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International Journal of Nanomedicine Volume 7, 2012 - Issue
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Original Research

Nano-TiO2/PEEK bioactive composite as a bone substitute material: in vitro and in vivo studies

Xiaomian Wu1 Research Center for Oral Diseases and Biomedical Science, College of Stomatology, Chongqing Medical University, Chongqing
,
Xiaochen Liu2 Center for Biomedical Materials and Tissue Engineering, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing
,
Jie Wei3 Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai
,
Jian Ma4 Hospital of Stomatology, Tongji University, Shanghai, People’s Republic of China
,
Feng Deng1 Research Center for Oral Diseases and Biomedical Science, College of Stomatology, Chongqing Medical University, ChongqingCorrespondence[email protected] [email protected]
&
Shicheng Wei1 Research Center for Oral Diseases and Biomedical Science, College of Stomatology, Chongqing Medical University, Chongqing
Pages 1215-1225 | Published online: 05 Mar 2012

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Mugilan Thanigachalam & Aezhisai Vallavi Muthusamy Subramanian. (2022) Evaluation of PEEK-TiO2- SiO2 nanocomposite as biomedical implants with regard to in-vitro biocompatibility and material characterization. Journal of Biomaterials Science, Polymer Edition 33:6, pages 727-746.
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Mugilan Thanigachalam & Aezhisai Vallavi Muthusamy Subramanian. (2022) In-vitro cytotoxicity assessment and cell adhesion study of functionalized nTiO2 reinforced PEEK biocompatible polymer composite. Polymer-Plastics Technology and Materials 61:5, pages 566-576.
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Dong Xie, Chenhui Xu, Cheng Ye, Shiqi Mei, Longqing Wang, Qi Zhu, Qing Chen, Qi Zhao, Zhiyan Xu, Jie Wei & Lili Yang. (2021) Fabrication of Submicro-Nano Structures on Polyetheretherketone Surface by Femtosecond Laser for Exciting Cellular Responses of MC3T3-E1 Cells/Gingival Epithelial Cells. International Journal of Nanomedicine 16, pages 3201-3216.
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Jin-Hong Yan, Chun-Hui Wang, Ke-Wen Li, Qi Zhang, Min Yang, Wei-Long Di-Wu, Ming Yan, Yue Song, Jing-Jing Ba, Long Bi & Yi-Sheng Han. (2018) Enhancement of surface bioactivity on carbon fiber-reinforced polyether ether ketone via graphene modification. International Journal of Nanomedicine 13, pages 3425-3440.
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Sunarso, Akira Tsuchiya, Naoyuki Fukuda, Riki Toita, Kanji Tsuru & Kunio Ishikawa. (2018) Effect of micro-roughening of poly(ether ether ketone) on bone marrow derived stem cell and macrophage responses, and osseointegration. Journal of Biomaterials Science, Polymer Edition 29:12, pages 1375-1388.
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Chunxia Gao, Donglei Wei, Huilin Yang, Tao Chen & Lei Yang. (2015) Nanotechnology for treating osteoporotic vertebral fractures. International Journal of Nanomedicine 10, pages 5139-5157.
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Yi Deng, Xiaochen Liu, Anxiu Xu, Lixin Wang, Zuyuan Luo, Yunfei Zheng, Feng Deng, Jie Wei, Zhihui Tang & Shicheng Wei. (2015) Effect of surface roughness on osteogenesis in vitro and osseointegration in vivo of carbon fiber-reinforced polyetheretherketone–nanohydroxyapatite composite. International Journal of Nanomedicine 10, pages 1425-1447.
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Ning Li, Kaihuan Yu, Kaixin Lin, Dehua Tao & Li Qiang. Compressive mechanical properties of hierarchical porous bioactivity PEEK gradient materials. Mechanics of Advanced Materials and Structures 0:0, pages 1-8.
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Articles from other publishers (22)

Ramesh K Nadiger, Lekha K Pillai & Roseline D Meshramkar. (2023) Evaluation of Osteoblastic Activity of Polyether Ether Ketone Modified by Ultraviolet Radiation: An In Vitro Study. International Journal of Prosthodontics and Restorative Dentistry 12:3, pages 106-109.
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Zhikun Li, Yifan Li, Wei Xu, Jimin Yu, Shichao Tong, Xiangyang Zhang & Xiaojian Ye. (2023) 3D-printed polyether-ether-ketone/n-TiO 2 composite enhances the cytocompatibility and osteogenic differentiation of MC3T3-E1 cells by downregulating miR-154-5p . Open Medicine 18:1.
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Harjeet Singh Gandhi. (2023) The Correlation between Mechanobiology and Fracture Healing; Osteosynthesis, Biomaterial Optimization and TRIZ Design Principles to Develop Ameliorative Implants for Reconstruction of Median Osteochondrotomy of the Sternum. Journal of Long-Term Effects of Medical Implants 33:3, pages 35-86.
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Nallammai Muthiah, Yagiz Ugur Yolcu, Nima Alan, Nitin Agarwal, David Kojo Hamilton & Alp Ozpinar. (2022) Evolution of polyetheretherketone (PEEK) and titanium interbody devices for spinal procedures: a comprehensive review of the literature. European Spine Journal 31:10, pages 2547-2556.
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Justy N. Francis, Indranil Banerjee, Ankita Chugh & Jaiveer Singh. (2022) Additive manufacturing of polyetheretherketone and its composites: A review. Polymer Composites 43:9, pages 5802-5819.
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Hitomi KIMURA, Hiroki TSUKA, Koji MORITA, Isao HIRATA, Fumiko NISHIO, Hitoshi ABEKURA, Kazuya DOI & Kazuhiro TSUGA. (2022) Nd:YVO<sub>4</sub> laser groove treatment can improve the shear bond strength between dental PEEK and adhesive resin cement with an adhesive system. Dental Materials Journal 41:3, pages 382-391.
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Kamalan Kirubaharan Amirtharaj Mosas, Ashok Raja Chandrasekar, Arish Dasan, Amirhossein Pakseresht & Dušan Galusek. (2022) Recent Advancements in Materials and Coatings for Biomedical Implants. Gels 8:5, pages 323.
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Şükran Melda ESKİTOROS TOĞAY & Ulya TOKGOZ. (2022) SURFACE MODIFIED TITANIUM DIOXIDE/POLY (LACTIC ACID) NANOCOMPOSITE FILMS FOR TISSUE ENGINEERINGDOKU MÜHENDİSLİĞİ İÇİN YÜZEYİ MODİFİYE EDİLMİŞ TİTANYUM DİOKSİT/POLİ (LAKTİK ASİT) NANOKOMPOZİT FİLMLER. SDÜ Tıp Fakültesi Dergisi 29:1, pages 111-120.
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Dan Yu, Xiaoyue Lei & Huiyong Zhu. (2022) Modification of polyetheretherketone (PEEK) physical features to improve osteointegration物理因素修饰对聚醚醚酮植入物骨整合的影响. Journal of Zhejiang University-SCIENCE B 23:3, pages 189-203.
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Jian-Chih Chen, Chih-Hua Chen, Kai-Chi Chang, Shih-Ming Liu, Chia-Ling Ko, Chi-Jen Shih, Ying-Sui Sun & Wen-Cheng Chen. (2021) Evaluation of the Grafting Efficacy of Active Biomolecules of Phosphatidylcholine and Type I Collagen on Polyether Ether Ketone: In Vitro and In Vivo. Polymers 13:13, pages 2081.
Crossref
Xiaolei Hu, Ling Xu, Xuewei Fu, Jiao Huang, Ping Ji, Zhiwei Zhang, Feng Deng & Xiaomian Wu. (2021) The TiO 2 -μ implant residual is more toxic than the Al 2 O 3 -n implant residual via blocking LAP and inducing macrophage polarization . Nanoscale 13:19, pages 8976-8990.
Crossref
Xinming Gu, Xiaolin Sun, Yue Sun, Jia Wang, Yiping Liu, Kaixuan Yu, Yao Wang & Yanmin Zhou. (2021) Bioinspired Modifications of PEEK Implants for Bone Tissue Engineering. Frontiers in Bioengineering and Biotechnology 8.
Crossref
Zach Pennington, A. Karim Ahmed & Daniel M. Sciubba. 2021. Handbook of Spine Technology. Handbook of Spine Technology 603 632 .
Zhangyu Ma, Xingyu Zhao, Jing Zhao, Zhilong Zhao, Qihui Wang & Congxiao Zhang. (2020) Biologically Modified Polyether Ether Ketone as Dental Implant Material. Frontiers in Bioengineering and Biotechnology 8.
Crossref
Zhiwei Zhang, Xuewei Fu, Ling Xu, Xiaolei Hu, Feng Deng, Zhiqiang Yang, Lin Jiang, Tiwei Fu, Pengfei Zhou, Jinlin Song, Ping Ji, Jiao Huang & Xiaomian Wu. (2020) Nanosized Alumina Particle and Proteasome Inhibitor Bortezomib Prevented inflammation and Osteolysis Induced by Titanium Particle via Autophagy and NF-κB Signaling. Scientific Reports 10:1.
Crossref
Zach Pennington, A. Karim Ahmed & Daniel M. Sciubba. 2020. Handbook of Spine Technology. Handbook of Spine Technology 1 30 .
Gaoyan Zhong, Mohammad Vaezi, Xinliang Mei, Ping Liu & Shoufeng Yang. (2019) Strategy for Controlling the Properties of Bioactive Poly-Ether-Ether-Ketone/Hydroxyapatite Composites for Bone Tissue Engineering Scaffolds. ACS Omega 4:21, pages 19238-19245.
Crossref
Hyun-Do Jung, Tae-Sik Jang, Ji Eun Lee, Seong Je Park, Yong Son & Suk-Hee Park. (2019) Enhanced bioactivity of titanium-coated polyetheretherketone implants created by a high-temperature 3D printing process. Biofabrication 11:4, pages 045014.
Crossref
Margaret E. Brennan Fournet, Farah Alwani Azaman, Suzan Gunbay, Yuan Yuan Chen & Declan M. Devine. 2019. Polymer-Based Additive Manufacturing. Polymer-Based Additive Manufacturing 121 142 .
Corrado Piconi & Monica Sandri. (2017) New Materials for Dental Implantology. Key Engineering Materials 750, pages 189-194.
Crossref
Davood Almasi, Nida Iqbal, Maliheh Sadeghi, Izman Sudin, Mohammed Rafiq Abdul Kadir & Tunku Kamarul. (2016) Preparation Methods for Improving PEEK’s Bioactivity for Orthopedic and Dental Application: A Review. International Journal of Biomaterials 2016, pages 1-12.
Crossref
Shariq Najeeb, Zohaib Khurshid, Jukka Pekka Matinlinna, Fahad Siddiqui, Mohammad Zakaria Nassani & Kusai Baroudi. (2015) Nanomodified Peek Dental Implants: Bioactive Composites and Surface Modification—A Review. International Journal of Dentistry 2015, pages 1-7.
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