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Original Research

Salvage treatment with apatinib for advanced non-small-cell lung cancer

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Pages 1821-1825 | Published online: 23 Mar 2017

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Read on this site (12)

Qian Geng, Hua Shen, Wenyu Zhu, Yingzhi Lu, Mengjie Wang, Hua Jiang & Dongqing Li. (2020) Safety and Efficacy of Low-Dosage Apatinib Monotherapy in Advanced Lung Squamous-Cell Carcinoma: A Prospective Cohort Study. OncoTargets and Therapy 13, pages 11529-11535.
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Hongchao Zhen, Guangxin Li, Pengfei Zhao, Ying Zhang, Jing Wang, Junxian Yu & Bangwei Cao. (2020) Raltitrexed Enhances the Antitumor Effect of Apatinib in Human Esophageal Squamous Carcinoma Cells via Akt and Erk Pathways. OncoTargets and Therapy 13, pages 12325-12339.
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Guohui Liu, Yanbo Wang, Chunbo Wang, Yunlong He & Mingyan E. (2020) Clinical efficacy and safety of apatinib as maintenance treatment in patients with advanced esophageal squamous cell carcinoma. Expert Review of Clinical Pharmacology 13:12, pages 1423-1430.
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A Spagnuolo, G Palazzolo, C Sementa & C Gridelli. (2020) Vascular endothelial growth factor receptor tyrosine kinase inhibitors for the treatment of advanced non-small cell lung cancer. Expert Opinion on Pharmacotherapy 21:4, pages 491-506.
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Lan Shao, Wenxian Wang, Zhengbo Song & Yiping Zhang. (2019) The efficacy and safety of anlotinib treatment for advanced lung cancer. OncoTargets and Therapy 12, pages 6549-6554.
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Shen-Cun Fang, Wen Huang, Ying-Ming Zhang, Hai-Tao Zhang & Wei-Ping Xie. (2019) Hypertension as a predictive biomarker in patients with advanced non-small-cell lung cancer treated with apatinib. OncoTargets and Therapy 12, pages 985-992.
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Deze Zhao, Helei Hou & Xiaochun Zhang. (2018) Progress in the treatment of solid tumors with apatinib: a systematic review. OncoTargets and Therapy 11, pages 4137-4147.
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Xiaofen Li, Xia Li, Xuefeng Fang & Ying Yuan. (2018) Long-term progression-free survival of third-line apatinib in lung squamous cell carcinoma. OncoTargets and Therapy 11, pages 4047-4050.
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Fengying Wu, Shijia Zhang, Guanghui Gao, Jing Zhao, Shengxiang Ren & Caicun Zhou. (2018) Successful treatment using apatinib with or without docetaxel in heavily pretreated advanced non-squamous non-small cell lung cancer: A case report and literature review. Cancer Biology & Therapy 19:3, pages 141-144.
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Da-xiong Zeng, Chang-guo Wang, Jian-an Huang & Jun-hong Jiang. (2017) Apatinib in the treatment of advanced lung adenocarcinoma with KRAS mutation. OncoTargets and Therapy 10, pages 4269-4272.
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Jianqiang Li & Lifen Wang. (2017) Efficacy and safety of apatinib treatment for advanced esophageal squamous cell carcinoma. OncoTargets and Therapy 10, pages 3965-3969.
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Jinling Bi, Haiyuan Liu & Yong Huang. (2017) The effect of apatinib in the treatment of metastatic renal cell carcinoma: a case report and review of the literature. International Medical Case Reports Journal 10, pages 223-227.
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Wenxian Wang, Lan Shao, Yibing Xu, Zhengbo Song, Guangyuan Lou, Yiping Zhang & Ming Chen. (2022) Efficacy and safety of anlotinib with and without EGFR-TKIs or immunotherapy in the treatment of elder patients with non-small-cell lung cancer: a retrospective study. BMC Pulmonary Medicine 22:1.
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Jijin Wang, Di Huang, Wenjing Yang, Qingxu Song, Yibin Jia, Pengxiang Chen & Yufeng Cheng. (2022) The efficacy and safety of Apatinib in the treatment of advanced non-small cell lung cancer: A retrospective trial. Frontiers in Oncology 12.
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Cheng Chen, Xiaoting Duan, Yanfeng Shen & Guiying Li. (2022) The clinical efficacy and safety of TACE combined with apatinib for advanced hepatocellular carcinoma: A propensity score matching analysis. Indian Journal of Cancer 0:0, pages 0.
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Congcong Ren, Jing Zhao, Lin Kang, Yan Di, Gang Qiu & Qingxue Wang. (2021) Successful treatment of radiotherapy and apatinib in patient with mediastinal mixed non-seminomatous germ cell tumor. Medicine 100:43, pages e27617.
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Bin Wei, Yuanyuan Wang, Jiawei Wang, Xiaomin Cai, Lingyan Xu, Jingjing Wu, Ying Wang, Wen Liu, Yanhong Gu, Wenjie Guo & Qiang Xu. (2020) Apatinib suppresses tumor progression and enhances cisplatin sensitivity in esophageal cancer via the Akt/β-catenin pathway. Cancer Cell International 20:1.
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Wei Li, Chengguan Feng, Weihong Di, Shanwen Hong, Hui Chen, Mubashir Ejaz, Yang Yang & Tian-rui Xu. (2020) Clinical use of vascular endothelial growth factor receptor inhibitors for the treatment of renal cell carcinoma. European Journal of Medicinal Chemistry 200, pages 112482.
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Fen Wang, Xia Yuan, Jun Jia, Xiaoxia Bi, Zeqiang Zhou, Qiming Zhou, Xia Li, Changguo Luo, Minghui Deng, Liangjie Yi, Yong Li, Jianxin Lu, Wenzhi Su, Hanbin Chen, Yu Zhu & Shubin Wang. (2020) Apatinib Monotherapy for Chemotherapy-Refractory Metastatic Colorectal Cancer: A Multi-centre, Single-Arm, Prospective Study. Scientific Reports 10:1.
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Jianxia Wen, Tao Yang, Jian Wang, Xiao Ma, Yuling Tong & Yanling Zhao. (2020) Kanglaite Injection Combined with Chemotherapy versus Chemotherapy Alone for the Improvement of Clinical Efficacy and Immune Function in Patients with Advanced Non-Small-Cell Lung Cancer: A Systematic Review and Meta-Analysis. Evidence-Based Complementary and Alternative Medicine 2020, pages 1-15.
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Jian Li, Xiwen Tong & Hongtao Li. (2020) Efficacy and safety of apatinib monotherapy in elderly patients with advanced metastatic non-small cell lung cancer. Indian Journal of Cancer 57:1, pages 13.
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Jianmiao Liang, Weiguang Gu, Jun Jin, Hua Zhang, Zecheng Chen, Yicong Tang, Shunda Zhang, Shuang Yang, Yanming Deng & Weineng Feng. (2020) Efficacy and safety of apatinib as third- or further-line therapy for patients with advanced NSCLC: a retrospective study. Therapeutic Advances in Medical Oncology 12, pages 175883592096847.
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Jian-Chun Duan, Zhi-Jie Wang, Lin Lin, Jun-Ling Li, Yan Wang, Hua Bai, Xing-Sheng Hu, Yu-Tao Liu, Xue-Zhi Hao, Hong-Yu Wang, Rui Wan, Xin Wang & Jie Wang. (2019) Apatinib, a novel VEGFR inhibitor plus docetaxel in advanced lung adenocarcinoma patients with wild-type EGFR: a phase I trial. Investigational New Drugs 37:4, pages 731-737.
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Jing Tang, Xu Yong Li, Jing Bo Liang, De Wu, Li Peng & Xiaobing Li. (2019) Apatinib Plus Chemotherapy Shows Clinical Activity in Advanced NSCLC: A Retrospective Study. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 27:6, pages 635-641.
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Qian Jiang, Ning-Ling Zhang, Dai-Yuan Ma, Bang-Xian Tan, Xin Hu & Xiang-Dong Fang. (2019) Efficacy and safety of apatinib plus docetaxel as the second or above line treatment in advanced nonsquamous NSCLC. Medicine 98:26, pages e16065.
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Zhichao Tian, Zhiyuan Gu, Xin Wang, Zhiyong Liu, Weitao Yao, Jiaqiang Wang, Peng Zhang, Qiqing Cai & Hong Ge. (2019) Efficacy and safety of apatinib in treatment of osteosarcoma after failed standard multimodal therapy. Medicine 98:19, pages e15650.
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Da-xiong Zeng, Wei Lei, Chang-guo Wang, Jian-an Huang & Jun-hong Jiang. (2018) Low dosage of apatinib monotherapy as rescue treatment in advanced lung squamous cell carcinoma. Cancer Chemotherapy and Pharmacology 83:3, pages 439-442.
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Jin Liu, Yulong Zheng & Nong Xu. (2019) Low dose of apatinib in treating chemotherapy and EGFR-TKI refractory non-small cell lung cancer. Medicine 98:5, pages e14328.
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Jianxin Chen, Junhui Wang & Qian Miao. (2019) Careful dose modification of apatinib as third or further-line treatment in advanced gastric cancer patients with poor performance status. Medicine 98:45, pages e17890.
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Jiao Leng, Dai-Rong Li, Lu-Mi Huang, Xiao-Hui Ji & Dong-Lin Wang. (2019) Apatinib is effective as third-line and more treatment of advanced metastatic non-small-cell lung cancer. Medicine 98:36, pages e16967.
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Jun Jin, Jiahao Du & Yanwei Wu. (2019) Apatinib monotherapy for advanced VEGFR-2-negative nasopharyngeal carcinoma. Medicine 98:1, pages e13491.
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Lijun Hu, Fei Sun, Zhiqiang Sun, Xinchu Ni, Jian Wang, Jianlin Wang, Mengyun Zhou, Yue Feng, Ze Kong, Qiu Hua & Jingping Yu. (2018) Apatinib enhances the radiosensitivity of the esophageal cancer cell line KYSE‑150 by inducing apoptosis and cell cycle redistribution. Oncology Letters.
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Di Wu, Li Liang, Ligong Nie, Jun Nie, Ling Dai, Weiheng Hu, Jie Zhang, Xiaoling Chen, Jindi Han, Xiangjuan Ma, Guangming Tian, Sen Han, Jieran Long, Yang Wang, Ziran Zhang, Tao Xin & Jian Fang. (2018) Efficacy, safety and predictive indicators of apatinib after multilines treatment in advanced nonsquamous nonsmall cell lung cancer: Apatinib treatment in nonsquamous NSCLC. Asia-Pacific Journal of Clinical Oncology 14:6, pages 446-452.
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Zedong Du, Yanxin Yu, Dajun Wu, Guangyu Zhang, Yang Wang, Liang He & RongQin Meng. (2018) Apatinib for salvage treatment of advanced malignant pleural mesothelioma. Medicine 97:45, pages e13105.
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Fengying Wu, Shijia Zhang, Anwen Xiong, Guanghui Gao, Wei Li, Weijing Cai, Chunxia Su, Xiaoxia Chen, Fei Zhou, Jing Zhao, Shengxiang Ren & Caicun Zhou. (2018) A Phase II Clinical Trial of Apatinib in Pretreated Advanced Non-squamous Non–small-cell Lung Cancer. Clinical Lung Cancer 19:6, pages e831-e842.
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Zui Liu, Wei Ou, Ning Li & Si-Yu Wang. (2018) Apatinib monotherapy for advanced non-small cell lung cancer after the failure of chemotherapy or other targeted therapy. Thoracic Cancer 9:10, pages 1285-1290.
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Jie-Tao Ma, Jing Sun, Li Sun, Shu-Ling Zhang, Le-Tian Huang & Cheng-Bo Han. (2018) Efficacy and safety of apatinib in patients with advanced nonsmall cell lung cancer that failed prior chemotherapy or EGFR-TKIs. Medicine 97:35, pages e12083.
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Dexiang Yang, Ranran Dai, Qi Zhang & Ping Fang. (2018) Apatinib for heavily treated patients with non-small cell lung cancer: Report of a case series and literature review. Saudi Journal of Biological Sciences 25:5, pages 888-894.
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Jianping Xu, Xiaoyan Liu, Sheng Yang, Xiangru Zhang & Yuankai Shi. (2018) Clinical response to apatinib monotherapy in advanced non-small cell lung cancer. Asia-Pacific Journal of Clinical Oncology 14:3, pages 264-269.
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Xiaojin Li, Anjian Xu, Huihui Li, Bei Zhang, Bangwei Cao & Jian Huang. (2018) Novel role of apatinib as a multi-target RTK inhibitor in the direct suppression of hepatocellular carcinoma cells. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864:5, pages 1693-1701.
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Lesley J. Scott. (2018) Apatinib: A Review in Advanced Gastric Cancer and Other Advanced Cancers. Drugs 78:7, pages 747-758.
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Miaomiao Gou, Haiyan Si, Yong Zhang, Niansong Qian, Zhikuan Wang, Weiwei Shi & Guanghai Dai. (2018) Efficacy and safety of apatinib in patients with previously treated metastatic colorectal cancer: a real-world retrospective study. Scientific Reports 8:1.
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Yong Zhang, Miaomiao Gou, Chun Han, Juan Li, Lijie Wang, Qian Qiao, Yi Hu, Li Bai & Zhefeng Liu. (2018) Efficacy and safety of apatinib as second-line therapy for advanced gastric cancer. Anti-Cancer Drugs 29:2, pages 184-189.
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Shencun Fang, Meiling Zhang, Guihong Wei & Kai-Hua Lu. (2017) Apatinib as a third- or further- line treatment in patients with advanced NSCLC harboring wild-type EGFR. Oncotarget 9:6, pages 7175-7181.
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Yinlong Kong, Lin Sun, Zhenyu Hou, Yongqiang Zhang, Ping Chen, Yunlong Cui, Xiaolin Zhu, Tianqiang Song, Qiang Li, Huikai Li, Ti Zhang & Lunxiu Qin. (2017) Apatinib is effective for treatment of advanced hepatocellular carcinoma. Oncotarget 8:62, pages 105596-105605.
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