References
- CaputoMMokhtariAMiceliAControlled reoxygenation during cardiopulmonary bypass decreases markers of organ damage, inflammation, and oxidative stress in single-ventricle patients undergoing pediatric heart surgeryJ Thorac Cardiovasc Surg20141483 792 801.e825052821
- HomiHMJonesWLde LangeFMackensenGBGrocottHPExacerbation of systemic inflammation and increased cerebral infarct volume with cardiopulmonary bypass after focal cerebral ischemia in the ratJ Thorac Cardiovasc Surg20101403 660 666.e120236669
- McDonaghDLBergerMMathewJPGraffagninoCMilanoCANewmanMFNeurological complications of cardiac surgeryLancet Neurol2014135 490 50224703207
- PatelNMinhasJSChungEMRisk factors associated with cognitive decline after cardiac surgery: a systematic reviewCardiovasc Psychiatry Neurol20152015 37061226491558
- HowellKWClevelandJCJrMengXInterleukin 6 production during cardiac surgery correlates with increasing ageJ Surg Res20162011 76 8126850187
- OukTAmrGAzzaouiRLipid-lowering drugs prevent neurovascular and cognitive consequences of cardiopulmonary bypassVascul Pharmacol201680 59 6626779598
- ZhangWWengGLiMOriginal Research: Establishment of an early embolus-related cerebral injury model after cardiopulmonary bypass in miniature pigsExp Biol Med (Maywood)201624116 1819 182427190268
- LiaoZCaoDHanXBoth JNK and P38 MAPK pathways participate in the protection by dexmedetomidine against isoflurane-induced neuroapoptosis in the hippocampus of neonatal ratsBrain Res Bull2014107 69 7825026397
- ZengXWangHXingXWangQLiWDexmedetomidine protects against transient global cerebral ischemia/reperfusion induced oxidative stress and inflammation in diabetic ratsPLoS One2016113 e015162026982373
- SiYNBaoHGXuLDexmedetomidine protects against ischemia/reperfusion injury in rat kidneyEur Rev Med Pharmacol Sci20141813 1843 185125010612
- SiYBaoHHanLDexmedetomidine protects against renal ischemia and reperfusion injury by inhibiting the JAK/STAT signaling activationJ Transl Med201311 14123759023
- ZhaoJLiGZhangYSuXHangCThe potential role of JAK2/STAT3 pathway on the anti-apoptotic effect of recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of ratsCytokine2011562 343 35021843949
- TaoZChengMWangSCJAK2/STAT3 pathway mediating inflammatory responses in heatstroke-induced ratsInt J Clin Exp Pathol201586 6732 673926261556
- OlivaAAJrKangYSanchez-MolanoJFuronesCAtkinsCMSTAT3 signaling after traumatic brain injuryJ Neurochem20121205 710 72022145815
- ZhaoJBZhangYLiGZSuXFHangCHActivation of JAK2/STAT pathway in cerebral cortex after experimental traumatic brain injury of ratsNeurosci Lett20114982 147 15221596098
- KimJYinTYinMExamination of physiological function and biochemical disorders in a rat model of prolonged asphyxia-induced cardiac arrest followed by cardio pulmonary bypass resuscitationPLoS One2014911 e11201225383962
- LvJWeiYChenYDexmedetomidine attenuates propofol-induce neuroapoptosis partly via the activation of the PI3k/Akt/GSK3β pathway in the hippocampus of neonatal ratsEnviron Toxicol Pharmacol201752 121 12828411582
- HatashitaSHoffJTSalamatSMIschemic brain edema and the osmotic gradient between blood and brainJ Cereb Blood Flow Metab198884 552 5593392116
- Komine-KobayashiMZhangNLiuMNeuroprotective effect of recombinant human granulocyte colony-stimulating factor in transient focal ischemia of miceJ Cereb Blood Flow Metab2006263 402 41316049425
- LiuXZhangXZhangJDiosmin protects against cerebral ischemia/reperfusion injury through activating JAK2/STAT3 signal pathway in miceNeuroscience2014268 318 32724680937
- HoriDHogueCWJrShahACerebral autoregulation monitoring with ultrasound-tagged near-infrared spectroscopy in cardiac surgery patientsAnesth Analg20151215 1187 119326334746
- MatataBMScawnNMorganMA single-center randomized trial of intraoperative zero-balanced ultrafiltration during cardiopulmonary bypass for patients with impaired kidney function undergoing cardiac surgeryJ Cardiothorac Vasc Anesth2015295 1236 124726119403
- ZhangXKZhouXPZhangQZhuFThe preventive effects of dexmedetomidine against intestinal ischemia-reperfusion injury in Wistar ratsIran J Basic Med Sci2015186 604 60926221485
- WangYWuCHanBDexmedetomidine attenuates repeated propofol exposure-induced hippocampal apoptosis, PI3K/Akt/Gsk-3β signaling disruption, and juvenile cognitive deficits in neonatal ratsMol Med Rep2016141 769 77527222147
- HwangLChoiIYKimSEDexmedetomidine ameliorates intracerebral hemorrhage-induced memory impairment by inhibiting apoptosis and enhancing brain-derived neurotrophic factor expression in the rat hippocampusInt J Mol Med2013315 1047 105623503673
- ChengXYGuXYGaoQZongQFLiXHZhangYEffects of dexmedetomidine postconditioning on myocardial ischemia and the role of the PI3K/Akt-dependent signaling pathway in reperfusion injuryMol Med Rep2016141 797 80327221008
- SugitaSOkabeTSakamotoAContinuous infusion of dexmedetomidine improves renal ischemia-reperfusion injury in rat kidneyJ Nippon Med Sch2013802 131 13923657066
- Reagan-ShawSNihalMAhmadNDose translation from animal to human studies revisitedFASEB J2008223 659 66117942826
- KunisawaTUenoMKurosawaADexmedetomidine can stabilize hemodynamics and spare anesthetics before cardiopulmonary bypassJ Anesth2011256 818 82221901330
- ZhuYJPengKMengXWJiFHAttenuation of neuroinflammation by dexmedetomidine is associated with activation of a cholinergic anti-inflammatory pathway in a rat tibial fracture modelBrain Res20161644 1 827163720
- SifringerMvon HaefenCKrainMNeuroprotective effect of dexmedetomidine on hyperoxia-induced toxicity in the neonatal rat brainOxid Med Cell Longev20152015 53037125653737
- PanWLinLZhangNNeuroprotective effects of dexmedetomidine against hypoxia-induced nervous system injury are related to inhibition of NF-κB/COX-2 pathwaysCell Mol Neurobiol2016367 1179 118826683659
- LuoXZhengXHuangHProtective effects of dexmedetomidine on brain function of glioma patients undergoing craniotomy resection and its underlying mechanismClin Neurol Neurosurg2016146 105 10827206212
- DengHZuoXZhangJα-Lipoic acid protects against cerebral ischemia/reperfusion-induced injury in ratsMol Med Rep2015115 3659 366525572614
- KimYRKimHNJangJYEffects of electroacupuncture on apoptotic pathways in a rat model of focal cerebral ischemiaInt J Mol Med2013326 1303 131024085154
- FujiiYShiraiMInamoriSInsufflation of hydrogen gas restrains the inflammatory response of cardiopulmonary bypass in a rat modelArtif Organs2013372 136 14123020073
- TropSMarshallJCMazerCDPerioperative cardiovascular system failure in South Asians undergoing cardiopulmonary bypass is associated with prolonged inflammation and increased Toll-like receptor signaling in inflammatory monocytesJ Surg Res20141871 43 5224176205
- JongmanRMZijlstraJGKokWFOff-pump CABG surgery reduces systemic inflammation compared with on-pump surgery but does not change systemic endothelial responses: a prospective randomized studyShock2014422 121 12824727871
- BulowNMColpoEPereiraRPDexmedetomidine decreases the inflammatory response to myocardial surgery under mini-cardiopulmonary bypassBraz J Med Biol Res2016494 e464626909786
- PodgoreanuMVWhiteWDMorrisRWInflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgeryCirculation20061141 Suppl I275 I28116820586
- SteinbrennerHBilgicEPintoASelenium pretreatment for mitigation of ischemia/reperfusion injury in cardiovascular surgery: influence on acute organ damage and inflammatory responseInflammation2016394 1363 137627192987
- de JongPRSchadenbergAWvan den BroekTSTAT3 regulates monocyte TNF-alpha production in systemic inflammation caused by cardiac surgery with cardiopulmonary bypassPLoS One201274 e3507022506067
- OwaisKHuangTMahmoodFCardiopulmonary bypass decreases activation of the signal transducer and activator of transcription 3 (STAT3) pathway in diabetic human myocardiumAnn Thorac Surg20151005 1636 164526228595
- LiLLiHLiMCurcumin protects against cerebral ischemia-reperfusion injury by activating JAK2/STAT3 signaling pathway in ratsInt J Clin Exp Med201589 14985 1499126628981
- KimHCKimEBaeJISevoflurane postconditioning reduces apoptosis by activating the JAK-STAT pathway after transient global cerebral ischemia in ratsJ Neurosurg Anesthesiol2017291 37 4527337676
- HristovaMRocha-FerreiraEFontanaXInhibition of signal transducer and activator of transcription 3 (STAT3) reduces neonatal hypoxic-ischaemic brain damageJ Neurochem20161365 981 99426669927
- JiaLWangFGuXPropofol postconditioning attenuates hippocampus ischemia-reperfusion injury via modulating JAK2/STAT3 pathway in rats after autogenous orthotropic liver transplantationBrain Res20171657 202 20727998796