Advanced search
Publication Cover
OncoTargets and Therapy Volume 10, 2017 - Issue
Submit an article Journal homepage
77
Views
16
CrossRef citations to date
0
Altmetric
Original Research

PD-1 blockade restores impaired function of ex vivo expanded CD8+ T cells and enhances apoptosis in mismatch repair deficient EpCAM+PD-L1+ cancer cells

Rajeev Kumar1 Clinical Research Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China;2 Cancer Immunology and Immunotherapy Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of ChinaCorrespondence[email protected]
,
Fang Yu1 Clinical Research Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China
,
Yuan-Huan Zhen3 Department of Colorectal Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China
,
Bo Li2 Cancer Immunology and Immunotherapy Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China
,
Jun Wang1 Clinical Research Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China
,
Yuan Yang1 Clinical Research Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China;2 Cancer Immunology and Immunotherapy Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China
,
Hui-Xin Ge4 Department of Surgery, The Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, People’s Republic of China
,
Ping-Sheng Hu1 Clinical Research Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China;2 Cancer Immunology and Immunotherapy Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China
&
Jin Xiu1 Clinical Research Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China;2 Cancer Immunology and Immunotherapy Centre, The Affiliated Hospital of Guizhou Medical University, Guiyang, People’s Republic of China
 show all
Pages 3453-3465 | Published online: 13 Jul 2017

Citations (16)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Zhuo Chen, Zhengkui Jiang, Wenzhou Zhang & Baoxia He. (2018) Silencing the expression of copine-III enhances the sensitivity of hepatocellular carcinoma cells to the molecular targeted agent sorafenib. Cancer Management and Research 10, pages 3057-3067.
Read now
Ewelina Grywalska, Marcin Pasiarski, Stanisław Góźdź & Jacek Roliński. (2018) Immune-checkpoint inhibitors for combating T-cell dysfunction in cancer. OncoTargets and Therapy 11, pages 6505-6524.
Read now

Articles from other publishers (14)

Seon-Mi Lee, Sanghoon Lee, Hyun-Woong Cho, Kyung-Jin Min, Jin-Hwa Hong, Jae-Yun Song, Jae-Kwan Lee & Nak-Woo Lee. (2023) Application of Immune Checkpoint Inhibitors in Gynecological Cancers: What Do Gynecologists Need to Know before Using Immune Checkpoint Inhibitors?. International Journal of Molecular Sciences 24:2, pages 974.
Crossref
Marion Thibaudin, Emeric Limagne, Léa Hampe, Elise Ballot, Caroline Truntzer & Francois Ghiringhelli. (2022) Targeting PD-L1 and TIGIT could restore intratumoral CD8 T cell function in human colorectal cancer. Cancer Immunology, Immunotherapy 71:10, pages 2549-2563.
Crossref
Sakuya Inanaga, Masaya Igase, Yusuke Sakai, Kenji Hagimori, Hiroshi Sunahara, Hiro Horikirizono, Kazuhito Itamoto, Kenji Baba, Yoshiharu Ohsato & Takuya Mizuno. (2022) Relationship of microsatellite instability to mismatch repair deficiency in malignant tumors of dogs. Journal of Veterinary Internal Medicine 36:5, pages 1760-1769.
Crossref
Sakuya Inanaga, Masaya Igase, Yusuke Sakai, Mika Tanabe, Nozomi Shimonohara, Kazuhito Itamoto, Munekazu Nakaichi & Takuya Mizuno. (2021) Mismatch repair deficiency in canine neoplasms. Veterinary Pathology 58:6, pages 1058-1063.
Crossref
Zhongxiao Lin, Min Wen, Enxing Yu, Xiao Lin, Hua Wang, Jiayu Chen, ChaoJie Yao, Hengli Zhang, Junnan Ru, Kankai Wang, Ying Zhang, Lijie Huang, Qichuan Zhuge & Su Yang. (2021) ANXA1 as a Prognostic and Immune Microenvironmental Marker for Gliomas Based on Transcriptomic Analysis and Experimental Validation. Frontiers in Cell and Developmental Biology 9.
Crossref
Roberto Ferrarese, Raffaella Alessia Zuppardo, Marta Puzzono, Alessandro Mannucci, Virginia Amato, Ilaria Ditonno, Maria Grazia Patricelli, Annalisa Russo Raucci, Massimo Clementi, Ugo Elmore, Riccardo Rosati, Pier Alberto Testoni, Nicasio Mancini & Giulia Martina Cavestro. (2020) Oral and Fecal Microbiota in Lynch Syndrome. Journal of Clinical Medicine 9:9, pages 2735.
Crossref
Thi-Anh-Thuy Tran, Young-Hee Kim, Thi-Hoang-Oanh Duong, Shin Jung, In-Young Kim, Kyung-Sub Moon, Woo-Youl Jang, Hyun-Ju Lee, Je-Jung Lee & Tae-Young Jung. (2020) Peptide Vaccine Combined Adjuvants Modulate Anti-tumor Effects of Radiation in Glioblastoma Mouse Model. Frontiers in Immunology 11.
Crossref
Woan Ting Tay, Yi-Hsien Fang, Suet Theng Beh, Yen-Wen Liu, Ling-Wei Hsu, Chia-Jui Yen & Ping-Yen Liu. (2020) Programmed Cell Death-1: Programmed Cell Death-Ligand 1 Interaction Protects Human Cardiomyocytes Against T-Cell Mediated Inflammation and Apoptosis Response In Vitro. International Journal of Molecular Sciences 21:7, pages 2399.
Crossref
Noam Mamet, Yaniv Amir, Erez Lavi, Liron Bassali, Gil Harari, Itai Rusinek, Nir Skalka, Elinor Debby, Mor Greenberg, Adva Zamir, Anastasia Paz, Neria Reiss, Gil Loewenthal, Irit Avivi, Avichai Shimoni, Guy Neev, Almogit Abu-Horowitz & Ido Bachelet. (2020) Discovery of tumoricidal DNA oligonucleotides by response-directed in vitro evolution. Communications Biology 3:1.
Crossref
Dongliang Li, Shingo Toji, Kazue Watanabe, Toshihiko Torigoe & Tomohide Tsukahara. (2019) Identification of novel human leukocyte antigen‐A*11:01‐restricted cytotoxic T‐lymphocyte epitopes derived from osteosarcoma antigen papillomavirus binding factor. Cancer Science 110:4, pages 1156-1168.
Crossref
Danuta Nowicka, Ewelina Grywalska, Agata Surdacka, Agnieszka Grafka & Jacek Roliński. (2019) Frequencies of PD-1- and PD-L1- positive T CD3+CD4+, T CD3+CD8+ and B CD19+ lymphocytes and its correlations with other immune cells in patients with recurrent furunculosis. Microbial Pathogenesis 126, pages 85-91.
Crossref
Ming Yi, Dechao Jiao, Hanxiao Xu, Qian Liu, Weiheng Zhao, Xinwei Han & Kongming Wu. (2018) Biomarkers for predicting efficacy of PD-1/PD-L1 inhibitors. Molecular Cancer 17:1.
Crossref
Snigdha Majumder, Rakshit Shah, Jisha Elias, Malini Manoharan, Priyanka Shah, Anjali Kumari, Papia Chakraborty, Vasumathi Kode, Yogesh Mistry, Karunakaran Coral, Bharti Mittal, Sakthivel Murugan SM, Lakshmi Mahadevan, Ravi Gupta, Amitabha Chaudhuri & Arati Khanna-Gupta. (2018) A cancer vaccine approach for personalized treatment of Lynch Syndrome. Scientific Reports 8:1.
Crossref
Christiane Thallinger, Thorsten Füreder, Matthias Preusser, Gerwin Heller, Leonhard Müllauer, Christoph Höller, Helmut Prosch, Natalija Frank, Rafal Swierzewski, Walter Berger, Ulrich Jäger & Christoph Zielinski. (2017) Review of cancer treatment with immune checkpoint inhibitors. Wiener klinische Wochenschrift 130:3-4, pages 85-91.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.