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Review

New developments in the combination treatment of COPD: focus on umeclidinium/vilanterol

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Pages 1201-1208 | Published online: 10 Oct 2013

Keep up to date with the latest research on this topic with citation updates for this article.

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Corrado Pelaia, Anna Ferrante Bannera, Fioramante Lello Rotundo, Francesco Giuseppe Tropea, Giuseppe Armentaro, Angelantonio Maglio, Angela Sciacqua, Alessandro Vatrella & Girolamo Pelaia. (2023) Clinical and Functional Effects of Inhaled Dual Therapy Umeclidinium/Vilanterol in Patients with Chronic Obstructive Pulmonary Disease: A Real-Life Study. International Journal of Chronic Obstructive Pulmonary Disease 18, pages 995-1002.
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Antonio Molino, Giovanna Calabrese & Mauro Maniscalco. (2018) Patient considerations in the treatment of COPD: focus on the new combination inhaler fluticasone furoate/umeclidinium/vilanterol. Patient Preference and Adherence 12, pages 993-1001.
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Nooreen Shaikh, Malcolm Johnson, David A Hall, Kian Fan Chung, John H Riley, Sally Worsley & Pankaj K Bhavsar. (2017) Intracellular interactions of umeclidinium and vilanterol in human airway smooth muscle. International Journal of Chronic Obstructive Pulmonary Disease 12, pages 1903-1913.
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Donald P Tashkin. (2016) A review of nebulized drug delivery in COPD. International Journal of Chronic Obstructive Pulmonary Disease 11, pages 2585-2596.
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Reynold A Panettieri Jr. (2015) Bronchodilators, receptors and cross-talk: Together is better?. Postgraduate Medicine 127:7, pages 771-780.
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Igor Z Barjaktarevic, Anthony F Arredondo & Christopher B Cooper. (2015) Positioning new pharmacotherapies for COPD. International Journal of Chronic Obstructive Pulmonary Disease 10, pages 1427-1442.
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Anoop Prakash, K Suresh Babu & Jaymin B Morjaria. (2015) Profile of inhaled glycopyrronium bromide as monotherapy and in fixed-dose combination with indacaterol maleate for the treatment of COPD. International Journal of Chronic Obstructive Pulmonary Disease 10, pages 111-123.
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James F Davidson, James F Donohue & Jill A Ohar. (2015) Umeclidinium/vilanterol combination inhaler efficacy and potential impact on current chronic obstructive pulmonary disease management guidelines. Expert Opinion on Drug Safety 14:2, pages 317-324.
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Maria Gabriella Matera, Paola Rogliani, Barbara Rinaldi & Mario Cazzola. (2015) Umeclidinium bromide + vilanterol for the treatment of chronic obstructive pulmonary disease. Expert Review of Clinical Pharmacology 8:1, pages 35-41.
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Mario Malerba, Jaymin Bhagwanji Morjaria & Alessandro Radaeli. (2014) Differential pharmacology and clinical utility of emerging combination treatments in the management of COPD – role of umeclidinium/vilanterol. International Journal of Chronic Obstructive Pulmonary Disease 9, pages 687-695.
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Andrea Segreti, Luigino Calzetta, Paola Rogliani & Mario Cazzola. (2014) Umeclidinium for the treatment of chronic obstructive pulmonary disease. Expert Review of Respiratory Medicine 8:6, pages 665-671.
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Maria Gabriella Matera, Paola Rogliani & Mario Cazzola. (2014) Muscarinic receptor antagonists for the treatment of chronic obstructive pulmonary disease. Expert Opinion on Pharmacotherapy 15:7, pages 961-977.
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Javier de Miguel-Díez & Rodrigo Jiménez-García. (2014) Considerations for new dual-acting bronchodilator treatments for chronic obstructive pulmonary disease. Expert Opinion on Investigational Drugs 23:4, pages 453-456.
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A. Vezzelli, S. Verzè, L. Morbioli, L. Solazzo, A. Greco, C. Benetti, V. Cenacchi & M. Breda. (2023) Development and validation of a bioanalytical method for the quantification of CHF6550 and its metabolite (CHF6671) in rat plasma and lung homogenate using LC–MS/MS. Journal of Chromatography B 1222, pages 123678.
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N. P. Knyazheskaya, E. Кh. Anaev, A. S. Belevskiy & M. A. Makarova. (2022) Double broncholytic combination of umeclidnium/ vilanterol in COPD therapy: issues of efficacy and safety. Meditsinskiy sovet = Medical Council 16:18, pages 49-54.
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Zhiguo Wang & Baofeng YangZhiguo Wang & Baofeng Yang. 2022. Polypharmacology. Polypharmacology 271 299 .
Tao Song, Mingyu Zhang, Jun Wu, Fenghua Chen, Ying Wang, Yujie Ma & Zhijie Dai. (2020) Glioma progression is suppressed by Naringenin and APO2L combination therapy via the activation of apoptosis in vitro and in vivo. Investigational New Drugs 38:6, pages 1743-1754.
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Bartolome R. Celli. (2018) Pharmacological Therapy of COPD. Chest 154:6, pages 1404-1415.
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Zhi-Chao Yang & Ji Ma. (2018) Actein enhances TRAIL effects on suppressing gastric cancer progression by activating p53/Caspase-3 signaling. Biochemical and Biophysical Research Communications 497:4, pages 1177-1183.
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Disala Fernando, Sarah Siederer, Sunita Singh, Ian Schneider, Ashutosh Gupta, Marcy Powell, Duncan Richards, Michelle P. McIntosh, Peter Lambert & Susan Fowles. (2017) Safety, Tolerability and Pharmacokinetics of Single Doses of Oxytocin Administered via an Inhaled Route in Healthy Females: Randomized, Single-blind, Phase 1 Study. EBioMedicine 22, pages 249-255.
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Ying Xu, Jing Li, Qian-Jun Li, Yan-Ling Feng & Feng Pan. (2017) Betulinic acid promotes TRAIL function on liver cancer progression inhibition through p53/Caspase-3 signaling activation. Biomedicine & Pharmacotherapy 88, pages 349-358.
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S. N. Avdeev & Z. R. Aisanov. (2016) MAXIMAL BRONCHODILATION WITH STARTING THERAPY OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE: AN INFLUENCE ON THE COURSE OF THE DISEASE. PULMONOLOGIYA 26:5, pages 604-609.
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Li Wang, Chun-juan Zhai, Yao Liu, Yi Liu & Shu-juan Jiang. (2016) Umeclidinium Plus Vilanterol Versus Placebo, Umeclidinium, or Vilanterol Monotherapies for Chronic Obstructive Pulmonary Disease: A Meta-Analysis of Randomized Controlled Trials. Clinical Drug Investigation 36:11, pages 865-875.
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S. N. Avdeev, Z. R. Aysanov, A. S. Belevskiy, A. A. Vizel'G. L. Ignatova, N. P. Knyazheskaya, I. V. Leshchenko, S. I. Ovcharenko, V. I. TrofimovE. I. Shmelev. (2016) Perspectives of pharmacological therapy of chronic obstructive pulmonary disease: opportunities of dual bronchodilation and a role of inhaled steroids. Expert Council Consensus. PULMONOLOGIYA 26:1, pages 65-72.
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Jolyon Mitchell. 2016. Developing Drug Products in an Aging Society. Developing Drug Products in an Aging Society 331 382 .
Clive Page & Mario Cazzola. 2017. Pharmacology and Therapeutics of Asthma and COPD. Pharmacology and Therapeutics of Asthma and COPD 197 212 .
Gustavo J. Rodrigo & Hugo Neffen. (2015) A Systematic Review of the Efficacy and Safety of a Fixed-Dose Combination of Umeclidinium and Vilanterol for the Treatment of COPD. Chest 148:2, pages 397-407.
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Luigino Calzetta, Maria Gabriella Matera & Mario Cazzola. (2015) Pharmacological interaction between LABAs and LAMAs in the airways: optimizing synergy. European Journal of Pharmacology 761, pages 168-173.
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M. A. Soriano-Ursúa, J. G. Trujillo-Ferrara, J. A. Arias-Montaño & R. Villalobos-Molina. (2015) Insights into a defined secondary binding region on β-adrenoceptors and putative roles in ligand binding and drug design. MedChemComm 6:6, pages 991-1002.
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Dave Singh. (2015) New combination bronchodilators for chronic obstructive pulmonary disease: current evidence and future perspectives. British Journal of Clinical Pharmacology 79:5, pages 695-708.
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Hannah A. Blair & Emma D. Deeks. (2014) Umeclidinium/Vilanterol: A Review of Its Use as Maintenance Therapy in Adults with Chronic Obstructive Pulmonary Disease. Drugs 75:1, pages 61-74.
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Mario Cazzola, Luigino Calzetta, Clive P. Page, Paola Rogliani, Francesco Facciolo, Amadeu Gavaldà & Maria Gabriella Matera. (2014) Pharmacological characterization of the interaction between aclidinium bromide and formoterol fumarate on human isolated bronchi. European Journal of Pharmacology 745, pages 135-143.
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Virginia Norris & Claire Ambery. (2014) Use of Propranolol Blockade to Explore the Pharmacology of GSK961081, a Bi-Functional Bronchodilator, in Healthy Volunteers: Results from Two Randomized Trials. Drugs in R&D 14:4, pages 241-251.
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Adrian Gillissen. (2014) Frischer Wind für COPD-geplagte Lungen. MMW - Fortschritte der Medizin 156:14, pages 68-72.
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