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Xenobiotica
the fate of foreign compounds in biological systems
Volume 6, 1976 - Issue 7
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Original Article

A New Metabolic Pathway of Bromazepam Involving Attachment of a Methylthio Group

Mitsuru Tateishi Nippon Roche Research Center, Department of Biochemistry, Kajiwara, Kamakura, Japan
&
Hirotoshi Shimizu Nippon Roche Research Center, Department of Biochemistry, Kajiwara, Kamakura, Japan
Pages 431-439 | Received 08 Dec 1975, Published online: 30 Sep 2009

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Mitsuru Tateishi. (1983) Methylthlolated Metabolites. Drug Metabolism Reviews 14:6, pages 1207-1234.
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S. J. Hart, K. Healey, M. C. Smail & I. C. Calder. (1982) 3-Thiomethylparacetamol sulphate and glucuronide: metabolites of paracetamol and N-hydroxyparacetamol. Xenobiotica 12:6, pages 381-386.
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R. Kaul, B. Hempel & G. Kiefer. (1982) Structure of a novel sulphur-containing metabolite of Acluracil (1-allyl-3,5-diethyl-6-chlorouracil). Xenobiotica 12:8, pages 495-498.
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J. J. Rafter & L. Nilsson. (1981) Involvement of the intestinal microflora in the formation of sulphur-containing metabolites of caffeine. Xenobiotica 11:11, pages 771-778.
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I. J. G. Climie, D. H. Hutson & G. Stoydin. (1981) Metabolism of the epoxy resin component 2,2-bis[4-(2,3-epoxypropoxy)phenyl]propane, the diglycidyl ether of bisphenol a (DGEBPA) in the mouse.; Part II. Identification of metabolites in urine and faeces following a single oral dose of 14C-DGEBPA. Xenobiotica 11:6, pages 401-424.
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Peter Jenner & Bernard Testa. (1978) Novel Pathways in Drug Metabolism. Xenobiotica 8:1, pages 1-25.
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Articles from other publishers (20)

Thambi Dorai, John T. Pinto, Travis T. Denton, Boris F. Krasnikov & Arthur J.L. Cooper. (2022) The metabolic importance of the glutaminase II pathway in normal and cancerous cells. Analytical Biochemistry 644, pages 114083.
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Yorishige Imamura, Atsuko Noda, Takafumi Imamura, Yoko Ono, Tadashi Okawara & Hiroshi Noda. (2003) A novel methylthio metabolite of s-triazolo[3,4-a]phthalazine, a lead compound for the development of antianxiety drugs, in rats. Life Sciences 74:1, pages 29-36.
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Seija Sinkkonen. (1993) Environmental analysis of chlorinated aromatic thioethers, sulphoxides and sulphones. Journal of Chromatography A 642:1-2, pages 47-52.
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Marjorie G. Horning, Khingkan Lertratanangkoon & Brian S. Middleditch. (2005) Mass spectrometry of methylthio metabolites of aromatic hydrocarbons and related substances. Mass Spectrometry Reviews 8:3, pages 147-164.
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M.G. Horning, L.-S. Sheng, J.G. Nowlin, K. Lertratanangkoon & E.C. Horning. (1987) Analytical methods for the study of urinary thioether metabolites in the rat and guinea pig. Journal of Chromatography A 399, pages 303-319.
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T Mio & K Sumino. (1985) Mechanism of biosynthesis of methylsulfones from PCBs and related compounds.. Environmental Health Perspectives 59, pages 129-135.
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James L. Stevens & William B. Jakoby. 1985. Glutamate, Glutamine, Glutathione, and Related Compounds. Glutamate, Glutamine, Glutathione, and Related Compounds 510 515 .
John A. Nash, Laurence J. King, Edward A. Lock & Trevor Green. (1984) The metabolism and disposition of hexachloro-1:3-butadiene in the rat and its relevance to nephrotoxicity. Toxicology and Applied Pharmacology 73:1, pages 124-137.
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H Tomisawa, S Suzuki, S Ichihara, H Fukazawa & M Tateishi. (1984) Purification and characterization of C-S lyase from Fusobacterium varium. A C-S cleavage enzyme of cysteine conjugates and some S-containing amino acids.. Journal of Biological Chemistry 259:4, pages 2588-2593.
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Ravinder Kaul, Bernd Hempel & Gebhard Kiefer. (1982) 2- 14C-1 -Allyl-3,5-diethyl-6-chlorouracil II: Isolation and Structures of the Major Sulfur-Free and Three Minor Sulfur-Containing Metabolites and Mechanism of Biotransformation. Journal of Pharmaceutical Sciences 71:8, pages 897-900.
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S. Suzuki, H. Tomisawa, S. Ichihara, H. Fukazawa & M. Tateishi. (1982) A C-S bond cleavage enzyme of cysteine conjugates in intestinal microorganisms. Biochemical Pharmacology 31:11, pages 2137-2140.
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W.G. Stillwell. (1981) Methylthilation: a new pathway of drug metabolism. Trends in Pharmacological Sciences 2, pages 250-252.
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M. Tateishi, C. Koitabashi & S. Ichihara. (1980) New metabolites of isopropylantipyrine in the rat. Biochemical Pharmacology 29:19, pages 2705-2708.
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?ke Bergman, Ingvar Brandt, Ywonne Larsson & Carl Axel Wachtmeister. (1980) Cysteine and methionine?Precursors of methyl sulphone metabolites of 2,4?,5-trichlorobiphenyl in mice. Chemico-Biological Interactions 31:1, pages 65-71.
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M. TATEISHI & HIROTOSHI SHIMIZU. 1980. Enzymatic Basis of Detoxication. Enzymatic Basis of Detoxication 121 130 .
L.F. Chasseaud. 1979. 175 274 .
M. Tateishi, S. Suzuki & H. Shimizu. (1978) Cysteine conjugate beta-lyase in rat liver. A novel enzyme catalyzing formation of thiol-containing metabolites of drugs.. Journal of Biological Chemistry 253:24, pages 8854-8859.
Crossref
Mitsuru Tateishi, Shuji Suzuki & Hirotoshi Shimizu. (1978) The metabolism of bromazepam in the rat?identification of mercapturic acid and its conversion in vitro to methylthio-bromazepam. Biochemical Pharmacology 27:5, pages 809-810.
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B. Jansson & Å. Bergman. (1978) Sulfur-containing derivatives of hexachlorobenzene (HCB) - metabolites in the rat. Chemosphere 7:3, pages 257-268.
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Hugh M. McIlhenny. 1977. 201 209 .

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