Advanced search
Publication Cover
OncoTargets and Therapy Volume 10, 2017 - Issue
Submit an article Journal homepage
52
Views
70
CrossRef citations to date
0
Altmetric
Original Research

Downregulation of long noncoding RNA TUG1 inhibits proliferation and induces apoptosis through the TUG1/miR-142/ZEB2 axis in bladder cancer cells

Qian LiuDepartment of Urology Surgery, Huaihe Hospital of Henan University, Kaifeng, People’s Republic of China
,
Hui LiuDepartment of Urology Surgery, Huaihe Hospital of Henan University, Kaifeng, People’s Republic of China
,
Hepeng ChengDepartment of Urology Surgery, Huaihe Hospital of Henan University, Kaifeng, People’s Republic of China
,
Yang LiDepartment of Urology Surgery, Huaihe Hospital of Henan University, Kaifeng, People’s Republic of China
,
Xiaodong LiDepartment of Urology Surgery, Huaihe Hospital of Henan University, Kaifeng, People’s Republic of China
&
Chaoyang ZhuDepartment of Urology Surgery, Huaihe Hospital of Henan University, Kaifeng, People’s Republic of ChinaCorrespondence[email protected]
Pages 2461-2471 | Published online: 05 May 2017

Citations (70)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (8)

Zunxian Wang, Bo Wei & Shuxia Ma. (2023) EGR1/LINC00839/SOX5 axis modulates migration, invasion and Gemcitabine resistance of bladder cancer cells. Cancer Biology & Therapy 24:1.
Read now
Yingying Qi, Lina Guo, Yanchao Liu, Tonghang Zhao, Xianwen Liu & Yang Zhang. (2021) Sevoflurane Limits Glioma Progression by Regulating Cell Proliferation, Apoptosis, Migration, and Invasion via miR-218-5p/DEK/β-Catenin Axis in Glioma. Cancer Management and Research 13, pages 2057-2069.
Read now
Shizhen Niu, Feng Xiang & Huaihai Jia. (2021) Downregulation of lncRNA XIST promotes proliferation and differentiation, limits apoptosis of osteoblasts through regulating miR-203-3p/ZFPM2 axis. Connective Tissue Research 62:4, pages 381-392.
Read now
Yanhong Liu, Yuanyuan Jiang, Lidong Xu, Chongxing Qu, Lei Zhang, Xingguo Xiao, Wenxia Chen, Kunkun Li, Qianping Liang & Huili Wu. (2020) circ-NRIP1 Promotes Glycolysis and Tumor Progression by Regulating miR-186-5p/MYH9 Axis in Gastric Cancer. Cancer Management and Research 12, pages 5945-5956.
Read now
Qiang Zhou, Tongzhou Hu & Yuan Xu. (2020) Anticancer potential of TUG1 knockdown in cisplatin-resistant osteosarcoma through inhibition of MET/Akt signalling. Journal of Drug Targeting 28:2, pages 204-211.
Read now
Yaya Yu & Swei Sunny Hann. (2019) Novel Tumor Suppressor lncRNA Growth Arrest-Specific 5 (GAS5) In Human Cancer. OncoTargets and Therapy 12, pages 8421-8436.
Read now
Xiang-Sheng Li, Fa-Zheng Shen, Li-Yong Huang, Lei Hui, Rui-Hua Liu, Yan-Juan Ma & Bao-Zhe Jin. (2019) lncRNA small nucleolar RNA host gene 20 predicts poor prognosis in glioma and promotes cell proliferation by silencing P21. OncoTargets and Therapy 12, pages 805-814.
Read now
Yanghua Fan, Yu He, Xi Zhou, Yong Liu & Fu Wang. (2019) Meta-analysis of the prognostic value of lncRNA DANCR for cancer patients in China. Cancer Management and Research 11, pages 2027-2037.
Read now

Articles from other publishers (62)

Ali Ghasemi, Zohreh Qaffaripour, Mehdi Tourani, Kiarash Saleki, Nasim Rahmani-Kukia, Seyyed Hossein Khatami & Mortaza Taheri-Anganeh. (2023) The relationship between long non-coding RNAs and Wnt/β-catenin signaling pathway in the pathogenesis of Alzheimer’s disease. Experimental Neurology 366, pages 114434.
Crossref
Kun Li, Tongyue Yao & Ziqiang Wang. (2023) lncRNA-mediated ceRNA network in bladder cancer. Non-coding RNA Research 8:2, pages 135-145.
Crossref
V. Yu. Startsev, S. L. Vorobyov, N. I. Tyapkin, A. E. Saad & G. V. Kondratiev. (2023) Modern mRNA-based molecular diagnostics for prediction of urothelial carcinoma behavior. Cancer Urology 19:1, pages 151-159.
Crossref
Ruina Li, Hui Xu & Xiaoling Gao. (2023) The ceRNA network regulates epithelial-mesenchymal transition in colorectal cancer. Heliyon 9:3, pages e14143.
Crossref
Hao Wang, Yanfei Feng, Xiangyi Zheng & Xin Xu. (2023) The Diagnostic and Therapeutic Role of snoRNA and lincRNA in Bladder Cancer. Cancers 15:4, pages 1007.
Crossref
Peng Lu, Yingchun Jiang & Zongyu Xia. (2022) Long noncoding RNA TUG1 decreases bladder cancer chemo-sensitivity toward doxorubicin through elevating KPNA2 expression and activating the PI3K/AKT pathway via adsorbing miR-582-5p. Anti-Cancer Drugs 34:1, pages 144-154.
Crossref
Mehrdad Hashemi, Shima Hajimazdarany, Chakrabhavi Dhananjaya Mohan, Maryam Mohammadi, Shamin Rezaei, Yeganeh Olyaee, Yeganeh Goldoost, Amin Ghorbani, Seyed Reza Mirmazloomi, Nazanin Gholinia, Amirabbas Kakavand, Shokooh Salimimoghadam, Yavuz Nuri Ertas, Kanchugarakoppal S. Rangappa, Afshin Taheriazam & Maliheh Entezari. (2022) Long non-coding RNA/epithelial-mesenchymal transition axis in human cancers: Tumorigenesis, chemoresistance, and radioresistance. Pharmacological Research 186, pages 106535.
Crossref
Asmaa Mohammed, Olfat G. Shaker, Mahmoud A. F. Khalil, Mohammed Gomaa, Shaimaa A. Fathy, Abeer K. Abu-El-Azayem, Amira Samy, Mahmoud I. Aboelnor, Mohamed S. Gomaa, Othman M. Zaki & Randa Erfan. (2022) Long non-coding RNA NBAT1, TUG1, miRNA-335, and miRNA-21 as potential biomarkers for acute ischemic stroke and their possible correlation to thyroid hormones. Frontiers in Molecular Biosciences 9.
Crossref
Gang Zhang, Song‐Lin Liu, Wen‐Ting Yi, Yu‐Ping Dong & Yin‐Xu Wan. (2022) Long noncoding RNA ZFPM2‐AS1 regulates renal cell carcinoma progression via miR ‐130a‐3p/ ESCO2 . The Kaohsiung Journal of Medical Sciences 38:6, pages 530-541.
Crossref
Keke Tang, Di Lv, Lingling Miao, Yushan Mao & Xiaoyan Yu. (2022) LncRNA TUG1 functions as a ceRNA for miR‐1‐3p to promote cell proliferation in hepatic carcinogenesis. Journal of Clinical Laboratory Analysis 36:5.
Crossref
Guowen Li, Heyuan Luo, Zhiyong Ding, Haofeng Liang, Zhoupeng Lai, Shuzhen Chen & Yuliang Huang. (2022) Silencing of circ_0000205 mitigates interleukin-1β-induced apoptosis and extracellular matrix degradation in chondrocytes via targeting miR-766-3p/ADAMTS5 axis. Innate Immunity 28:2, pages 79-90.
Crossref
华 张. (2022) Advances in the Regulation of Vascular Smooth Muscle Cell Proliferation by Long Non-Coding RNA through ceRNA. Advances in Clinical Medicine 12:09, pages 8359-8364.
Crossref
Julian C. Krappinger, Lilli Bonstingl, Katrin Pansy, Katja Sallinger, Nick I. Wreglesworth, Lukas Grinninger, Alexander Deutsch, Amin El-Heliebi, Thomas Kroneis, Ramsay J. Mcfarlane, Christoph W. Sensen & Julia Feichtinger. (2021) Non-coding Natural Antisense Transcripts: Analysis and Application. Journal of Biotechnology 340, pages 75-101.
Crossref
Jun-Bin Yuan, Lan Gu, Liu Chen, Yu Yin & Ben-Yi Fan. (2021) Annexin A8 regulated by lncRNA-TUG1/miR-140-3p axis promotes bladder cancer progression and metastasis. Molecular Therapy - Oncolytics 22, pages 36-51.
Crossref
Hongshuai Jia & Chunsheng Hao. (2021) Exploring dysregulated miRNAs in cryptorchidism: a systematic review. Journal of International Medical Research 49:3, pages 030006052199995.
Crossref
Mohammad Sarfi, Maryam Abbastabar & Ehsan Khalili. (2021) Increased expression of urinary exosomal LnCRNA TUG-1 in early bladder cancer. Gene Reports 22, pages 101010.
Crossref
Guanlin Wu, Weidong Weng, Pengfei Xia, Shixian Yan, Cheng Zhong, Lei Xie, Yu Xie & Gang Fan. (2021) Wnt signalling pathway in bladder cancer. Cellular Signalling 79, pages 109886.
Crossref
Xiaoqi Yang, Tao Ye, Haoran Liu, Peng Lv, Chen Duan, Xiaoliang Wu, Kehua Jiang, Hongyan Lu, Ding Xia, Ejun Peng, Zhiqiang Chen, Kun Tang & Zhangqun Ye. (2021) Expression profiles, biological functions and clinical significance of circRNAs in bladder cancer. Molecular Cancer 20:1.
Crossref
Congyi Tang, Yi Cai, Huichuan Jiang, Zhengtong Lv, Changzhao Yang, Haozhe Xu, Zhi Li & Yuan Li. (2020) LncRNA MAGI2-AS3 inhibits bladder cancer progression by targeting the miR-31-5p/TNS1 axis. Aging 12:24, pages 25547-25563.
Crossref
Jinghua Zhong, Chunlei He, Fangtian Xu, Xianyun Xu, Lulin Liu, Mingjun Xu, Zheng Guo, Yili Wang, Jiahua Liao & Yonghong Li. (2020) Lupeol inhibits osteosarcoma progression by up-regulation of HMGA2 via regulating miR-212-3p. Journal of Orthopaedic Surgery and Research 15:1.
Crossref
Xi Zhou, Yanghua Fan, Yu He, Anna Mou, Fu Wang, Yong Liu & Zhen Wu. (2020) Clinicopathological and Prognostic Value of Gastric Carcinoma Highly Expressed Transcript 1 in Cancer: A Meta-Analysis. Journal of Oncology 2020, pages 1-14.
Crossref
Milad Ashrafizadeh, Hui Li Ang, Ebrahim Rahmani Moghadam, Shima Mohammadi, Vahideh Zarrin, Kiavash Hushmandi, Saeed Samarghandian, Ali Zarrabi, Masoud Najafi, Reza Mohammadinejad & Alan Prem Kumar. (2020) MicroRNAs and Their Influence on the ZEB Family: Mechanistic Aspects and Therapeutic Applications in Cancer Therapy. Biomolecules 10:7, pages 1040.
Crossref
Xuewu Chen & Hongguang Xu. (2020) LncRNA SNHG15 regulates osteosarcoma progression in vitro and in vivo via sponging miR-346 and regulating TRAF4 expression. Open Life Sciences 15:1, pages 423-436.
Crossref
Gang Li, Jie Yang, Tie Chong, Yue’e Huang, Ying Liu & Hongliang Li. (2020) TUG1 knockdown inhibits the tumorigenesis and progression of prostate cancer by regulating microRNA-496/Wnt/β-catenin pathway. Anti-Cancer Drugs 31:6, pages 592-600.
Crossref
Yu Tang, Jing Hu, Zhiying Zhong, Yanfeng Liu & Yunxia Wang. (2020) Long Noncoding RNA TUG1 Promotes the Function in ox-LDL-Treated HA-VSMCs via miR-141-3p/ROR2 Axis. Cardiovascular Therapeutics 2020, pages 1-12.
Crossref
Jing Han, Yawei Li, Baolian Zhang, Hong Liu, Mengyao Wu & Xiaolan Zhang. (2020) lncRNA TUG1 regulates ulcerative colitis through miR-142-5p/SOCS1 axis. Microbial Pathogenesis 143, pages 104139.
Crossref
Guoning Su, Zhibing Yan & Min Deng. (2020) Sevoflurane inhibits proliferation, invasion, but enhances apoptosis of lung cancer cells by Wnt/β-catenin signaling via regulating lncRNA PCAT6/ miR-326 axis. Open Life Sciences 15:1, pages 159-172.
Crossref
Jia Chen, Yuanwei Li, Zhiqiu Li & Lin Cao. (2020) LncRNA MST1P2/miR‐133b axis affects the chemoresistance of bladder cancer to cisplatin‐based therapy via Sirt1/p53 signaling. Journal of Biochemical and Molecular Toxicology 34:4.
Crossref
Chong Guo, Yuying Qi, Jiayuan Qu, Liyue Gai, Yue Shi & Chengfu Yuan. (2020) Pathophysiological Functions of the lncRNA TUG1. Current Pharmaceutical Design 26:6, pages 688-700.
Crossref
Yunfei Hao, Xiaoli Li, Hecheng Chen, Hongzhi Huo, Zongbao Liu & Erqing Chai. (2020) Over-expression of long noncoding RNA HOTAIRM1 promotes cell proliferation and invasion in human glioblastoma by up-regulating SP1 via sponging miR-137. NeuroReport 31:2, pages 109-117.
Crossref
Yin Tang, Ping Yang, Yunfeng Zhu & Yong Su. (2019) LncRNA TUG1 contributes to ESCC progression via regulating miR‐148a‐3p/MCL‐1/Wnt/β‐catenin axis in vitro. Thoracic Cancer 11:1, pages 82-94.
Crossref
Wen-Yuan Zhang, Qing-Hong Liu, Tie-Jun Wang, Jun Zhao, Xiao-Hua Cheng & Jin-Shan Wang. (2019) CircZFR serves as a prognostic marker to promote bladder cancer progression by regulating miR-377/ZEB2 signaling. Bioscience Reports 39:12.
Crossref
Victor G. Martinez, Ester Munera-Maravilla, Alejandra Bernardini, Carolina Rubio, Cristian Suarez-Cabrera, Cristina Segovia, Iris Lodewijk, Marta Dueñas, Mónica Martínez-Fernández & Jesus Maria Paramio. (2019) Epigenetics of Bladder Cancer: Where Biomarkers and Therapeutic Targets Meet. Frontiers in Genetics 10.
Crossref
Soudeh Ghaforui‐Fard, Reza Vafaee & Mohammad Taheri. (2019) Taurine‐upregulated gene 1 : A functional long noncoding RNA in tumorigenesis . Journal of Cellular Physiology 234:10, pages 17100-17112.
Crossref
Hui Zhou, Lina Sun & Fusheng Wan. (2019) Molecular mechanisms of TUG1 in the proliferation, apoptosis, migration and invasion of cancer cells (Review). Oncology Letters.
Crossref
Maliheh Astaneh & Soudeh Ghafouri-Fard. (2019) Long non-coding RNAs as regulators of Wnt/β catenin pathway. Gene Reports 16, pages 100404.
Crossref
Masoumeh Fardi, Mohammadreza Alivand, Behzad Baradaran, Majid Farshdousti Hagh & Saeed Solali. (2019) The crucial role of ZEB2: From development to epithelial‐to‐mesenchymal transition and cancer complexity. Journal of Cellular Physiology 234:9, pages 14783-14799.
Crossref
Qiang Su, Yang Liu, Xiang-Wei Lv, Zi-Liang Ye, Yu-Han Sun, Bing-Hui Kong & Zhen-Bai Qin. (2019) Inhibition of lncRNA TUG1 upregulates miR-142-3p to ameliorate myocardial injury during ischemia and reperfusion via targeting HMGB1- and Rac1-induced autophagy. Journal of Molecular and Cellular Cardiology 133, pages 12-25.
Crossref
Xue Zou, Jialiang Wang, Li Tang & Qian Wen. (2019) LncRNA TUG1 contributes to cardiac hypertrophy via regulating miR-29b-3p. In Vitro Cellular & Developmental Biology - Animal 55:7, pages 482-490.
Crossref
Wenmei Su, Chunfang Guo, Lihui Wang, Zhuwen Wang, Xia Yang, Feiyu Niu, Daniel Tzou, Xiao Yang, Xiaobi Huang, Jiancong Wu, Xiaorao Chen, Lei Zou, Zhixiong Yang & Guoan Chen. (2019) LncRNA MIR22HG abrogation inhibits proliferation and induces apoptosis in esophageal adenocarcinoma cells via activation of the STAT3/c-Myc/FAK signaling. Aging 11:13, pages 4587-4596.
Crossref
. (2019) Retracted : Downregulation of lncRNA TUG1 contributes to the development of sepsis‐associated acute kidney injury via regulating miR‐142‐3p/sirtuin 1 axis and modulating NF‐κB pathway . Journal of Cellular Biochemistry 120:7, pages 11331-11341.
Crossref
Wei Zhu, Hailang Liu, Xinguang Wang, Jinjin Lu & Weimin Yang. (2019) Long noncoding RNAs in bladder cancer prognosis: A meta-analysis. Pathology - Research and Practice 215:6, pages 152429.
Crossref
Gan Yu, Hui Zhou, Weimin Yao, Lirong Meng & Bin Lang. (2019) lncRNA TUG1 Promotes Cisplatin Resistance by Regulating CCND2 via Epigenetically Silencing miR-194-5p in Bladder Cancer. Molecular Therapy - Nucleic Acids 16, pages 257-271.
Crossref
Tongzhou Hu, Zhenghua Fei, Huafang Su, Raoying Xie & Liting Chen. (2019) Polydatin inhibits proliferation and promotes apoptosis of doxorubicin-resistant osteosarcoma through LncRNA TUG1 mediated suppression of Akt signaling. Toxicology and Applied Pharmacology 371, pages 55-62.
Crossref
Shruti Mishra, Sumit S. Verma, Vipin Rai, Nikee Awasthee, Srinivas Chava, Kam Man Hui, Alan Prem Kumar, Kishore B. Challagundla, Gautam Sethi & Subash C. Gupta. (2019) Long non-coding RNAs are emerging targets of phytochemicals for cancer and other chronic diseases. Cellular and Molecular Life Sciences 76:10, pages 1947-1966.
Crossref
Zhaoju Tian, Shuang Cao, Cheng Li, Mingfang Xu, Huaiqing Wei, Han Yang, Qiyu Sun, Qikui Ren & Le Zhang. (2018) LncRNA PVT1 regulates growth, migration, and invasion of bladder cancer by miR‐31/ CDK1 . Journal of Cellular Physiology 234:4, pages 4799-4811.
Crossref
Hui Shan, Yunbo Yang, Xuhui Zhu, Xiuwu Han, Peng Zhang & Xiaodong Zhang. (2018) FAM83H‐AS1 is associated with clinical progression and modulates cell proliferation, migration, and invasion in bladder cancer. Journal of Cellular Biochemistry 120:3, pages 4687-4693.
Crossref
Nadiah Abu, Kha Wai Hon, Shivapriya Jeyaraman & Rahman Jamal. (2018) Long noncoding RNAs as biotargets in cisplatin-based drug resistance. Future Oncology 14:29, pages 3085-3095.
Crossref
Sima P. Porten. (2018) Epigenetic Alterations in Bladder Cancer. Current Urology Reports 19:12.
Crossref
Tonghuai Li, Yan Chen, Jingjing Zhang & Shaoxiao Liu. (2018) LncRNA TUG1 promotes cells proliferation and inhibits cells apoptosis through regulating AURKA in epithelial ovarian cancer cells. Medicine 97:36, pages e12131.
Crossref
Peng Guo, Guohui Zhang, Jialin Meng, Qian He, Zhihui Li & Yawei Guan. (2018) Upregulation of Long Noncoding RNA TUG1 Promotes Bladder Cancer Cell Proliferation, Migration, and Invasion by Inhibiting miR-29c. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 26:7, pages 1083-1091.
Crossref
Mohammad Taheri, Mir Davood Omrani & Soudeh Ghafouri-Fard. (2017) Long non-coding RNA expression in bladder cancer. Biophysical Reviews 10:4, pages 1205-1213.
Crossref
Harpreet Kaur, Deepaneeta Sarmah, Jackson Saraf, Kanchan Vats, Kiran Kalia, Anupom Borah, Dileep R. Yavagal, Kunjan R. Dave, Zhumur Ghosh & Pallab Bhattacharya. (2018) Noncoding RNAs in ischemic stroke: time to translate. Annals of the New York Academy of Sciences 1421:1, pages 19-36.
Crossref
Tong-Huai Li, Jing-Jing Zhang, Shao-Xiao Liu & Yan Chen. (2018) Long non-coding RNA taurine-upregulated gene 1 predicts unfavorable prognosis, promotes cells proliferation, and inhibits cells apoptosis in epithelial ovarian cancer. Medicine 97:19, pages e0575.
Crossref
Edyta Wieczorek & Edyta Reszka. (2018) mRNA, microRNA and lncRNA as novel bladder tumor markers. Clinica Chimica Acta 477, pages 141-153.
Crossref
Chuhai Xie, Binwei Chen, Boyi Wu, Jianhong Guo & Yanming Cao. (2018) LncRNA TUG1 promotes cell proliferation and suppresses apoptosis in osteosarcoma by regulating miR-212-3p/FOXA1 axis. Biomedicine & Pharmacotherapy 97, pages 1645-1653.
Crossref
Caterina Gulìa, Stefano Baldassarra, Fabrizio Signore, Giuliano Rigon, Valerio Pizzuti, Marco Gaffi, Vito Briganti, Alessandro Porrello & Roberto Piergentili. (2017) Role of Non-Coding RNAs in the Etiology of Bladder Cancer. Genes 8:11, pages 339.
Crossref
Yongping Zhou, Yuxuan Lu, Runmin Li, Nana Yan, Xiding Li & Tu Dai. (2017) Prognostic role of long non-coding RNA TUG1 expression in various cancers: a meta-analysis. Oncotarget 8:59, pages 100499-100507.
Crossref
Qunjun Gao, Haibiao Xie, Hengji Zhan, Jianfa Li, Yuchen Liu & Weiren Huang. (2017) Prognostic Values of Long Noncoding RNA GAS5 in Various Carcinomas: An Updated Systematic Review and Meta-Analysis. Frontiers in Physiology 8.
Crossref
Dalong Xie, Hui Zhang, Xuanhao Hu & Chao Shang. (2017) Knockdown of long non-coding RNA Taurine Up-Regulated 1 inhibited doxorubicin resistance of bladder urothelial carcinoma via Wnt/β-catenin pathway. Oncotarget 8:51, pages 88689-88696.
Crossref
Yetao Xu, Zhiping Ge, Erbao Zhang, Qing Zuo, Shiyun Huang, Nana Yang, Dan Wu, Yuanyuan Zhang, Yanzi Chen, Haoqin Xu, Huan Huang, Zhiyan Jiang & Lizhou Sun. (2017) The lncRNA TUG1 modulates proliferation in trophoblast cells via epigenetic suppression of RND3. Cell Death & Disease 8:10, pages e3104-e3104.
Crossref
Cecilia Pop-Bica, Diana Gulei, Roxana Cojocneanu-Petric, Cornelia Braicu, Bogdan Petrut & Ioana Berindan-Neagoe. (2017) Understanding the Role of Non-Coding RNAs in Bladder Cancer: From Dark Matter to Valuable Therapeutic Targets. International Journal of Molecular Sciences 18:7, pages 1514.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.