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Drug Design, Development and Therapy Volume 9, 2015 - Issue
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Original Research

The investigational Aurora kinase A inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells

Jin-Ping Li1 Department of Surgical Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China;2 Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA
,
Yin-Xue Yang3 Department of Colorectal Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China
,
Qi-Lun Liu1 Department of Surgical Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China
,
Shu-Ting Pan1 Department of Surgical Oncology, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, People’s Republic of China;4 Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China
,
Zhi-Xu He5 Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of China
,
Xueji Zhang6 Research Center for Bioengineering and Sensing Technology, University of Science and Technology Beijing, Beijing, People’s Republic of China
,
Tianxin Yang7 Department of Internal Medicine, University of Utah and Salt Lake Veterans Affairs Medical Center, Salt Lake City, UT, USA
,
Xiao-Wu Chen8 Department of General Surgery, The First People’s Hospital of Shunde, Southern Medical University, Shunde, Foshan, Guangdong, People’s Republic of China
,
Dong Wang9 Cancer Center, Daping Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing, People’s Republic of China
,
Jia-Xuan Qiu4 Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of ChinaCorrespondence[email protected]
&
Shu-Feng Zhou2 Department of Pharmaceutical Sciences, College of Pharmacy, University of South Florida, Tampa, FL, USA;5 Guizhou Provincial Key Laboratory for Regenerative Medicine, Stem Cell and Tissue Engineering Research Center and Sino-US Joint Laboratory for Medical Sciences, Guizhou Medical University, Guiyang, Guizhou, People’s Republic of ChinaCorrespondence[email protected]
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Pages 1627-1652 | Published online: 16 Mar 2015

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Hui-yun Hwang, Sung Min Cho & Ho Jeong Kwon. (2017) Approaches for discovering novel bioactive small molecules targeting autophagy. Expert Opinion on Drug Discovery 12:9, pages 909-923.
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Xin Jin, Qingqing Mo, Yu Zhang, Yue Gao, Yuan Wu, Jing Li, Xing Hao, Ding Ma, Qinglei Gao & Pingbo Chen. (2016) The p38 MAPK inhibitor BIRB796 enhances the antitumor effects of VX680 in cervical cancer. Cancer Biology & Therapy 17:5, pages 566-576.
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Lu Wang, Li Yao, Xiaoyu Li, Juan Chen, Chenghua Lou & Yiqi Wang. (2019) Stephanthraniline A suppresses proliferation of HCT116 human colon cancer cells through induction of caspase-dependent apoptosis, dysregulation of mitochondrial function, cell cycle arrest and regulation of Akt/p38 signaling pathways. The Journal of Toxicological Sciences 44:8, pages 523-533.
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Shuaijun Dong, Xiefu Zhang & Dechun Liu. (2019) Overexpression of long noncoding RNA GAS5 suppresses tumorigenesis and development of gastric cancer by sponging miR-106a-5p through the Akt/mTOR pathway. Biology Open.
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Utkarsh Painuly, Vijay Ramakrishnan, Teresa Kimlinger, Linda Wellik, Jessica Haug, Wilson Gonsalves, Lintao Bi, Zhongxia Huang, S. Vincent Rajkumar & Shaji Kumar. (2018) Aurora kinase and FGFR3 inhibition results in significant apoptosis in molecular subgroups of multiple myeloma. Oncotarget 9:77, pages 34582-34594.
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Alexander Baumann, Anna Maria S. Buchberger, Guido Piontek, Dominik Schüttler, Martina Rudelius, Rudolf Reiter, Lena Gebel, Gerhard Piendl, Gero Brockhoff & Anja Pickhard. (2018) The Aurora-Kinase A Phe31-Ile polymorphism as possible predictor of response to treatment in head and neck squamous cell carcinoma. Oncotarget 9:16, pages 12769-12780.
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Eun Hee Han, Jin-Young Min, Shin-Ae Yoo, Sung-Joon Park, Yun-Jeong Choe, Hee Sub Yun, Zee-Won Lee, Sun Woo Jin, Hyung Gyun Kim, Hye Gwang Jeong, Hyun Kyoung Kim, Nam Doo Kim & Young-Ho Chung. (2017) A small-molecule inhibitor targeting the AURKC-IκBα interaction decreases transformed growth of MDA-MB-231 breast cancer cells. Oncotarget 8:41, pages 69691-69708.
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Angela Alexander, Cansu Karakas, Xian Chen, Jason P.W. Carey, Min Yi, Melissa Bondy, Patricia Thompson, Kwok Leung Cheung, Ian O. Ellis, Yun Gong, Savitri Krishnamurthy, Ricardo H. Alvarez, Naoto T. Ueno, Kelly K. Hunt & Khandan Keyomarsi. (2017) Cyclin E overexpression as a biomarker for combination treatment strategies in inflammatory breast cancer. Oncotarget 8:9, pages 14897-14911.
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Yoo Hong Min, Wootae Kim & Ja-Eun Kim. (2016) The Aurora kinase A inhibitor TC-A2317 disrupts mitotic progression and inhibits cancer cell proliferation. Oncotarget 7:51, pages 84718-84735.
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Jonas Cicenas. (2016) The Aurora kinase inhibitors in cancer research and therapy. Journal of Cancer Research and Clinical Oncology 142:9, pages 1995-2012.
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Anastasia R. Goloudina, Elena Y. Kochetkova, Tatyana V. Pospelova & Oleg N. Demidov. (2016) Wip1 phosphatase: between p53 and MAPK kinases pathways. Oncotarget 7:21, pages 31563-31571.
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