IAP proteins as targets for drug development in oncology

References

• CrookNEClemRJMillerLKAn apoptosis-inhibiting baculovirus gene with a zinc finger-like motifJ Virol1993674216821748445726
   PubMed Web of Science ®Google Scholar
• RotheMPanMGHenzelWJAyresTMGoeddelDVThe TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteinsCell1995837124312528548810
   PubMed Web of Science ®Google Scholar
• RoyNMahadevanMSMcLeanMThe gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophyCell19958011671787813013
   PubMed Web of Science ®Google Scholar
• DuckettCSNavaVEGedrichRWA conserved family of cellular genes related to the baculovirus iap gene and encoding apoptosis inhibitorsEMBO J19961511268526948654366
   PubMed Web of Science ®Google Scholar
• UrenAGPakuschMHawkinsCJPulsKLVauxDLCloning and expression of apoptosis inhibitory protein homologs that function to inhibit apoptosis and/or bind tumor necrosis factor receptor-associated factorsProc Natl Acad Sci U S A19969310497449788643514
   PubMed Web of Science ®Google Scholar
• AmbrosiniGAdidaCAltieriDCA novel anti-apoptosis gene, survivin, expressed in cancer and lymphomaNat Med1997389179219256286
   PubMed Web of Science ®Google Scholar
• ChenZNaitoMHoriSMashimaTYamoriTTsuruoTA human IAP-family gene, apollon, expressed in human brain cancer cellsBiochem Biophys Res Commun1999264384785410544019
   PubMed Web of Science ®Google Scholar
• VucicDStennickeHRPisabarroMTSalvesenGSDixitVMML-IAP, a novel inhibitor of apoptosis that is preferentially expressed in human melanomasCurr Biol200010211359136611084335
   PubMed Web of Science ®Google Scholar
• RichterBWMirSSEibenLJMolecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein familyMol Cell Biol200121134292430111390657
   PubMed Web of Science ®Google Scholar
• SrinivasulaSMHegdeRSalehAA conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosisNature2001410682411211611242052
   PubMed Web of Science ®Google Scholar
• LiuZSunCOlejniczakETStructural basis for binding of Smac/DIABLO to the XIAP BIR3 domainNature200040868151004100811140637
   PubMed Web of Science ®Google Scholar
• HegdeRSrinivasulaSMZhangZIdentification of Omi/HtrA2 as a mitochondrial apoptotic serine protease that disrupts inhibitor of apoptosis protein-caspase interactionJ Biol Chem2002277143243811606597
   PubMed Web of Science ®Google Scholar
• ShiYA conserved tetrapeptide motif: potentiating apoptosis through IAP-bindingCell Death Differ200292939511840157
   PubMed Web of Science ®Google Scholar
• VerhagenAMSilkeJEkertPGHtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteinsJ Biol Chem2002277144545411604410
   PubMed Web of Science ®Google Scholar
• LuMLinSCHuangYXIAP induces NF-kappaB activation via the BIR1/TAB1 interaction and BIR1 dimerizationMol Cell200726568970217560374
   PubMed Web of Science ®Google Scholar
• SamuelTWelshKLoberTTogoSHZapataJMReedJCDistinct BIR domains of cIAP1 mediate binding to and ubiquitination of tumor necrosis factor receptor-associated factor 2 and second mitochondrial activator of caspasesJ Biol Chem200628121080109016282325
   PubMed Web of Science ®Google Scholar
• VarfolomeevEWaysonSMDixitVMFairbrotherWJVucicDThe inhibitor of apoptosis protein fusion c-IAP2.MALT1stimulates NF-kappaB activation independently of TRAF1 AND TRAF2J Biol Chem200628139290222902916891304
   PubMed Web of Science ®Google Scholar
• MacePDSmitsCVauxDLSilkeJDayCLAsymmetric recruitment of cIAPs by TRAF2J Mol Biol2010400181520447407
   PubMed Web of Science ®Google Scholar
• BroemerMTenevTRigboltKTSystematic in vivo RNAi analysis identifies IAPs as NEDD8-E3 ligasesMol Cell201040581082221145488
   PubMed Web of Science ®Google Scholar
• VucicDDixitVMWertzIEUbiquitylation in apoptosis: a post-translational modification at the edge of life and deathNat Rev Mol Cell Biol201112743945221697901
   PubMed Web of Science ®Google Scholar
• BroemerMMeierPUbiquitin-mediated regulation of apoptosisTrends Cell Biol200919313014019217783
   PubMed Web of Science ®Google Scholar
• HuangHKJoazeiroCABonfocoEKamadaSLeversonJDHunterTThe inhibitor of apoptosis, cIAP2, functions as a ubiquitin-protein ligase and promotes in vitro monoubiquitination of caspases 3 and 7J Biol Chem200027535266612666410862606
   PubMed Web of Science ®Google Scholar
• SuzukiYNakabayashiYTakahashiRUbiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell deathProc Natl Acad Sci U S A200198158662866711447297
   PubMed Web of Science ®Google Scholar
• ChoiYEButterworthMMalladiSDuckettCSCohenGMBrattonSBThe E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processingJ Biol Chem200928419127721278219258326
   PubMed Web of Science ®Google Scholar
• Gyrd-HansenMMeierPIAPs: from caspase inhibitors to modulators of NF-kappaB, inflammation and cancerNat Rev Cancer201010856157420651737
   PubMed Web of Science ®Google Scholar
• BeugSTCheungHHLaCasseECKornelukRGModulation of immune signalling by inhibitors of apoptosisTrends Immunol2012331153554522836014
   PubMed Web of Science ®Google Scholar
• OberoiTKDoganTHockingJCIAPs regulate the plasticity of cell migration by directly targeting Rac1 for degradationEMBO J2011311142822117219
   PubMed Web of Science ®Google Scholar
• XuLZhuJHuXc-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1Mol Cell200728591492218082613
   PubMed Web of Science ®Google Scholar
• CartierJBertheletJMarivinACellular inhibitor of apoptosis protein-1 (cIAP1) can regulate E2F1 transcription factor-mediated control of cyclin transcriptionJ Biol Chem201128630264062641721653699
   PubMed Web of Science ®Google Scholar
• GottfriedYRotemALotanRStellerHLarischSThe mitochondrial ARTS protein promotes apoptosis through targeting XIAPEMBO J20042371627163515029247
   PubMed Web of Science ®Google Scholar
• García-FernándezMKisselHBrownSSept4/ARTS is required for stem cell apoptosis and tumor suppressionGenes Dev201024202282229320952537
   PubMed Web of Science ®Google Scholar
• ZenderLSpectorMSXueWIdentification and validation of oncogenes in liver cancer using an integrative oncogenomic approachCell200612571253126716814713
   PubMed Web of Science ®Google Scholar
• ChengLZhouZFlesken-NikitinARb inactivation accelerates neoplastic growth and substitutes for recurrent amplification of cIAP1, cIAP2 and Yap1 in sporadic mammary carcinoma associated with p53 deficiencyOncogene201029425700571120676140
   PubMed Web of Science ®Google Scholar
• ReardonDAMichalkiewiczEBoyettJMExtensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridizationCancer Res19975718404240479307291
   PubMed Web of Science ®Google Scholar
• BashyamMDBairRKimYHArray-based comparative genomic hybridization identifies localized DNA amplifications and homozygous deletions in pancreatic cancerNeoplasia20057655656216036106
   PubMed Web of Science ®Google Scholar
• ImotoITsudaHHirasawaAExpression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapyCancer Res200262174860486612208731
   PubMed Web of Science ®Google Scholar
• DaiZZhuWGMorrisonCDA comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenesHum Mol Genet200312779180112651874
   PubMed Web of Science ®Google Scholar
• SnijdersAMSchmidtBLFridlyandJRare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinomaOncogene200524264232424215824737
   PubMed Web of Science ®Google Scholar
• ImotoIYangZQPimkhaokhamAIdentification of cIAP1 as a candidate target gene within an amplicon at 11q22 in esophageal squamous cell carcinomasCancer Res200161186629663411559525
   PubMed Web of Science ®Google Scholar
• GarrisonJBSamuelTReedJCTRAF2-binding BIR1 domain of c-IAP2/MALT1 fusion protein is essential for activation of NF-kappaBOncogene200928131584159319234489
   PubMed Web of Science ®Google Scholar
• KeatsJJFonsecaRChesiMPromiscuous mutations activate the noncanonical NF-kappaB pathway in multiple myelomaCancer Cell200712213114417692805
   PubMed Web of Science ®Google Scholar
• AnnunziataCMDavisREDemchenkoYFrequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myelomaCancer Cell200712211513017692804
   PubMed Web of Science ®Google Scholar
• FilipovichAHZhangKSnowALMarshRAX-linked lymphoproliferative syndromes: brothers or distant cousins?Blood2010116183398340820660790
   PubMed Web of Science ®Google Scholar
• CoumarMSTsaiFYKanwarJRSarvagallaSCheungCHTreat cancers by targeting survivin: just a dream or future reality?Cancer Treat Rev [Epub February 28, 2013]
   Google Scholar
• EckelmanBPDragMSnipasSJSalvesenGSThe mechanism of peptide-binding specificity of IAP BIR domainsCell Death Differ200815592092818239672
   PubMed Web of Science ®Google Scholar
• TenevTZachariouAWilsonRDitzelMMeierPIAPs are functionally non-equivalent and regulate effector caspases through distinct mechanismsNat Cell Biol200571707715580265
   PubMed Web of Science ®Google Scholar
• ScottFLDenaultJBRiedlSJShinHRenatusMSalvesenGSXIAP inhibits caspase-3 and -7 using two binding sites: evolutionarily conserved mechanism of IAPsEMBO J200524364565515650747
   PubMed Web of Science ®Google Scholar
• ShiozakiENChaiJRigottiDJMechanism of XIAP-mediated inhibition of caspase-9Mol Cell200311251952712620238
   PubMed Web of Science ®Google Scholar
• RiedlSJRenatusMSchwarzenbacherRStructural basis for the inhibition of caspase-3 by XIAPCell2001104579180011257232
   PubMed Web of Science ®Google Scholar
• HolcikMYehCKornelukRGChowTTranslational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell deathOncogene200019364174417710962579
   PubMed Web of Science ®Google Scholar
• GuLZhuNZhangHDurdenDLFengYZhouMRegulation of XIAP translation and induction by MDM2 following irradiationCancer Cell200915536337519411066
   PubMed Web of Science ®Google Scholar
• MacePDRiedlSJMolecular cell death platforms and assembliesCurr Opin Cell Biol201022682883620817427
   PubMed Web of Science ®Google Scholar
• MicheauOTschoppJInduction of TNF receptor I-mediated apoptosis via two sequential signaling complexesCell2003114218119012887920
   PubMed Web of Science ®Google Scholar
• TenevTBianchiKDardingMThe Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPsMol Cell201143343244821737329
   PubMed Web of Science ®Google Scholar
• FeoktistovaMGeserickPKellertBcIAPs block ripoptosome formation, a RIP1/caspase-8 containing intracellular cell death complex differentially regulated by cFLIP isoformsMol Cell201143344946321737330
   PubMed Web of Science ®Google Scholar
• BertrandMJMilutinovicSDicksonKMcIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitinationMol Cell200830668970018570872
   PubMed Web of Science ®Google Scholar
• DynekJNGoncharovTDueberECc-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signallingEMBO J201029244198420921113135
   PubMed Web of Science ®Google Scholar
• ParkSMYoonJBLeeTHReceptor interacting protein is ubiquitinated by cellular inhibitor of apoptosis proteins (c-IAP1 and c-IAP2) in vitroFEBS Lett20045661–315115615147886
   PubMed Web of Science ®Google Scholar
• GeserickPHupeMMoulinMCellular IAPs inhibit a cryptic CD95-induced cell death by limiting RIP1 kinase recruitmentJ Cell Biol200918771037105420038679
   PubMed Web of Science ®Google Scholar
• VinceJEWongWWGentleIInhibitor of apoptosis proteins limit RIP3 kinase-dependent interleukin-1 activationImmunity201236221522722365665
   PubMed Web of Science ®Google Scholar
• HaasTLEmmerichCHGerlachBRecruitment of the linear ubiquitin chain assembly complex stabilizes the TNF-R1 signaling complex and is required for TNF-mediated gene inductionMol Cell200936583184420005846
   PubMed Web of Science ®Google Scholar
• O’DonnellMALegarda-AddisonDSkountzosPYehWCTingATUbiquitination of RIP1 regulates an NF-kappaB-independent cell-death switch in TNF signalingCurr Biol200717541842417306544
   PubMed Web of Science ®Google Scholar
• VanlangenakkerNVanden BergheTBogaertPcIAP1 and TAK1 protect cells from TNF-induced necrosis by preventing RIP1/RIP3-dependent reactive oxygen species productionCell Death Differ201118465666521052097
   PubMed Web of Science ®Google Scholar
• HaydenMSGhoshSNF-kappaB, the first quarter-century: remarkable progress and outstanding questionsGenes Dev201226320323422302935
   PubMed Web of Science ®Google Scholar
• ShihVFTsuiRCaldwellAHoffmannAA single NFκB system for both canonical and non-canonical signalingCell Res20112118610221102550
   PubMed Web of Science ®Google Scholar
• VarfolomeevEGoncharovTFedorovaAVc-IAP1 and c-IAP2 are critical mediators of tumor necrosis factor alpha (TNFalpha)-induced NF-kappaB activationJ Biol Chem200828336242952429918621737
   PubMed Web of Science ®Google Scholar
• BertrandMJDoironKLabbéKKornelukRGBarkerPASalehMCellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2Immunity200930678980119464198
   PubMed Web of Science ®Google Scholar
• DamgaardRBNachburUYabalMThe ubiquitin ligase XIAP recruits LUBAC for NOD2 signaling in inflammation and innate immunityMol Cell201246674675822607974
   PubMed Web of Science ®Google Scholar
• KriegACorreaRGGarrisonJBXIAP mediates NOD signaling via interaction with RIP2Proc Natl Acad Sci U S A200910634145241452919667203
   PubMed Web of Science ®Google Scholar
• VarfolomeevEGoncharovTMaeckerHCellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptorsSci Signal20125216ra2222434933
   PubMed Web of Science ®Google Scholar
• JinHSLeeDHKimDHChungJHLeeSJLeeTHcIAP1, cIAP2, and XIAP act cooperatively via nonredundant pathways to regulate genotoxic stress-induced nuclear factor-kappaB activationCancer Res20096951782179119223549
   PubMed Web of Science ®Google Scholar
• HinzMStilmannMArslanSÇKhannaKKDittmarGScheidereitCA cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-κB activationMol Cell2010401637420932475
   PubMed Web of Science ®Google Scholar
• Hofer-WarbinekRSchmidJAStehlikCBinderBRLippJde MartinRActivation of NF-kappa B by XIAP, the X chromosome-linked inhibitor of apoptosis, in endothelial cells involves TAK1J Biol Chem200027529220642206810807933
   PubMed Web of Science ®Google Scholar
• Birkey ReffeySWurthnerJUParksWTRobertsABDuckettCSX-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signalingJ Biol Chem200127628265422654911356828
   PubMed Web of Science ®Google Scholar
• SannaMGda Silva CorreiaJDucreyOIAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibitionMol Cell Biol20022261754176611865055
   PubMed Web of Science ®Google Scholar
• ZarnegarBJWangYMahoneyDJNoncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIKNat Immunol20089121371137818997794
   PubMed Web of Science ®Google Scholar
• VallabhapurapuSMatsuzawaAZhangWNonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signalingNat Immunol20089121364137018997792
   PubMed Web of Science ®Google Scholar
• FelthamRMoulinMVinceJETumor necrosis factor (TNF) signaling, but not TWEAK (TNF-like weak inducer of apoptosis)-triggered cIAP1 (cellular inhibitor of apoptosis protein 1) degradation, requires cIAP1 RING dimerization and E2 bindingJ Biol Chem201028523175251753620356846
   PubMed Web of Science ®Google Scholar
• MaoAPLiSZhongBVirus-triggered ubiquitination of TRAF3/6 by cIAP1/2 is essential for induction of interferon-beta (IFN-beta) and cellular antiviral responseJ Biol Chem2010285139470947620097753
   PubMed Web of Science ®Google Scholar
• RosebeckSMaddenLJinXCleavage of NIK by the API2-MALT1 fusion oncoprotein leads to noncanonical NF-kappaB activationScience2011331601646847221273489
   PubMed Web of Science ®Google Scholar
• SamuelTOkadaKHyerMWelshKZapataJMReedJCcIAP1 Localizes to the nuclear compartment and modulates the cell cycleCancer Res200565121021815665297
   PubMed Web of Science ®Google Scholar
• TanimotoTTsudaHImazekiNNuclear expression of cIAP-1, an apoptosis inhibiting protein, predicts lymph node metastasis and poor patient prognosis in head and neck squamous cell carcinomasCancer Lett2005224114115115911110
   PubMed Web of Science ®Google Scholar
• CheXYangDZongHNuclear cIAP1 overexpression is a tumor stage- and grade-independent predictor of poor prognosis in human bladder cancer patientsUrol Oncol201230445045621795072
   PubMed Web of Science ®Google Scholar
• FuldaSRegulation of cell migration, invasion and metastasis by IAP proteins and their antagonistsOncogene [Epub March 11, 2013]
   Google Scholar
• McManusDCLefebvreCACherton-HorvatGLoss of XIAP protein expression by RNAi and antisense approaches sensitizes cancer cells to functionally diverse chemotherapeuticsOncogene200423498105811715378029
   PubMed Web of Science ®Google Scholar
• LacasseECPulling the plug on a cancer cell by eliminating XIAP with AEG35156Cancer Lett2013332221522422776562
   PubMed Web of Science ®Google Scholar
• KatragaddaLCarterBZBorthakurGXIAP antisense therapy with AEG 35156 in acute myeloid leukemiaExpert Opin Investig Drugs2013225663670
   PubMed Web of Science ®Google Scholar
• DeanEJodrellDConnollyKPhase I trial of AEG35156 administered as a 7-day and 3-day continuous intravenous infusion in patients with advanced refractory cancerJ Clin Oncol200927101660166619237630
   PubMed Web of Science ®Google Scholar
• SchimmerADEsteyEHBorthakurGPhase I/II trial of AEG35156 X-linked inhibitor of apoptosis protein antisense oligonucleotide combined with idarubicin and cytarabine in patients with relapsed or primary refractory acute myeloid leukemiaJ Clin Oncol200927284741474619652057
   PubMed Web of Science ®Google Scholar
• MahadevanDChalasaniPRensvoldDPhase I trial of AEG35156 an antisense oligonucleotide to XIAP plus gemcitabine in patients with metastatic pancreatic ductal adenocarcinomaAm J Clin Oncol201336323924322441342
   PubMed Web of Science ®Google Scholar
• SchimmerADHerrWHanelMAddition of AEG35156 XIAP antisense oligonucleotide in reinduction chemotherapy does not improve remission rates in patients with primary refractory acute myeloid leukemia in a randomized phase II studyClin Lymphoma Myeloma Leuk201111543343821729686
   PubMed Web of Science ®Google Scholar
• ChaiJYanNHuhJRMolecular mechanism of Reaper-Grim-Hid-mediated suppression of DIAP1-dependent Dronc ubiquitinationNat Struct Biol2003101189289814517550
   PubMedGoogle Scholar
• ChaiJDuCWuJWKyinSWangXShiYStructural and biochemical basis of apoptotic activation by Smac/DIABLONature2000406679885586210972280
   PubMed Web of Science ®Google Scholar
• WuGChaiJSuberTLStructural basis of IAP recognition by Smac/DIABLONature200040868151008101211140638
   PubMed Web of Science ®Google Scholar
• HuangYRichRLMyszkaDGWuHRequirement of both the second and third BIR domains for the relief of X-linked inhibitor of apoptosis protein (XIAP)-mediated caspase inhibition by SmacJ Biol Chem200327849495174952214512414
   PubMed Web of Science ®Google Scholar
• DuCFangMLiYLiLWangXSmac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibitionCell20001021334210929711
   PubMed Web of Science ®Google Scholar
• ArntCRChioreanMVHeldebrantMPGoresGJKaufmannSHSynthetic Smac/DIABLO peptides enhance the effects of chemotherapeutic agents by binding XIAP and cIAP1 in situJ Biol Chem200227746442364424312218061
   PubMed Web of Science ®Google Scholar
• YangLMashimaTSatoSPredominant suppression of apoptosome by inhibitor of apoptosis protein in non-small cell lung cancer H460 cells: therapeutic effect of a novel polyarginine-conjugated Smac peptideCancer Res200363483183712591734
   PubMed Web of Science ®Google Scholar
• FuldaSWickWWellerMDebatinKMSmac agonists sensitize for Apo2L/TRAIL- or anticancer drug-induced apoptosis and induce regression of malignant glioma in vivoNat Med20028880881512118245
   PubMed Web of Science ®Google Scholar
• GuoFNimmanapalliRParanawithanaSEctopic overexpression of second mitochondria-derived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative-(BMS 247550) and Apo-2L/TRAIL-induced apoptosisBlood20029993419342611964312
   PubMed Web of Science ®Google Scholar
• FranklinMCKadkhodayanSAckerlyHStructure and function analysis of peptide antagonists of melanoma inhibitor of apoptosis (ML-IAP)Biochemistry200342278223823112846571
   PubMed Web of Science ®Google Scholar
• OostTKSunCArmstrongRCDiscovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancerJ Med Chem200447184417442615317454
   PubMed Web of Science ®Google Scholar
• SunHNikolovska-ColeskaZYangCYStructure-based design of potent, conformationally constrained Smac mimeticsJ Am Chem Soc200412651166861668715612682
   PubMed Web of Science ®Google Scholar
• LiLThomasRMSuzukiHDe BrabanderJKWangXHarranPGA small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell deathScience200430556891471147415353805
   PubMed Web of Science ®Google Scholar
• ZobelKWangLVarfolomeevEDesign, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPsACS Chem Biol20061852553317168540
   PubMed Web of Science ®Google Scholar
• SharmaSKStraubCZawelLDevelopment of peptidomimetics targeting IAPsInt J Pept Res Ther2006121213219617919
   PubMed Web of Science ®Google Scholar
• SunHNikolovska-ColeskaZLuJDesign, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimeticJ Med Chem200649267916792017181177
   PubMed Web of Science ®Google Scholar
• HoughtonPJKangMHReynoldsCPInitial testing (stage 1) of LCL161, a SMAC mimetic, by the Pediatric Preclinical Testing ProgramPediatr Blood Cancer201258463663921681929
   PubMed Web of Science ®Google Scholar
• ChauhanDNeriPVelankarMTargeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)Blood200710931220122717032924
   PubMed Web of Science ®Google Scholar
• ChenKFLinJPShiauCWInhibition of Bcl-2 improves effect of LCL161, a SMAC mimetic, in hepatocellular carcinoma cellsBiochem Parmacol2012843268277
   Web of Science ®Google Scholar
• YuanZSyrkinGAdemABlockade of inhibitors of apoptosis (IAPs) in combination with tumor-targeted delivery of tumor necrosis factor-α leads to synergistic antitumor activityCancer Gene Ther2013201465623154431
   PubMed Web of Science ®Google Scholar
• XuYZhouLHuangJRole of Smac in determining the chemotherapeutic response of esophageal squamous cell carcinomaClin Cancer Res201117165412542221676925
   PubMed Web of Science ®Google Scholar
• ZieglerDSKeatingJKesariSA small-molecule IAP inhibitor overcomes resistance to cytotoxic therapies in malignant gliomas in vitro and in vivoNeuro Oncol201113882082921724651
   PubMed Web of Science ®Google Scholar
• KeatingJTsoliMHallahanARIngramWJHaberMZieglerDSTargeting the inhibitor of apoptosis proteins as a novel therapeutic strategy in medulloblastomaMol Cancer Ther201211122654266323012247
   PubMed Web of Science ®Google Scholar
• FlygareJABeresiniMBudhaNDiscovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152)J Med Chem20125594101411322413863
   PubMed Web of Science ®Google Scholar
• FlanaganLSebastiaJDelgadoMELennonJCRehmMDimerization of Smac is crucial for its mitochondrial retention by XIAP subsequent to mitochondrial outer membrane permeabilizationBiochim Biophys Acta20111813581982621354220
   PubMed Web of Science ®Google Scholar
• SunHNikolovska-ColeskaZLuJDesign, synthesis, and characterization of a potent, nonpeptide, cell-permeable, bivalent Smac mimetic that concurrently targets both the BIR2 and BIR3 domains in XIAPJ Am Chem Soc200712949152791529417999504
   PubMed Web of Science ®Google Scholar
• LuJBaiLSunHSM-164: a novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAPCancer Res200868229384939319010913
   PubMed Web of Science ®Google Scholar
• BrunckhorstMKLernerDWangSYuQAT-406, an orally active antagonist of multiple inhibitor of apoptosis proteins, inhibits progression of human ovarian cancerCancer Biol Ther201213980481122669575
   PubMed Web of Science ®Google Scholar
• CaiQSunHPengYA Potent and orally active antagonist (SM-406/AT-406) of multiple inhibitor of apoptosis proteins (IAPs) in clinical development for cancer treatmentJ Med Chem20115482714272621443232
   PubMed Web of Science ®Google Scholar
• FuldaSInhibitor of apoptosis (IAP) proteins as therapeutic targets for radiosensitization of human cancersCancer Treat Rev201238676076622342104
   PubMed Web of Science ®Google Scholar
• FlygareJAFairbrotherWJSmall-molecule pan-IAP antagonists: a patent reviewExpert Opin Ther Pat201020225126720100005
   PubMed Web of Science ®Google Scholar
• FelthamRBettjemanBBudhidarmoRSmac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerizationJ Biol Chem201128619170151702821393245
   PubMed Web of Science ®Google Scholar
• DueberECSchoefflerAJLingelAAntagonists induce a conformational change in cIAP1 that promotes autoubiquitinationScience2011334605437638022021857
   PubMed Web of Science ®Google Scholar
• VarfolomeevEBlankenshipJWWaysonSMIAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosisCell2007131466968118022362
   PubMed Web of Science ®Google Scholar
• VinceJEWongWWKhanNIAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosisCell2007131468269318022363
   PubMed Web of Science ®Google Scholar
• PetersenSLWangLYalcin-ChinAAutocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosisCancer Cell200712544545617996648
   PubMed Web of Science ®Google Scholar
• CohenFAlickeBElliottLOOrally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffoldJ Med Chem20095261723173019228017
   PubMed Web of Science ®Google Scholar
• NdubakuCVarfolomeevEWangLAntagonism of c-IAP and XIAP proteins is required for efficient induction of cell death by small-molecule IAP antagonistsACS Chem Biol20094755756619492850
   PubMed Web of Science ®Google Scholar
• GalbánSHwangCRumbleJMCytoprotective effects of IAPs revealed by a small molecule antagonistBiochem J2009417376577118851715
   PubMed Web of Science ®Google Scholar
• AllensworthJLSauerSJLyerlyHKMorseMADeviGRSmac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-alpha-independent mechanismBreast Cancer Res Treat2013137235937123225169
   PubMed Web of Science ®Google Scholar
• KnightsAJFucikovaJPasamAKoernigSCebonJInhibitor of apoptosis protein (IAP) antagonists demonstrate divergent immunomodulatory properties in human immune subsets with implications for combination therapyCancer Immunol Immunother201362232133522923192
   PubMed Web of Science ®Google Scholar
• WongHBudhaNRWestKDogs are more sensitive to antagonists of inhibitor of apoptosis proteins than rats and humans: a translational toxicokinetic/toxicodynamic analysisToxicol Sci2012130120521322843607
   PubMed Web of Science ®Google Scholar
• EricksonRITarrantJCainGToxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacologyToxicol Sci2013131124725822956632
   PubMed Web of Science ®Google Scholar
• InfanteJRPorterDSenSKA phase I study of LCL161, an oral IAP inhibitor, in patients with advanced cancerPaper presented at: 101st Annual Meeting of the American Association for Cancer ResearchApril 17–21, 2010Washington, DC. Philadelphia, PAAACR2010 Abstract nr 2775
   Google Scholar
• EmeagiPUVan LintSGoyvaertsCProinflammatory characteristics of SMAC/DIABLO-induced cell death in antitumor therapyCancer Res20127261342135222379024
   PubMed Web of Science ®Google Scholar
• YangCDavisJLZengRAntagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activationCancer Discov20133221222323269702
   PubMed Web of Science ®Google Scholar
• TammIRichterSScholzFXIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosisHematol J20045648949515570290
   PubMedGoogle Scholar
• Grzybowska-IzydorczykOCebulaBRobakTSmolewskiPExpression and prognostic significance of the inhibitor of apoptosis protein (IAP) family and its antagonists in chronic lymphocytic leukaemiaEur J Cancer201046480081020045309
   PubMed Web of Science ®Google Scholar
• HussainARUddinSAhmedMPrognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signallingJ Pathol2010222218019020632385
   PubMed Web of Science ®Google Scholar
• LiMSongTYinZFNaYQXIAP as a prognostic marker of early recurrence of nonmuscular invasive bladder cancerChin Med J (Engl)2007120646947317439739
   PubMed Web of Science ®Google Scholar
• ZhangYZhuJTangYX-linked inhibitor of apoptosis positive nuclear labeling: a new independent prognostic biomarker of breast invasive ductal carcinomaDiagn Pathol201164921645409
   PubMed Web of Science ®Google Scholar
• LiuSSTsangBKCheungANAnti-apoptotic proteins, apoptotic and proliferative parameters and their prognostic significance in cervical carcinomaEur J Cancer20013791104111011378340
   PubMed Web of Science ®Google Scholar
• XiangGWenXWangHChenKLiuHExpression of X-linked inhibitor of apoptosis protein in human colorectal cancer and its correlation with prognosisJ Surg Oncol2009100870871219777490
   PubMed Web of Science ®Google Scholar
• MoussataDAmaraSSiddeekBXIAP as a radioresistance factor and prognostic marker for radiotherapy in human rectal adenocarcinomaAm J Pathol201218141271127822867709
   PubMed Web of Science ®Google Scholar
• ShiYHDingWXZhouJExpression of X-linked inhibitor-of-apoptosis protein in hepatocellular carcinoma promotes metastasis and tumor recurrenceHepatology200848249750718666224
   PubMed Web of Science ®Google Scholar
• AugelloCCarusoLMaggioniMInhibitors of apoptosis proteins (IAPs) expression and their prognostic significance in hepatocellular carcinomaBMC Cancer2009912519397802
   PubMed Web of Science ®Google Scholar
• HiscuttELHillDSMartinSTargeting X-linked inhibitor of apoptosis protein to increase the efficacy of endoplasmic reticulum stress-induced apoptosis for melanoma therapyJ Invest Dermatol201013092250225820520630
   PubMed Web of Science ®Google Scholar
• FerreiraCGvan der ValkPSpanSWExpression of X-linked inhibitor of apoptosis as a novel prognostic marker in radically resected non-small cell lung cancer patientsClin Cancer Res2001782468247411489828
   PubMed Web of Science ®Google Scholar
• FerreiraCGvan der ValkPSpanSWAssessment of IAP (inhibitor of apoptosis) proteins as predictors of response to chemotherapy in advanced non-small-cell lung cancer patientsAnn Oncol200112679980511484955
   PubMed Web of Science ®Google Scholar
• SeligsonDBHongoFHuerta-YepezSExpression of X-linked inhibitor of apoptosis protein is a strong predictor of human prostate cancer recurrenceClin Cancer Res200713206056606317947468
   PubMed Web of Science ®Google Scholar
• KrajewskaMKrajewskiSBanaresSElevated expression of inhibitor of apoptosis proteins in prostate cancerClin Cancer Res20039134914492514581366
   PubMed Web of Science ®Google Scholar
• RampUKriegTCaliskanEXIAP expression is an independent prognostic marker in clear-cell renal carcinomasHum Pathol20043581022102815297970
   PubMed Web of Science ®Google Scholar
• YanYMahotkaCHeikausSDisturbed balance of expression between XIAP and Smac/DIABLO during tumour progression in renal cell carcinomasBr J Cancer20049171349135715328523
   PubMed Web of Science ®Google Scholar
• MizutaniYNakanishiHLiYNOverexpression of XIAP expression in renal cell carcinoma predicts a worse prognosisInt J Oncol200730491992517332931
   PubMed Web of Science ®Google Scholar
• GuLQLiFYZhaoLBRAFV600E mutation and X-linked inhibitor of apoptosis expression in papillary thyroid carcinomaThyroid200919434735419355825
   PubMed Web of Science ®Google Scholar
• EspositoIKleeffJAbiatariIOverexpression of cellular inhibitor of apoptosis protein 2 is an early event in the progression of pancreatic cancerJ Clin Pathol200760888589516775116
   PubMed Web of Science ®Google Scholar
• VallatLMagdelénatHMerle-BéralHThe resistance of B-CLL cells to DNA damage-induced apoptosis defined by DNA microarraysBlood2003101114598460612586635
   PubMed Web of Science ®Google Scholar
• SilvaKLVasconcellosDVCastroEDCoelhoAMLindenRMaiaRCApoptotic effect of fludarabine is independent of expression of IAPs in B-cell chronic lymphocytic leukemiaApoptosis200611227728516502265
   PubMed Web of Science ®Google Scholar
• PonnelleTChapusotCMartinLSubcellular expression of c-IAP1 and c-IAP2 in colorectal cancers: relationships with clinicopathological features and prognosisPathol Res Pract20031991172373114708638
   PubMed Web of Science ®Google Scholar
• QiSMogiSTsudaHExpression of cIAP-1 correlates with nodal metastasis in squamous cell carcinoma of the tongueInt J Oral Maxillofac Surg200837111047105318621506
   PubMed Web of Science ®Google Scholar
• StanculescuABembinsterLABorgenKBergamaschiAWileyEFrasorJEstrogen promotes breast cancer cell survival in an inhibitor of apoptosis (IAP)-dependent mannerHorm Cancer20101312713521152357
   PubMedGoogle Scholar
• AkagiTMotegiMTamuraAA novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade B-cell lymphoma of mucosa-associated lymphoid tissueOncogene199918425785579410523859
   PubMed Web of Science ®Google Scholar
• DierlammJBaensMWlodarskaIThe apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomasBlood199993113601360910339464
   PubMed Web of Science ®Google Scholar
• AnnunziataCMDavisREDemchenkoYFrequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myelomaCancer Cell200712211513017692804
   PubMed Web of Science ®Google Scholar
• El-MesallamyHOHegabHMKamalAMExpression of inhibitor of apoptosis protein (IAP) livin/BIRC7 in acute leukemia in adults: correlation with prognostic factors and outcomeLeuk Res201135121616162221700335
   PubMed Web of Science ®Google Scholar
• ChoiJHwangYKSungKWExpression of Livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemiaBlood2007109247147716990595
   PubMed Web of Science ®Google Scholar
• GazzanigaPGradiloneAGiulianiLExpression and prognostic significance of LIVIN, SURVIVIN and other apoptosis-related genes in the progression of superficial bladder cancerAnn Oncol2003141859012488298
   PubMed Web of Science ®Google Scholar
• WangXXuJJuSNiHZhuJWangHLivin gene plays a role in drug resistance of colon cancer cellsClin Biochem2010437–865566020171199
   PubMed Web of Science ®Google Scholar
• WangTSDingQQGuoRHExpression of livin in gastric cancer and induction of apoptosis in SGC-7901 cells by shRNA-mediated silencing of livin geneBiomed Pharmacother201064533333819914791
   PubMed Web of Science ®Google Scholar
• NachmiasBAshhabYBucholtzVCaspase-mediated cleavage converts Livin from an antiapoptotic to a proapoptotic factor: implications for drug-resistant melanomaCancer Res200363196340634914559822
   PubMed Web of Science ®Google Scholar
• KimDKAlvaradoCSAbramowskyCRExpression of inhibitor-of-apoptosis protein (IAP) livin by neuroblastoma cells: correlation with prognostic factors and outcomePediatr Dev Pathol20058662162916328668
   PubMed Web of Science ®Google Scholar
• NedelcuTKubistaBKollerALivin and Bcl-2 expression in highgrade osteosarcomaJ Cancer Res Clin Oncol2008134223724417632732
   PubMed Web of Science ®Google Scholar
• KempkensteffenCHinzSChristophFExpression of the apoptosis inhibitor livin in renal cell carcinomas: correlations with pathology and outcomeTumour Biol200728313213817519534
   PubMed Web of Science ®Google Scholar
• HaferkampABedkeJVetterCHigh nuclear Livin expression is a favourable prognostic indicator in renal cell carcinomaBJU Int2008102111700170618990137
   PubMed Web of Science ®Google Scholar
• KempkensteffenCHinzSKrauseHExpression of splicing variants of the inhibitor of apoptosis livin in testicular germ cell tumorsTumour Biol2008292768218515985
   PubMedGoogle Scholar
• PlutaAWrzesien-KusACebula-ObrzutBInfluence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patientsLeuk Res201034101308131320061022
   PubMed Web of Science ®Google Scholar
• MizutaniYKatsuokaYBonavidaBLow circulating serum levels of second mitochondria-derived activator of caspase (Smac/DIABLO) in patients with bladder cancerInt J Oncol20124041246125022218530
   PubMed Web of Science ®Google Scholar
• PlutaPCebula-ObrzutBEhemannVCorrelation of Smac/DIABLO protein expression with the clinico-pathological features of breast cancer patientsNeoplasma201158543043521744997
   PubMed Web of Science ®Google Scholar
• Arellano-LlamasAGarciaFJPerezDHigh Smac/DIABLO expression is associated with early local recurrence of cervical cancerBMC Cancer2006625617067390
   PubMed Web of Science ®Google Scholar
• EndoKKohnoeSWatanabeAClinical significance of Smac/DIABLO expression in colorectal cancerOncol Rep200921235135519148507
   PubMed Web of Science ®Google Scholar
• DobrzyckaBTerlikowskiSJBernaczykPSPrognostic significance of smac/DIABLO in endometrioid endometrial cancerFolia Histochem Cytobiol201148467868121478115
   PubMed Web of Science ®Google Scholar
• SekimuraAKonishiAMizunoKExpression of Smac/DIABLO is a novel prognostic marker in lung cancerOncol Rep200411479780215010875
   PubMed Web of Science ®Google Scholar
• MizutaniYKatsuokaYBonavidaBPrognostic significance of second mitochondria-derived activator of caspase (Smac/DIABLO) expression in bladder cancer and target for therapyInt J Oncol201037250350820596678
   PubMed Web of Science ®Google Scholar
• ShibataTMahotkaCWethkampNHeikausSGabbertHERampUDisturbed expression of the apoptosis regulators XIAP, XAF1, and Smac/DIABLO in gastric adenocarcinomasDiagn Mol Pathol20071611817471152
   PubMedGoogle Scholar
• KempkensteffenCHinzSChristophFExpression levels of the mitochondrial IAP antagonists Smac/DIABLO and Omi/HtrA2 in clear-cell renal cell carcinomas and their prognostic valueJ Cancer Res Clin Oncol2008134554355017922292
   PubMed Web of Science ®Google Scholar
• OuyangYQzur HausenAOrlowska-VolkMExpression levels of hnRNP G and hTra2-beta1 correlate with opposite outcomes in endometrial cancer biologyInt J Cancer201112892010201920607830
   PubMed Web of Science ®Google Scholar
• YangXXingHGaoQRegulation of HtrA2/Omi by X-linked inhibitor of apoptosis protein in chemoresistance in human ovarian cancer cellsGynecol Oncol200597241342115863139
   PubMed Web of Science ®Google Scholar
• HuXYXuYMChenXCPingHChenZHZengFQImmunohistochemical analysis of Omi/HtrA2 expression in prostate cancer and benign prostatic hyperplasiaAPMIS20061141289389817207090
   PubMed Web of Science ®Google Scholar
• HuXChenXPingHChenZZengFLuGImmunohistochemical analysis of Omi/HtrA2 expression in prostate cancer and benign prostatic hyperplasiaJ Huazhong Univ Sci Technolog Med Sci200525667167316696322
   PubMedGoogle Scholar
• LeeSHLeeJWKimHSImmunohistochemical analysis of Omi/HtrA2 expression in stomach cancerAPMIS2003111558659012887511
   PubMed Web of Science ®Google Scholar
• Zurawa-JanickaDKobielaJGalczynskaNChanges in expression of human serine protease HtrA1, HtrA2 and HtrA3 genes in benign and malignant thyroid tumorsOncol Rep20122851838184422923201
   PubMed Web of Science ®Google Scholar
• NarkiewiczJLapinska-SzumczykSZurawa-JanickaDSkorko-GlonekJEmerichJLipinskaBExpression of human HtrA1, HtrA2, HtrA3 and TGF-beta1 genes in primary endometrial cancerOncol Rep20092161529153719424634
   PubMed Web of Science ®Google Scholar
• NarkiewiczJKlasa-MazurkiewiczDZurawa-JanickaDSkorko-GlonekJEmerichJLipinskaBChanges in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancerClin Biochem2008417–856156918241672
   PubMed Web of Science ®Google Scholar
• GottfriedYVoldavskyEYodkoLSaboEBen-ItzhakOLarischSExpression of the pro-apoptotic protein ARTS in astrocytic tumors: correlation with malignancy grade and survival rateCancer2004101112614262115517578
   PubMed Web of Science ®Google Scholar
• ElhasidRSaharDMerlingAMitochondrial pro-apoptotic ARTS protein is lost in the majority of acute lymphoblastic leukemia patientsOncogene200423325468547515122323
   PubMed Web of Science ®Google Scholar
• CarterBZMakDHMorrisSJXIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34+38– cells in a phase 1/2 study of patients with relapsed/refractory AMLApoptosis2011161677420938744
   PubMed Web of Science ®Google Scholar
• ViertlDPerillo-AdamerFRigottiSThe SMAC-mimetic Debio 1143 efficiently enhanced chemo and radiotherapy in head and neck squamous cell carcinoma modelsPaper presented at: 140th Annual Meeting of the American Association for Cancer ResearchApril 6–10, 2013Washington, DC. Philadelphia, PAAACR2013 Abstract nr 2055
   Google Scholar
• MaWWZhangHHylanderBTL32711, a novel Smac mimetic, exerts significant antitumor efficacy in primary pancreatic adenocarcinoma modelPaper presented at: 103rd Annual Meeting of the American Association for Cancer ResearchMarch 31–April 4, 2012Chicago, IL. Philadelphia, PAAACR2012 Abstract nr 1939
   Google Scholar
• SmithMACarolHEvansKBirinapant (TL32711), a small molecule Smac mimetic, induces regressions in childhood acute lymphoblastic leukemia (ALL) xenografts that express TNFα and synergizes with TNFα in vitro – a report from the Pediatric Preclinical Testing Program (PPTP)Blood20121203565
   Web of Science ®Google Scholar
• CernaJDDonnaCNaokoTNormanCMAMStephenYRadiosensitization of GBM by a novel peptidomimetic of the second mitochondria-derived activator of caspases (SMAC)Paper presented at: 104th Annual Meeting of the American Association for Cancer ResearchApril 6–10, 2013Washington, DC. Philadelphia, PAAACR2013 Abstract nr 1599
   Google Scholar
• BenetatosCABurnsJMBordenECThe Smac mimetic Birinapant synergistically induces apoptosis in combination with type i interferons and GM-CSFPaper presented at: 104th Annual Meeting of the American Association for Cancer ResearchApril 6–10, 2013Washington, DC. Philadelphia, PAAACR2013 Abstract 3336
   Google Scholar
• AmaravadiRKSchilderRJDyGKPhase 1study of the Smac mimetic TL32711 in adult subjects with advanced solid tumors and lymphoma to evaluate safety, pharmacokinetics, pharmacodynamics, and antitumor activityPaper presented at: 102nd Annual Meeting of the American Association for Cancer ResearchApril 2–6, 2011Orlando, FL. Philadelphia, PAAACR2010 Abstract nr LB-406
   Google Scholar
• FlygareJABeresiniMBudhaNDiscovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152)J Med Chem20125594101411322413863
   PubMed Web of Science ®Google Scholar
• EricksonRITarrantJCainGToxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacologyToxicol Sci2013131124725822956632
   PubMed Web of Science ®Google Scholar