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Original Research

Tolerability and efficacy of glycemic control with saxagliptin in older patients (aged ≥ 65 years) with inadequately controlled type 2 diabetes mellitus

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Pages 419-430 | Published online: 16 Apr 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (11)

André J. Scheen. (2021) Careful use to minimize adverse events of oral antidiabetic medications in the elderly. Expert Opinion on Pharmacotherapy 22:16, pages 2149-2165.
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Takashi Kadowaki, Masakazu Haneda, Hiroshi Ito, Makoto Ueno, Miyuki Matsukawa, Tomoko Yamakura, Kazuyo Sasaki, Mayumi Kimura & Hiroaki Iijima. (2018) Safety and efficacy of long-term treatment with teneligliptin: Interim analysis of a post-marketing surveillance of more than 10,000 Japanese patients with type 2 diabetes mellitus. Expert Opinion on Pharmacotherapy 19:2, pages 83-91.
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Huan Yu & Vincent C Woo. (2017) Emerging use of combination therapies for the management of type 2 diabetes – focus on saxagliptin and dapagliflozin. Diabetes, Metabolic Syndrome and Obesity 10, pages 317-332.
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Chen Xiaoyan, Wang Jing, Huang Xiaochun, Tan Yuyu, Deng Shunyou & Fu Yingyu. (2016) Effects of vildagliptin versus saxagliptin on daily acute glucose fluctuations in Chinese patients with T2DM inadequately controlled with a combination of metformin and sulfonylurea. Current Medical Research and Opinion 32:6, pages 1131-1136.
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Simona Cernea, Avivit Cahn & Itamar Raz. (2016) Saxagliptin for the treatment of diabetes - a focus on safety. Expert Opinion on Drug Safety 15:5, pages 697-707.
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André J Scheen. (2015) Safety of dipeptidyl peptidase-4 inhibitors for treating type 2 diabetes. Expert Opinion on Drug Safety 14:4, pages 505-524.
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André J Scheen. (2015) A review of gliptins for 2014. Expert Opinion on Pharmacotherapy 16:1, pages 43-62.
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George S Panagoulias & John Doupis. (2014) Clinical utility in the treatment of type 2 diabetes with the saxagliptin/metformin fixed combination. Patient Preference and Adherence 8, pages 227-236.
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Nayyar Iqbal, Elsie Allen & Peter Öhman. (2014) Long-term safety and tolerability of saxagliptin add-on therapy in older patients (aged ≥65 years) with type 2 diabetes. Clinical Interventions in Aging 9, pages 1479-1487.
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Richard E Pratley. (2014) Linagliptin use in older individuals with type 2 diabetes. Clinical Interventions in Aging 9, pages 1109-1114.
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Ye-Fong Du, Horng-Yih Ou, Elizabeth A Beverly & Ching-Ju Chiu. (2014) Achieving glycemic control in elderly patients with type 2 diabetes: a critical comparison of current options. Clinical Interventions in Aging 9, pages 1963-1980.
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Articles from other publishers (22)

André J. Scheen. (2021) Efficacy / safety balance of DPP-4 inhibitors versus SGLT2 inhibitors in elderly patients with type 2 diabetes. Diabetes & Metabolism 47:6, pages 101275.
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Ivan I. Dedov, Marina V. Shestakova, Alexander Y. Mayorov, Minara S. Shamkhalova, Olga Yu. Sukhareva, Gagik R. Galstyan, Alla Y. Tokmakova, Tatiana V. Nikonova, Elena V. Surkova, Irina V. Kononenko, Daria N. Egorova, Lyudmila I. Ibragimova, Ekaterina A. Shestakova, Inna I. Klefortova, Igor A. Sklyanik, Ivona Ya. Yarek-Martynova, Anastasia S. Severina, Sergey A. Martynov, Olga K. Vikulova, Viktor Y. Kalashnikov, Irina Z. Bondarenko, Irina S. Gomova, Elena G. Starostina, Alexander S. Ametov, Mikhail B. Antsiferov, Tatiana P. Bardymova, Irina A. Bondar, Farida V. Valeeva, Tatiana Y. Demidova, Ashot M. Mkrtumyan, Nina A. Petunina, Lyudmila A. Ruyatkina, Lyudmila A. Suplotova, Olga V. Ushakova & Yurii Sh. Khalimov. (2020) Diabetes mellitus type 2 in adults. Diabetes mellitus 23:2S, pages 4-102.
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Giorgio Sesti, Angelo Avogaro, Sara Belcastro, Benedetta Maria Bonora, Marina Croci, Giuseppe Daniele, Marco Dauriz, Francesco Dotta, Caterina Formichi, Simona Frontoni, Cecilia Invitti, Emanuela Orsi, Fabiana Picconi, Veronica Resi, Enzo Bonora & Francesco Purrello. (2019) Ten years of experience with DPP-4 inhibitors for the treatment of type 2 diabetes mellitus. Acta Diabetologica 56:6, pages 605-617.
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Junghyun Noh. (2019) Pharmacological Therapy of Diabetes in the Elderly. The Journal of Korean Diabetes 20:4, pages 225.
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Graydon S. Meneilly, Aileen Knip, David B. Miller, Diana Sherifali, Daniel Tessier & Afshan Zahedi. (2018) Diabetes in Older People. Canadian Journal of Diabetes 42, pages S283-S295.
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R. Gómez-Huelgas, F. Gómez Peralta, L. Rodríguez Mañas, F. Formiga, M. Puig Domingo, J.J. Mediavilla Bravo, C. Miranda & J. Ena. (2018) Tratamiento de la diabetes mellitus tipo 2 en el paciente anciano. Revista Española de Geriatría y Gerontología 53:2, pages 89-99.
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R. Gómez-Huelgas, F. Gómez Peralta, L. Rodríguez Mañas, F. Formiga, M. Puig Domingo, J.J. Mediavilla Bravo, C. Miranda & J. Ena. (2018) Treatment of type 2 diabetes mellitus in elderly patients. Revista Clínica Española (English Edition) 218:2, pages 74-88.
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R. Gómez-Huelgas, F. Gómez Peralta, L. Rodríguez Mañas, F. Formiga, M. Puig Domingo, J.J. Mediavilla Bravo, C. Miranda & J. Ena. (2018) Tratamiento de la diabetes mellitus tipo 2 en el paciente anciano. Revista Clínica Española 218:2, pages 74-88.
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G. Sesti, R. Antonelli Incalzi, E. Bonora, A. Consoli, A. Giaccari, S. Maggi, G. Paolisso, F. Purrello, G. Vendemiale & N. Ferrara. (2018) Management of diabetes in older adults. Nutrition, Metabolism and Cardiovascular Diseases 28:3, pages 206-218.
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Mikaela Sjöstrand, Cheryl Wei, William Cook, Kristina Johnsson, Pia S. Pollack, Christina Stahre & Boaz Hirshberg. (2017) Assessment of Saxagliptin Efficacy: Meta-Analysis of 14 Phase 2 and 3 Clinical Trials. Diabetes Therapy 8:3, pages 587-599.
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David W. Boulton. (2016) Clinical Pharmacokinetics and Pharmacodynamics of Saxagliptin, a Dipeptidyl Peptidase-4 Inhibitor. Clinical Pharmacokinetics 56:1, pages 11-24.
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Shira Perl, William Cook, Cheryl Wei, Peter Ohman & Boaz Hirshberg. (2016) Effects of Glimepiride versus Saxagliptin on β-Cell Function and Hypoglycemia: A Post Hoc Analysis in Older Patients with Type 2 Diabetes Inadequately Controlled with Metformin. Clinical Therapeutics 38:12, pages 2578-2588.
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J.-F. Blicklé. (2016) Quelle place pour les nouveaux antidiabétiques dans la prise en charge du diabète du sujet âgé ?. Médecine des Maladies Métaboliques 10:6, pages 574-580.
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Francesc Formiga, Ricardo Gómez-Huelgas & Leocadio Rodríguez Mañas. (2016) Características diferenciales de la diabetes mellitus tipo 2 en el paciente anciano. Papel de los inhibidores de la dipeptidil peptidasa 4. Revista Española de Geriatría y Gerontología 51:1, pages 44-51.
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Deborah Hinnen. (2015) Dipeptidyl Peptidase-4 Inhibitors in Diverse Patient Populations With Type 2 Diabetes. The Diabetes Educator 41:1_suppl, pages 19S-31S.
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Rajeev Jain. (2015) Utility of Saxagliptin in the Treatment of Type 2 Diabetes: Review of Efficacy and Safety. Advances in Therapy 32:11, pages 1065-1084.
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G. Schernthaner, S. Durán-Garcia, M. Hanefeld, G. Langslet, L. Niskanen, C. J. Östgren, E. Malvolti & E. Hardy. (2015) Efficacy and tolerability of saxagliptin compared with glimepiride in elderly patients with type 2 diabetes: a randomized, controlled study (GENERATION). Diabetes, Obesity and Metabolism 17:7, pages 630-638.
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Lawrence A. Leiter, Hwee Teoh, Eugene Braunwald, Ofri Mosenzon, Avivit Cahn, K.M. Prasanna Kumar, Alena Smahelova, Boaz Hirshberg, Christina Stahre, Robert Frederich, Francois Bonnici, Benjamin M. Scirica, Deepak L. Bhatt & Itamar Raz. (2015) Efficacy and Safety of Saxagliptin in Older Participants in the SAVOR-TIMI 53 Trial. Diabetes Care 38:6, pages 1145-1153.
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Jennifer D. Goldman-Levine. (2015) Combination Therapy When Metformin Is Not an Option for Type 2 Diabetes. Annals of Pharmacotherapy 49:6, pages 688-699.
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A. Avogaro, A. Dardano, S. V. de Kreutzenberg & S. Del Prato. (2015) Dipeptidyl peptidase-4 inhibitors can minimize the hypoglycaemic burden and enhance safety in elderly people with diabetes. Diabetes, Obesity and Metabolism 17:2, pages 107-115.
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W. M. Valencia & H. Florez. (2014) Pharmacological treatment of diabetes in older people. Diabetes, Obesity and Metabolism 16:12, pages 1192-1203.
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Aaditya Singhal, Alissa R. Segal & Medha N. Munshi. (2014) Diabetes in Long-Term Care Facilities. Current Diabetes Reports 14:3.
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