L. Lang & Binu Shrestha. (2017) Adaptive immune constraints on C. difficile vaccination. Expert Review of Vaccines 16:11, pages 1053-1055.
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Greg Hussack & Jamshid Tanha. (2016) An update on antibody-based immunotherapies for Clostridium difficile infection. Clinical and Experimental Gastroenterology 9, pages 209-224.
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Song Zhao, Chandrabali Ghose-Paul, Keshan Zhang, Saul Tzipori & Xingmin Sun. (2014) Immune-based treatment and prevention of Clostridium difficile infection. Human Vaccines & Immunotherapeutics 10:12, pages 3522-3530.
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Harsh Mathur, Mary C Rea, Paul D Cotter, R Paul Ross & Colin Hill. (2014) The potential for emerging therapeutic options for Clostridium difficile infection. Gut Microbes 5:6, pages 696-710.
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Milena M Awad, Priscilla A Johanesen, Glen P Carter, Edward Rose & Dena Lyras. (2014) Clostridium difficile virulence factors: Insights into an anaerobic spore-forming pathogen. Gut Microbes 5:5, pages 579-593.
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Rosanna Leuzzi, Roberto Adamo & Maria Scarselli. (2014) Vaccines against Clostridium difficile. Human Vaccines & Immunotherapeutics 10:6, pages 1466-1477.
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Chandrabali Ghose. (2013) Clostridium difficile infection in the twenty-first century. Emerging Microbes & Infections 2:1, pages 1-8.
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Articles from other publishers (34)

Joshua Heuler, Harish Chandra & Xingmin Sun. (2023) Mucosal Vaccination Strategies against Clostridioides difficile Infection. Vaccines 11:5, pages 887.
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Nolan W. Frame, Mikel Jason Allas, Brittany Pequegnat, Evguenii Vinogradov, Victor C.-H. Liao, Sameer Al-Abdul-Wahid, Luis Arroyo, Emma Allen-Vercoe, Todd L. Lowary & Mario A. Monteiro. (2023) Structure and synthesis of a vaccine and diagnostic target for Enterocloster bolteae, an autism-associated gut pathogen – Part II. Carbohydrate Research 526, pages 108805.
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Rajendra Rohokale & Zhongwu Guo. (2023) Development in the Concept of Bacterial Polysaccharide Repeating Unit-Based Antibacterial Conjugate Vaccines. ACS Infectious Diseases 9:2, pages 178-212.
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Luis G. Arroyo, Douglas C. Hodgins, Bruce Guest, Marcio Costa, Zuchao Ma & Mario A. Monteiro. (2022) Serum IgM antibody response to Clostridioides difficile polysaccharide PS-II vaccination in pony foals. Anaerobe 77, pages 102635.
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Matthew Phanchana, Phurt Harnvoravongchai, Supapit Wongkuna, Tanaporn Phetruen, Wichuda Phothichaisri, Supakan Panturat, Methinee Pipatthana, Sitthivut Charoensutthivarakul, Surang Chankhamhaengdecha & Tavan Janvilisri. (2021) Frontiers in antibiotic alternatives for Clostridioides difficile infection . World Journal of Gastroenterology 27:42, pages 7210-7232.
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Gillian A. Lang, Binu Shrestha, Souwelimatou Amadou Amani, Tyler M. Shadid, Jimmy D. Ballard & Mark L. Lang. (2021) α-Galactosylceramide-Reactive NKT Cells Increase IgG1 Class Switch against a Clostridioides difficile Polysaccharide Antigen and Enhance Immunity against a Live Pathogen Challenge. Infection and Immunity 89:11.
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A.D. Cox, F. St. Michael, A. Aubry, P.C.R. Strong, A.C. Hayes & S.M. Logan. (2020) Comparison of polysaccharide glycoconjugates as candidate vaccines to combat Clostridiodes (Clostridium) difficile. Glycoconjugate Journal 38:4, pages 493-508.
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Ravinder Mettu, Chiang-Yun Chen & Chung-Yi Wu. (2020) Synthetic carbohydrate-based vaccines: challenges and opportunities. Journal of Biomedical Science 27:1.
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Chantelle M. Cairns, Henk van Faassen, Frank St. Michael, Annie Aubry, Kevin A. Henry, Martin A. Rossotti, Susan M. Logan, Greg Hussack, Nicolas Gisch, Wouter F. J. Hogendorf, Christian M. Pedersen & Andrew D. Cox. (2020) Development and Characterization of Mouse Monoclonal Antibodies Specific for Clostridiodes (Clostridium) difficile Lipoteichoic Acid . ACS Chemical Biology 15:4, pages 1050-1058.
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Zhongrui Ma, Gao-Lan Zhang, Madhusudhan Reddy Gadi, Yuxi Guo, Peng Wang & Lei Li. (2020) Clostridioides difficile cd2775 Encodes a Unique Mannosyl-1-Phosphotransferase for Polysaccharide II Biosynthesis . ACS Infectious Diseases 6:4, pages 680-686.
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Felix Broecker, Erik Wegner, Bruna M. S. Seco, Paulina Kaplonek, Maria Bräutigam, Armin Ensser, Frederick Pfister, Christoph Daniel, Christopher E. Martin, Jochen Mattner & Peter H. Seeberger. (2019) Synthetic Oligosaccharide-Based Vaccines Protect Mice from Clostridioides difficile Infections . ACS Chemical Biology 14:12, pages 2720-2728.
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Brittany Pequegnat & Mario A. Monteiro. (2019) Carbohydrate Scaffolds for the Study of the Autism-associated Bacterium, Clostridium bolteae. Current Medicinal Chemistry 26:35, pages 6341-6348.
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Marjorie Pizarro-Guajardo, Nayaret Chamorro-Veloso, Roberto Mauricio Vidal & Daniel Paredes-Sabja. (2019) New insights for vaccine development against Clostridium difficile infections. Anaerobe 58, pages 73-79.
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Duolong Zhu, Joseph A. Sorg & Xingmin Sun. (2018) Clostridioides difficile Biology: Sporulation, Germination, and Corresponding Therapies for C. difficile Infection. Frontiers in Cellular and Infection Microbiology 8.
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Wuqiong Song, Juntao Cai, Xiaopeng Zou, Xiaoli Wang, Jing Hu & Jian Yin. (2018) Applications of controlled inversion strategies in carbohydrate synthesis. Chinese Chemical Letters 29:1, pages 27-34.
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Jean-François Bruxelle, Séverine Péchiné & Anne Collignon. 2018. Updates on Clostridium difficile in Europe. Updates on Clostridium difficile in Europe 197 225 .
Mackenzie Henderson, Amanda Bragg, Germin Fahim, Monica Shah & Evelyn Hermes-DeSantis. (2017) A Review of the Safety and Efficacy of Vaccines as Prophylaxis for Clostridium difficile Infections. Vaccines 5:3, pages 25.
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Kang Yu, Ningning Bi, Chenghe Xiong, Shuihong Cai, Zhongzhu Long, Zhongwu Guo & Guofeng Gu. (2017) Synthesis of Defined and Functionalized Glycans of Lipoteichoic Acid: A Cell Surface Polysaccharide from Clostridium difficile . Organic Letters 19:12, pages 3123-3126.
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Felix Broecker & Peter H. Seeberger. 2017. Chemical Glycobiology Part A. Synthesis, Manipulation and Applications of Glycans. Chemical Glycobiology Part A. Synthesis, Manipulation and Applications of Glycans 311 334 .
Michele Chu, Michael J. G. Mallozzi, Bryan P. Roxas, Lisa Bertolo, Mario A. Monteiro, Al Agellon, V. K. Viswanathan & Gayatri Vedantam. (2016) A Clostridium difficile Cell Wall Glycopolymer Locus Influences Bacterial Shape, Polysaccharide Production and Virulence. PLOS Pathogens 12:10, pages e1005946.
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Eric Sheldon, Nicholas Kitchin, Yahong Peng, Joseph Eiden, William Gruber, Erik Johnson, Kathrin U. Jansen, Michael W. Pride & Louise Pedneault. (2016) A phase 1, placebo-controlled, randomized study of the safety, tolerability, and immunogenicity of a Clostridium difficile vaccine administered with or without aluminum hydroxide in healthy adults. Vaccine 34:18, pages 2082-2091.
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Mario A. Monteiro. 2016. Vaccine Design. Vaccine Design 397 408 .
Shanguang Guo, Weiwei Yan, Sean P. McDonough, Nengfeng Lin, Katherine J. Wu, Hongxuan He, Hua Xiang, Maosheng Yang, Maira Aparecida S. Moreira & Yung-Fu Chang. (2015) The recombinant Lactococcus lactis oral vaccine induces protection against C. difficile spore challenge in a mouse model. Vaccine 33:13, pages 1586-1595.
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Chandrabali Ghose & Ciarán P. Kelly. (2015) The Prospect for Vaccines to Prevent Clostridium difficile Infection. Infectious Disease Clinics of North America 29:1, pages 145-162.
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Neil Ravenscroft, Paolo Costantino, Philippe Talaga, Roberto Rodriguez & William Egan. 2015. Vaccine Analysis: Strategies, Principles, and Control. Vaccine Analysis: Strategies, Principles, and Control 301 381 .
Julia Hütter & Bernd Lepenies. 2015. Carbohydrate-Based Vaccines. Carbohydrate-Based Vaccines 1 10 .
Wouter F. J. HogendorfNicolas GischDominik SchwudkeHolger HeineMikael BolsChristian Marcus Pedersen. (2014) Total Synthesis of Five Lipoteichoic acids of Clostridium difficile . Chemistry – A European Journal 20:42, pages 13511-13516.
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Qifang Wang & Chang-Chun Ling. (2014) Addressing the global need to combat multidrug resistance: carbohydrates may hold the key. Future Medicinal Chemistry 6:14, pages 1539-1543.
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Chakkumkal Anish, Benjamin Schumann, Claney Lebev Pereira & Peter H. Seeberger. (2014) Chemical Biology Approaches to Designing Defined Carbohydrate Vaccines. Chemistry & Biology 21:1, pages 38-50.
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Andrew D. Cox, Frank St. Michael, Annie Aubry, Chantelle M. Cairns, Philippa C. R. Strong, Alexander C. Hayes & Susan M. Logan. (2013) Investigating the candidacy of a lipoteichoic acid-based glycoconjugate as a vaccine to combat Clostridium difficile infection. Glycoconjugate Journal 30:9, pages 843-855.
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X. Chen & J. T. Lamont. (2013) Overview of Clostridium difficile infection: implications for China. Gastroenterology Report 1:3, pages 153-158.
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Yuening Jiao, Zuchao Ma, Doug Hodgins, Brittany Pequegnat, Lisa Bertolo, Luis Arroyo & Mario A. Monteiro. (2013) Clostridium difficile PSI polysaccharide: synthesis of pentasaccharide repeating block, conjugation to exotoxin B subunit, and detection of natural anti-PSI IgG antibodies in horse serum. Carbohydrate Research 378, pages 15-25.
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Brittany Pequegnat, Martin Sagermann, Moez Valliani, Michael Toh, Herbert Chow, Emma Allen-Vercoe & Mario A. Monteiro. (2013) A vaccine and diagnostic target for Clostridium bolteae, an autism-associated bacterium. Vaccine 31:26, pages 2787-2790.
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Christopher E. Martin, Felix Broecker, Steffen Eller, Matthias A. Oberli, Chakkumkal Anish, Claney L. Pereira & Peter H. Seeberger. (2013) Glycan arrays containing synthetic Clostridium difficile lipoteichoic acid oligomers as tools toward a carbohydrate vaccine. Chemical Communications 49:64, pages 7159.
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