363
Views
39
CrossRef citations to date
0
Altmetric
Original Research

Add-on prolonged-release melatonin for cognitive function and sleep in mild to moderate Alzheimer’s disease: a 6-month, randomized, placebo-controlled, multicenter trial

, , , , , , & show all
Pages 947-961 | Published online: 18 Jun 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (9)

Colin Tuft, Elie Matar, Zoe Menczel Schrire, Ronald R Grunstein, Brendon J Yee & Camilla M Hoyos. (2023) Current Insights into the Risks of Using Melatonin as a Treatment for Sleep Disorders in Older Adults. Clinical Interventions in Aging 18, pages 49-59.
Read now
Binish Javed, Amaan Javed, Chia Siang Kow & Syed Shahzad Hasan. (2023) Pharmacological and non-pharmacological treatment options for sleep disturbances in Alzheimer’s disease. Expert Review of Neurotherapeutics 23:6, pages 501-514.
Read now
Jonathan G. Mun, Dan Wang, Denise L. Doerflein Fulk, Mina Fakhary, Scott J. Gualco, Ryan W. Grant & Susan Hazels Mitmesser. (2023) A Randomized, Double-Blind, Crossover Study to Investigate the Pharmacokinetics of Extended-Release Melatonin Compared to Immediate-Release Melatonin in Healthy Adults. Journal of Dietary Supplements 0:0, pages 1-13.
Read now
Masaya Shigemoto & Kiyohisa Natsume. (2023) Detection of circadian rhythm disturbance of carbachol-induced beta wave dynamics in rat hippocampal slices using neural networks. SICE Journal of Control, Measurement, and System Integration 0:0, pages 1-7.
Read now
Sonda Jallouli, Sameh Ghroubi, Imen Ben Dhia, Abdelmoneem Yahia, Mohamed Habib Elleuch, Salma Sakka, Chokri Mhiri & Omar Hammouda. (2022) Effect of melatonin intake on postural balance, functional mobility and fall risk in persons with multiple sclerosis: a pilot study. International Journal of Neuroscience 0:0, pages 1-11.
Read now
Elena Urrestarazu & Jorge Iriarte. (2016) Clinical management of sleep disturbances in Alzheimer’s disease: current and emerging strategies. Nature and Science of Sleep 8, pages 21-33.
Read now
Katheleen J Gardiner. (2015) Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations. Drug Design, Development and Therapy 9, pages 103-125.
Read now
Nava Zisapel. (2015) Current Phase II investigational therapies for insomnia. Expert Opinion on Investigational Drugs 24:3, pages 401-411.
Read now

Articles from other publishers (30)

Jung-Won Shin. (2023) Neuroprotective effects of melatonin in neurodegenerative and autoimmune central nervous system diseases. encephalitis 3:2, pages 44-53.
Crossref
Yutaka Nakagawa & Shizuo Yamada. (2022) The Relationships Among Metal Homeostasis, Mitochondria, and Locus Coeruleus in Psychiatric and Neurodegenerative Disorders: Potential Pathogenetic Mechanism and Therapeutic Implications. Cellular and Molecular Neurobiology 43:3, pages 963-989.
Crossref
Daniel P. Cardinali, Seithikurippu R. Pandi-Perumal & Gregory M. Brown. 2023. Sleep and Clocks in Aging and Longevity. Sleep and Clocks in Aging and Longevity 277 312 .
Miss. Jagruti V. Kumbhar, Miss. Payal S. Rakshe, Miss. Kajal S. Gunjal, Miss. Pratiksha N. Uchale & Prof. Sachin V. Datkhile. (2022) A Review on Role of Nutraceutical in Alzhemer’s Disease. International Journal of Advanced Research in Science, Communication and Technology, pages 99-109.
Crossref
Teresa Pardo-Moreno, Anabel González-Acedo, Antonio Rivas-Domínguez, Victoria García-Morales, Francisco Jose García-Cozar, Juan Jose Ramos-Rodríguez & Lucía Melguizo-Rodríguez. (2022) Therapeutic Approach to Alzheimer’s Disease: Current Treatments and New Perspectives. Pharmaceutics 14:6, pages 1117.
Crossref
Xuemin Peng, Rongping Fan, Lei Xie, Xiaoli Shi, Kun Dong, Shujun Zhang, Jing Tao, Weijie Xu, Delin Ma, Juan Chen & Yan Yang. (2022) A Growing Link between Circadian Rhythms, Type 2 Diabetes Mellitus and Alzheimer’s Disease. International Journal of Molecular Sciences 23:1, pages 504.
Crossref
Benson OA Botchway, Favour C Okoye, Yili Chen, William E Arthur & Marong Fang. (2022) Alzheimer Disease: Recent Updates on Apolipoprotein E and Gut Microbiome Mediation of Oxidative Stress, and Prospective Interventional Agents. Aging and disease 13:1, pages 87.
Crossref
Gholami Fatemeh, Moradi Sajjad, Rasaei Niloufar, Soveid Neda, Setayesh Leila & Mirzaei Khadijeh. (2021) Effect of melatonin supplementation on sleep quality: a systematic review and meta-analysis of randomized controlled trials. Journal of Neurology 269:1, pages 205-216.
Crossref
Charles Pinto & Kirti Yeshwant Tandel. 2022. Sleep and Neuropsychiatric Disorders. Sleep and Neuropsychiatric Disorders 561 585 .
Werner Cassel & Petra Cassel. (2021) Schlafstörungen in der Gynäkologie: Schwangerschaft, Geburt, Stillzeit, Älter-WerdenSleep disorders in gynecology: pregnancy, birth, breastfeeding and aging. Der Gynäkologe 54:10, pages 783-790.
Crossref
Jesús Enrique García-Aviles, Rebeca Méndez-Hernández, Mara A. Guzmán-Ruiz, Miguel Cruz, Natalí N. Guerrero-Vargas, Javier Velázquez-Moctezuma & Gabriela Hurtado-Alvarado. (2021) Metabolic Disturbances Induced by Sleep Restriction as Potential Triggers for Alzheimer’s Disease. Frontiers in Integrative Neuroscience 15.
Crossref
Paul J. Fitzgerald. (2021) Norepinephrine May Oppose Other Neuromodulators to Impact Alzheimer’s Disease. International Journal of Molecular Sciences 22:14, pages 7364.
Crossref
Matthias Scheiner, Matthias Hoffmann, Feng He, Eleonora Poeta, Arnaud Chatonnet, Barbara Monti, Tangui Maurice & Michael Decker. (2021) Selective Pseudo-irreversible Butyrylcholinesterase Inhibitors Transferring Antioxidant Moieties to the Enzyme Show Pronounced Neuroprotective Efficacy In Vitro and In Vivo in an Alzheimer’s Disease Mouse Model. Journal of Medicinal Chemistry 64:13, pages 9302-9320.
Crossref
Grazia Ilaria Caruso, Simona Federica Spampinato, Giuseppe Costantino, Sara Merlo & Maria Angela Sortino. (2021) SIRT1-Dependent Upregulation of BDNF in Human Microglia Challenged with Aβ: An Early but Transient Response Rescued by Melatonin. Biomedicines 9:5, pages 466.
Crossref
Dalia M. Kopustinskiene & Jurga Bernatoniene. (2021) Molecular Mechanisms of Melatonin-Mediated Cell Protection and Signaling in Health and Disease. Pharmaceutics 13:2, pages 129.
Crossref
Tamlyn Watermeyer, Catherine Robb, Sarah Gregory & Chinedu Udeh-Momoh. (2021) Therapeutic implications of hypothalamic-pituitaryadrenal-axis modulation in Alzheimer’s disease: A narrative review of pharmacological and lifestyle interventions. Frontiers in Neuroendocrinology 60, pages 100877.
Crossref
Nadia Ferlazzo, Giulia Andolina, Attilio Cannata, Maria Giovanna Costanzo, Valentina Rizzo, Monica Currò, Riccardo Ientile & Daniela Caccamo. (2020) Is Melatonin the Cornucopia of the 21st Century?. Antioxidants 9:11, pages 1088.
Crossref
W. Cassel & P. Cassel. (2020) Guter Schlaf im besten AlterBien dormir dans la force de l’âge. Journal für Gynäkologische Endokrinologie/Schweiz 23:3, pages 86-93.
Crossref
Takuro Kitamura, Soichiro Miyazaki, Harun Bin Sulaiman, Ryota Akaike, Yuki Ito & Hideaki Suzuki. (2020) Insomnia and obstructive sleep apnea as potential triggers of dementia: is personalized prediction and prevention of the pathological cascade applicable?. EPMA Journal 11:3, pages 355-365.
Crossref
Md. Sahab Uddin, Devesh Tewari, Abdullah Al Mamun, Md. Tanvir Kabir, Kamal Niaz, Mir Imam Ibne Wahed, George E. Barreto & Ghulam Md. Ashraf. (2020) Circadian and sleep dysfunction in Alzheimer’s disease. Ageing Research Reviews 60, pages 101046.
Crossref
Howard A. FinkEric J. LinskensRoderick MacDonaldPombie C. SilvermanJ. Riley McCartenKristine M.C. TalleyMary L. FortePriyanka J. DesaiVictoria A. NelsonMargaret A. MillerLaura S. HemmyMichelle BrasureBrent C. TaylorWeiwen NgJeannine M. OuelletteKerry M. SheetsTimothy J. WiltMary Butler. (2020) Benefits and Harms of Prescription Drugs and Supplements for Treatment of Clinical Alzheimer-Type Dementia. Annals of Internal Medicine 172:10, pages 656-668.
Crossref
Linyi Li, Zhenxiang Zhao, Jianjun Ma, Jinhua Zheng, Shen Huang, Shiyu Hu, Qi Gu & Siyuan Chen. (2020) Elevated Plasma Melatonin Levels Are Correlated With the Non-motor Symptoms in Parkinson’s Disease: A Cross-Sectional Study. Frontiers in Neuroscience 14.
Crossref
Khara Lucius. (2019) Nutritional and Botanical Approaches for Cognitive Health—Part 1. Alternative and Complementary Therapies 25:4, pages 211-218.
Crossref
Daniel P. Cardinali. (2019) Melatonin: Clinical Perspectives in Neurodegeneration. Frontiers in Endocrinology 10.
Crossref
W. Cassel & P. Cassel. (2018) Guter Schlaf im besten AlterSleep well in the prime of life. Gynäkologische Endokrinologie 17:1, pages 49-55.
Crossref
Jan Homolak, Monika Mudrovčić, Barbara Vukić & Karlo Toljan. (2018) Circadian Rhythm and Alzheimer’s Disease. Medical Sciences 6:3, pages 52.
Crossref
I. Buendia, E. Parada, E. Navarro, R. León, P. Negredo, J. Egea & M. G. López. (2015) Subthreshold Concentrations of Melatonin and Galantamine Improves Pathological AD-Hallmarks in Hippocampal Organotypic Cultures. Molecular Neurobiology 53:5, pages 3338-3348.
Crossref
Josiel Mileno Mack, Marissa Giovanna Schamne, Tuane Bazanella Sampaio, Renata Aparecida Nedel Pértile, Pedro Augusto Carlos Magno Fernandes, Regina P. Markus & Rui Daniel Prediger. (2016) Melatoninergic System in Parkinson’s Disease: From Neuroprotection to the Management of Motor and Nonmotor Symptoms. Oxidative Medicine and Cellular Longevity 2016, pages 1-31.
Crossref
Michelle A. Miller. (2015) The Role of Sleep and Sleep Disorders in the Development, Diagnosis, and Management of Neurocognitive Disorders. Frontiers in Neurology 6.
Crossref
Daniel F. Kripke. (2015) Is suvorexant a better choice than alternative hypnotics?. F1000Research 4, pages 456.
Crossref