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Drug Design, Development and Therapy Volume 10, 2016 - Issue
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Original Research

Design, synthesis, and characterization of (1-(4-aryl)- 1H-1,2,3-triazol-4-yl)methyl, substituted phenyl-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylates against Mycobacterium tuberculosis

Katharigatta N Venugopala1 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia;2 Department of Biotechnology and Food Technology, Durban University of Technology, Durban, South AfricaCorrespondence[email protected]
,
G B Dharma Rao3 Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal, India
,
Subhrajyoti Bhandary3 Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal, India
,
Melendhran Pillay4 Department of Microbiology, National Health Laboratory Services, KZN Academic Complex, Inkosi Albert Luthuli Central Hospital, Durban, South Africa
,
Deepak Chopra3 Department of Chemistry, Indian Institute of Science Education and Research Bhopal, Bhopal, India
,
Bandar E Aldhubiab1 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia
,
Mahesh Attimarad1 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia
,
Osama Ibrahim Alwassil1 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia
,
Sree Harsha1 Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia
&
Koleka Mlisana4 Department of Microbiology, National Health Laboratory Services, KZN Academic Complex, Inkosi Albert Luthuli Central Hospital, Durban, South Africa
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Pages 2681-2690 | Published online: 25 Aug 2016

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Ramasamy Duraisamy, Nizar A. Al-Shar’i, Sandeep Chandrashekharappa, Pran Kishore Deb, Raquel M. Gleiser, Christophe Tratrat, Deepak Chopra, Madhusudana Reddy Muthukurpalya Bhojegowd, Dhakshanamurthy Thirumalai, Mohamed A. Morsy, Yasmine F. Ibrahim, Viresh Mohanlall & Katharigatta N. Venugopala. (2023) Synthesis, biological evaluation, and computational investigation of ethyl 2,4,6-trisubstituted-1,4-dihydropyrimidine-5-carboxylates as potential larvicidal agents against Anopheles arabiensis. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-13.
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Mubarak H. Shaikh, Dnyaneshwar D. Subhedar, Satish V. Akolkar, Amol A. Nagargoje, Vijay M. Khedkar, Dhiman Sarkar & Bapurao B. Shingate. (2022) Tetrazoloquinoline-1,2,3-Triazole Derivatives as Antimicrobial Agents: Synthesis, Biological Evaluation and Molecular Docking Study. Polycyclic Aromatic Compounds 42:4, pages 1920-1941.
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Nitin Rode, Aafaq Tantray, Amruta Shelar, Rajendra Patil & Santosh Terdale. (2022) Amino acid ionic liquid-catalyzed synthesis, anti-Leishmania activity, molecular docking, molecular dynamic simulation, and ADME study of 3,4-dihydropyrimidin-2(1H)-(thio)ones. Synthetic Communications 52:2, pages 190-204.
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Dina Abed Bakhotmah. (2021) Synthesis of Fluorine and Phosphorus Compounds Bearing an Amino Pyrimidine-Substituted Pyrazolo[3,4-d]Pyrimidine Moiety as Molluscicidal Agents against Some Snails. Polycyclic Aromatic Compounds 41:4, pages 897-905.
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Katharigatta N. Venugopala, Sandeep Chandrashekharappa, Pran Kishore Deb, Christophe Tratrat, Melendhran Pillay, Deepak Chopra, Nizar A. Al-Shar’i, Wafa Hourani, Lina A. Dahabiyeh, Pobitra Borah, Rahul D. Nagdeve, Susanta K. Nayak, Basavaraj Padmashali, Mohamed A. Morsy, Bandar E. Aldhubiab, Mahesh Attimarad, Anroop B. Nair, Nagaraja Sreeharsha, Michelyne Haroun, Sheena Shashikanth, Viresh Mohanlall & Raghuprasad Mailavaram. (2021) Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 1471-1486.
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Pran Kishore Deb, Nizar A. Al-Shar’i, Katharigatta N. Venugopala, Melendhran Pillay & Pobitra Borah. (2021) In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies of substituted 1,2,4-oxadiazole analogues against Mycobacterium tuberculosis. Journal of Enzyme Inhibition and Medicinal Chemistry 36:1, pages 869-884.
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Katharigatta N Venugopala, Christophe Tratrat, Melendhran Pillay, Sandeep Chandrashekharappa, Omar Husham Ahmed Al-Attraqchi, Bandar E Aldhubiab, Mahesh Attimarad, Osama I Alwassil, Anroop B Nair, Nagaraja Sreeharsha, Rashmi Venugopala, Mohamed A Morsy, Michelyne Haroun, Hezekiel M Kumalo, Bharti Odhav & Koleka Mlisana. (2020) In silico Design and Synthesis of Tetrahydropyrimidinones and Tetrahydropyrimidinethiones as Potential Thymidylate Kinase Inhibitors Exerting Anti-TB Activity Against Mycobacterium tuberculosis. Drug Design, Development and Therapy 14, pages 1027-1039.
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Katharigatta N. Venugopala, Mohammed A. Khedr, Melendhran Pillay, Susanta K. Nayak, Sandeep Chandrashekharappa, Bandar E. Aldhubiab, Sree Harsha, Mahesh Attimard & Bharti Odhav. (2019) Benzothiazole analogs as potential anti-TB agents: computational input and molecular dynamics. Journal of Biomolecular Structure and Dynamics 37:7, pages 1830-1842.
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Mohammed A. Khedr, Melendhran Pillay, Sandeep Chandrashekharappa, Deepak Chopra, Bandar E. Aldhubiab, Mahesh Attimarad, Osama Ibrahim Alwassil, Koleka Mlisana, Bharti Odhav & Katharigatta N. Venugopala. (2018) Molecular modeling studies and anti-TB activity of trisubstituted indolizine analogues; molecular docking and dynamic inputs. Journal of Biomolecular Structure and Dynamics 36:8, pages 2163-2178.
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Ozge Gungor, Yunus Emre Veziroglu, Aysegul Kose, Seyit Ali Gungor & Muhammet Kose. New 1,2,3-triazoles and their oxime derivatives: AChE/BChE enzyme inhibitory and DNA binding properties. Journal of Biomolecular Structure and Dynamics 0:0, pages 1-18.
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VershaRavi Kumar RanaAnjaneyulu Bendi. (2024) Chemistry of Medicinally Important Dihydropyrimidinone-based Heterocycle Scaffolds. Mini-Reviews in Organic Chemistry 21:2, pages 172-215.
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Katharigatta N. Venugopala, Nizar A. Al-Shar’i, Lina A. Dahabiyeh, Wafa Hourani, Pran Kishore Deb, Melendhran Pillay, Bashaer Abu-Irmaileh, Yasser Bustanji, Sandeep Chandrashekharappa, Christophe Tratrat, Mahesh Attimarad, Anroop B. Nair, Nagaraja Sreeharsha, Pottathil Shinu, Michelyne Haroun, Mahmoud Kandeel, Abdulmalek Ahmed Balgoname, Rashmi Venugopala & Mohamed A. Morsy. (2022) Antitubercular, Cytotoxicity, and Computational Target Validation of Dihydroquinazolinone Derivatives. Antibiotics 11:7, pages 831.
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Zhenyou Tan, Jun Deng, Qiongxian Ye & Zhenfeng Zhang. (2021) Triazole-containing hybrids with anti- Mycobacterium tuberculosis potential – Part I: 1,2,3-Triazole . Future Medicinal Chemistry 13:7, pages 643-662.
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Michelyne Haroun, Christophe Tratrat, Hafedh Kochkar & Anroop B. Nair. (2021) Recent Advances in the Development of 1,2,3-Triazole-containing Derivatives as Potential Antifungal Agents and Inhibitors of Lanoster ol 14α-Demethylase. Current Topics in Medicinal Chemistry 21:6, pages 462-506.
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