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Cancer Management and Research Volume 11, 2019 - Issue
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Original Research

Novel Hsp90 Inhibitor C086 Potently Inhibits Non-Small Cell Lung Cancer Cells As A Single Agent Or In Combination With Gefitinib

Liman Wang1 Institute of Materia Medica, School of Pharmacy, Fuijan Provincial Key Laboratory of Natural Medicine Pharmacology, Fujian Medical University, Fuzhou350122, People’s Republic of China;2 Department of Pharmacy, Fujian Provincial Hospital Jinshan Branch/Fujian Provincial Hospital South Branch, Fuzhou350028, People’s Republic of China;3 Provincial Clinical Medical College of Fujian Medical University, Fuzhou350000, People’s Republic of China
,
Yingjuan Fan1 Institute of Materia Medica, School of Pharmacy, Fuijan Provincial Key Laboratory of Natural Medicine Pharmacology, Fujian Medical University, Fuzhou350122, People’s Republic of China
,
Hanhao Mei1 Institute of Materia Medica, School of Pharmacy, Fuijan Provincial Key Laboratory of Natural Medicine Pharmacology, Fujian Medical University, Fuzhou350122, People’s Republic of China
,
Yang Liu1 Institute of Materia Medica, School of Pharmacy, Fuijan Provincial Key Laboratory of Natural Medicine Pharmacology, Fujian Medical University, Fuzhou350122, People’s Republic of China
,
Lianru Zhang4 State Key Laboratory of Cellular Stress Biology, School of Life Science, Xiamen University, Xiamen361005, People’s Republic of China
,
Jianhua Xu1 Institute of Materia Medica, School of Pharmacy, Fuijan Provincial Key Laboratory of Natural Medicine Pharmacology, Fujian Medical University, Fuzhou350122, People’s Republic of ChinaCorrespondence[email protected]
&
Xuhui Huang2 Department of Pharmacy, Fujian Provincial Hospital Jinshan Branch/Fujian Provincial Hospital South Branch, Fuzhou350028, People’s Republic of China;3 Provincial Clinical Medical College of Fujian Medical University, Fuzhou350000, People’s Republic of China
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Pages 8937-8945 | Published online: 16 Oct 2019

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Ameneh Jafari, Mostafa Rezaei-Tavirani, Behrouz Farhadihosseinabadi, Shahrouz Taranejoo & Hakimeh Zali. (2020) HSP90 and Co-chaperones: Impact on Tumor Progression and Prospects for Molecular-Targeted Cancer Therapy. Cancer Investigation 38:5, pages 310-328.
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Yanping Deng, Chun Chen, Zhifeng Xiao, Xiuwang Huang & Jianhua Xu. (2020) Enhanced anti-hepatoma effect of a novel curcumin analog C086 via solid dispersion technology. Drug Delivery 27:1, pages 927-937.
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Articles from other publishers (7)

Yue Zhu & Zhaoxia Dai. (2024) HSP90: A promising target for NSCLC treatments. European Journal of Pharmacology 967, pages 176387.
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Xin Xie, Nan Zhang, Xiang Li, He Huang, Cheng Peng, Wei Huang, Leonard J. Foster, Gu He & Bo Han. (2023) Small-molecule dual inhibitors targeting heat shock protein 90 for cancer targeted therapy. Bioorganic Chemistry 139, pages 106721.
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Jie Gao, Manqian Zhang, Xingwang Zu, Xue Gu, Erwei Hao, Xiaotao Hou & Gang Bai. (2023) Glucuronic acid metabolites of phenolic acids target AKT-PH domain to improve glucose metabolism. Chinese Herbal Medicines 15:3, pages 398-406.
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Jen-Chung Ko, Jyh-Cheng Chen, Jou-Min Hsieh, Pei-Yu Tseng, Chen-Shan Chiang, Li-Ling Liu, Chin-Cheng Chien, I-Hsiang Huang, Qiao-Zhen Chang, Bo-Cheng Mu & Yun-Wei Lin. (2022) Heat shock protein 90 inhibitor 17-AAG down-regulates thymidine phosphorylase expression and potentiates the cytotoxic effect of tamoxifen and erlotinib in human lung squamous carcinoma cells. Biochemical Pharmacology 204, pages 115207.
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Ge Fang, Chuanjing Cheng, Manqian Zhang, Xiaoyao Ma, Shengnan Yang, Xiaotao Hou, Jiagang Deng, Yuanyuan Hou & Gang Bai. (2021) The glucuronide metabolites of kaempferol and quercetin, targeting to the AKT PH domain, activate AKT/GSK3β signaling pathway and improve glucose metabolism. Journal of Functional Foods 82, pages 104501.
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Mangze Hu, Yu Zhao, Yuejiao Cao, Qianru Tang, Ziqin Feng, Jun Ni & Xiaorong Zhou. (2020) DRP1 promotes lactate utilization in KRAS ‐mutant non‐small‐cell lung cancer cells . Cancer Science 111:10, pages 3588-3599.
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Steven De Almeida, Mathilde Regimbeau, Gaëtan Jego, Carmen Garrido, François Girodon & François Hermetet. (2020) Heat Shock Proteins and PD-1/PD-L1 as Potential Therapeutic Targets in Myeloproliferative Neoplasms. Cancers 12:9, pages 2592.
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