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International Journal of Chronic Obstructive Pulmonary Disease Volume 11, 2016 - Issue
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Study Protocol

The Belgian trial with azithromycin for acute COPD exacerbations requiring hospitalization: an investigator-initiated study protocol for a multicenter, randomized, double-blind, placebo-controlled trial

Kristina Vermeersch1 KU Leuven, Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, Faculty of Medicine, Leuven, Belgium
,
Maria Gabrovska2 Department of Pneumology, Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium
,
Griet Deslypere3 Department of Pneumology, Jessa Ziekenhuis, Hasselt, Belgium
,
Ingel K Demedts4 Department of Respiratory Medicine, AZ Delta Roeselare-Menen, Roeselare, Belgium
,
Hans Slabbynck5 Department of Respiratory Medicine, ZNA Middelheim, Antwerpen, Belgium
,
Joseph Aumann3 Department of Pneumology, Jessa Ziekenhuis, Hasselt, Belgium
,
Vincent Ninane2 Department of Pneumology, Centre Hospitalier Universitaire Saint-Pierre, Brussels, Belgium
,
Geert M Verleden1 KU Leuven, Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, Faculty of Medicine, Leuven, Belgium
,
Thierry Troosters1 KU Leuven, Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, Faculty of Medicine, Leuven, Belgium;6 KU Leuven, Department of Rehabilitation Sciences, Faculty of Kinesiology and Rehabilitation Sciences, Leuven, Belgium
,
Kris Bogaerts7 KU Leuven, Department of Public Health and Primary Care, I–BioStat, Leuven, Belgium;8 Hasselt University, Hasselt, Belgium
,
Guy G Brusselle9 Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
&
Wim Janssens1 KU Leuven, Laboratory of Respiratory Diseases, Department of Clinical and Experimental Medicine, Faculty of Medicine, Leuven, BelgiumCorrespondence[email protected]
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Pages 687-696 | Published online: 31 Mar 2016

Citations (11)

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Oliver Van Oekelen, Kristina Vermeersch, Stephanie Everaerts, Bert Vandenberk, Rik Willems & Wim Janssens. (2018) Significance of prolonged QTc in acute exacerbations of COPD requiring hospitalization. International Journal of Chronic Obstructive Pulmonary Disease 13, pages 1937-1947.
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Marco Mantero, Paola Rogliani, Marta Di Pasquale, Eva Polverino, Ernesto Crisafulli, Monica Guerrero, Andrea Gramegna, Mario Cazzola & Francesco Blasi. (2017) Acute exacerbations of COPD: risk factors for failure and relapse. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 2687-2693.
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Articles from other publishers (9)

Nour Baalbaki, Christopher Giuliano, Carrie L. Hartner, Pramodini Kale-Pradhan & Leonard Johnson. (2022) Azithromycin Versus Beta-lactams in Hospitalized Patients with Acute Exacerbations of COPD. Journal of General Internal Medicine 37:16, pages 4183-4188.
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Kristina Vermeersch, Ann Belmans, Kris Bogaerts, Iwein Gyselinck, Nina Cardinaels, Maria Gabrovska, Joseph Aumann, Ingel K. Demedts, Jean-Louis Corhay, Eric Marchand, Hans Slabbynck, Christel Haenebalcke, Stefanie Vermeersch, Geert M. Verleden, Thierry Troosters, Vincent Ninane, Guy G. Brusselle & Wim Janssens. (2019) Treatment failure and hospital readmissions in severe COPD exacerbations treated with azithromycin versus placebo – a post-hoc analysis of the BACE randomized controlled trial. Respiratory Research 20:1.
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Kristina Vermeersch, Maria Gabrovska, Joseph Aumann, Ingel K. Demedts, Jean-Louis Corhay, Eric Marchand, Hans Slabbynck, Christel Haenebalcke, Michiel Haerens, Shane Hanon, Paul Jordens, Rudi Peché, Antoine Fremault, Tine Lauwerier, Anja Delporte, Bert Vandenberk, Rik Willems, Stephanie Everaerts, Ann Belmans, Kris Bogaerts, Geert M. Verleden, Thierry Troosters, Vincent Ninane, Guy G. Brusselle & Wim Janssens. (2019) Azithromycin during Acute Chronic Obstructive Pulmonary Disease Exacerbations Requiring Hospitalization (BACE). A Multicenter, Randomized, Double-Blind, Placebo-controlled Trial. American Journal of Respiratory and Critical Care Medicine 200:7, pages 857-868.
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Tyree H. Kiser, Paul M. Reynolds, Marc Moss, Ellen L. Burnham, P. Michael Ho & Richard William Vandivier. (2019) Impact of Macrolide Antibiotics on Hospital Readmissions and Other Clinically Important Outcomes in Critically Ill Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Propensity Score–Matched Cohort Study. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 39:3, pages 242-252.
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Malene Plejdrup Hansen, Anna M Scott, Amanda McCullough, Sarah Thorning, Jeffrey K Aronson, Elaine M Beller, Paul P Glasziou, Tammy C Hoffmann, Justin Clark & Chris B Del Mar. (2019) Adverse events in people taking macrolide antibiotics versus placebo for any indication. Cochrane Database of Systematic Reviews 2019:1.
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Nan Ma, Ting-Ting Deng, Qin Wang, Zhou-Ling Luo, Cai-Feng Zhu, Ju-Feng Qiu, Xiao-Juan Tang, Mei Huang, Jing Bai, Zhi-Yi He, Xiao-Ning Zhong & Mei-Hua Li. (2019) Erythromycin Regulates Cigarette Smoke-Induced Proinflammatory Mediator Release Through Sirtuin 1-Nuclear Factor κB Axis in Macrophages and Mice Lungs. Pathobiology 86:5-6, pages 237-247.
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Samantha C Herath, Rebecca Normansell, Samantha Maisey & Phillippa Poole. (2018) Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD). Cochrane Database of Systematic Reviews 2018:10.
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Daniel Runggaldier, Taro Minami, Daniel Golding & Kamran Manzoor. (2018) Acute COPD exacerbation presenting with pronounced intrabullous haemorrhage and haemoptysis. BMJ Case Reports, pages bcr-2018-225339.
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Rianne de Vries, Yennece W.F. Dagelet, Pien Spoor, Erik Snoey, Patrick M.C. Jak, Paul Brinkman, Erica Dijkers, Simon K. Bootsma, Fred Elskamp, Frans H.C. de Jongh, Eric G. Haarman, Johannes C.C.M in ‘t Veen, Anke-Hilse Maitland-van der Zee & Peter J. Sterk. (2018) Clinical and inflammatory phenotyping by breathomics in chronic airway diseases irrespective of the diagnostic label. European Respiratory Journal 51:1, pages 1701817.
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