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Review

Targeting myeloid-derived suppressor cells in the treatment of hepatocellular carcinoma: current state and future perspectives

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Pages 71-84 | Published online: 07 May 2019

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Dandan Lin, Yu Mei, Lei Lei, Zuhairah Binte Hanafi, Ziqi Jin, Yonghao Liu, Yuan Song, Yinsheng Zhang, Bo Hu, Chunliang Liu, Jinhua Lu & Haiyan Liu. (2022) Immune suppressive function of IL-1α release in the tumor microenvironment regulated by calpain 1. OncoImmunology 11:1.
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Muluneh Ademe. (2020) Paradoxes in the Phenotype, Frequency and Roles of Myeloid-Derived Suppressor Cells During HIV Infection. HIV/AIDS - Research and Palliative Care 12, pages 151-156.
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Zhao-Shan Niu, Wen-Hong Wang & Xiao-Jun Niu. (2022) Recent progress in molecular mechanisms of postoperative recurrence and metastasis of hepatocellular carcinoma. World Journal of Gastroenterology 28:46, pages 6433-6477.
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Uasim Harkus, Miriam Wankell, Pranavan Palamuthusingam, Craig McFarlane & Lionel Hebbard. (2022) Immune checkpoint inhibitors in HCC: Cellular, molecular and systemic data. Seminars in Cancer Biology 86, pages 799-815.
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Dazhi Tian, Yang Yu, Li Zhang, Jisan Sun & Wentao Jiang. (2022) 23-hydroxybetulinic acid reduces tumorigenesis, metastasis and immunosuppression in a mouse model of hepatocellular carcinoma via disruption of the MAPK signaling pathway. Anti-Cancer Drugs 33:9, pages 815-825.
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Shuai Chen, Jianghong Cheng, Yanhong Zhong, Ruimin Liu, Zhongxian Lu & Xianyang Luo. (2022) Liver-specific overexpression of Gab2 accelerates hepatocellular carcinoma progression by activating immunosuppression of myeloid-derived suppressor cells. Oncogene 41:24, pages 3316-3327.
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Hui Li. (2022) Intercellular crosstalk of liver sinusoidal endothelial cells in liver fibrosis, cirrhosis and hepatocellular carcinoma. Digestive and Liver Disease 54:5, pages 598-613.
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Xiaoqiang Yin, Tongchui Wu, Yadong Lan & Wulin Yang. (2022) Current progress of immune checkpoint inhibitors in the treatment of advanced hepatocellular carcinoma. Bioscience Reports 42:2.
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Adeleye O. Adeshakin, Funmilayo O. Adeshakin, Dehong Yan & Xiaochun Wan. (2022) Regulating Histone Deacetylase Signaling Pathways of Myeloid-Derived Suppressor Cells Enhanced T Cell-Based Immunotherapy. Frontiers in Immunology 13.
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Dev Karan. (2021) CCL23 in Balancing the Act of Endoplasmic Reticulum Stress and Antitumor Immunity in Hepatocellular Carcinoma. Frontiers in Oncology 11.
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Jie Chen, Yong-Jian Chen, Nan Jiang, Jian-Liang Xu, Zi-Ming Liang, Ming-Jun Bai, Yan-Fang Xing, Zhuo Liu, Xiang-Yuan Wu & Xing Li. (2021) Neutrophil-to-Apolipoprotein A1 Ratio Predicted Overall Survival in Hepatocellular Carcinoma Receiving Transarterial Chemoembolization. The Oncologist 26:8, pages e1434-e1444.
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Yueqi Zhang, Hongbing Wang & Hua Xiao. (2021) Metformin Actions on the Liver: Protection Mechanisms Emerging in Hepatocytes and Immune Cells against NASH-Related HCC. International Journal of Molecular Sciences 22:9, pages 5016.
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Jessica K. Mandula & Paulo C. Rodriguez. (2021) Tumor-related stress regulates functional plasticity of MDSCs. Cellular Immunology 363, pages 104312.
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Latika Singh, Eric S. Muise, Anannya Bhattacharya, Jeff Grein, Sarah Javaid, Peter Stivers, Jun Zhang, Yujie Qu, Barbara Joyce-Shaikh, Andrey Loboda, Chunsheng Zhang, Michael Meehl, Derek Y. Chiang, Sheila H. Ranganath, Michael Rosenzweig & Philip E. Brandish. (2021) ILT3 (LILRB4) Promotes the Immunosuppressive Function of Tumor-Educated Human Monocytic Myeloid-Derived Suppressor Cells. Molecular Cancer Research 19:4, pages 702-716.
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Tsz Tung Kwong, Chi Hang Wong, Jing Ying Zhou, Alfred Sze Lok Cheng, Joseph Jao Yiu Sung, Anthony Wing Hung Chan & Stephen Lam Chan. (2021) Chemotherapy-induced recruitment of myeloid-derived suppressor cells abrogates efficacy of immune checkpoint blockade. JHEP Reports 3:2, pages 100224.
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Suresh Gopi Kalathil & Yasmin Thanavala. (2021) Importance of myeloid derived suppressor cells in cancer from a biomarker perspective. Cellular Immunology 361, pages 104280.
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Astha Malik, Unmesha Thanekar, Surya Amarachintha, Reena Mourya, Shreya Nalluri, Alexander Bondoc & Pranavkumar Shivakumar. (2021) “Complimenting the Complement”: Mechanistic Insights and Opportunities for Therapeutics in Hepatocellular Carcinoma. Frontiers in Oncology 10.
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Maham Farshidpour, Monjur Ahmed, Shilpa Junna & Juanita L Merchant. (2021) Myeloid-derived suppressor cells in gastrointestinal cancers: A systemic review. World Journal of Gastrointestinal Oncology 13:1, pages 1-11.
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Peiwen Chen, Wen-Hao Hsu, Jincheng Han, Yan Xia & Ronald A. DePinho. (2021) Cancer Stemness Meets Immunity: From Mechanism to Therapy. Cell Reports 34:1, pages 108597.
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Alex L. Wilkinson, Maria Qurashi & Shishir Shetty. (2020) The Role of Sinusoidal Endothelial Cells in the Axis of Inflammation and Cancer Within the Liver. Frontiers in Physiology 11.
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Wenzhe Yin, Jun Xu, Chao Li, Xiankui Dai, Tong Wu & Jifeng Wen. (2020) Plantamajoside inhibits the proliferation and epithelial‐to‐mesenchymal transition in hepatocellular carcinoma cells via modulating hypoxia‐inducible factor‐1α‐dependent gene expression. Cell Biology International 44:8, pages 1616-1627.
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Changpei Cheng, Qiyang Shou, Jiali Lang, Lu Jin, Xia Liu, Dongxin Tang, Zhu Yang & Huiying Fu. (2020) Gehua Jiecheng Decoction Inhibits Diethylnitrosamine-Induced Hepatocellular Carcinoma in Mice by Improving Tumor Immunosuppression Microenvironment. Frontiers in Pharmacology 11.
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Stephen P Hack, Jessica Spahn, Minshan Chen, Ann-Lii Cheng, Ahmed Kaseb, Masatoshi Kudo, Han Chu Lee, Adam Yopp, Pierce Chow & Shukui Qin. (2020) IMbrave 050: a Phase III trial of atezolizumab plus bevacizumab in high-risk hepatocellular carcinoma after curative resection or ablation. Future Oncology 16:15, pages 975-989.
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Sean H. Colligan, Stephanie L. Tzetzo & Scott I. Abrams. (2020) Myeloid-driven mechanisms as barriers to antitumor CD8+ T cell activity. Molecular Immunology 118, pages 165-173.
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Takahiro Kodama & Tetsuo Takehara. 2020. Liver Immunology. Liver Immunology 505 524 .
Eleni-Kyriaki Vetsika, Aristeidis Koukos & Athanasios Kotsakis. (2019) Myeloid-Derived Suppressor Cells: Major Figures that Shape the Immunosuppressive and Angiogenic Network in Cancer. Cells 8:12, pages 1647.
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Anita Thyagarajan, Mamdouh Salman A. Alshehri, Kelly L.R. Miller, Catherine M. Sherwin, Jeffrey B. Travers & Ravi P. Sahu. (2019) Myeloid-Derived Suppressor Cells and Pancreatic Cancer: Implications in Novel Therapeutic Approaches. Cancers 11:11, pages 1627.
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Sabina I. Hlavaty, Yu-Mei Chang, Rachel P. Orth, Mark Goulian, Paul J. Planet, Douglas H. Thamm, Jennifer A. Punt & Oliver A. Garden. (2019) Bacterial Killing Activity of Polymorphonuclear Myeloid-Derived Suppressor Cells Isolated From Tumor-Bearing Dogs. Frontiers in Immunology 10.
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Amit Mahipal, Sri Harsha Tella, Anuhya Kommalapati, Alexander Lim & Richard Kim. (2019) Immunotherapy in Hepatocellular Carcinoma: Is There a Light at the End of the Tunnel?. Cancers 11:8, pages 1078.
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