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Drug Design, Development and Therapy Volume 11, 2017 - Issue
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Original Research

Dexmedetomidine reduces the neuronal apoptosis related to cardiopulmonary bypass by inhibiting activation of the JAK2–STAT3 pathway

Yanhua Chen1 Department of Anesthesiology, Cardiovascular Institute
,
Xu Zhang2 Department of Anesthesiology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China
,
Bingdong Zhang1 Department of Anesthesiology, Cardiovascular Institute
,
Guodong He2 Department of Anesthesiology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China
,
Lifang Zhou2 Department of Anesthesiology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China
&
Yubo Xie2 Department of Anesthesiology, the First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaCorrespondence[email protected]
Pages 2787-2799 | Published online: 26 Sep 2017

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Read on this site (2)

Jijun Xiong, Jie Quan, Chaosheng Qin, Xiaogang Wang, Qinghua Dong & Bingdong Zhang. (2022) Remifentanil pretreatment attenuates brain nerve injury in response to cardiopulmonary bypass by blocking AKT/NRF2 signal pathway. Immunopharmacology and Immunotoxicology 44:4, pages 574-585.
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He Zhu, Aolin Ren, Kang Zhou, Qiuchong Chen, Mengjun Zhang & Jindong Liu. (2020) Impact of Dexmedetomidine Infusion on Postoperative Acute Kidney Injury in Elderly Patients Undergoing Major Joint Replacement: A Retrospective Cohort Study. Drug Design, Development and Therapy 14, pages 4695-4701.
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Articles from other publishers (13)

Sebastian Gatica, Cristobal Aravena, Yolanda Prado, Diego Aravena, Cesar Echeverría, Juan F. Santibanez, Claudia A. Riedel, Jimmy Stehberg & Felipe Simon. 2023. Advances in Molecular Pathology. Advances in Molecular Pathology 163 181 .
Gang Li, Jun Zhou, Jicheng Wei & Bin Liu. (2022) Dexmedetomidine Ameliorated Cognitive Dysfunction Induced by Intestinal Ischemia Reperfusion in Mice with Possible Relation to the Anti-inflammatory Effect Through the Locus Coeruleus Norepinephrine System. Neurochemical Research 47:11, pages 3440-3453.
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Yijun Hu, Hong Zhou, Huanxin Zhang, Yunlong Sui, Zhen Zhang, Yuntao Zou, Kunquan Li, Yunyi Zhao, Jiangbo Xie & Lunzhong Zhang. (2022) The neuroprotective effect of dexmedetomidine and its mechanism. Frontiers in Pharmacology 13.
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Tong Jia, Zhen Xing, Huijuan Wang and & Guoli Li. (2021) Protective effect of dexmedetomidine on intestinal mucosal barrier function in rats after cardiopulmonary bypass. Experimental Biology and Medicine 247:6, pages 498-508.
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Huan Liu, Jianli Li, Li Jiang, Jinhua He, Huanhuan Zhang & Keyan Wang. (2022) Dexmedetomidine pretreatment alleviates cerebral ischemia/reperfusion injury by inhibiting neuroinflammation through the JAK2/STAT3 pathway. Brazilian Journal of Medical and Biological Research 55.
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Pengjiu Feng, Aimin Zhang, Ming Su, Hai Cai, Xiaogang Wang & Yan Zhang. (2021) Dexmedetomidine inhibits apoptosis of astrocytes induced by oxygen-glucose deprivation via targeting JAK/STAT3 signal pathway. Brain Research 1750, pages 147141.
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Jijun XiongJie QuanChaosheng QinXiaogang WangQinghua DongBingdong Zhang. (2020) Retracted: Dexmedetomidine Exerts Brain-Protective Effects Under Cardiopulmonary Bypass Through Inhibiting the Janus Kinase 2/Signal Transducers and Activators of Transcription 3 Pathway . Journal of Interferon & Cytokine Research 40:2, pages 116-124.
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Jia Ding, Yuwen Chen & Yuan Gao. (2019) Effect of propofol, midazolam and dexmedetomidine on ICU patients with sepsis and on arterial blood gas. Experimental and Therapeutic Medicine.
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Huayun Zhang, Jichen Sha, Xiujing Feng, Xueyuan Hu, Yongping Chen, Bei Li & Honggang Fan. (2019) Dexmedetomidine ameliorates LPS induced acute lung injury via GSK-3β/STAT3-NF-κB signaling pathway in rats. International Immunopharmacology 74, pages 105717.
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Chong Liu, Qiang Fu, Rong Mu, Fang Wang, Chunjing Zhou, Li Zhang, Baojin Yu, Yang Zhang, Tao Fang & Fengshi Tian. (2018) Dexmedetomidine alleviates cerebral ischemia-reperfusion injury by inhibiting endoplasmic reticulum stress dependent apoptosis through the PERK-CHOP-Caspase-11 pathway. Brain Research 1701, pages 246-254.
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Azeem Alam, Zac Hana, Zhaosheng Jin, Ka Chun Suen & Daqing Ma. (2018) Surgery, neuroinflammation and cognitive impairment. EBioMedicine 37, pages 547-556.
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William A. Kofke, Yue Ren, John G. Augoustides, Hongzhe Li, Katherine Nathanson, Robert Siman, Qing Cheng Meng, Weiming Bu, Sukanya Yandrawatthana, Guy Kositratna, Cecilia Kim & Joseph E. Bavaria. (2018) Reframing the Biological Basis of Neuroprotection Using Functional Genomics: Differentially Weighted, Time-Dependent Multifactor Pathogenesis of Human Ischemic Brain Damage. Frontiers in Neurology 9.
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A. V. Grechko, Yuri Yu. Kiryachkov & M. V. Petrova. (2018) Modern aspects of the relationship between the functional state of the autonomic nervous system and clinical and laboratory indices of the bodyʼs homeostasis in brain injuries. Annals of Critical Care:2, pages 79-86.
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