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Original Research

An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke

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Pages 1647-1655 | Published online: 25 Jul 2016

Keep up to date with the latest research on this topic with citation updates for this article.

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Sukhwinder Singh Sohal. (2017) Fluticasone propionate and increased risk of pneumonia in COPD: is it PAFR-dependent?. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 3425-3427.
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Shakti Dhar Shukla, Philip M Hansbro & Eugene Haydn Walters. (2017) Upregulated pneumococcal adhesion molecule (platelet-activating factor receptor) may predispose COPD patients to community-acquired pneumonia. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 3111-3113.
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Articles from other publishers (30)

Mary Ashley Brown, Maisha Jabeen, Gurpreet Bharj & Timothy S.C. Hinks. (2022) Non-typeable Haemophilus influenzae airways infection: the next treatable trait in asthma? . European Respiratory Review 31:165, pages 220008.
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Chenying Zhang, Shuangshuang Gu & Xiuwen Kang. (2021) CircRNA circ_0006892 regulates miR‐24/ PHLPP2 axis to mitigate cigarette smoke extract‐induced bronchial epithelial cell injury . Biotechnology and Applied Biochemistry 69:2, pages 735-748.
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Yuan-Chieh Yeh, Ly Hien Doan, Zi-Yi Huang, Li-Wei Chu, Tzu-Hau Shi, Ying-Ray Lee, Cheng-Tao Wu, Chao-Hsiung Lin, Shu-Tuan Chiang, Hui-Kang Liu, Tsung-Hsien Chuang, Yueh-Hsin Ping, Hsiao-Sheng Liu & Chi-Ying F. Huang. (2022) Honeysuckle (Lonicera japonica) and Huangqi (Astragalus membranaceus) Suppress SARS-CoV-2 Entry and COVID-19 Related Cytokine Storm in Vitro. Frontiers in Pharmacology 12.
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Kian Fan Chung. 2022. Encyclopedia of Respiratory Medicine. Encyclopedia of Respiratory Medicine 462 473 .
Rajendra KC & Ronan F. O’Toole. (2021) Draft genome sequence of a nontypeable Haemophilus influenzae strain used in the study of human respiratory infection. BMC Research Notes 14:1.
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E. Haydn Walters, Shakti D. Shukla, Malik Q. Mahmood & Chris Ward. (2021) Fully integrating pathophysiological insights in COPD: an updated working disease model to broaden therapeutic vision. European Respiratory Review 30:160, pages 200364.
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Noriaki Kamio, Mayumi Hayata, Muneaki Tamura, Hajime Tanaka & Kenichi Imai. (2021) Porphyromonas gingivalis enhances pneumococcal adhesion to human alveolar epithelial cells by increasing expression of host platelet‐activating factor receptor . FEBS Letters 595:11, pages 1604-1612.
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Lee K. Page, Karl J. Staples, C. Mirella Spalluto, Alastair Watson & Tom M. A. Wilkinson. (2021) Influence of Hypoxia on the Epithelial-Pathogen Interactions in the Lung: Implications for Respiratory Disease. Frontiers in Immunology 12.
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Rajendra KC & Ronan F. O’Toole. 2021. Targeting Cellular Signalling Pathways in Lung Diseases. Targeting Cellular Signalling Pathways in Lung Diseases 471 484 .
Adonis D’MelloAshleigh N. Riegler, Eriel Martínez, Sarah M. Beno, Tiffany D. Ricketts, Ellen F. Foxman, Carlos J. Orihuela & Hervé Tettelin. (2020) An in vivo atlas of host–pathogen transcriptomes during Streptococcus pneumoniae colonization and disease . Proceedings of the National Academy of Sciences 117:52, pages 33507-33518.
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Jing Zhang, Zhenxing Zhu, Xu Zuo, He Pan, Yinuo Gu, Yuze Yuan, Guoqiang Wang, Shiji Wang, Ruipeng Zheng, Zhongmin Liu, Fang Wang & Jingtong Zheng. (2020) The role of NTHi colonization and infection in the pathogenesis of neutrophilic asthma. Respiratory Research 21:1.
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Rajendra KC, Isabel K. Hyland, Jason A. Smith, Shakti D. Shukla, Philip M. Hansbro, Graeme R. Zosky, Gunasegaran Karupiah & Ronan F. O’Toole. (2020) Cow Dung Biomass Smoke Exposure Increases Adherence of Respiratory Pathogen Nontypeable Haemophilus influenzae to Human Bronchial Epithelial Cells. Exposure and Health 12:4, pages 883-895.
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Manmeet Bhalla, Jun Hui Yeoh, Claire Lamneck, Sydney E. Herring, Essi Y.I. Tchalla, Lauren R. Heinzinger, John M. Leong & Elsa N. Bou Ghanem. (2019) A1 adenosine receptor signaling reduces Streptococcus pneumoniae adherence to pulmonary epithelial cells by targeting expression of platelet‐activating factor receptor . Cellular Microbiology 22:2.
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Shakti D. Shukla, E. Haydn Walters, Jodie L. Simpson, Simon Keely, Peter A.B. Wark, Ronan F. O'Toole & Philip M. Hansbro. (2019) Hypoxia‐inducible factor and bacterial infections in chronic obstructive pulmonary disease. Respirology 25:1, pages 53-63.
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Xuxu Gou, Qiao Zhang, Sunil More, Gayan Bamunuarachchi, Yurong Liang, Faizan Haider Khan, Rachel Maranville, Emily Zuniga, Changzheng Wang & Lin Liu. (2019) Repeated Exposure to Streptococcus pneumoniae Exacerbates Chronic Obstructive Pulmonary Disease. The American Journal of Pathology 189:9, pages 1711-1720.
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Brianna Atto, Mathew Suji Eapen, Pawan Sharma, Urs Frey, Alaina J. Ammit, James Markos, Collin Chia, Josie Larby, Greg Haug, Heinrich C. Weber, George Mabeza, Stephen Tristram, Stephen Myers, Dominic P. Geraghty, Katie L. Flanagan, Philip M. Hansbro & Sukhwinder Singh Sohal. (2019) New therapeutic targets for the prevention of infectious acute exacerbations of COPD: role of epithelial adhesion molecules and inflammatory pathways. Clinical Science 133:14, pages 1663-1703.
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Ger Rijkers, Sophie Croon & Thuc Anh Nguyen. (2019) Rocking Pneumonia and the Boogie Woogie Flu. European Medical Journal, pages 48-54.
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Mathew Suji Eapen, Pawan Sharma, Isobel E. Thompson, Wenying Lu, Stephen Myers, Philip M. Hansbro & Sukhwinder Singh Sohal. (2019) Heparin-binding epidermal growth factor (HB-EGF) drives EMT in patients with COPD: implications for disease pathogenesis and novel therapies. Laboratory Investigation 99:2, pages 150-157.
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María-José Giménez, Lorenzo Aguilar & Juan José Granizo. (2018) Revisiting cefditoren for the treatment of community-acquired infections caused by human-adapted respiratory pathogens in adults. Multidisciplinary Respiratory Medicine 13:1.
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Rajendra KC, Shakti D. Shukla, Sanjay S. Gautam, Philip M. Hansbro & Ronan F. O’Toole. (2018) The role of environmental exposure to non‐cigarette smoke in lung disease. Clinical and Translational Medicine 7:1.
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Ifrah Sohail, Sumit Ghosh, Santhosh Mukundan, Susan Zelewski & M. Nadeem Khan. (2018) Role of Inflammatory Risk Factors in the Pathogenesis of Streptococcus pneumoniae. Frontiers in Immunology 9.
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Isabel K. Hyland, Ronan F. O'Toole, Jason A. Smith & Alex C. Bissember. (2018) Progress in the Development of Platelet-Activating Factor Receptor (PAFr) Antagonists and Applications in the Treatment of Inflammatory Diseases. ChemMedChem 13:18, pages 1873-1884.
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Sukhwinder Singh Sohal. (2018) Inhaled corticosteroids and increased microbial load in COPD: potential role of epithelial adhesion molecules. European Respiratory Journal 51:2, pages 1702257.
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Lisa Miyashita, Reetika Suri, Emma Dearing, Ian Mudway, Rosamund E Dove, Daniel R. Neill, Richard Van Zyl-Smit, Aras Kadioglu & Jonathan Grigg. (2018) E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells. European Respiratory Journal 51:2, pages 1701592.
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K C Rajendra, Graeme R Zosky, Shakti D Shukla & Ronan F O’Toole. (2018) A cost-effective technique for generating preservable biomass smoke extract and measuring its effect on cell receptor expression in human bronchial epithelial cells. Biology Methods and Protocols 3:1.
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Shakti Dhar Shukla, Malik Quasir Mahmood, Steven Weston, Roger Latham, Hans Konrad Muller, Sukhwinder Singh Sohal & Eugene Haydn Walters. (2017) The main rhinovirus respiratory tract adhesion site (ICAM-1) is upregulated in smokers and patients with chronic airflow limitation (CAL). Respiratory Research 18:1.
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Sukhwinder Singh Sohal, Philip M. Hansbro, Shakti Dhar Shukla, Mathew Suji Eapen & Eugene Haydn Walters. (2017) Potential Mechanisms of Microbial Pathogens in Idiopathic Interstitial Lung Disease. Chest 152:4, pages 899-900.
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Xiao-Xi Lv, Shan-Shan Liu, Ke Li, Bing Cui, Chang Liu & Zhuo-Wei Hu. (2017) Cigarette smoke promotes COPD by activating platelet-activating factor receptor and inducing neutrophil autophagic death in mice. Oncotarget 8:43, pages 74720-74735.
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Rajendra Kc, Shakti D Shukla, Eugene H Walters & Ronan F O'Toole. (2017) Temporal upregulation of host surface receptors provides a window of opportunity for bacterial adhesion and disease. Microbiology 163:4, pages 421-430.
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Ronan F. O’Toole, Shakti D. Shukla & Eugene H. Walters. (2016) Does upregulated host cell receptor expression provide a link between bacterial adhesion and chronic respiratory disease?. Journal of Translational Medicine 14:1.
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