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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 8
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Animal Pharmacokinetics and Metabolism

Pharmacokinetics and metabolism of AMG 232, a novel orally bioavailable inhibitor of the MDM2–p53 interaction, in rats, dogs and monkeys: in vitro–in vivo correlation

Qiuping YeDepartment of Pharmacokinetics and Drug Metabolism and Correspondence[email protected]
,
Min JiangDepartment of Pharmacokinetics and Drug Metabolism and
,
Wotang T. HuangDepartment of Pharmacokinetics and Drug Metabolism and
,
Yun LingDepartment of Pharmacokinetics and Drug Metabolism and
,
Steven H. OlsonDepartment of Therapeutic Discovery, Amgen Inc., South San Francisco, CA, USA
,
Daqing SunDepartment of Therapeutic Discovery, Amgen Inc., South San Francisco, CA, USA
,
Guifen XuDepartment of Pharmacokinetics and Drug Metabolism and
,
Xuelei YanDepartment of Therapeutic Discovery, Amgen Inc., South San Francisco, CA, USA
,
Bradley K. WongDepartment of Pharmacokinetics and Drug Metabolism and
&
Lixia JinDepartment of Pharmacokinetics and Drug Metabolism and
show all
Pages 681-692 | Received 29 Oct 2014, Accepted 19 Jan 2015, Published online: 23 Mar 2015

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Lu Zhang, Bill Poland, Michelle Green, Shekman Wong & J. Greg Slatter. (2022) A population pharmacokinetic-pharmacodynamic model of navtemadlin, its glucuronide metabolite (M1) and serum macrophage inhibitory cykokine-1 (MIC-1). Xenobiotica 52:6, pages 555-566.
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Articles from other publishers (9)

Amanda B. Kagan, Nicole M. Anders, Avelina Hemingway, Eudocia Q. Lee, Kevin R. Kelly, Hans C. Lee, Meng Xu‐Welliver, Richard Piekarz & Michelle A. Rudek. (2022) Quantitation of navtemadlin in human plasma and brain tissue by liquid chromatography–tandem mass spectrometry. Biomedical Chromatography 36:11.
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Shuai Wang & Fen-Er Chen. (2022) Small-molecule MDM2 inhibitors in clinical trials for cancer therapy. European Journal of Medicinal Chemistry 236, pages 114334.
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Shekman Wong, Cecile Krejsa, Dana Lee, Anna Harris, Emilie Simard, Xiaohui Wang, Martine Allard, Terry Podoll, Terry O'Reilly & J. Greg Slatter. (2022) Pharmacokinetics and Macrophage Inhibitory Cytokine‐1 Pharmacodynamics of the Murine Double Minute 2 Inhibitor, Navtemadlin (KRT‐232) in Fed and Fasted Healthy Subjects. Clinical Pharmacology in Drug Development 11:5, pages 640-653.
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Adekemi Taylor, Dana Lee, Martine Allard, Bill Poland & J. Greg Slatter. (2021) Phase 1 Concentration‐QTc and Cardiac Safety Analysis of the MDM2 Antagonist KRT‐232 in Patients With Advanced Solid Tumors, Multiple Myeloma, or Acute Myeloid Leukemia. Clinical Pharmacology in Drug Development.
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Yosup Rew & John Eksterowicz. 2020. Protein – Protein Interaction Regulators. Protein – Protein Interaction Regulators 280 301 .
Guochao Liao, Deying Yang, Leilei Ma, Wenwei Li, Liqin Hu, Liming Zeng, Peng Wu, Lixin Duan & Zhongqiu Liu. (2018) The development of piperidinones as potent MDM2-P53 protein-protein interaction inhibitors for cancer therapy. European Journal of Medicinal Chemistry 159, pages 1-9.
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I.R. Hardcastle. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 154 201 .
Ian Robert Hardcastle. 2018. Cancer II. Cancer II 399 399 .
Natalia Estrada-Ortiz, Constantinos G. Neochoritis & Alexander Dömling. (2016) How To Design a Successful p53-MDM2/X Interaction Inhibitor: A Thorough Overview Based on Crystal Structures. ChemMedChem 11:8, pages 757-772.
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