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International Journal of Chronic Obstructive Pulmonary Disease Volume 13, 2018 - Issue
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Original Research

Phenotyping COPD exacerbations using imaging and blood-based biomarkers

Nawaf M Alotaibi1 Centre for Heart Lung Innovation, James Hogg Research Centre, St Paul’s Hospital, Vancouver, BC, Canada;2 Division of Pulmonary Medicine, Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia
,
Virginia Chen1 Centre for Heart Lung Innovation, James Hogg Research Centre, St Paul’s Hospital, Vancouver, BC, Canada;3 Institute for Heart Lung Health;4 PROOF Centre of Excellence
,
Zsuzsanna Hollander1 Centre for Heart Lung Innovation, James Hogg Research Centre, St Paul’s Hospital, Vancouver, BC, Canada;3 Institute for Heart Lung Health;4 PROOF Centre of Excellence
,
Cameron J Hague5 Department of Radiology, St Paul’s Hospital
,
Darra T Murphy5 Department of Radiology, St Paul’s Hospital
,
Jonathon A Leipsic5 Department of Radiology, St Paul’s Hospital
,
Mari L DeMarco1 Centre for Heart Lung Innovation, James Hogg Research Centre, St Paul’s Hospital, Vancouver, BC, Canada;6 Department of Pathology and Laboratory Medicine
,
J Mark FitzGerald7 Division of Respiratory Medicine, Department of Medicine, University of British Columbia;8 The Lung Centre, Vancouver General Hospital
,
Bruce M McManus1 Centre for Heart Lung Innovation, James Hogg Research Centre, St Paul’s Hospital, Vancouver, BC, Canada;3 Institute for Heart Lung Health;4 PROOF Centre of Excellence;6 Department of Pathology and Laboratory Medicine
,
Raymond T Ng4 PROOF Centre of Excellence;9 Department of Computer Sciences, University of British Columbia, Vancouver, BC, Canada
&
Don D Sin1 Centre for Heart Lung Innovation, James Hogg Research Centre, St Paul’s Hospital, Vancouver, BC, Canada;3 Institute for Heart Lung Health;7 Division of Respiratory Medicine, Department of Medicine, University of British ColumbiaCorrespondence[email protected]
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Pages 217-229 | Published online: 08 Jan 2018

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Yue Zhang, Lianping Ren, Jinyuan Sun, Fengfeng Han & Xuejun Guo. (2021) Increased Serum Soluble Interleukin-2 Receptor Associated with Severity of Acute Exacerbation of Chronic Obstructive Pulmonary Disease. International Journal of Chronic Obstructive Pulmonary Disease 16, pages 2561-2573.
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Bojidar A Rangelov, Alexandra L Young, Joseph Jacob, Anthony P Cahn, Sarah Lee, Frederick J Wilson, David J Hawkes & John R Hurst. (2020) Thoracic Imaging at Exacerbation of Chronic Obstructive Pulmonary Disease: A Systematic Review. International Journal of Chronic Obstructive Pulmonary Disease 15, pages 1751-1787.
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Nawaf M Alotaibi, Virginia Chen, Zsuzsanna Hollander, Jonathon A Leipsic, Cameron J Hague, Darra T Murphy, Mari L DeMarco, JM FitzGerald, Bruce M McManus, Raymond T Ng & Don D Sin. (2019) Phenotyping and outcomes of hospitalized COPD patients using rapid molecular diagnostics on sputum samples. International Journal of Chronic Obstructive Pulmonary Disease 14, pages 311-319.
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Dhuha Al-Sajee, Xuanzhi Yin & Gail M. Gauvreau. (2019) An evaluation of roflumilast and PDE4 inhibitors with a focus on the treatment of asthma. Expert Opinion on Pharmacotherapy 20:5, pages 609-620.
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Ji-Yong Moon, Fernando Sergio Leitao Filho, Kimeya Shahangian, Hiroto Takiguchi & Don D. Sin. (2018) Blood and sputum protein biomarkers for chronic obstructive pulmonary disease (COPD). Expert Review of Proteomics 15:11, pages 923-935.
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Articles from other publishers (11)

Bartolome R. Celli, Leonardo M. Fabbri, Shawn D. AaronAlvar AgustiRobert D. BrookGerard J. CrinerFrits M. E. FranssenMarc HumbertJohn R. HurstMaria Montes de OcaLeonardo PantoniAlberto PapiRoberto Rodriguez-RoisinSanjay SethiDaiana StolzAntoni Torres, Claus F. Vogelmeier & Jadwiga A. Wedzicha. (2023) Differential Diagnosis of Suspected Chronic Obstructive Pulmonary Disease Exacerbations in the Acute Care Setting: Best Practice. American Journal of Respiratory and Critical Care Medicine 207:9, pages 1134-1144.
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Chunyan Huang, Shaofeng Li, Chao Xu, Wenlong Song, Lei Xu, Zhihui Lan & Liangji Liu. (2022) Buyuan decoction inhibits autophagy in a rat model of chronic obstructive pulmonary disease. Archives of Biological Sciences Arhiv za bioloske nauke 74:1, pages 5-14.
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Yalin Zhao, Meihua Li, Yanxia Yang, Tao Wu, Qingyuan Huang, Qinghua Wu & Chaofeng Ren. (2021) Identification of Macrophage Polarization-Related Genes as Biomarkers of Chronic Obstructive Pulmonary Disease Based on Bioinformatics Analyses. BioMed Research International 2021, pages 1-17.
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Massa Zantah, Yaniv Dotan, Chandra Dass, Hauqing Zhao, Nathaniel Marchetti & Gerard J. Criner. (2020) Acute exacerbations of COPD versus IPF in patients with combined pulmonary fibrosis and emphysema. Respiratory Research 21:1.
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Ernesto Crisafulli, Alessandra Manco, Miquel Ferrer, Arturo Huerta, Claudio Micheletto, Domenico Girelli, Enrico Clini & Antoni Torres. (2020) Pneumonic versus Nonpneumonic Exacerbations of Chronic Obstructive Pulmonary Disease. Seminars in Respiratory and Critical Care Medicine 41:06, pages 817-829.
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Holly R. Keir, Alison Dicker, Mike Lonergan, Megan Crichton, Bruce E. Miller, Ruth Tal-Singer & James D. Chalmers. (2020) Clinical endotypes of exacerbation are associated with differences in microbial composition and diversity in COPD. European Respiratory Journal 56:4, pages 2000391.
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Kate Milne & Don D. Sin. 2020. Cardiac Considerations in Chronic Lung Disease. Cardiac Considerations in Chronic Lung Disease 229 245 .
David M. Mannino. (2019) Biomarkers for chronic obstructive pulmonary disease diagnosis and progression. Current Opinion in Pulmonary Medicine 25:2, pages 144-149.
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Vanessa M McDonald, Christian R Osadnik & Peter G Gibson. (2019) Treatable traits in acute exacerbations of chronic airway diseases. Chronic Respiratory Disease 16, pages 147997311986795.
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Maria Montes de Oca & Maria Laucho-Contreras. (2018) Is It Time to Change the Definition of Acute Exacerbation of Chronic Obstructive Pulmornary Disease? What Do We Need to Add?. Medical Sciences 6:2, pages 50.
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John R Hurst. (2018) Consolidation and Exacerbation of COPD. Medical Sciences 6:2, pages 44.
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