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Review

Review of the safety, efficacy and patient acceptability of the levonorgestrel-releasing intrauterine system

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Pages 293-302 | Published online: 21 Oct 2008

Keep up to date with the latest research on this topic with citation updates for this article.

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Giulio Evangelisti, Fabio Barra, Umberto Perrone, Nadine Di Donato, Stefano Bogliolo, Marcello Ceccaroni & Simone Ferrero. (2022) Comparing the pharmacokinetic and pharmacodynamic qualities of current and future therapies for uterine fibroids. Expert Opinion on Drug Metabolism & Toxicology 18:7-8, pages 441-457.
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Andrea J Rapkin, Yelena Korotkaya & Kathrine C Taylor. (2019) Contraception counseling for women with premenstrual dysphoric disorder (PMDD): current perspectives. Open Access Journal of Contraception 10, pages 27-39.
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J. Bitzer, A. Rapkin & C. N. Soares. (2018) Managing the risks of mood symptoms with LNG-IUS: a clinical perspective. The European Journal of Contraception & Reproductive Health Care 23:5, pages 321-325.
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Xiaoning Chen, Qianxi Li, Xiaoye Wang, Jing Chen, Wen Lv, Bin Shi, Hong Wang, Jianru Luo & Jian Li. (2018) Bleeding pattern difference between levonorgestrel intrauterine system and copper intrauterine devices inserted immediately post-abortion: a multicenter, prospective, observational cohort study in Chinese women. Current Medical Research and Opinion 34:5, pages 873-880.
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Nataliya Brima, Hannat Akintomide, Vivian Iguyovwe & Susan Mann. (2015) A comparison of the expected and actual pain experienced by women during insertion of an intrauterine contraceptive device. Open Access Journal of Contraception 6, pages 21-26.
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Articles from other publishers (20)

Beth I. Schwartz, Benjamin Bear, Vanessa L. Short & Anne E. Kazak. (2023) Outcomes of Menstrual Management Use in Transgender and Gender-Diverse Adolescents. Obstetrics & Gynecology 141:4, pages 748-755.
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Beth I. Schwartz, Benjamin Bear & Anne E. Kazak. (2023) Menstrual Management Choices in Transgender and Gender Diverse Adolescents. Journal of Adolescent Health 72:2, pages 207-213.
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Søren Vinther Larsen, Brice Ozenne, Kristin Köhler-Forsberg, Asbjørn Seenithamby Poulsen, Vibeke Høyrup Dam, Claus Svarer, Gitte Moos Knudsen, Martin Balslev Jørgensen & Vibe Gedso Frokjaer. (2022) The Impact of Hormonal Contraceptive Use on Serotonergic Neurotransmission and Antidepressant Treatment Response: Results From the NeuroPharm 1 Study. Frontiers in Endocrinology 13.
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Karina Castillo, Kevin Zambrano, Diego Barba, Paola Robayo, Serena Sanon, Andres Caicedo & Alfredo Jose Jijon Chiriboga. (2022) Long-acting reversible contraceptives effects in abnormal uterine bleeding, a review of the physiology and management. European Journal of Obstetrics & Gynecology and Reproductive Biology 270, pages 231-238.
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Karlijn Pellikaan, Yassine Ben Brahim, Anna G. W. Rosenberg, Kirsten Davidse, Christine Poitou, Muriel Coupaye, Anthony P. Goldstone, Charlotte Høybye, Tania P. Markovic, Graziano Grugni, Antonino Crinò, Assumpta Caixàs, Talia Eldar-Geva, Harry J. Hirsch, Varda Gross-Tsur, Merlin G. Butler, Jennifer L. Miller, Paul-Hugo M. van der Kuy, Sjoerd A. A. van den Berg, Jenny A. Visser, Aart J. van der Lely & Laura C. G. de Graaff. (2021) Hypogonadism in Women with Prader-Willi Syndrome—Clinical Recommendations Based on a Dutch Cohort Study, Review of the Literature and an International Expert Panel Discussion. Journal of Clinical Medicine 10:24, pages 5781.
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Rebecca Gormley, Brian Vickers, Brooke Cheng & Wendy V. Norman. (2021) Comparing options for females seeking permanent contraception in high resource countries: a systematic review. Reproductive Health 18:1.
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Fabio R. Silva, Antonio Jose Grande, Ana Cristina Lacerda Macedo, Tamy Colonetti, Marina C. Rocha, Maria Laura Rodrigues Uggioni, Bruno R. Silva & Maria Inês da Rosa. (2021) Meta-Analysis of Breast Cancer Risk in Levonorgestrel-Releasing Intrauterine System Users. Clinical Breast Cancer 21:6, pages 497-508.
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Aurelian Ghita, Cristina Alexandrescu, Sanziana Istrate, Anca Evsei & Ana Ghita. (2021) Vasculitis associated with the use of an intrauterine device: A case report. Experimental and Therapeutic Medicine 22:5.
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Sophie E. Aapkes, Lucas H. P. Bernts, Thijs R. M. Barten, Marjan Berg, Ron T. Gansevoort & Joost P. H. Drenth. (2021) Estrogens in polycystic liver disease: A target for future therapies?. Liver International 41:9, pages 2009-2019.
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Magdalena Zgliczynska, Karol Kocaj, Iwona Szymusik, Magdalena Maria Dutsch-Wicherek, Michal Ciebiera & Katarzyna Kosinska-Kaczynska. (2020) Levonorgestrel-Releasing Intrauterine System as a Contraceptive Method in Nulliparous Women: A Systematic Review. Journal of Clinical Medicine 9:7, pages 2101.
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Ahmed M. Abbas, Ahmed Samy, Khaled Atwa, Hanan M. Ghoneim, Mariam Lotfy, Heba Saber Mohammed, Asmaa M. Abdellah, Amira M. El Bahie, Ahmed A. Aboelroose, Asmaa M. El Gedawy, Mona Mostafa, Mohamed A. Elsenity, Mohammed Samy, Sarah Safwat, Rehab M. Abdelrahman, Adel S. Salah El Din, Esraa Badran, Abdelrahman M. Abdelkader & Ameer Abdallah. (2020) The role of levonorgestrel intra‐uterine system in the management of adenomyosis: A systematic review and meta‐analysis of prospective studies. Acta Obstetricia et Gynecologica Scandinavica 99:5, pages 571-581.
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Georgios A. Maragkos, Rouzbeh Motiei-Langroudi, Aristotelis S. Filippidis & Efstathios Papavassiliou. (2019) Intracranial hypertension after Chiari decompression resolving after removal of a levonorgestrel-releasing intrauterine device: case report. Journal of Neurosurgery 131:4, pages 1000-1003.
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Claire Langlade, Amandine Gouverneur, Pauline Bosco‐Lévy, Aurore Gouraud, Marie‐Christine Pérault‐Pochat, Johana Béné, Ghada Miremont‐Salamé & Antoine Pariente. (2019) Adverse events reported for Mirena levonorgestrel‐releasing intrauterine device in France and impact of media coverage. British Journal of Clinical Pharmacology 85:9, pages 2126-2133.
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Pauline Bosco-Lévy, Amandine Gouverneur, Claire Langlade, Ghada Miremont & Antoine Pariente. (2019) Safety of levonorgestrel 52 mg intrauterine system compared to copper intrauterine device: a population-based cohort study. Contraception 99:6, pages 345-349.
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Talia Sierra. (2019) Helping patients select long-acting reversible contraceptives. JAAPA 32:4, pages 23-27.
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Karthik Tappa, Udayabhanu Jammalamadaka, David H. Ballard, Todd Bruno, Marissa R. Israel, Harika Vemula, J. Mark Meacham, David K. Mills, Pamela K Woodard & Jeffery A. Weisman. (2017) Medication eluting devices for the field of OBGYN (MEDOBGYN): 3D printed biodegradable hormone eluting constructs, a proof of concept study. PLOS ONE 12:8, pages e0182929.
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Jurate Aleknaviciute, Joke H.M. Tulen, Yolanda B. De Rijke, Christian G. Bouwkamp, Mark van der Kroeg, Mirjam Timmermans, Vincent L. Wester, Veerle Bergink, Witte J.G. Hoogendijk, Henning Tiemeier, Elisabeth F.C. van Rossum, Cornelis G. Kooiman & Steven A. Kushner. (2017) The levonorgestrel-releasing intrauterine device potentiates stress reactivity. Psychoneuroendocrinology 80, pages 39-45.
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Joanna Davies & Rezan A. Kadir. (2017) Heavy menstrual bleeding: An update on management. Thrombosis Research 151, pages S70-S77.
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Carla Maria Araujo Andrade, Edward Araujo Júnior, Maria Regina Torloni, Antonio Fernandes Moron & Cristina Aparecida Falbo Guazzelli. (2016) Three-dimensional versus two-dimensional ultrasound for assessing levonorgestrel intrauterine device location: A pilot study. Journal of Clinical Ultrasound 44:2, pages 72-77.
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Margaret Perry. (2014) Using the levonorgestrel intrauterine system. Practice Nursing 25:3, pages 130-135.
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