An antagonist of the platelet-activating factor receptor inhibits adherence of both nontypeable Haemophilus influenzae and Streptococcus pneumoniae to cultured human bronchial epithelial cells exposed to cigarette smoke

References

• WHOThe Top 10 Causes of DeathGenevaWorld Health Organization2014
   Google Scholar
• LokkeALangePScharlingHFabriciusPVestboJDeveloping COPD: a 25 year follow up study of the general populationThorax2006611193593917071833
   PubMed Web of Science ®Google Scholar
• LundbackBLindbergALindstromMNot 15 but 50% of smokers develop COPD? – Report from the obstructive lung disease in northern Sweden studiesRespir Med200397211512212587960
   PubMed Web of Science ®Google Scholar
• TaylorJDCOPD and the response of the lung to tobacco smoke exposurePulm Pharmacol Ther201023537638320382250
   PubMed Web of Science ®Google Scholar
• NuortiJPButlerJCFarleyMMCigarette smoking and invasive pneumococcal disease. Active Bacterial Core Surveillance TeamN Engl J Med20003421068168910706897
   PubMed Web of Science ®Google Scholar
• VossMWonnenbergBHoneckerACigarette smoke-promoted acquisition of bacterial pathogens in the upper respiratory tract leads to enhanced inflammation in miceRespir Res20151614125890119
   PubMed Web of Science ®Google Scholar
• SethiSMurphyTFInfection in the pathogenesis and course of chronic obstructive pulmonary diseaseN Engl J Med2008359222355236519038881
   PubMed Web of Science ®Google Scholar
• CabelloHTorresACelisRBacterial colonization of distal airways in healthy subjects and chronic lung disease: a bronchoscopic studyEur Respir J1997105113711449163659
   PubMed Web of Science ®Google Scholar
• BeasleyVJoshiPVSinganayagamAMolyneauxPLJohnstonSLMalliaPLung microbiology and exacerbations in COPDInt J Chron Obstruct Pulmon Dis2012755556922969296
   PubMed Web of Science ®Google Scholar
• GriggJThe platelet activating factor receptor: a new anti-infective target in respiratory disease?Thorax201267984084122802333
   PubMed Web of Science ®Google Scholar
• ShuklaSSohalSReidDGriggJWaltersEPlatelet activating factor receptor (PAFr) expression is increased in airways of COPD patients but is not attenuated by inhaled corticosteroidsPaper presented at: European Respiratory Society Annual Congress2013Barcelona, Spain
   Google Scholar
• ShuklaSDPlatelet-activating factor receptor and signal transduction mechanismsFASEB J199266229623011312046
   PubMed Web of Science ®Google Scholar
• CundellDRGerardNPGerardCIdanpaan-HeikkilaITuomanenEIStreptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factorNature199537765484354387566121
   PubMed Web of Science ®Google Scholar
• SwordsWEBuscherBAVer Steeg IiKNon-typeable Haemophilus influenzae adhere to and invade human bronchial epithelial cells via an interaction of lipooligosaccharide with the PAF receptorMol Microbiol2000371132710931302
   PubMed Web of Science ®Google Scholar
• ShuklaSDSohalSSO’TooleRFEapenMSWaltersEHPlatelet activating factor receptor: gateway for bacterial chronic airway infection in chronic obstructive pulmonary disease and potential therapeutic targetExpert Rev Respir Med20159447348526207607
   PubMed Web of Science ®Google Scholar
• ShuklaSDSohalSSMahmoodMQReidDMullerHKWaltersEHAirway epithelial platelet-activating factor receptor expression is markedly upregulated in chronic obstructive pulmonary diseaseInt J Chron Obstruct Pulmon Dis2014985386125143722
   PubMed Web of Science ®Google Scholar
• ShuklaSDMullerHKLathamRSohalSSWaltersEHPlatelet-activating factor receptor (PAFr) is upregulated in small airways and alveoli of smokers and COPD patientsRespirology201621350451026662379
   PubMed Web of Science ®Google Scholar
• GriggJWaltersHSohalSSCigarette smoke and platelet-activating factor receptor dependent adhesion of Streptococcus pneumoniae to lower airway cellsThorax2012671090891322550083
   PubMed Web of Science ®Google Scholar
• CellaiCLaurenzanaAVannucchiAMGrowth inhibition and differentiation of human breast cancer cells by the PAFR antagonist WEB-2086Br J Cancer200694111637164216721373
   PubMed Web of Science ®Google Scholar
• CellaiCLaurenzanaAVannucchiAMDella MalvaNBianchiLPaolettiFSpecific PAF antagonist WEB-2086 induces terminal differentiation of murine and human leukemia cellsFASEB J200216773373511923217
   PubMed Web of Science ®Google Scholar
• KatoMImotoKMiyakeHOdaTMiyajiSNakamuraMApafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigsJ Pharmacol Sci200495443544215286429
   PubMed Web of Science ®Google Scholar
• AvadhanulaVRodriguezCAUlettGCBakaletzLOAddersonEENontypeable Haemophilus influenzae adheres to intercellular adhesion molecule 1 (ICAM-1) on respiratory epithelial cells and upregulates ICAM-1 expressionInfect Immun200674283083816428725
   PubMed Web of Science ®Google Scholar
• AdamouJEWizemannTMBarrenPLangermannSAdherence of Streptococcus pneumoniae to Human Bronchial Epithelial Cells (BEAS-2B)Infection Immun1998662820822
   Web of Science ®Google Scholar
• MushtaqNEzzatiMHallLAdhesion of Streptococcus pneumoniae to human airway epithelial cells exposed to urban particulate matterJ Allergy Clin Immunol2011127512361242.e123221247619
   PubMed Web of Science ®Google Scholar
• LathamRZhangBTristramSIdentifying Haemophilus haemolyticus and Haemophilus influenzae by SYBR Green real-time PCRJ Microbiol Methods2015112676925753676
   PubMed Web of Science ®Google Scholar
• SaliABlundellTLComparative protein modelling by satisfaction of spatial restraintsJ Mol Biol199323437798158254673
   PubMed Web of Science ®Google Scholar
• ZhangJYangJJangRZhangYGPCR-I-TASSER: A hybrid approach to G protein-coupled receptor structure modeling and the application to the human genomeStructure20152381538154926190572
   PubMed Web of Science ®Google Scholar
• TrottOOlsonAJAutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreadingJ Comput Chem201031245546119499576
   PubMed Web of Science ®Google Scholar
• O’BoyleNMBanckMJamesCAMorleyCVandermeerschTHutchisonGROpen Babel: an open chemical toolboxJ Cheminform201133321982300
   PubMed Web of Science ®Google Scholar
• SannerMFPython: a programming language for software integration and developmentJ Mol Graph Model1999171576110660911
   PubMed Web of Science ®Google Scholar
• Marti-LliterasPLopez-GomezAMauroSNontypable Haemophilus influenzae displays a prevalent surface structure molecular pattern in clinical isolatesPLoS One201166e2113321698169
   PubMed Web of Science ®Google Scholar
• SwordsWEKettererMRShaoJCampbellCAWeiserJNApicellaMABinding of the non-typeable Haemophilus influenzae lipooligosaccharide to the PAF receptor initiates host cell signallingCell Microbiol20013852553611488814
   PubMed Web of Science ®Google Scholar
• ClarkSESnowJLiJZolaTAWeiserJNPhosphorylcholine allows for evasion of bactericidal antibody by Haemophilus influenzaePLoS Pathog201283e100252122396641
   PubMed Web of Science ®Google Scholar
• WeiserJNPanNMcGowanKLMusherDMartinARichardsJPhosphorylcholine on the lipopolysaccharide of Haemophilus influenzae contributes to persistence in the respiratory tract and sensitivity to serum killing mediated by C-reactive proteinJ Exp Med199818746316409463413
   PubMed Web of Science ®Google Scholar
• WeiserJNShchepetovMChongSTDecoration of lipopolysaccharide with phosphorylcholine: a phase-variable characteristic of Haemophilus influenzaeInfect Immun19976539439509038301
   PubMed Web of Science ®Google Scholar
• McCreaKWXieJMarrsCFGilsdorfJRPrevalence of genetic differences in phosphorylcholine expression between nontypeable Haemophilus influenzae and Haemophilus haemolyticusBMC Microbiol20101028621073698
   PubMed Web of Science ®Google Scholar
• WeiserJNLoveJMMoxonERThe molecular mechanism of phase variation of H. influenzae lipopolysaccharideCell19895946576652479481
   PubMed Web of Science ®Google Scholar
• MichelVYuanZRamsubirSBakovicMCholine transport for phospholipid synthesisExp Biol Med (Maywood)2006231549050416636297
   PubMed Web of Science ®Google Scholar
• FanXPericoneCDLysenkoEGoldfineHWeiserJNMultiple mechanisms for choline transport and utilization in Haemophilus influenzaeMol Microbiol200350253754814617177
   PubMed Web of Science ®Google Scholar
• RijneveldAWWeijerSFlorquinSImproved host defense against pneumococcal pneumonia in platelet-activating factor receptor-deficient miceJ Infect Dis2004189471171614767826
   PubMed Web of Science ®Google Scholar
• van der SluijsKFvan EldenLJNijhuisMInvolvement of the platelet-activating factor receptor in host defense against Streptococcus pneumoniae during postinfluenza pneumoniaAm J Physiol Lung Cell Mol Physiol20062901L194L19916100290
   PubMed Web of Science ®Google Scholar
• IshizukaSYamayaMSuzukiTAcid exposure stimulates the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells: effects on platelet-activating factor receptor expressionAm J Respir Cell Mol Biol200124445946811306440
   PubMed Web of Science ®Google Scholar