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Review

Targeting the kidney and glucose excretion with dapagliflozin: preclinical and clinical evidence for SGLT2 inhibition as a new option for treatment of type 2 diabetes mellitus

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Pages 135-148 | Published online: 23 Jul 2012

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Deborah Mudali, Jaison Jeevanandam & Michael K. Danquah. (2020) Probing the characteristics and biofunctional effects of disease-affected cells and drug response via machine learning applications. Critical Reviews in Biotechnology 40:7, pages 951-977.
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Serge Jabbour. (2017) Durability of response to dapagliflozin: a review of long-term efficacy and safety. Current Medical Research and Opinion 33:9, pages 1685-1696.
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Kalliopi Pafili, Efstratios Maltezos & Nikolaos Papanas. (2017) Dapagliflozin for the treatment of type 1 diabetes mellitus. Expert Opinion on Investigational Drugs 26:7, pages 873-881.
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Hui Shao, Suodi Zhai, Dajin Zou, Mohammed Umer Mir, Nadine K. Zawadzki, Qian Shi, Shuqian Liu & Lizheng Shi. (2017) Cost-effectiveness analysis of dapagliflozin versus glimepiride as monotherapy in a Chinese population with type 2 diabetes mellitus. Current Medical Research and Opinion 33:2, pages 359-369.
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Markus F Scheerer, Roland Rist, Orm Proske, Annika Meng & Karel Kostev. (2016) Changes in HbA1c, body weight, and systolic blood pressure in type 2 diabetes patients initiating dapagliflozin therapy: a primary care database study. Diabetes, Metabolic Syndrome and Obesity 9, pages 337-345.
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Neil Skolnik, Harmony Bonnes, Helen Yeh & Arie Katz. (2016) Dapagliflozin in the treatment of patients with type 2 diabetes presenting with high baseline A1C. Postgraduate Medicine 128:4, pages 356-363.
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Jay H Shubrook, Babak Baradar Bokaie & Sarah E Adkins. (2015) Empagliflozin in the treatment of type 2 diabetes: evidence to date. Drug Design, Development and Therapy 9, pages 5793-5803.
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Matthew R. Weir, Irina Kline, John Xie, Robert Edwards & Keith Usiskin. (2014) Effect of canagliflozin on serum electrolytes in patients with type 2 diabetes in relation to estimated glomerular filtration rate (eGFR). Current Medical Research and Opinion 30:9, pages 1759-1768.
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William N Washburn & Simon M Poucher. (2013) Differentiating sodium-glucose co-transporter-2 inhibitors in development for the treatment of type 2 diabetes mellitus. Expert Opinion on Investigational Drugs 22:4, pages 463-486.
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Julia Kenkre, Tricia Tan & Stephen Bloom. (2013) Treating the obese diabetic. Expert Review of Clinical Pharmacology 6:2, pages 171-183.
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Articles from other publishers (35)

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Mariavittoria D’Acierno, Roberta Resaz, Anna Iervolino, Rikke Nielsen, Donato Sardella, Sabrina Siccardi, Vincenzo Costanzo, Luciano D’Apolito, Yoko Suzumoto, Daniela Segalerba, Simonetta Astigiano, Alessandra F. Perna, Giovambattista Capasso, Alessandra Eva & Francesco Trepiccione. (2022) Dapagliflozin Prevents Kidney Glycogen Accumulation and Improves Renal Proximal Tubule Cell Functions in a Mouse Model of Glycogen Storage Disease Type 1b. Journal of the American Society of Nephrology 33:10, pages 1864-1875.
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Yustika Sari, Dono Indarto & Brian Wasita. (2022) The Effects of Star Fruit (Averrhoa carambola Linn.) Extract on Body Mass Index, Fasting Blood Glucose, and Triglyceride Levels in Male Rats with Obesity and Type 2 Diabetes Mellitus. Open Access Macedonian Journal of Medical Sciences 10:A, pages 744-751.
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Sangita Swapnasrita, Aurélie Carlier & Anita T. Layton. (2022) Sex-Specific Computational Models of Kidney Function in Patients With Diabetes. Frontiers in Physiology 13.
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Hongju Wu & Vecihi Batuman. 2022. Diabetes and Kidney Disease. Diabetes and Kidney Disease 601 635 .
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Shanshan Hu, Xun Deng, Yanjiao Ma, Zhilei Li, Yuhang Wang & Yong Wang. (2020) Cost-Utility Analysis of Dapagliflozin Versus Saxagliptin Treatment as Monotherapy or Combination Therapy as Add-on to Metformin for Treating Type 2 Diabetes Mellitus. Applied Health Economics and Health Policy 19:1, pages 69-79.
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Prashant S. Devrukhakar & M. Shiva Shankar. (2020) Degradation Pathway Proposal, Structure Elucidation, and In Silico Toxicity Prediction of Dapagliflozin Propane Diol Hydrolytic Degradation Products. Chromatographia 83:10, pages 1233-1245.
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Constantin Berger & Daniela Zdzieblo. (2020) Glucose transporters in pancreatic islets. Pflügers Archiv - European Journal of Physiology 472:9, pages 1249-1272.
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ManashPratim Baruah, BM Makkar, VikrantB Ghatnatti & Kaushik Mandal. (2019) Sodium glucose co-transporter-2 inhibitor: Benefits beyond glycemic control. Indian Journal of Endocrinology and Metabolism 23:1, pages 140.
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Mamdouh A. Oraby, Mohammed F. El-Yamany, Marwa M. Safar, Naglaa Assaf & Hamdy A. Ghoneim. (2019) Dapagliflozin attenuates early markers of diabetic nephropathy in fructose-streptozotocin-induced diabetes in rats. Biomedicine & Pharmacotherapy 109, pages 910-920.
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Soad L. Kabil & Nevertyty M. Mahmoud. (2018) Canagliflozin protects against non-alcoholic steatohepatitis in type-2 diabetic rats through zinc alpha-2 glycoprotein up-regulation. European Journal of Pharmacology 828, pages 135-145.
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Stephanie Fraser & Sarah Osgood. (2017) Current practices and future outlook on the integration of biomarkers in the drug development process. Bioanalysis 9:22, pages 1827-1837.
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Natalia G. Vallianou, Eleni Geladari & Christos E. Kazazis. (2017) SGLT-2 inhibitors: Their pleiotropic properties. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 11:4, pages 311-315.
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Tuba M. Ansary, Yoshihide Fujisawa, Asadur Rahman, Daisuke Nakano, Hirofumi Hitomi, Hideki Kobara, Tsutomu Masaki, Jens M. Titze, Kento Kitada & Akira Nishiyama. (2017) Responses of renal hemodynamics and tubular functions to acute sodium–glucose cotransporter 2 inhibitor administration in non-diabetic anesthetized rats. Scientific Reports 7:1.
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M. Joubert & Y. Reznik. (2017) Use of GLP-1 receptor agonists for type 2 diabetes treatment intensification after basal insulin failure. Diabetes & Metabolism 43, pages 2S34-2S38.
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Tushar Madaan, Mohd. Akhtar & Abul Kalam Najmi. (2016) Sodium glucose CoTransporter 2 (SGLT2) inhibitors: Current status and future perspective. European Journal of Pharmaceutical Sciences 93, pages 244-252.
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W. J. Wan Seman, N. Kori, S. Rajoo, H. Othman, N. Mohd Noor, N. A Wahab, N. Sukor, N. Mustafa & N. A. Kamaruddin. (2016) Switching from sulphonylurea to a sodium-glucose cotransporter2 inhibitor in the fasting month of Ramadan is associated with a reduction in hypoglycaemia. Diabetes, Obesity and Metabolism 18:6, pages 628-632.
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C. D. Sjöström, M. Hashemi, J. Sugg, A. Ptaszynska & E. Johnsson. (2015) Dapagliflozin-induced weight loss affects 24-week glycated haemoglobin and blood pressure levels. Diabetes, Obesity and Metabolism 17:8, pages 809-812.
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Eva M. Vivian. (2015) Dapagliflozin: A new sodium–glucose cotransporter 2 inhibitor for treatment of type 2 diabetes. American Journal of Health-System Pharmacy 72:5, pages 361-372.
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Theodosios D. Filippatos, Evangelos N. Liberopoulos & Moses S. Elisaf. (2014) Dapagliflozin in patients with type 2 diabetes mellitus. Therapeutic Advances in Endocrinology and Metabolism 6:1, pages 29-41.
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M.C. Thomas, K. Jandeleit-Dahm & F. Bonnet. (2014) Beyond Glycosuria: Exploring the intrarenal effects of SGLT-2 inhibition in diabetes. Diabetes & Metabolism 40:6, pages S17-S22.
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Agata Ptaszynska, Kristina M. Johnsson, Shamik J. Parikh, Tjerk W. A. de Bruin, Anne Marie Apanovitch & James F. List. (2014) Safety Profile of Dapagliflozin for Type 2 Diabetes: Pooled Analysis of Clinical Studies for Overall Safety and Rare Events. Drug Safety 37:10, pages 815-829.
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Matt Hrapchak, Bachir Latli, Xiao-Jun Wang, Heewon Lee, Scot Campbell, Jinhua J. Song & Chris H. Senanayake. (2014) Synthesis of empagliflozin, a novel and selective sodium-glucose co-transporter-2 inhibitor, labeled with carbon-14 and carbon-13. Journal of Labelled Compounds and Radiopharmaceuticals 57:12, pages 687-694.
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Naoto Terami, Daisuke Ogawa, Hiromi Tachibana, Takashi Hatanaka, Jun Wada, Atsuko Nakatsuka, Jun Eguchi, Chikage Sato Horiguchi, Naoko Nishii, Hiroshi Yamada, Kohji Takei & Hirofumi Makino. (2014) Long-Term Treatment with the Sodium Glucose Cotransporter 2 Inhibitor, Dapagliflozin, Ameliorates Glucose Homeostasis and Diabetic Nephropathy in db/db Mice. PLoS ONE 9:6, pages e100777.
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Merlin C. Thomas. (2014) Renal effects of dapagliflozin in patients with type 2 diabetes. Therapeutic Advances in Endocrinology and Metabolism 5:3, pages 53-61.
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S. Goring, N. Hawkins, G. Wygant, M. Roudaut, R. Townsend, I. Wood & A. H. Barnett. (2014) Dapagliflozin compared with other oral anti-diabetes treatments when added to metformin monotherapy: a systematic review and network meta-analysis. Diabetes, Obesity and Metabolism 16:5, pages 433-442.
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S. Grandy, A. M. Langkilde, J. E. Sugg, S. Parikh & C. D. Sjöström. (2014) Health-related quality of life (EQ-5D) among type 2 diabetes mellitus patients treated with dapagliflozin over 2 years. International Journal of Clinical Practice 68:4, pages 486-494.
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K. Tatarkiewicz, C. Polizzi, C. Villescaz, L. J. D'Souza, Y. Wang, S. Janssen & D. G. Parkes. (2013) Combined antidiabetic benefits of exenatide and dapagliflozin in diabetic mice. Diabetes, Obesity and Metabolism 16:4, pages 376-380.
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Pitchai Balakumar, Karupiah Sundram & Sokkalingam A. Dhanaraj. (2014) Dapagliflozin: Glucuretic action and beyond. Pharmacological Research 82, pages 34-39.
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Mark Tirmenstein, Thomas E. Dorr, Evan B. Janovitz, Deborah Hagan, Lynn M. Abell, Joelle M. Onorato, Jean M. Whaley, Michael J. Graziano & Timothy P. Reilly. (2013) Nonclinical Toxicology Assessments Support the Chronic Safety of Dapagliflozin, a First-in-Class Sodium-Glucose Cotransporter 2 Inhibitor. International Journal of Toxicology 32:5, pages 336-350.
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Anthony H. Barnett. (2013) Complementing Insulin Therapy to Achieve Glycemic Control. Advances in Therapy 30:6, pages 557-576.
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