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International Journal of Nanomedicine Volume 7, 2012 - Issue
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Original Research

Gelatinase-stimuli strategy enhances the tumor delivery and therapeutic efficacy of docetaxel-loaded poly(ethylene glycol)-poly(ɛ-caprolactone) nanoparticles

Qin Liu1 The Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing 210008, China
,
Ru-Tian Li1 The Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing 210008, China
,
Han-Qing Qian2 Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
,
Mi Yang1 The Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing 210008, China
,
Zhen-Shu Zhu2 Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
,
Wei Wu2 Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
,
Xiao-Ping Qian1 The Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing 210008, China
,
Li-Xia Yu1 The Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing 210008, China
,
Xi-Qun Jiang2 Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering College of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China
&
Bao-Rui Liu1 The Comprehensive Cancer Center of Drum-Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing 210008, ChinaCorrespondence[email protected]
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Pages 281-295 | Published online: 20 Jan 2012

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Qin Wang, Ying-Tzu Yen, Chen Xie, Fangcen Liu, Qin Liu, Jia Wei, Lixia Yu, Lifeng Wang, Fanyan Meng, Rutian Li & Baorui Liu. (2021) Combined delivery of salinomycin and docetaxel by dual-targeting gelatinase nanoparticles effectively inhibits cervical cancer cells and cancer stem cells. Drug Delivery 28:1, pages 510-519.
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Qin Wang, Fangcen Liu, Lifeng Wang, Chen Xie, Puyuan Wu, Shiyao Du, Shujuan Zhou, Zhichen Sun, Qin Liu, Lixia Yu, Baorui Liu & Rutian Li. (2020) Enhanced and Prolonged Antitumor Effect of Salinomycin-Loaded Gelatinase-Responsive Nanoparticles via Targeted Drug Delivery and Inhibition of Cervical Cancer Stem Cells. International Journal of Nanomedicine 15, pages 1283-1295.
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Sergio Miguel Espinoza, Harshal Indrabhan Patil, Eduardo San Martin Martinez, Rocio Casañas Pimentel & Pradum Pundlikrao Ige. (2020) Poly-ε-caprolactone (PCL), a promising polymer for pharmaceutical and biomedical applications: Focus on nanomedicine in cancer. International Journal of Polymeric Materials and Polymeric Biomaterials 69:2, pages 85-126.
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Yimu Li, Hui Zhang & Guang-Xi Zhai. (2017) Intelligent polymeric micelles: development and application as drug delivery for docetaxel. Journal of Drug Targeting 25:4, pages 285-295.
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Nannan Lu, Rutian Li, Qin Liu, Bing Hu, Xiaoling Xu, Chushu Ji, Xinghua Han, Pin Wang & Baorui Liu. (2016) Antitumor and antimetastatic effects of pemetrexed-loaded targeted nanoparticles in B16 bearing mice. Drug Delivery 23:7, pages 2566-2574.
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Fang-bo Cui, Qin Liu, Ru-Tian Li, Jie Shen, Pu-yuan Wu, Li-Xia Yu, Wen-jing Hu, Feng-lei Wu, Chun-Ping Jiang, Guo-feng Yue, Xiao-Ping Qian, Xi-Qun Jiang & Bao-Rui Liu. (2014) Enhancement of radiotherapy efficacy by miR-200c-loaded gelatinase-stimuli PEG-Pep-PCL nanoparticles in gastric cancer cells. International Journal of Nanomedicine 9, pages 2345-2358.
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Zhongbing Liu, Jinwei Li, Juan Li, Juan Huang, Famin Ke, Qiaona Qi, Xing Jiang & Zhirong Zhong. (2012) Mannan-modified Ad5-PTEN treatment combined with docetaxel improves the therapeutic effect in H22 tumor-bearing mice. International Journal of Nanomedicine 7, pages 5039-5049.
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Di Li, Jian Xun Ding, Zhao Hui Tang, Hai Sun, Xiu Li Zhuang, Jing Zhe Xu & Xue Si Chen. (2012) In vitro evaluation of anticancer nanomedicines based on doxorubicin and amphiphilic Y-shaped copolymers. International Journal of Nanomedicine 7, pages 2687-2697.
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