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Drug Design, Development and Therapy Volume 10, 2016 - Issue
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Original Research

Flurbiprofen–antioxidant mutual prodrugs as safer nonsteroidal anti-inflammatory drugs: synthesis, pharmacological investigation, and computational molecular modeling

Zaman Ashraf1 Department of Chemistry, Allama Iqbal Open University, Islamabad, Pakistan;2 Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, Republic of Korea
,
Alamgeer3 Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha, Pakistan
,
Munazza Kanwal1 Department of Chemistry, Allama Iqbal Open University, Islamabad, Pakistan
,
Mubashir Hassan2 Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, Republic of Korea
,
Sahar Abdullah3 Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha, Pakistan
,
Mamuna Waheed3 Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha, Pakistan
,
Haseeb Ahsan3 Department of Pharmacology, Faculty of Pharmacy, University of Sargodha, Sargodha, Pakistan
&
Song Ja Kim2 Department of Biological Sciences, College of Natural Sciences, Kongju National University, Gongju, Republic of KoreaCorrespondence[email protected]
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Pages 2401-2419 | Published online: 27 Jul 2016

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Zaman Ashraf, Tariq Mahmood, Mubashir Hassan, Samina Afzal, Hummera Rafique, Khurram Afzal & Jalifah Latip. (2019) Dexibuprofen amide derivatives as potential anticancer agents: synthesis, in silico docking, bioevaluation, and molecular dynamic simulation. Drug Design, Development and Therapy 13, pages 1643-1657.
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Muhammad Tahir Aqeel, Nisar ur-Rahman, Arif-ullah Khan, Zaman Ashraf, Muhammad Latif, Hummera Rafique & Usman Rasheed. (2018) Antihyperlipidemic studies of newly synthesized phenolic derivatives: in silico and in vivo approaches. Drug Design, Development and Therapy 12, pages 2443-2453.
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Divya Vemula, Perka Jayasurya, Varthiya Sushmitha, Yethirajula Naveen Kumar & Vasundhra Bhandari. (2023) CADD, AI and ML in drug discovery: A comprehensive review. European Journal of Pharmaceutical Sciences 181, pages 106324.
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Gülce Taşkor Önel & Nezire Saygılı. (2022) Synthesis and Cyclooxygenase Enzyme Inhibitory Activity of Flurbiprofen Analogues: Simple Methodology of Their Nanoemulsion Systems. ChemistrySelect 7:27.
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Muhammad Usman Munir, Mahnoor Ikraam, Muhammad Nadeem, Syed Haroon Khalid, Sajid Asghar, Ikrima Khalid, Muhammad Irfan, Nayyer Islam, Nyla Ajaz & Ikram Ullah Khan. (2022) Fabrication, In Vitro and In Vivo Evaluation of Non-Ordered Mesoporous Silica-Based Ternary Solid Dispersions for Enhanced Solubility of Flurbiprofen. Pharmaceuticals 15:7, pages 856.
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Nija B.Arun Rasheed & Kottaimuthu A. (2020) Development, Characterization, and Pharmacological Investigation of Sesamol and Thymol Conjugates of Mefenamic Acid. Journal of Evolution of Medical and Dental Sciences 9:52, pages 3909-3916.
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Akhil Bansal, Alka Bali & Ajitesh Balaini. (2020) Synthesis and Evaluation of Substituted Aryl Thiazoles With Antioxidant Potential as Gastro-sparing Anti-inflammatory Agents. Letters in Drug Design & Discovery 17:12, pages 1566-1578.
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Muge Gulen, Basak Unver KolumanAkkan Avci & Salim Satar. (2019) Flurbiprofen-Associated Hemolytic Anemia. American Journal of Therapeutics 26:6, pages e723-e726.
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Shikha Sehajpal, Deo Nandan Prasad & Rajesh K. Singh. (2019) Novel ketoprofen–antioxidants mutual codrugs as safer nonsteroidal anti‐inflammatory drugs: Synthesis, kinetic and pharmacological evaluation. Archiv der Pharmazie 352:7.
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Jyoti, Divya Dheer, Davinder Singh, Gulshan Kumar, Manvika Karnatak, Suresh Chandra, Ved Prakash Verma & Ravi Shankar. (2019) Thymol Chemistry: A Medicinal Toolbox. Current Bioactive Compounds 15:5, pages 454-474.
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Happy Agarwal & Venkat Kumar Shanmugam. (2019) Anti-inflammatory activity screening of Kalanchoe pinnata methanol extract and its validation using a computational simulation approach. Informatics in Medicine Unlocked 14, pages 6-14.
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Muhammad Hanif, Mubashir Hassan, Muhammad Rafiq, Qamar Abbas, Ansa Ishaq, Saba Shahzadi, Sung-Yum Seo & Muhammad Saleem. (2018) Microwave-Assisted Synthesis, In Vivo Anti-Inflammatory and In Vitro Anti-Oxidant Activities, and Molecular Docking Study of New Substituted Schiff Base Derivatives. Pharmaceutical Chemistry Journal 52:5, pages 424-437.
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Jaya P. Peesa, Lakshmana R. Atmakuri, Prasanna R. Yalavarthi, Basaveswara R. Mandava Venkata, Arun Rasheed & Vengalrao Pachava. (2017) Oxaprozin prodrug as safer nonsteroidal anti‐inflammatory drug: Synthesis and pharmacological evaluation. Archiv der Pharmazie 351:2.
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