Advanced search
Publication Cover
International Journal of Nanomedicine Volume 1, 2006 - Issue 4
Submit an article Journal homepage
124
Views
104
CrossRef citations to date
0
Altmetric
Review

Biological and clinical characterization of paclitaxel poliglumex (PPX, CT-2103), a macromolecular polymer–drug conjugate

Stewart D ChipmanCell Therapeutics Inc., Seattle, WA, USA
,
Fred B OldhamCell Therapeutics Inc., Seattle, WA, USA
,
Gabriella PezzoniCell Therapeutics Inc., Seattle, WA, USA
&
Jack W SingerCorrespondence[email protected]
Pages 375-383 | Published online: 09 Oct 2022

Citations (104)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (6)

Moraima Morales-Cruz, Yamixa Delgado, Betzaida Castillo, Cindy M Figueroa, Anna M Molina, Anamaris Torres, Melissa Milián & Kai Griebenow. (2019) Smart Targeting To Improve Cancer Therapeutics. Drug Design, Development and Therapy 13, pages 3753-3772.
Read now
Ruo Du, Ting Zhong, Wei-Qiang Zhang, Ping Song, Wen-Ding Song, Yang Zhao, Chao Wang, Yi-Qun Tang, Xuan Zhang & Qiang Zhang. (2014) Antitumor effect of iRGD-modified liposomes containing conjugated linoleic acid–paclitaxel (CLA-PTX) on B16-F10 melanoma. International Journal of Nanomedicine 9, pages 3091-3105.
Read now
Vladimir N Uversky. (2013) The alphabet of intrinsic disorder. Intrinsically Disordered Proteins 1:1.
Read now
Wenbin Wu, Yonghui Zheng, Rui Wang, Weili Huang, Lei Liu, Xiuli Hu, Shi Liu, Jun Yue, Ti Tong & Xiabin Jing. (2012) Antitumor activity of folate-targeted, paclitaxelloaded polymeric micelles on a human esophageal EC9706 cancer cell line. International Journal of Nanomedicine 7, pages 3487-3502.
Read now
Mitsunori Harada, Caname Iwata, Hiroyuki Saito, Kenta Ishii, Tatsuyuki Hayashi, Masakazu Yashiro, Kosei Hirakawa, Kohei Miyazono, Yasuki Kato & Mitsunobu R Kano. (2012) NC-6301, a polymeric micelle rationally optimized for effective release of docetaxel, is potent but is less toxic than native docetaxel in vivo. International Journal of Nanomedicine 7, pages 2713-2727.
Read now
John Nemunaitis, Neil Senzer, Barry Cooper, Michael Nemunaitis, Cynthia Bedell, Jack W Singer & Fred B Oldham. (2011) Procoagulant inhibitory properties of paclitaxel poliglumex. International Journal of General Medicine 4, pages 5-11.
Read now

Articles from other publishers (98)

William M.R. Matshe, Lesego L. Tshweu, Sindisiwe Mvango, Zamani E.D. Cele, Avashnee S. Chetty, Lynne A. Pilcher, Ibukun M. Famuyide, Lyndy J. McGaw, Dale Taylor, Liezl Gibhard, Gregory S. Basarab & Mohammed O. Balogun. (2023) A Water‐Soluble Polymer‐Lumefantrine Conjugate for the Intravenous Treatment of Severe Malaria. Macromolecular Bioscience 23:5.
Crossref
Tetiana Melnyk, Esther Masiá, Oleksandr Zagorodko, Inmaculada Conejos-Sánchez & María J. Vicent. (2023) Rational design of poly-L-glutamic acid-palbociclib conjugates for pediatric glioma treatment. Journal of Controlled Release 355, pages 385-394.
Crossref
Dipanjan Karati & Dileep Kumar. (2022) Exploring the structural and functional requirements of Phyto-compounds and their synthetic scaffolds as anticancer agents: Medicinal chemistry perspective. Pharmacological Research - Modern Chinese Medicine 4, pages 100123.
Crossref
Nompumelelo Mthimkhulu, Karabo S. Mosiane, Ekene E. Nweke, Mohammed Balogun & Pascaline N. Fru. (2022) Prospects of Delivering Natural Compounds by Polymer-Drug Conjugates in Cancer Therapeutics. Anti-Cancer Agents in Medicinal Chemistry 22:9, pages 1699-1713.
Crossref
Elahehnaz Parhizkar, Soliman Mohammadi Samani, Amirhossein Sakhteman, Saeid Daneshamouz, Golnaz Parhizkar & Fatemeh Ahmadi. (2022) Synthesis, cytotoxicity assay, pharmacokinetics, biodistribution and modeling study of cabazitaxel-dextran nanoconjugates: targeted vs non targeted delivery. Colloids and Surfaces B: Biointerfaces 209, pages 112187.
Crossref
Zhiguo Wang & Baofeng YangZhiguo Wang & Baofeng Yang. 2022. Polypharmacology. Polypharmacology 397 533 .
Jia Su, Chao Liu, Haohao Bai, Wei Cong, Hua Tang, Honggang Hu, Li Su, Shipeng He & Yong Wang. (2022) Development of novel bone targeting peptide–drug conjugate of 13-aminomethyl-15-thiomatrine for osteoporosis therapy. RSC Advances 12:1, pages 221-227.
Crossref
Xu Wang, Ziyuan Song, Shiqi Wei, Guonan Ji, Xuetao Zheng, Zihuan Fu & Jianjun Cheng. (2021) Polypeptide-based drug delivery systems for programmed release. Biomaterials 275, pages 120913.
Crossref
Jeffrey Stiltner, Kayla McCandless & Maliha Zahid. (2021) Cell-Penetrating Peptides: Applications in Tumor Diagnosis and Therapeutics. Pharmaceutics 13:6, pages 890.
Crossref
Justyna Odrobińska & Dorota Neugebauer. (2020) PEG Grafted Polymethacrylates Bearing Antioxidants as a New Class of Polymer Conjugates for Application in Cosmetology. Materials 13:16, pages 3455.
Crossref
Bibifatima Kaupbayeva & Alan J. Russell. (2020) Polymer-enhanced biomacromolecules. Progress in Polymer Science 101, pages 101194.
Crossref
Anupam Sarma, Malay K. Das & Tapash Chakraborty. 2020. Nano Medicine and Nano Safety. Nano Medicine and Nano Safety 377 403 .
Seoungkyun Kim, Manse Kim, Secheon Jung, Kiyoon Kwon, Junyong Park, Sukhwan Kim, Inchan Kwon & Giyoong Tae. (2019) Co-delivery of therapeutic protein and catalase-mimic nanoparticle using a biocompatible nanocarrier for enhanced therapeutic effect. Journal of Controlled Release 309, pages 181-189.
Crossref
Shazia Parveen, Farukh Arjmand & Sartaj Tabassum. (2019) Clinical developments of antitumor polymer therapeutics. RSC Advances 9:43, pages 24699-24721.
Crossref
Olga Vasiljeva, Daniel R. Hostetter, Stephen J. Moore & Michael B. Winter. (2019) The multifaceted roles of tumor-associated proteases and harnessing their activity for prodrug activation. Biological Chemistry 400:8, pages 965-977.
Crossref
A. I. Petushkova, L. V. Savvateeva, D. O. Korolev & A. A. ZamyatninJr.Jr.. (2019) Cysteine Cathepsins: Potential Applications in Diagnostics and Therapy of Malignant Tumors. Biochemistry (Moscow) 84:7, pages 746-761.
Crossref
Alexander M. Cryer & Andrew J. Thorley. (2019) Nanotechnology in the diagnosis and treatment of lung cancer. Pharmacology & Therapeutics 198, pages 189-205.
Crossref
Walid S. Kamoun, Dmitri B. Kirpotin, Zhaohua Richard Huang, Suresh K. Tipparaju, Charles O. Noble, Mark E. Hayes, Lia Luus, Alexander Koshkaryev, Jaeyeon Kim, Ken Olivier, Tad Kornaga, Shinji Oyama, Vasileios Askoxylakis, Christine Pien, Geoffrey Kuesters, Nancy Dumont, Alexey A. Lugovskoy, Sarah A. Schihl, John H. Wilton, Melissa L. Geddie, James Suchy, Stephanie Grabow, Neeraj Kohli, C. Patrick Reynolds, Rachel Blaydes, Yu Zhou, Andrew J. Sawyer, James D. Marks & Daryl C. Drummond. (2019) Antitumour activity and tolerability of an EphA2-targeted nanotherapeutic in multiple mouse models. Nature Biomedical Engineering 3:4, pages 264-280.
Crossref
Katia Maso, Antonella Grigoletto, María J. Vicent & Gianfranco Pasut. 2019. 1 50 .
Gopalakrishna Pillai. 2019. Applications of Targeted Nano Drugs and Delivery Systems. Applications of Targeted Nano Drugs and Delivery Systems 221 256 .
Arunkumar Palaniappan & Indulekha Singaravelu. 2019. Biotechnology Products in Everyday Life. Biotechnology Products in Everyday Life 15 35 .
Longbing Ling, Muhammad Ismail, Yawei Du, Qing Xia, Wei He, Chen Yao & Xinsong Li. (2018) High Drug Loading, Reversible Disulfide Core-Cross-Linked Multifunctional Micelles for Triggered Release of Camptothecin. Molecular Pharmaceutics 15:12, pages 5479-5492.
Crossref
Xin Jin, Sajid Asghar, Mei Zhang, Zhipeng Chen, Lin Huang, Qineng Ping & Yanyu Xiao. (2018) N-acetylcysteine modified hyaluronic acid-paclitaxel conjugate for efficient oral chemotherapy through mucosal bioadhesion ability. Colloids and Surfaces B: Biointerfaces 172, pages 655-664.
Crossref
Juan J. Arroyo-Crespo, Ana Armiñán, David Charbonnier, Leandro Balzano-Nogueira, Francisco Huertas-López, Cristina Martí, Sonia Tarazona, Jerónimo Forteza, Ana Conesa & María J. Vicent. (2018) Tumor microenvironment-targeted poly-L-glutamic acid-based combination conjugate for enhanced triple negative breast cancer treatment. Biomaterials 186, pages 8-21.
Crossref
Sindisiwe Mvango, William M. R. Matshe, Abideen O. Balogun, Lynne A. Pilcher & Mohammed O. Balogun. (2018) Nanomedicines for Malaria Chemotherapy: Encapsulation vs. Polymer Therapeutics. Pharmaceutical Research 35:12.
Crossref
Parichehr Hassanzadeh, Fatemeh Atyabi & Rassoul Dinarvand. (2018) Ignoring the modeling approaches: Towards the shadowy paths in nanomedicine. Journal of Controlled Release 280, pages 58-75.
Crossref
Rajan Jog & Diane J. Burgess. 2018. Fundamentals of Nanoparticles. Fundamentals of Nanoparticles 279 342 .
Handan Yavuz, Kemal Çetin, Semra Akgönüllü, Dilek Battal & Adil Denizli. 2018. Design and Development of New Nanocarriers. Design and Development of New Nanocarriers 439 473 .
Sheikh Tasnim Jahan, Sams M. A. Sadat, Matthew Walliser & Azita Haddadi. (2017) Targeted Therapeutic Nanoparticles: An Immense Promise to Fight against Cancer. Journal of Drug Delivery 2017, pages 1-24.
Crossref
Lin Han, Ye Xiao, Mingxue Fan, Jing Wang, Zhiqiang Yan, Yiting Wang, Lei Yu, Hui Peng & Jianzhong Zhu. (2017) Synthesis and biological evaluation of an anticancer drug delivery system: Poly(l-γ-glutamyl-l-carbocisteine)-paclitaxel nanoconjugate. Materials Science and Engineering: C 81, pages 113-119.
Crossref
Daniel Merk & Manfred Schubert-Zsilavecz. 2017. Drug Selectivity. Drug Selectivity 207 245 .
Ezequiel Bernabeu, Maximiliano Cagel, Eduardo Lagomarsino, Marcela Moretton & Diego A. Chiappetta. (2017) Paclitaxel: What has been done and the challenges remain ahead. International Journal of Pharmaceutics 526:1-2, pages 474-495.
Crossref
Lik Voon Kiew, Hoay Yan Cheah, Siew Hui Voon, Elena Gallon, Julie Movellan, Kia Hui Ng, Serkan Alpugan, Hong Boon Lee, Fabienne Dumoulin, María J. Vicent & Lip Yong Chung. (2017) Near-infrared activatable phthalocyanine-poly-L-glutamic acid conjugate: increased cellular uptake and light–dark toxicity ratio toward an effective photodynamic cancer therapy. Nanomedicine: Nanotechnology, Biology and Medicine 13:4, pages 1447-1458.
Crossref
Benoit Louage, Olivier De Wever, Wim E. Hennink & Bruno G De Geest. (2017) Developments and future clinical outlook of taxane nanomedicines. Journal of Controlled Release 253, pages 137-152.
Crossref
Antonio Tabernero, Álvaro González-Garcinuño, José Mª Sánchez-Álvarez, Miguel A. Galán & Eva M. Martín del Valle. (2017) Development of a nanoparticle system based on a fructose polymer: Stability and drug release studies. Carbohydrate Polymers 160, pages 26-33.
Crossref
Sam P Tarassoli, Alejandra Martinez de Pinillos Bayona, Hayley Pye, C Alexander Mosse, John F Callan, Alexander MacRobert, Anthony P McHale & Nikolitsa Nomikou. (2017) Cathepsin B-degradable, NIR-responsive nanoparticulate platform for target-specific cancer therapy. Nanotechnology 28:5, pages 055101.
Crossref
S.-H. Kim, T.H. Nguyen & H.D. Maynard. 2017. Comprehensive Biomaterials II. Comprehensive Biomaterials II 493 505 .
Ju Yeon Choi, Raj Kumar Thapa, Chul Soon Yong & Jong Oh Kim. (2016) Nanoparticle-based combination drug delivery systems for synergistic cancer treatment. Journal of Pharmaceutical Investigation 46:4, pages 325-339.
Crossref
Qingxuan Li, Lu Gan, Hong Tao, Qian Wang, Lin Ye, Aiying Zhang & Zengguo Feng. (2016) The synthesis and application of heparin-based smart drug carrier. Carbohydrate Polymers 140, pages 260-268.
Crossref
Qin Song, Xing Wang, Yaoqi Wang, Yanqin Liang, Yanxia Zhou, Xiaoning Song, Bing He, Hua Zhang, Wenbing Dai, Xueqing Wang & Qiang Zhang. (2015) Reduction Responsive Self-Assembled Nanoparticles Based on Disulfide-Linked Drug–Drug Conjugate with High Drug Loading and Antitumor Efficacy. Molecular Pharmaceutics 13:1, pages 190-201.
Crossref
Zhihui Su, Yanchao Liang, Yao Yao, Tianqi Wang & Na Zhang. (2016) Polymeric complex micelles based on the double-hydrazone linkage and dual drug-loading strategy for pH-sensitive docetaxel delivery. Journal of Materials Chemistry B 4:6, pages 1122-1133.
Crossref
Suchithra A. Senevirathne, Katherine E. Washington, Michael C. Biewer & Mihaela C. Stefan. (2016) PEG based anti-cancer drug conjugated prodrug micelles for the delivery of anti-cancer agents. Journal of Materials Chemistry B 4:3, pages 360-370.
Crossref
Dalit Landesman-Milo, Shahd Qassem & Dan Peer. 2016. Nanomedicine. Nanomedicine 131 155 .
Swapnil S. Desale, Jinjin Zhang & Tatiana K. Bronich. 2016. Nanomaterials in Pharmacology. Nanomaterials in Pharmacology 1 26 .
Aljona Gaiko-Shcherbak, Gloria Fabris, Georg Dreissen, Rudolf Merkel, Bernd Hoffmann & Erik Noetzel. (2015) The Acinar Cage: Basement Membranes Determine Molecule Exchange and Mechanical Stability of Human Breast Cell Acini. PLOS ONE 10:12, pages e0145174.
Crossref
Sophie Marchal, Amélie El Hor, Marie Millard, Véronique Gillon & Lina Bezdetnaya. (2015) Anticancer Drug Delivery: An Update on Clinically Applied Nanotherapeutics. Drugs 75:14, pages 1601-1611.
Crossref
James W.A. Ritchie & Robert J. Williams. (2015) Cancer Research UK Centre for Drug Development: translating 21st-century science into the cancer medicines of tomorrow. Drug Discovery Today 20:8, pages 995-1003.
Crossref
Dalit Landesman-Milo, Srinivas Ramishetti & Dan Peer. (2015) Nanomedicine as an emerging platform for metastatic lung cancer therapy. Cancer and Metastasis Reviews 34:2, pages 291-301.
Crossref
Hairong Wang, Jinlin He, Dongling Cao, Mingzu Zhang, Fei Li, Kam Chiu Tam & Peihong Ni. (2015) Synthesis of an acid-labile polymeric prodrug DOX-acetal-PEG-acetal-DOX with high drug loading content for pH-triggered intracellular drug release. Polymer Chemistry 6:26, pages 4809-4818.
Crossref
Ana Sousa-Herves, Patrick Würfel, Nicole Wegner, Jayant Khandare, Kai Licha, Rainer Haag, Pia Welker & Marcelo Calderón. (2015) Dendritic polyglycerol sulfate as a novel platform for paclitaxel delivery: pitfalls of ester linkage. Nanoscale 7:9, pages 3923-3932.
Crossref
Te-Wei Chu & Jindřich Kopeček. (2015) Drug-free macromolecular therapeutics – a new paradigm in polymeric nanomedicines. Biomaterials Science 3:7, pages 908-922.
Crossref
Inmaculada Conejos-Sánchez, Isabel Cardoso, Marta Oteo-Vives, Eduardo Romero-Sanz, Alison Paul, Amparo Ruiz Sauri, Miguel A. Morcillo, Maria J. Saraiva & María J. Vicent. (2015) Polymer-doxycycline conjugates as fibril disrupters: An approach towards the treatment of a rare amyloidotic disease. Journal of Controlled Release 198, pages 80-90.
Crossref
Tom O. McDonald, Marco Siccardi, Darren Moss, Neill Liptrott, Marco Giardiello, Steve Rannard & Andrew Owen. 2015. Nanoengineering. Nanoengineering 173 223 .
Anjan Kumar Mohanty, Fahima Dilnawaz, Guru Prasad Mohanta & Sanjeeb Kumar Sahoo. 2015. Targeted Drug Delivery : Concepts and Design. Targeted Drug Delivery : Concepts and Design 389 407 .
João Conniot, Joana M. Silva, Joana G. Fernandes, Liana C. Silva, Rogério Gaspar, Steve Brocchini, Helena F. Florindo & Teresa S. Barata. (2014) Cancer immunotherapy: nanodelivery approaches for immune cell targeting and tracking. Frontiers in Chemistry 2.
Crossref
Emma M. Pelegri-O’Day, En-Wei Lin & Heather D. Maynard. (2014) Therapeutic Protein–Polymer Conjugates: Advancing Beyond PEGylation. Journal of the American Chemical Society 136:41, pages 14323-14332.
Crossref
Amit Rajora, Divyashree Ravishankar, Helen Osborn & Francesca Greco. (2014) Impact of the Enhanced Permeability and Retention (EPR) Effect and Cathepsins Levels on the Activity of Polymer-Drug Conjugates. Polymers 6:8, pages 2186-2220.
Crossref
Wanyi Tai, Ran Mo, Yue Lu, Tianyue Jiang & Zhen Gu. (2014) Folding graft copolymer with pendant drug segments for co-delivery of anticancer drugs. Biomaterials 35:25, pages 7194-7203.
Crossref
Tanima Bose, Diane Latawiec, Partha Pratim Mondal & Subhra Mandal. (2014) Overview of nano-drugs characteristics for clinical application: the journey from the entry to the exit point. Journal of Nanoparticle Research 16:8.
Crossref
Kevin S. Chu, Mathew C. Finniss, Allison N. Schorzman, Jennifer L. Kuijer, J. Christopher Luft, Charles J. Bowerman, Mary E. Napier, Zishan A. Haroon, William C. Zamboni & Joseph M. DeSimone. (2014) Particle Replication in Nonwetting Templates Nanoparticles with Tumor Selective Alkyl Silyl Ether Docetaxel Prodrug Reduces Toxicity. Nano Letters 14:3, pages 1472-1476.
Crossref
Jabeena Khazir, Bilal Ahmad Mir, Lynne Pilcher & Darren L. Riley. (2014) Role of plants in anticancer drug discovery. Phytochemistry Letters 7, pages 173-181.
Crossref
Mitulkumar A. Patel & Benedict Law. 2014. Engineering in Translational Medicine. Engineering in Translational Medicine 691 731 .
Nate Larson, Jiyuan Yang, Abhijit Ray, Darwin L. Cheney, Hamidreza Ghandehari & Jindřich Kopeček. (2013) Biodegradable multiblock poly(N-2-hydroxypropyl)methacrylamide gemcitabine and paclitaxel conjugates for ovarian cancer cell combination treatment. International Journal of Pharmaceutics 454:1, pages 435-443.
Crossref
Ruth Duncan, Yee-Nee Sat-Klopsch, Angelika M. Burger, Michael C. Bibby, Heinz H. Fiebig & Edward A. Sausville. (2013) Validation of tumour models for use in anticancer nanomedicine evaluation: the EPR effect and cathepsin B-mediated drug release rate. Cancer Chemotherapy and Pharmacology 72:2, pages 417-427.
Crossref
Venkat Ratnam Devadasu, Vivekanand Bhardwaj & M. N. V. Ravi Kumar. (2012) Can Controversial Nanotechnology Promise Drug Delivery?. Chemical Reviews 113:3, pages 1686-1735.
Crossref
Hye-Rim Lee & Kyung-Chul Choi. (2013) 4-tert-Octylphenol stimulates the expression of cathepsins in human breast cancer cells and xenografted breast tumors of a mouse model via an estrogen receptor-mediated signaling pathway. Toxicology 304, pages 13-20.
Crossref
Rui Zhang, Kui Luo, Jiyuan Yang, Monika Sima, Yongen Sun, Margit M. Janát-Amsbury & Jindřich Kopeček. (2013) Synthesis and evaluation of a backbone biodegradable multiblock HPMA copolymer nanocarrier for the systemic delivery of paclitaxel. Journal of Controlled Release 166:1, pages 66-74.
Crossref
Gopalakrishna Pillai & Maria L Ceballos-Coronel. (2013) Science and technology of the emerging nanomedicines in cancer therapy: A primer for physicians and pharmacists. SAGE Open Medicine 1, pages 205031211351375.
Crossref
Inmaculada Conejos-Sánchez, Aroa Duro-Castano, Alexander Birke, Matthias Barz & María J. Vicent. (2013) A controlled and versatile NCA polymerization method for the synthesis of polypeptides. Polymer Chemistry 4:11, pages 3182.
Crossref
Sonke Svenson. (2012) Clinical translation of nanomedicines. Current Opinion in Solid State and Materials Science 16:6, pages 287-294.
Crossref
Barbara Mognetti, Alessandro Barberis, Silvia Marino, Giovanni Berta, Silvia Francia, Francesco Trotta & Roberta Cavalli. (2012) In vitro enhancement of anticancer activity of paclitaxel by a Cremophor free cyclodextrin-based nanosponge formulation. Journal of Inclusion Phenomena and Macrocyclic Chemistry 74:1-4, pages 201-210.
Crossref
Richard M. England, Inmaculada Conejos–sánchez & María J. Vicent*. 2012. Nanostructured Biomaterials for Overcoming Biological Barriers. Nanostructured Biomaterials for Overcoming Biological Barriers 456 482 .
Ela Markovsky, Hemda Baabur-Cohen, Anat Eldar-Boock, Liora Omer, Galia Tiram, Shiran Ferber, Paula Ofek, Dina Polyak, Anna Scomparin & Ronit Satchi-Fainaro. (2012) Administration, distribution, metabolism and elimination of polymer therapeutics. Journal of Controlled Release 161:2, pages 446-460.
Crossref
Nate Larson & Hamidreza Ghandehari. (2012) Polymeric Conjugates for Drug Delivery. Chemistry of Materials 24:5, pages 840-853.
Crossref
Saurabh Wadhwa & Russell J. Mumper. (2012) Polypeptide conjugates of d-penicillamine and idarubicin for anticancer therapy. Journal of Controlled Release 158:2, pages 215-223.
Crossref
Shuang Cai, Taryn R Bagby & M Laird Forrest. (2011) Development of regional chemotherapies: feasibility, safety and efficacy in clinical use and preclinical studies. Therapeutic Delivery 2:11, pages 1467-1484.
Crossref
Khalid Abu Ajaj & Felix Kratz. 2011. Drug Delivery in Oncology. Drug Delivery in Oncology 839 884 .
Coralie Deladriere, Rut Lucas & María J. Vicent. 2011. Drug Delivery in Oncology. Drug Delivery in Oncology 805 837 .
Ruth Duncan. (2011) Polymer therapeutics as nanomedicines: new perspectives. Current Opinion in Biotechnology 22:4, pages 492-501.
Crossref
Michael K. Danquah, Xin A. Zhang & Ram I. Mahato. (2011) Extravasation of polymeric nanomedicines across tumor vasculature. Advanced Drug Delivery Reviews 63:8, pages 623-639.
Crossref
Jeremy D. Heidel & Mark E. Davis. (2010) Clinical Developments in Nanotechnology for Cancer Therapy. Pharmaceutical Research 28:2, pages 187-199.
Crossref
Matthias Barz, Robert Luxenhofer, Rudolf Zentel & María J. Vicent. (2011) Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics. Polymer Chemistry 2:9, pages 1900.
Crossref
S.-H. Kim, T.H. Nguyen & H.D. Maynard. 2011. Comprehensive Biomaterials. Comprehensive Biomaterials 377 388 .
Giuseppe Cirillo, Kai Kraemer, Susanne Fuessel, Francesco Puoci, Manuela Curcio, Umile Gianfranco Spizzirri, Ilaria Altimari & Francesca Iemma. (2010) Biological Activity of a Gallic Acid−Gelatin Conjugate. Biomacromolecules 11:12, pages 3309-3315.
Crossref
Joaquin Sanchis, Fabiana Canal, Rut Lucas & María J Vicent. (2010) Polymer–drug conjugates for novel molecular targets. Nanomedicine 5:6, pages 915-935.
Crossref
Katrin SplithWanning HuUlrich SchatzschneiderRonald GustIngo OttLiliane A. OnambeleAram ProkopInes Neundorf. (2010) Protease-Activatable Organometal−Peptide Bioconjugates with Enhanced Cytotoxicity on Cancer Cells. Bioconjugate Chemistry 21:7, pages 1288-1296.
Crossref
Bojana Apostolovic, Samuel P. E. Deacon, Ruth Duncan & Harm-Anton Klok. (2010) Hybrid Polymer Therapeutics Incorporating Bioresponsive, Coiled Coil Peptide Linkers. Biomacromolecules 11:5, pages 1187-1195.
Crossref
Jack W. Singer, Marc McKennon, Gabriella Pezzoni, Stefano di Giovine, Mara Cassin, Paola de Feudis, Cecilia Allievi, Patrizia Angiuli, Marco Natangelo, Enrico Vezzali & Stefano Fazioni. 2010. Macromolecular Anticancer Therapeutics. Macromolecular Anticancer Therapeutics 133 161 .
Franco Dosio, Silvia Arpicco, Barbara Stella, Paola Brusa & Luigi Cattel. (2009) Folate-mediated targeting of albumin conjugates of paclitaxel obtained through a heterogeneous phase system. International Journal of Pharmaceutics 382:1-2, pages 117-123.
Crossref
María J. Vicent, Helmut Ringsdorf & Ruth Duncan. (2009) Polymer therapeutics: Clinical applications and challenges for development. Advanced Drug Delivery Reviews 61:13, pages 1117-1120.
Crossref
Ruth Duncan. (2009) Development of HPMA copolymer–anticancer conjugates: Clinical experience and lessons learnt. Advanced Drug Delivery Reviews 61:13, pages 1131-1148.
Crossref
Francesca Greco & María J. Vicent. (2009) Combination therapy: Opportunities and challenges for polymer–drug conjugates as anticancer nanomedicines. Advanced Drug Delivery Reviews 61:13, pages 1203-1213.
Crossref
A. Cirstoiu-Hapca, F. Buchegger, L. Bossy, M. Kosinski, R. Gurny & F. Delie. (2009) Nanomedicines for active targeting: Physico-chemical characterization of paclitaxel-loaded anti-HER2 immunonanoparticles and in vitro functional studies on target cells. European Journal of Pharmaceutical Sciences 38:3, pages 230-237.
Crossref
Ding-Ding Guo, Cheng-Xiong Xu, Ji-Shan Quan, Chung-Kil Song, Hua Jin, Dae-Duk Kim, Yun-Jaie Choi, Myung-Haing Cho & Chong-Su Cho. (2009) Synergistic anti-tumor activity of paclitaxel-incorporated conjugated linoleic acid-coupled poloxamer thermosensitive hydrogel in vitro and in vivo. Biomaterials 30:27, pages 4777-4785.
Crossref
Anna Mero, Oddone Schiavon, Gianfranco Pasut, Francesco M. VeroneseElisa Emilitri & Paolo Ferruti. (2009) A Biodegradable Polymeric Carrier Based on PEG for Drug Delivery. Journal of Bioactive and Compatible Polymers 24:3, pages 220-234.
Crossref
Mark A. Morgan, Kathleen M. Darcy, Peter G. Rose, Koen DeGeest, Michael A. Bookman, James K. Aikins, Michael W. Sill, Robert S. Mannel, Cecilia Allievi & Merrill J. Egorin. (2008) Paclitaxel poliglumex and carboplatin as first-line therapy in ovarian, peritoneal or fallopian tube cancer: A phase I and feasibility trial of the Gynecologic Oncology Group. Gynecologic Oncology 110:3, pages 329-335.
Crossref
Francesca Leonelli, Angela La Bella, Luisa Migneco & Rinaldo Bettolo. (2008) Design, Synthesis and Applications of Hyaluronic Acid-Paclitaxel Bioconjugates†. Molecules 13:2, pages 360-378.
Crossref
Hans K. Lorenzo & Santos A. Susin. (2007) Therapeutic potential of AIF-mediated caspase-independent programmed cell death. Drug Resistance Updates 10:6, pages 235-255.
Crossref

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.