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Original Research

MicroRNA 543 suppresses breast cancer cell proliferation, blocks cell cycle and induces cell apoptosis via direct targeting of ERK/MAPK

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Pages 1423-1431 | Published online: 06 Mar 2017

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Maryam Mohsenikia, Solmaz Khalighfard, Ali Mohammad Alizadeh, Vahid Khori, Maziar Ghandian Zanjan, Mohammadreza Zare, Ramesh Omranipour, Elham Patrad, Hengamesadat Razavi, Ziba Veisi Malekshahi & Zahra Bagheri-Hosseinabadi. (2022) An innovative systematic approach introduced the involved lncRNA-miR-mRNA network in cell cycle and proliferation after conventional treatments in breast cancer patients. Cell Cycle 21:16, pages 1753-1774.
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Jia Hu, Youfang Chen, Xiaodong Li, Huikai Miao, Rongzhen Li, Dongni Chen & Zhesheng Wen. (2019) THUMPD3-AS1 Is Correlated With Non-Small Cell Lung Cancer And Regulates Self-Renewal Through miR-543 And ONECUT2. OncoTargets and Therapy 12, pages 9849-9860.
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Da-Wei Shen, Yun-Long Li, Yu-Jie Hou, Zhi-Dan Xu, Yong-Zhe Li & Jian-Yong Chang. (2019) MicroRNA-543 promotes cell invasion and impedes apoptosis in pituitary adenoma via activating the Wnt/β-catenin pathway by negative regulation of Smad7. Bioscience, Biotechnology, and Biochemistry 83:6, pages 1035-1044.
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Konstantina Panoutsopoulou, Margaritis Avgeris & Andreas Scorilas. (2018) miRNA and long non-coding RNA: molecular function and clinical value in breast and ovarian cancers. Expert Review of Molecular Diagnostics 18:11, pages 963-979.
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Mengya Su, Ping Huang & Qian Li. (2023) Long noncoding RNA SNHG6 promotes the malignant phenotypes of ovarian cancer cells via miR-543/YAP1 pathway. Heliyon 9:5, pages e16291.
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Ahmed Ismail, Hesham A. El-Mahdy, Ahmed I. Abulsoud, Al-Aliaa M. Sallam, Mahmoud Gomaa Eldeib, Elsayed G.E. Elsakka, Mohamed Bakr Zaki & Ahmed S. Doghish. (2023) Beneficial and detrimental aspects of miRNAs as chief players in breast cancer: A comprehensive review. International Journal of Biological Macromolecules 224, pages 1541-1565.
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Lige YaoLu ChenHanli ZhouFangfang DuanLiuyan WangYujie Zhang. (2022) Long Noncoding RNA NEAT1 Promotes the Progression of Breast Cancer by Regulating miR-138-5p/ ZFX Axis . Cancer Biotherapy and Radiopharmaceuticals 37:8, pages 636-649.
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Daoping Zhang, Xu Ding & Meirong Peng. (2021) LncRNA SNHG14 accelerates breast cancer progression through sponging miR-543 and regulating KLF7 expression. Archives of Gynecology and Obstetrics 305:6, pages 1507-1516.
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Y. L. Wang, R. H. Liang, C. Y. Wang, R. P. Zhang, S. Y. Wu, X. Han & G. L. Zhang. (2021) MicroRNA-543 inhibits the proliferation, migration, invasion, and epithelial-mesenchymal transition of triple-negative breast cancer cells via down-regulation of ACTL6A gene. Clinical and Translational Oncology 24:1, pages 84-92.
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Soudeh Ghafouri-Fard, Ali Khanbabapour Sasi, Atefe Abak, Hamed Shoorei, Ali Khoshkar & Mohammad Taheri. (2021) Contribution of miRNAs in the Pathogenesis of Breast Cancer. Frontiers in Oncology 11.
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Rong Li, Sihao Hou, Ming Zou, Kunqi Ye & Li Xiang. (2021) miR-543 impairs cell proliferation, migration, and invasion in breast cancer by suppressing VCAN. Biochemical and Biophysical Research Communications 570, pages 191-198.
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Cuicui Lu, Duncan Wei, Yahui Zhang, Peng Wang & Wen Zhang. (2021) Long Non-Coding RNAs as Potential Diagnostic and Prognostic Biomarkers in Breast Cancer: Progress and Prospects. Frontiers in Oncology 11.
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Elan C. McCarthy & Róisín M. Dwyer. (2021) Emerging Evidence of the Functional Impact of the miR379/miR656 Cluster (C14MC) in Breast Cancer. Biomedicines 9:7, pages 827.
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You-Quan Wang, Guo Huang, Juan Chen, Hong Cao & Wen-Ting Xu. (2021) LncRNA SNHG6 promotes breast cancer progression and epithelial-mesenchymal transition via miR-543/LAMC1 axis. Breast Cancer Research and Treatment 188:1, pages 1-14.
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Linlin Wang, Dan Liu, Jun Wei, Liwei Yuan, Shiyun Zhao, Yani Huang, Jingwen Ma & Zhijuan Yang. (2021) MiR-543 Inhibits the Migration and Epithelial-To-Mesenchymal Transition of TGF-β-Treated Endometrial Stromal Cells via the MAPK and Wnt/β-Catenin Signaling Pathways. Pathology and Oncology Research 27.
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Shokooh Salimimoghadam, Sina Taefehshokr, Reid Loveless, Yong Teng, Gloria Bertoli, Nima Taefehshokr, Fatemeh Musaviaroo, Khalil Hajiasgharzadeh & Behzad Baradaran. (2021) The role of tumor suppressor short non-coding RNAs on breast cancer. Critical Reviews in Oncology/Hematology 158, pages 103210.
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Cong Zhou, Xin Zhao & Shiwei Duan. (2020) The role of miR‐543 in human cancerous and noncancerous diseases. Journal of Cellular Physiology 236:1, pages 15-26.
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Adele Vivacqua. (2020) GPER1 and microRNA: Two Players in Breast Cancer Progression. International Journal of Molecular Sciences 22:1, pages 98.
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Soudeh Ghafouri-Fard, Hamed Shoorei, Farhad Tondro Anamag & Mohammad Taheri. (2020) The Role of Non-Coding RNAs in Controlling Cell Cycle Related Proteins in Cancer Cells. Frontiers in Oncology 10.
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Momi Saikia, Sunanda Paul & Supriyo Chakraborty. (2020) Role of microRNA in forming breast carcinoma. Life Sciences 259, pages 118256.
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Wei Ji, Qiang Mu, Xiang-Yu Liu, Xu-Chen Cao & Yue Yu. (2020) ZNF281-miR-543 Feedback Loop Regulates Transforming Growth Factor-β-Induced Breast Cancer Metastasis. Molecular Therapy - Nucleic Acids 21, pages 98-107.
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Yin Zhang, Jiayin An & Yuchun Pei. (2020) LncRNA SNHG6 promotes LMO3 expression by sponging miR-543 in glioma. Molecular and Cellular Biochemistry 472:1-2, pages 9-17.
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Gholamreza Rezaei Danbaran, Saeed Aslani, Nadia Sharafkandi, Maryam Hemmatzadeh, Ramin Hosseinzadeh, Gholamreza Azizi, Farhad Jadidi-Niaragh, Farhad Babaie & Hamed Mohammadi. (2020) How microRNAs affect the PD-L1 and its synthetic pathway in cancer. International Immunopharmacology 84, pages 106594.
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Shi Zeng, Chun Zhou, Dong-Hong Yang, Lun-Shan Xu, Hua-Jiang Yang, Min-Hui Xu & Hao Wang. (2020) LEF1-AS1 is implicated in the malignant development of glioblastoma via sponging miR-543 to upregulate EN2. Brain Research 1736, pages 146781.
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Maryam Abolghasemi, Sadra Samavarchi Tehrani, Tooba Yousefi, Ansar Karimian, Ata Mahmoodpoor, Aliakbar Ghamari, Farhad Jadidi‐Niaragh, Mehdi Yousefi, Hossein Samadi Kafil, Milad Bastami, Mahdi Edalati, Shirin Eyvazi, Mohsen Naghizadeh, Niloufar Targhazeh, Bahman Yousefi, Amin Safa, Maryam Majidinia & Vahid Rameshknia. (2019) MicroRNAs in breast cancer: Roles, functions, and mechanism of actions. Journal of Cellular Physiology 235:6, pages 5008-5029.
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Sepideh Dashti, Zahra Taherian-Esfahani, Vahid Kholghi-Oskooei, Rezvan Noroozi, Sharam Arsang-Jang, Soudeh Ghafouri-Fard & Mohammad Taheri. (2020) In silico identification of MAPK14-related lncRNAs and assessment of their expression in breast cancer samples. Scientific Reports 10:1.
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Lingmin Zhang, Jingxin Chen, Li Wang, Lin Chen, ZhaoZhao Du, Lin Zhu, Manli Cui, Mingxin Zhang & Liping Song. (2019) Linc‐PINT acted as a tumor suppressor by sponging miR‐543 and miR‐576‐5p in esophageal cancer. Journal of Cellular Biochemistry 120:12, pages 19345-19357.
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Hui-Yi Loh, Brendan P. Norman, Kok-Song Lai, Nik Mohd Afizan Nik Abd. Rahman, Noorjahan Banu Mohamed Alitheen & Mohd Azuraidi Osman. (2019) The Regulatory Role of MicroRNAs in Breast Cancer. International Journal of Molecular Sciences 20:19, pages 4940.
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TianMing Chen, Qi Xiao, XiaoJun Wang, ZhongQiu Wang, JingWen Hu, Zhi Zhang, ZhuNan Gong & ShiLin Chen. (2019) miR-16 regulates proliferation and invasion of lung cancer cells via the ERK/MAPK signaling pathway by targeted inhibition of MAPK kinase 1 (MEK1). Journal of International Medical Research 47:10, pages 5194-5204.
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Ze-Wen Yu, Wei Gao, Xin-Yao Feng, Jin-Yu Zhang, Hai-Xiang Guo, Chang-Jiang Wang, Jian Chen, Jin-Ping Hu, Wen-Zhi Ren & Bao Yuan. (2019) Roles of differential expression of miR-543-5p in GH regulation in rat anterior pituitary cells and GH3 cells. PLOS ONE 14:9, pages e0222340.
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Puyu Yang, Zhangxin Wu, Caihong Ma, Ningning Pan, Yang Wang & Liying Yan. (2019) Endometrial miR-543 Is Downregulated During the Implantation Window in Women With Endometriosis-Related Infertility. Reproductive Sciences 26:7, pages 900-908.
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Xiaoying Liu, Lu Gan & Jing Zhang. (2019) miR-543 inhibites cervical cancer growth and metastasis by targeting TRPM7. Chemico-Biological Interactions 302, pages 83-92.
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Y. Ge, J. Li, Y. Hao, Y. Hu, D. Chen, B. Wu & F. Fang. (2018) MicroRNA-543 functions as an osteogenesis promoter in human periodontal ligament-derived stem cells by inhibiting transducer of ERBB2, 2. Journal of Periodontal Research 53:5, pages 832-841.
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Zhengzheng Su, Mengni Zhang, Miao Xu, Xinglan Li, Junya Tan, Yunyi Xu, Xiuyi Pan, Ni Chen, Xueqin Chen & Qiao Zhou. (2018) MicroRNA181c inhibits prostate cancer cell growth and invasion by targeting multiple ERK signaling pathway components. The Prostate 78:5, pages 343-352.
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Jiao Guo, Chun-Dong Zhang, Jia-Xiang An, Yun-Yun Xiao, Shuai Shao, Nuo-Ming Zhou & Dong-Qiu Dai. (2018) Expression of miR-634 in gastric carcinoma and its effects on proliferation, migration, and invasion of gastric cancer cells. Cancer Medicine 7:3, pages 776-787.
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Yan Zhou, Bao-Zhong Ding, Yun-Peng Lin & Hai-Bo Wang. (2018) MiR-34a, as a suppressor, enhance the susceptibility of gastric cancer cell to luteolin by directly targeting HK1. Gene 644, pages 56-65.
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Fan Yang, Jianjun Ma, Qisheng Tang, Wei Zhang, Qiang Fu, Jinbo Sun, He Wang & Bin Song. (2018) MicroRNA-543 promotes the proliferation and invasion of clear cell renal cell carcinoma cells by targeting Krüppel-like factor 6. Biomedicine & Pharmacotherapy 97, pages 616-623.
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Gang Chen, Dongdong Wang, Xiongqi Zhao, Jun Cao, Yingpeng Zhao, Fan Wang, Jianhua Bai, Ding Luo & Li Li. (2017) miR-155-5p modulates malignant behaviors of hepatocellular carcinoma by directly targeting CTHRC1 and indirectly regulating GSK-3β-involved Wnt/β-catenin signaling. Cancer Cell International 17:1.
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Li-ping Liu, Mei Yang, Quan-zhou Peng, Ming-yue Li, Yu-sen Zhang, Yue-hua Guo, Yang Chen & Shi-yun Bao. (2017) UBE2T promotes hepatocellular carcinoma cell growth via ubiquitination of p53. Biochemical and Biophysical Research Communications 493:1, pages 20-27.
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