169
Views
89
CrossRef citations to date
0
Altmetric
Review

IAP proteins as targets for drug development in oncology

, &
Pages 1285-1304 | Published online: 16 Sep 2013

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (2)

Priya Samuel, Ryan Charles Pink, Susan Ann Brooks & David RaulFrancisco Carter. (2016) miRNAs and ovarian cancer: a miRiad of mechanisms to induce cisplatin drug resistance. Expert Review of Anticancer Therapy 16:1, pages 57-70.
Read now
Alexander W Hird, Brian M Aquila, Edward J Hennessy, Melissa M Vasbinder & Bin Yang. (2015) Small molecule inhibitor of apoptosis proteins antagonists: a patent review. Expert Opinion on Therapeutic Patents 25:7, pages 755-774.
Read now

Articles from other publishers (87)

Yuen Lam Dora Ng, Aleša Bricelj, Jacqueline A. Jansen, Arunima Murgai, Kirsten Peter, Katherine A. Donovan, Michael Gütschow, Jan Krönke, Christian Steinebach & Izidor Sosič. (2023) Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins. Journal of Medicinal Chemistry 66:7, pages 4703-4733.
Crossref
Samar Imbaby, Shereen E. Elkholy, Salwa Faisal, Asmaa K.K. Abdelmaogood, Amir E. Mehana, Basma S.A. Mansour, Samar M. Abd El-moneam & Samah M. Elaidy. (2023) The GSTP1/MAPKs/BIM/SMAC modulatory actions of nitazoxanide: Bioinformatics and experimental evidence in subcutaneous solid Ehrlich carcinoma-inoculated mice. Life Sciences 319, pages 121496.
Crossref
Paulina Gil-Kulik, Michał Leśniewski, Karolina Bieńko, Monika Wójcik, Marta Więckowska, Dominika Przywara, Alicja Petniak, Adrianna Kondracka, Małgorzata Świstowska, Rafał Szymanowski, Agnieszka Wilińska, Mateusz Wiliński, Bartosz J. Płachno, Marzena Kostuch, Mansur Rahnama-Hezavach, Mariusz Szuta, Anna Kwaśniewska, Anna Bogucka-Kocka & Janusz Kocki. (2023) Influence of Perinatal Factors on Gene Expression of IAPs Family and Main Factors of Pluripotency: OCT4 and SOX2 in Human Breast Milk Stem Cells—A Preliminary Report. International Journal of Molecular Sciences 24:3, pages 2476.
Crossref
Baptiste Dumétier, Aymeric Zadoroznyj, Jean Berthelet, Sébastien Causse, Jennifer Allègre, Pauline Bourgeois, Florine Cattin, Cindy Racoeur, Catherine Paul, Carmen Garrido & Laurence Dubrez. (2022) cIAP1/TRAF2 interplay promotes tumor growth through the activation of STAT3. Oncogene 42:3, pages 198-208.
Crossref
Fang-Min Zhong, Fang-Yi Yao, Jing Liu, Mei-Yong Li, Jun-Yao Jiang, Ying Cheng, Shuai Xu, Shu-Qi Li, Nan Zhang, Bo Huang & Xiao-Zhong Wang. (2023) Splicing factor-mediated regulation patterns reveals biological characteristics and aid in predicting prognosis in acute myeloid leukemia. Journal of Translational Medicine 21:1.
Crossref
Michelle Lizotte-Waniewski & Brittany Stinson. 2023. Encyclopedia of Cell Biology. Encyclopedia of Cell Biology 898 911 .
Debolina D. Biswas, Rebecca K. Martin, LaShardai N. Brown, Karli Mockenhaupt, Angela S. Gupta, Michael J. Surace, Anuj Tharakan, Jessie W. Yester, Reetika Bhardwaj, Daniel H. Conrad & Tomasz Kordula. (2022) Cellular inhibitor of apoptosis 2 (cIAP2) restricts neuroinflammation during experimental autoimmune encephalomyelitis. Journal of Neuroinflammation 19:1.
Crossref
Swaroop Kumar Pandey, Anna Shteinfer-Kuzmine, Vered Chalifa-Caspi & Varda Shoshan-Barmatz. (2022) Non-apoptotic activity of the mitochondrial protein SMAC/Diablo in lung cancer: Novel target to disrupt survival, inflammation, and immunosuppression. Frontiers in Oncology 12.
Crossref
Yun Li, Huajun Zhang, Yulia Merkher, Lin Chen, Na Liu, Sergey Leonov & Yongheng Chen. (2022) Recent advances in therapeutic strategies for triple-negative breast cancer. Journal of Hematology & Oncology 15:1.
Crossref
Zhiliang Zhang, Siqi Xiang, Ruxia Cui, Hang Peng, Roy Mridul & Mingjun Xiang. (2022) ILP-2: A New Bane and Therapeutic Target for Human Cancers. Frontiers in Oncology 12.
Crossref
Tiantian Che & Zhenghong Lin. (2022) The roles of ubiquitination‐mediated intrinsic apoptotic signalling in cancer therapy. Clinical and Translational Discovery 2:2.
Crossref
Vanessa Martins, Nicola Wilsher, Song Lin & Aram Oganesian. (2022) A validated liquid chromatography‐tandem mass spectroscopy method for the quantification of tolinapant in human plasma. Analytical Science Advances 3:5-6, pages 198-204.
Crossref
Izidor Sosič, Aleša Bricelj & Christian Steinebach. (2022) E3 ligase ligand chemistries: from building blocks to protein degraders. Chemical Society Reviews 51:9, pages 3487-3534.
Crossref
Aymeric Zadoroznyj & Laurence Dubrez. (2022) Cytoplasmic and Nuclear Functions of cIAP1. Biomolecules 12:2, pages 322.
Crossref
Assiya Kussainova, Olga Bulgakova, Akmaral Aripova, Zumama Khalid, Rakhmetkazhi Bersimbaev & Alberto Izzotti. (2022) The Role of Mitochondrial miRNAs in the Development of Radon-Induced Lung Cancer. Biomedicines 10:2, pages 428.
Crossref
Irfan Ahmad, AyedA Dera, Safia Irfan, Prasanna Rajagopalan, MirzaMasroor Ali Beg, MohammadY Alshahrani, MushtaqAhmad Mir, Mohammed Abohashrh, MohammadMahtab Alam, Shadma Wahab, AmitKumar Verma & Saurabh Srivastava. (2022) BV6 enhances apoptosis in Lung cancer cells by ameliorating caspase expressions through attenuation of XIAP, cIAP-1, and cIAP-2 proteins. Journal of Cancer Research and Therapeutics 18:6, pages 1651.
Crossref
Ayse Günes-Bayir. 2022. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects 503 515 .
Ruqaia Abbas & Sarit Larisch. (2021) Killing by Degradation: Regulation of Apoptosis by the Ubiquitin-Proteasome-System. Cells 10:12, pages 3465.
Crossref
Maliha Khan, Felipe Samaniego, Fredrick B. Hagemeister & Swaminathan P. Iyer. (2021) Emerging Therapeutic Landscape of Peripheral T-Cell Lymphomas Based on Advances in Biology: Current Status and Future Directions. Cancers 13:22, pages 5627.
Crossref
Abdullahi Alausa, Ugwu Chukwuebuka Victor, Ugwu Obiora Celestine, Ismail Abiodun Eweje, Toheeb Adewale Balogun, Rofiat Adeyemi, Mercy Olatinwo, Abdeen Tunde Ogunlana, Oladapo Oladipo & Barakat Olaleke. (2021) Phytochemical based sestrin2 pharmacological modulators in the treatment of adenocarcinomas. Phytomedicine Plus 1:4, pages 100133.
Crossref
Liang Zhou, Yu ZhangMark B. MeadsYun DaiYanxia Ning, Xiaoyan Hu, Lin Li, Kanika Sharma, Jewel Nkwocha, Rebecca Parker, Danny Bui, Jacquelyn McCarter, Lora Kramer, Cullen PurcellPraneeth R. Sudalagunta, Rafael R. Canevarolo, Maria D. Coelho Siqueira Silva, Gabriel De AvilaRaghunandan Reddy Alugubelli, Ariosto S. Silva, Maciej Kmeiciak, Andrea Ferreira-GonzalezKenneth H. ShainSteven Grant. (2021) IAP and HDAC inhibitors interact synergistically in myeloma cells through noncanonical NF-κB– and caspase-8–dependent mechanisms. Blood Advances 5:19, pages 3776-3788.
Crossref
Zigang Li, Hui Zhao & Chuan Wan. 2021. Cyclized Helical Peptides. Cyclized Helical Peptides 1 33 .
Grant R. Campbell & Stephen A. Spector. (2021) Induction of Autophagy to Achieve a Human Immunodeficiency Virus Type 1 Cure. Cells 10:7, pages 1798.
Crossref
Chee Wai Fhu & Azhar Ali. (2021) Dysregulation of the Ubiquitin Proteasome System in Human Malignancies: A Window for Therapeutic Intervention. Cancers 13:7, pages 1513.
Crossref
Xiao-jie Jiang, Zhi-wei Chen, Jian-feng Zhao, Chang-xi Liao, Qing-he Cai & Jing Lin. (2021) cIAP2 via NF-κB signalling affects cell proliferation and invasion in hepatocellular carcinoma. Life Sciences 266, pages 118867.
Crossref
Ayse Günes-Bayir. 2020. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects 1 13 .
Nir Shahar & Sarit Larisch. (2020) Inhibiting the inhibitors: Targeting anti-apoptotic proteins in cancer and therapy resistance. Drug Resistance Updates 52, pages 100712.
Crossref
Dana Mamriev, Ruqaia Abbas, Franca-Maria Klingler, Juliana Kagan, Nir Kfir, Alastair Donald, Keren Weidenfeld, David W. Sheppard, Dalit Barkan & Sarit Larisch. (2020) A small-molecule ARTS mimetic promotes apoptosis through degradation of both XIAP and Bcl-2. Cell Death & Disease 11:6.
Crossref
Monica M. Mita, Patricia M. LoRusso, Kyriakos P. Papadopoulos, Michael S. Gordon, Alain C. Mita, Roberta Ferraldeschi, Harold Keer, Aram Oganesian, Xiang Yao Su, Simone Jueliger & Anthony W. Tolcher. (2020) A Phase I Study of ASTX660, an Antagonist of Inhibitors of Apoptosis Proteins, in Adults with Advanced Cancers or Lymphoma. Clinical Cancer Research 26:12, pages 2819-2826.
Crossref
Julia Zinngrebe, Ferdinand Schlichtig, Johann M. Kraus, Malcolm Meyer, Elena Boldrin, Hans A. Kestler, Lüder‐Hinrich Meyer, Pamela Fischer‐Posovszky & Klaus‐Michael Debatin. (2020) Biomarker profile for prediction of response to SMAC mimetic monotherapy in pediatric precursor B‐cell acute lymphoblastic leukemia. International Journal of Cancer 146:11, pages 3219-3231.
Crossref
Baptiste Dumétier, Aymeric Zadoroznyj & Laurence Dubrez. (2020) IAP-Mediated Protein Ubiquitination in Regulating Cell Signaling. Cells 9:5, pages 1118.
Crossref
Ruqaia Abbas & Sarit Larisch. (2020) Targeting XIAP for Promoting Cancer Cell Death—The Story of ARTS and SMAC. Cells 9:3, pages 663.
Crossref
Chun‐wa Chung & Michael M. Hann. 2020. Structural Biology in Drug Discovery. Structural Biology in Drug Discovery 479 502 .
Konstantin Bagnjuk, Verena Jasmin Kast, Astrid Tiefenbacher, Melanie Kaseder, Toshihiko Yanase, Alexander Burges, Lars Kunz, Doris Mayr & Artur Mayerhofer. (2019) Inhibitor of apoptosis proteins are potential targets for treatment of granulosa cell tumors – implications from studies in KGN. Journal of Ovarian Research 12:1.
Crossref
Liang Zhou, Yu Zhang, Yun Leng, Yun Dai, Maciej Kmieciak, Lora Kramer, Kanika Sharma, Yan Wang, William Craun & Steven Grant. (2019) The IAP antagonist birinapant potentiates bortezomib anti-myeloma activity in vitro and in vivo. Journal of Hematology & Oncology 12:1.
Crossref
Xiaoming Shu, Zhejiang Zhu, Dan Cao, Li Zheng, Fang Wang, Heying Pei, Jiaolin Wen, Jianhong Yang, Dan Li, Peng Bai, Minghai Tang, Haoyu Ye, Aihua Peng, Weimin Li & Lijuan Chen. (2019) PEG-derivatized birinapant as a nanomicellar carrier of paclitaxel delivery for cancer therapy. Colloids and Surfaces B: Biointerfaces 182, pages 110356.
Crossref
Haihong Guo, Fabian Treude, Oliver H. Krämer, Bernhard Lüscher & Jörg Hartkamp. (2019) PAR-4 overcomes chemo-resistance in breast cancer cells by antagonizing cIAP1. Scientific Reports 9:1.
Crossref
Guosong Jiang, Chao Huang, Xin Liao, Jingxia Li, Xue-Ru Wu, Fuqing Zeng & Chuanshu Huang. (2019) The RING domain in the anti-apoptotic protein XIAP stabilizes c-Myc protein and preserves anchorage-independent growth of bladder cancer cells. Journal of Biological Chemistry 294:15, pages 5935-5944.
Crossref
Amalia Rosner, Olha Kravchenko & Baruch Rinkevich. (2019) IAP genes partake weighty roles in the astogeny and whole body regeneration in the colonial urochordate Botryllus schlosseri. Developmental Biology 448:2, pages 320-341.
Crossref
Michael Bobardt, Joseph Kuo, Udayan Chatterji, Sumit Chanda, Susan J. Little, Norbert Wiedemann, Gregoire Vuagniaux & Philippe A. Gallay. (2019) The inhibitor apoptosis protein antagonist Debio 1143 Is an attractive HIV-1 latency reversal candidate. PLOS ONE 14:2, pages e0211746.
Crossref
Pierre-Simon Bellaye, Alexandra Oudot, Jean-Marc Vrigneaud, Olivier Raguin, Francis Bichat, Anne Vaslin, Hélène Maby-El Hajjami, Claudio Zanna, Grégoire Vuagniaux, Pierre Fumoleau, Franck Denat, François Brunotte & Bertrand Collin. (2018) Nuclear Imaging Study of the Pharmacodynamic Effects of Debio 1143, an Antagonist of Multiple Inhibitor of Apoptosis Proteins (IAPs), in a Triple-Negative Breast Cancer Model. Contrast Media & Molecular Imaging 2018, pages 1-11.
Crossref
Emilia Apidi, Wan Rohani Wan Taib, Rosline Hassan, Nurul Syakima Ab Mutalib & Imilia Ismail. (2018) A review on effect of genetic features on treatment responses in acute myeloid leukemia. Meta Gene 18, pages 31-38.
Crossref
Christopher McCann, Nyree Crawford, Joanna Majkut, Caitriona Holohan, Chris W. D. Armstrong, Pamela J. Maxwell, Chee Wee Ong, Melissa J. LaBonte, Simon S. McDade, David J. Waugh & Daniel B. Longley. (2018) Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists. Cell Death & Disease 9:11.
Crossref
Marco Beauséjour, Ariane Boutin & Pierre H. Vachon. 2018. Apoptosis and Beyond. Apoptosis and Beyond 145 182 .
Christopher N. Johnson, Jong Sook Ahn, Ildiko M. Buck, Elisabetta Chiarparin, James E. H. Day, Anna Hopkins, Steven Howard, Edward J. Lewis, Vanessa Martins, Alessia Millemaggi, Joanne M. Munck, Lee W. Page, Torren Peakman, Michael Reader, Sharna J. Rich, Gordon Saxty, Tomoko Smyth, Neil T. Thompson, George A. Ward, Pamela A. Williams, Nicola E. Wilsher & Gianni Chessari. (2018) A Fragment-Derived Clinical Candidate for Antagonism of X-Linked and Cellular Inhibitor of Apoptosis Proteins: 1-(6-[(4-Fluorophenyl)methyl]-5-(hydroxymethyl)-3,3-dimethyl-1 H ,2 H ,3 H -pyrrolo[3,2- b ]pyridin-1-yl)-2-[(2 R ,5 R )-5-methyl-2-([(3R)-3-methylmorpholin-4-yl]methyl)piperazin-1-yl]ethan-1-one (ASTX660) . Journal of Medicinal Chemistry 61:16, pages 7314-7329.
Crossref
George A. Ward, Edward J. Lewis, Jong Sook Ahn, Christopher N. Johnson, John F. Lyons, Vanessa Martins, Joanne M. Munck, Sharna J. Rich, Tomoko Smyth, Neil T. Thompson, Pamela A. Williams, Nicola E. Wilsher, Nicola G. Wallis & Gianni Chessari. (2018) ASTX660, a Novel Non-peptidomimetic Antagonist of cIAP1/2 and XIAP, Potently Induces TNFα-Dependent Apoptosis in Cancer Cell Lines and Inhibits Tumor Growth. Molecular Cancer Therapeutics 17:7, pages 1381-1391.
Crossref
Virginia Morón-Calvente, Salvador Romero-Pinedo, Sofía Toribio-Castelló, Julio Plaza-Díaz, Ana C. Abadía-Molina, Domingo I. Rojas-Barros, Shawn T. Beug, Eric C. LaCasse, Alex MacKenzie, Robert Korneluk & Francisco Abadía-Molina. (2018) Inhibitor of apoptosis proteins, NAIP, cIAP1 and cIAP2 expression during macrophage differentiation and M1/M2 polarization. PLOS ONE 13:3, pages e0193643.
Crossref
Bradley T. Scroggins, Jeffrey Burkeen, Ayla O. White, Eun Joo Chung, Darmood Wei, Su I. Chung, Luca F. Valle, Shilpa S. Patil, Grace McKay-Corkum, Kathryn E. Hudak, W. Marston Linehan & Deborah E. Citrin. (2018) Mithramycin A Enhances Tumor Sensitivity to Mitotic Catastrophe Resulting From DNA Damage. International Journal of Radiation Oncology*Biology*Physics 100:2, pages 344-352.
Crossref
Clinton Yu & Lan Huang. (2017) Cross-Linking Mass Spectrometry: An Emerging Technology for Interactomics and Structural Biology. Analytical Chemistry 90:1, pages 144-165.
Crossref
Loredana Salerno, Giuseppe Romeo, Maria N. Modica, Emanuele Amata, Valeria Sorrenti, Ignazio Barbagallo & Valeria Pittalà. (2017) Heme oxygenase-1: A new druggable target in the management of chronic and acute myeloid leukemia. European Journal of Medicinal Chemistry 142, pages 163-178.
Crossref
Pengguo Zhang, Qingwei Zhou, Lin Tian, Xiangyu Zhou, Yue Zhou & Jiajun Chen. (2017) Experimental study of a novel tumstatin on C6 brain glioma in vitro. Oncology Letters 14:3, pages 2845-2851.
Crossref
Emiliano Tamanini, Ildiko M. BuckGianni ChessariElisabetta ChiarparinJames E. H. DayMartyn FredericksonCharlotte M. Griffiths-JonesKeisha HearnTom D. Heightman, Aman IqbalChristopher N. JohnsonEdward J. LewisVanessa MartinsTorren PeakmanMichael ReaderSharna J. RichGeorge A. WardPamela A. WilliamsNicola E. Wilsher. (2017) Discovery of a Potent Nonpeptidomimetic, Small-Molecule Antagonist of Cellular Inhibitor of Apoptosis Protein 1 (cIAP1) and X-Linked Inhibitor of Apoptosis Protein (XIAP). Journal of Medicinal Chemistry 60:11, pages 4611-4625.
Crossref
Lazaros Vasilikos, Lisanne M Spilgies, Janin Knop & Wendy Wei‐Lynn Wong. (2017) Regulating the balance between necroptosis, apoptosis and inflammation by inhibitors of apoptosis proteins. Immunology & Cell Biology 95:2, pages 160-165.
Crossref
Inês C. M. Simões, Inês P. D. Costa, João T. S. Coimbra, Maria J. Ramos & Pedro A. Fernandes. (2016) New Parameters for Higher Accuracy in the Computation of Binding Free Energy Differences upon Alanine Scanning Mutagenesis on Protein–Protein Interfaces. Journal of Chemical Information and Modeling 57:1, pages 60-72.
Crossref
Sailu Sarvagalla & Mohane Selvaraj Coumar. 2017. Pharmaceutical Sciences. Pharmaceutical Sciences 1115 1143 .
Darren Finlay, Peter Teriete, Mitchell Vamos, Nicholas D. P. Cosford & Kristiina Vuori. (2017) Inducing death in tumor cells: roles of the inhibitor of apoptosis proteins. F1000Research 6, pages 587.
Crossref
Rosalia de Necochea-Campion, Geoffrey P. Shouse, Qi Zhou, Saied Mirshahidi & Chien-Shing Chen. (2016) Aberrant splicing and drug resistance in AML. Journal of Hematology & Oncology 9:1.
Crossref
Mohamed El-Mesery, Mohamed E Shaker & Abdelaziz Elgaml. (2016) The SMAC mimetic BV6 induces cell death and sensitizes different cell lines to TNF-α and TRAIL-induced apoptosis. Experimental Biology and Medicine 241:18, pages 2015-2022.
Crossref
Ioanna Petta, Sam Lievens, Claude Libert, Jan Tavernier & Karolien De Bosscher. (2016) Modulation of Protein–Protein Interactions for the Development of Novel Therapeutics. Molecular Therapy 24:4, pages 707-718.
Crossref
Yijun Deng, Qiuzhe Xie, Matthew G. LaPorte, Anna T. A. Chasnoff, Mark A. Mortensen, Debasis Patra, Seth A. Putrelo, Robert S. Antonovich, Hong Cao, Jun Yan, Arthur J. Cooper, Susan R. Rippin, Matthew D. Alexander, Pavan Tirunahari Kumar, Mukta S. Hendi, Yu-Hua Lee, Thomas Haimowitz & Stephen M. Condon. (2016) Process Development and Synthesis of Birinapant: Large Scale Preparation and Acid-Mediated Dimerization of the Key Indole Intermediate. Organic Process Research & Development 20:2, pages 242-252.
Crossref
M Schirmer, L Trentin, M Queudeville, F Seyfried, S Demir, E Tausch, S Stilgenbauer, S M Eckhoff, L H Meyer & K-M Debatin. (2016) Intrinsic and chemo-sensitizing activity of SMAC-mimetics on high-risk childhood acute lymphoblastic leukemia. Cell Death & Disease 7:1, pages e2052-e2052.
Crossref
Sailu Sarvagalla & Mohane Selvaraj Coumar. 2016. Applied Case Studies and Solutions in Molecular Docking-Based Drug Design. Applied Case Studies and Solutions in Molecular Docking-Based Drug Design 249 277 .
GONGSHENG JIN, YADONG LAN, FUSHENG HAN, YIMING SUN, ZHE LIU, MINGLIANG ZHANG, XIANFU LIU, XIAOJING ZHANG, JIANGUO HU, HAO LIU & BENZHONG WANG. (2016) Smac mimetic-induced caspase-independent necroptosis requires RIP1 in breast cancer. Molecular Medicine Reports 13:1, pages 359-366.
Crossref
Carlos J. Díaz Osterman, Amber Gonda, TessaRae Stiff, Ulysses Sigaran, Malyn May Asuncion Valenzuela, Heather R. Ferguson Bennit, Ron B. Moyron, Salma Khan & Nathan R. Wall. (2016) Curcumin Induces Pancreatic Adenocarcinoma Cell Death Via Reduction of the Inhibitors of Apoptosis. Pancreas 45:1, pages 101-109.
Crossref
K. Brew & M. Lizotte-Waniewski. 2016. Encyclopedia of Cell Biology. Encyclopedia of Cell Biology 706 713 .
Stephanie Hehlgans, Julius Oppermann, Sebastian Reichert, Simone Fulda, Claus Rödel & Franz Rödel. (2015) The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis. Radiation Oncology 10:1.
Crossref
Mans Broekgaarden, Ruud Weijer, Thomas M. van Gulik, Michael R. Hamblin & Michal Heger. (2015) Tumor cell survival pathways activated by photodynamic therapy: a molecular basis for pharmacological inhibition strategies. Cancer and Metastasis Reviews 34:4, pages 643-690.
Crossref
Randy L. Talbott, Robert M. Borzilleri, Charu Chaudhry, Joseph Fargnoli, Henry Shen, Craig Fairchild, Bryan Barnhart, Marie Ortega, Thomas E. McDonagh, Ragini Vuppugalla, Gregory D. Vite, John T. Hunt, Marco Gottardis & Joseph G. Naglich. (2015) Pharmacology of smac mimetics; chemotype differentiation based on physical association with caspase regulators and cellular transport. Experimental Cell Research 338:2, pages 251-260.
Crossref
Min Li-Weber. (2015) Molecular mechanisms and anti-cancer aspects of the medicinal phytochemicals rocaglamides (=flavaglines). International Journal of Cancer 137:8, pages 1791-1799.
Crossref
Lan Zhang, Xupeng Tong, Jingjing Li, Yue Huang, Xinyue Hu, Yi Chen, Jian Huang, Jinhui Wang & Bo Liu. (2015) Apoptotic and autophagic pathways with relevant small-molecule compounds, in cancer stem cells. Cell Proliferation 48:4, pages 385-397.
Crossref
John F. DiPersio, Harry P. Erba, Richard A. Larson, Selina M. Luger, Martin S. Tallman, Jeffrey M. Brill, Gregoire Vuagniaux, Elisabeth Rouits, J. Mel Sorensen & Claudio Zanna. (2015) Oral Debio1143 (AT406), an Antagonist of Inhibitor of Apoptosis Proteins, Combined With Daunorubicin and Cytarabine in Patients With Poor-Risk Acute Myeloid Leukemia—Results of a Phase I Dose-Escalation Study. Clinical Lymphoma Myeloma and Leukemia 15:7, pages 443-449.
Crossref
Herbert I. Hurwitz, David C. Smith, Henry C. Pitot, Jeffrey M. Brill, Rashmi Chugh, Elisabeth Rouits, Joseph Rubin, John Strickler, Gregoire Vuagniaux, J. Mel Sorensen & Claudio Zanna. (2015) Safety, pharmacokinetics, and pharmacodynamic properties of oral DEBIO1143 (AT-406) in patients with advanced cancer: results of a first-in-man study. Cancer Chemotherapy and Pharmacology 75:4, pages 851-859.
Crossref
Chung-Ming Lin, Wei-Chien Kao, Chun-An Yeh, Hui-Jye Chen, Shinn-Zong Lin, Hsien-Hsu Hsieh, Wei-Shen Sun, Chih-Hsuan Chang & Huey-Shan Hung. (2015) Hyaluronic acid-fabricated nanogold delivery of the inhibitor of apoptosis protein-2 siRNAs inhibits benzo[ a ]pyrene-induced oncogenic properties of lung cancer A549 cells . Nanotechnology 26:10, pages 105101.
Crossref
Laurence Dubrez & Krishnaraj Rajalingam. (2015) IAPs and cell migration. Seminars in Cell & Developmental Biology 39, pages 124-131.
Crossref
Heidi L. Perez, Charu Chaudhry, Stuart L. Emanuel, Caroline Fanslau, Joseph Fargnoli, Jinping Gan, Kyoung S. Kim, Ming Lei, Joseph G. Naglich, Sarah C. Traeger, Ragini Vuppugalla, Donna D. Wei, Gregory D. Vite, Randy L. Talbott & Robert M. Borzilleri. (2015) Discovery of Potent Heterodimeric Antagonists of Inhibitor of Apoptosis Proteins (IAPs) with Sustained Antitumor Activity. Journal of Medicinal Chemistry 58:3, pages 1556-1562.
Crossref
Chia-Hung Hsieh, Yu-Jung Lin, Chung-Pu Wu, Hsu-Tung Lee, Woei-Cherng Shyu & Chi-Chung Wang. (2015) Livin Contributes to Tumor Hypoxia–Induced Resistance to Cytotoxic Therapies in Glioblastoma Multiforme. Clinical Cancer Research 21:2, pages 460-470.
Crossref
Yabing Chen, Kaiyu Yuan & Jay McDonald. 2015. Resistance of Cancer Cells to CTL-Mediated Immunotherapy. Resistance of Cancer Cells to CTL-Mediated Immunotherapy 235 265 .
Ali Bettaieb, Stéphanie Plenchette, Catherine Paul, Véronique Laurens, Sabrina Romagny & Jean-Fran|ois Jeannin. 2015. Nitric Oxide and Cancer: Pathogenesis and Therapy. Nitric Oxide and Cancer: Pathogenesis and Therapy 97 109 .
C. Ottmann. 2016. New Approaches to Drug Discovery. New Approaches to Drug Discovery 125 138 .
Longchuan Bai, David C. Smith & Shaomeng Wang. (2014) Small-molecule SMAC mimetics as new cancer therapeutics. Pharmacology & Therapeutics 144:1, pages 82-95.
Crossref
Shunbin Xiong, Tianyang Mu, Guowen Wang & Xuejun Jiang. (2014) Mitochondria-mediated apoptosis in mammals. Protein & Cell 5:10, pages 737-749.
Crossref
Yanyan Li, Xuelei Ma, Xi Wu, Xiaoxiao Liu & Lei Liu. (2014) Prognostic Significance of Survivin in Breast Cancer: Meta-analysis. The Breast Journal 20:5, pages 514-524.
Crossref
Michelle R. Arkin, Yinyan Tang & James A. Wells. (2014) Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality. Chemistry & Biology 21:9, pages 1102-1114.
Crossref
L. Campisi, R.J. Cummings & J. Magarian Blander. (2014) Death-Defining Immune Responses After Apoptosis. American Journal of Transplantation 14:7, pages 1488-1498.
Crossref
Bor-Chyuan Su & Fan-E Mo. (2014) CCN1 enables Fas ligand-induced apoptosis in cardiomyoblast H9c2 cells by disrupting caspase inhibitor XIAP. Cellular Signalling 26:6, pages 1326-1334.
Crossref
Stephen M. Condon, Yasuhiro Mitsuuchi, Yijun Deng, Matthew G. LaPorte, Susan R. Rippin, Thomas Haimowitz, Matthew D. Alexander, Pavan Tirunahari Kumar, Mukta S. Hendi, Yu-Hua Lee, Christopher A. Benetatos, Guangyao Yu, Gurpreet Singh Kapoor, Eric Neiman, Martin E. Seipel, Jennifer M. Burns, Martin A. Graham, Mark A. McKinlay, Xiaochun Li, Jiawei Wang, Yigong Shi, Rebecca Feltham, Bodhi Bettjeman, Mathew H. Cumming, James E. Vince, Nufail Khan, John Silke, Catherine L. Day & Srinivas K. Chunduru. (2014) Birinapant, a Smac-Mimetic with Improved Tolerability for the Treatment of Solid Tumors and Hematological Malignancies. Journal of Medicinal Chemistry 57:9, pages 3666-3677.
Crossref
James B Jaquith. (2014) Targeting the Inhibitor of Apoptosis Protein BIR3 Binding Domains. Pharmaceutical Patent Analyst 3:3, pages 297-312.
Crossref