862
Views
28
CrossRef citations to date
0
Altmetric
Original Research

Brain Targeting of Duloxetine HCL via Intranasal Delivery of Loaded Cubosomal Gel: In vitro Characterization, ex vivo Permeation, and in vivo Biodistribution Studies

, , ORCID Icon, ORCID Icon &
Pages 9517-9537 | Published online: 30 Nov 2020

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Laura Deruyver, Clément Rigaut, Alejandro Gomez-Perez, Pierre Lambert, Benoit Haut & Jonathan Goole. (2023) In vitro Evaluation of Paliperidone Palmitate Loaded Cubosomes Effective for Nasal-to-Brain Delivery. International Journal of Nanomedicine 18, pages 1085-1106.
Read now
Amira Mohamed Mohsen, Abeer A. A. Salama & Marwa Hasanein Asfour. (2023) Cubosome-based thermosensitive in situ gelling system for intranasal administration of lamotrigine with enhanced antiepileptic efficacy. Pharmaceutical Development and Technology 28:6, pages 520-534.
Read now
Mahmoud H. Teaima, Moaz A. Eltabeeb, Mohamed A. El-Nabarawi & Menna M. Abdellatif. (2022) Utilization of propranolol hydrochloride mucoadhesive invasomes as a locally acting contraceptive: in-vitro, ex-vivo, and in-vivo evaluation. Drug Delivery 29:1, pages 2549-2560.
Read now

Articles from other publishers (25)

Radwa M.A. Abd-Elal, Aya M. Essawy, Maha A. Salem, Mahitab Elsayed, Mona G. Khalil, Eman Abdelhakeem, Nouran A. Ali & Mai Ahmed Tawfik. (2023) Formulation, optimization, in-vivo biodistribution studies and histopathological safety assessment of duloxetine HCl-loaded ultra-elastic nanovesicles for antidepressant effect after intranasal and transdermal delivery. International Journal of Pharmaceutics: X 6, pages 100194.
Crossref
Mohamed Mahmoud Ali, Raguia Aly Shoukri & Carol Yousry. (2022) Thin film hydration versus modified spraying technique to fabricate intranasal spanlastic nanovesicles for rasagiline mesylate brain delivery: Characterization, statistical optimization, and in vivo pharmacokinetic evaluation. Drug Delivery and Translational Research 13:4, pages 1153-1168.
Crossref
Mahmoud H. Teaima, Merhan Taha El-Nadi, Raghda Rabe Hamed, Mohamed A. El-Nabarawi & Rehab Abdelmonem. (2023) Lyophilized Nasal Inserts of Atomoxetine HCl Solid Lipid Nanoparticles for Brain Targeting as a Treatment of Attention-Deficit/Hyperactivity Disorder (ADHD): A Pharmacokinetics Study on Rats. Pharmaceuticals 16:2, pages 326.
Crossref
Heba F. Salem, Adel A. Ali, Yasmine K. Rabea, Fatma I. Abo El-Ela & Rasha A. Khallaf. (2023) Optimization and Appraisal of Chitosan-Grafted PLGA Nanoparticles for Boosting Pharmacokinetic and Pharmacodynamic Effect of Duloxetine HCl Using Box-Benkhen Design. Journal of Pharmaceutical Sciences 112:2, pages 544-561.
Crossref
Cinzia Pagano, Luana Perioli & Maurizio Ricci. 2023. Nasal Drug Delivery. Nasal Drug Delivery 235 252 .
Heba F. Salem, Adel A. Ali, Yasmine K. Rabea, Fatma I. Abo El-Ela & Rasha A. Khallaf. (2022) Glycerosomal thermosensitive in situ gel of duloxetine HCl as a novel nanoplatform for rectal delivery: in vitro optimization and in vivo appraisal. Drug Delivery and Translational Research 12:12, pages 3083-3103.
Crossref
Gurudatta N. Desai, Panchaxari M. Dandagi & Taufik M. Kazi. (2022) Nanosized Intranasal Delivery of Novel Self-Assembled Cubic Liquid Crystals: Formulation and Evaluation. Journal of Pharmaceutical Innovation.
Crossref
Ana Vitoria Pupo Silvestrini, Bryan Wender Debiasi, Fabíola Garcia Praça & Maria Vitoria Lopes Badra Bentley. (2022) Progress and challenges of lyotropic liquid crystalline nanoparticles for innovative therapies. International Journal of Pharmaceutics 628, pages 122299.
Crossref
Ayesha Waheed, Saima Zameer, Niha Sultana, Asad Ali, Mohd. Aqil, Yasmin Sultana & Zeenat Iqbal. (2022) Engineering of QbD driven and ultrasonically shaped lyotropic liquid crystalline nanoparticles for Apigenin in the management of skin cancer. European Journal of Pharmaceutics and Biopharmaceutics 180, pages 269-280.
Crossref
Zhiyu Jin, Yu Han, Danshen Zhang, Zhongqiu Li, Yongshuai Jing, Beibei Hu & Shiguo Sun. (2022) Application of Intranasal Administration in the Delivery of Antidepressant Active Ingredients. Pharmaceutics 14:10, pages 2070.
Crossref
Mohd Yasir, Ameeduzzafar Zafar, Kaveripakkam M. Noorulla, Abdurazak J. Tura, Udai Vir Singh Sara, Dharamveer Panjwani, Mohammad Khalid, Misbahu J. Haji, Wondesen Gadisa Gobena, Teshome Gebissa & Debesa D. Dalecha. (2022) Nose to brain delivery of donepezil through surface modified NLCs: Formulation development, optimization, and brain targeting study. Journal of Drug Delivery Science and Technology 75, pages 103631.
Crossref
Xinyu Shan, Lihua Luo, Zhixin Yu & Jian You. (2022) Recent advances in versatile inverse lyotropic liquid crystals. Journal of Controlled Release 348, pages 1-21.
Crossref
Oluwaseyi Salau, Arvind Bagde, Anil Kalvala & Mandip Singh. (2022) Enhancement of transdermal permeation of cannabinoids and their pharmacodynamic evaluation in rats. International Journal of Pharmaceutics 624, pages 122016.
Crossref
Hassaan Umar, Habibah A. Wahab, Amirah Mohd Gazzali, Hafsa Tahir & Waqas Ahmad. (2022) Cubosomes: Design, Development, and Tumor-Targeted Drug Delivery Applications. Polymers 14:15, pages 3118.
Crossref
Essam M. Eissa, Mohammed H. Elkomy, Hussein M. Eid, Adel A. Ali, Mohammed A. S. Abourehab, Amal M. Alsubaiyel, Ibrahim A. Naguib, Izzeddin Alsalahat & Amira H. Hassan. (2022) Intranasal Delivery of Granisetron to the Brain via Nanostructured Cubosomes-Based In Situ Gel for Improved Management of Chemotherapy-Induced Emesis. Pharmaceutics 14:7, pages 1374.
Crossref
Shruti U. Rawal, Bhoomika M. Patel & Mayur M. Patel. (2022) New Drug Delivery Systems Developed for Brain Targeting. Drugs 82:7, pages 749-792.
Crossref
Mohammed A.S. Abourehab, Mohammad Javed Ansari, Anshul Singh, Ahmed Hassan, Mohamed A. Abdelgawad, Prachi Shrivastav, Bassam M. Abualsoud, Larissa Souza Amaral & Sheersha Pramanik. (2022) Cubosomes as an emerging platform for drug delivery: a review of the state of the art. Journal of Materials Chemistry B 10:15, pages 2781-2819.
Crossref
Yosif Almoshari. (2022) Development, Therapeutic Evaluation and Theranostic Applications of Cubosomes on Cancers: An Updated Review. Pharmaceutics 14:3, pages 600.
Crossref
Anna P Constantinou & Theoni K Georgiou. (2021) Pre‐clinical and clinical applications of thermoreversible hydrogels in biomedical engineering: a review. Polymer International 70:10, pages 1433-1448.
Crossref
Suliman Khan, Yasaman Vahdani, Arif Hussain, Setareh Haghighat, Fatemeh Heidari, Mina Nouri, Samir Haj Bloukh, Zehra Edis, Mohammad Mahdi Nejadi Babadaei, Mahsa Ale-Ebrahim, Anwarul Hasan, Majid Sharifi, Qian Bai, Mahbub Hassan & Mojtaba Falahati. (2021) Polymeric micelles functionalized with cell penetrating peptides as potential pH-sensitive platforms in drug delivery for cancer therapy: A review. Arabian Journal of Chemistry 14:8, pages 103264.
Crossref
Aida Maaz, Ian S. Blagbrough & Paul A. De Bank. (2021) In Vitro Evaluation of Nasal Aerosol Depositions: An Insight for Direct Nose to Brain Drug Delivery. Pharmaceutics 13:7, pages 1079.
Crossref
Asmaa Saleh, Maha Khalifa, Seham Shawky, Amjaad Bani-Ali & Heba Eassa. (2021) Zolmitriptan Intranasal Spanlastics for Enhanced Migraine Treatment; Formulation Parameters Optimized via Quality by Design Approach. Scientia Pharmaceutica 89:2, pages 24.
Crossref
Hetal P. Patel, Priyanka S. Chaudhari, Priyanshi A. Gandhi, Bhargavi V. Desai, Ditixa T. Desai, Praful P. Dedhiya, Bhavin A. Vyas & Furqan A. Maulvi. (2021) Nose to brain delivery of tailored clozapine nanosuspension stabilized using (+)-alpha-tocopherol polyethylene glycol 1000 succinate: Optimization and in vivo pharmacokinetic studies. International Journal of Pharmaceutics 600, pages 120474.
Crossref
Mohammed A. S. Abourehab, Ahmed Khames, Samar Genedy, Shahin Mostafa, Mohammad A. Khaleel, Mahmoud M. Omar & Amani M. El Sisi. (2021) Sesame Oil-Based Nanostructured Lipid Carriers of Nicergoline, Intranasal Delivery System for Brain Targeting of Synergistic Cerebrovascular Protection. Pharmaceutics 13:4, pages 581.
Crossref
Qinghua Wang, Shang Cheng, Fen Qin, Ailing Fu & Chen Fu. (2021) Application progress of RVG peptides to facilitate the delivery of therapeutic agents into the central nervous system. RSC Advances 11:15, pages 8505-8515.
Crossref