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Xenobiotica
the fate of foreign compounds in biological systems
Volume 9, 1979 - Issue 8
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Original Article

The biliary excretion of flavanones in the rat

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Pages 491-501 | Received 10 Dec 1978, Published online: 30 Sep 2009

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Kanae Gamo, Hiroyuki Miyachi, Kayoko Nakamura & Nobuyasu Matsuura. (2014) Hesperetin glucuronides induce adipocyte differentiation via activation and expression of peroxisome proliferator-activated receptor-γ. Bioscience, Biotechnology, and Biochemistry 78:6, pages 1052-1059.
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Ming Ji Jin, Unyong Kim, In Sook Kim, Yuri Kim, Dong-Hyun Kim, Sang Beom Han, Dong-Hyun Kim, Oh-Seung Kwon & Hye Hyun Yoo. (2010) Effects of Gut Microflora on Pharmacokinetics of Hesperidin: A Study on Non-Antibiotic and Pseudo-Germ-Free Rats. Journal of Toxicology and Environmental Health, Part A 73:21-22, pages 1441-1450.
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Christine Morand, Claudine Manach, Vanessa Crespy & Christian Remesy. (2000) Quercetin 3-O-β-glucoside is better absorbed than other quercetin forms and is not present in rat plasma. Free Radical Research 33:5, pages 667-676.
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PeterC. H. Hollman, LilianB. M. Tijburg & ChungS. Yang. (1997) Bioavailability of flavonoids from tea. Critical Reviews in Food Science and Nutrition 37:8, pages 719-738.
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I. Skjevrak, E. Solheim & R. R. Scheline. (1986) Dihydrochalcone metabolism in the rat: trihydroxylated derivatives related to phloretin. Xenobiotica 16:1, pages 35-45.
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Ramadan M. Abdelaziz, Ahmed Z. Abdelazem, Khalid S. Hashem & Yasser A. Attia. (2020) Protective effects of hesperidin against MTX-induced hepatotoxicity in male albino rats. Naunyn-Schmiedeberg's Archives of Pharmacology 393:8, pages 1405-1417.
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Chenlin Shen, Zhengyue Qian, Ruonan Chen, Xiaoming Meng, Tingting Hu, Zhaolin Chen, Yangyang Li, Cheng Huang, Chaojie Hu & Jun Li. (2015) Single Dose Oral and Intravenous Pharmacokinetics and Tissue Distribution of a Novel Hesperetin Derivative MTBH in Rats. European Journal of Drug Metabolism and Pharmacokinetics 41:6, pages 675-688.
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. (2010) Flavouring Group Evaluation 32 (FGE.32): Flavonoids (Flavanones and dihydrochalcones) from chemical groups 25 and 30. EFSA Journal 8:9, pages 1065.
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Constance Bock, Karl-Heinz Waldmann & Waldemar Ternes. (2008) Mangiferin and hesperidin metabolites are absorbed from the gastrointestinal tract of pigs after oral ingestion of a Cyclopia genistoides (honeybush tea) extract. Nutrition Research 28:12, pages 879-891.
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F I Kanaze, M I Bounartzi, M Georgarakis & I Niopas. (2006) Pharmacokinetics of the citrus flavanone aglycones hesperetin and naringenin after single oral administration in human subjects. European Journal of Clinical Nutrition 61:4, pages 472-477.
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Hikaru Matsumoto, Yoshinori Ikoma, Minoru Sugiura, Masamichi Yano & Yoshinori Hasegawa. (2004) Identification and Quantification of the Conjugated Metabolites Derived from Orally Administered Hesperidin in Rat Plasma. Journal of Agricultural and Food Chemistry 52:21, pages 6653-6659.
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Toshiyuki Kohri, Masayuki Suzuki & Fumio Nanjo. (2003) Identification of Metabolites of (−)-Epicatechin Gallate and Their Metabolic Fate in the Rat. Journal of Agricultural and Food Chemistry 51:18, pages 5561-5566.
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C Manach, C Morand, A Gil-Izquierdo, C Bouteloup-Demange & C Rémésy. (2003) Bioavailability in humans of the flavanones hesperidin and narirutin after the ingestion of two doses of orange juice. European Journal of Clinical Nutrition 57:2, pages 235-242.
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Hae Kyung Kim, Tae-Sook Jeong, Mi-Kyung Lee, Yong Bok Park & Myung-Sook Choi. (2003) Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats. Clinica Chimica Acta 327:1-2, pages 129-137.
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Hitoshi Matsumoto, Hiromi Inaba, Mitsuo Kishi, Shigeru Tominaga, Masao Hirayama & Takanori Tsuda. (2001) Orally Administered Delphinidin 3-Rutinoside and Cyanidin 3-Rutinoside Are Directly Absorbed in Rats and Humans and Appear in the Blood as the Intact Forms. Journal of Agricultural and Food Chemistry 49:3, pages 1546-1551.
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Catherine Felgines, Odile Texier, Christine Morand, Claudine Manach, Augustin Scalbert, Françoise Régerat & Christian Rémésy. (2000) Bioavailability of the flavanone naringenin and its glycosides in rats. American Journal of Physiology-Gastrointestinal and Liver Physiology 279:6, pages G1148-G1154.
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Kazuaki Kida, Masayuki Suzuki, Natsuki Matsumoto, Fumio Nanjo & Yukihiko Hara. (2000) Identification of Biliary Metabolites of (−)-Epigallocatechin Gallate in Rats. Journal of Agricultural and Food Chemistry 48:9, pages 4151-4155.
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Ulla Justesen, Eva Arrigoni, Bo R Larsen & Renato Amado. (2000) Degradation of Flavonoid Glycosides and Aglycones During in vitro Fermentation with Human Faecal Flora. LWT - Food Science and Technology 33:6, pages 424-430.
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F.A. Tomás-Barberan, F. Ferreres & M.I. Gil. 2000. Bioactive natural Products (Part D). Bioactive natural Products (Part D) 739 795 .
Ruksana Choudhury, George Chowrimootoo, Kaila Srai, Edward Debnam & Catherine A. Rice-Evans. (1999) Interactions of the Flavonoid Naringenin in the Gastrointestinal Tract and the Influence of Glycosylation. Biochemical and Biophysical Research Communications 265:2, pages 410-415.
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Lisa J. Wilcox, Nica M. Borradaile & Murray W. Huff. (2006) Antiatherogenic Properties of Naringenin, a Citrus Flavonoid. Cardiovascular Drug Reviews 17:2, pages 160-178.
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Jörg Heilmann & Irmgard Merfort. (2006) Aktueller Kenntnisstand zum Metabolismus von Flavonoiden II. Resorption und Metabolismus von Flavonen, Flavanonen, Flavanen, Proanthocyanidinen und Isoflavonoiden. Pharmazie in unserer Zeit 27:4, pages 173-183.
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Irmgard Merfort & Irmgard Merfort. (2006) Aktueller Kenntnisstand zum Metabolismus von Flavonoiden I. Resorption und Metabolismus von Flavonolen. Pharmazie in unserer Zeit 27:2, pages 58-65.
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Y. H. He & C. Kies. (1994) Green and black tea consumption by humans: Impact on polyphenol concentrations in feces, blood and urine. Plant Foods for Human Nutrition 46:3, pages 221-229.
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Weici Tang & Gerhard EisenbrandWeici Tang & Gerhard Eisenbrand. 1992. Chinese Drugs of Plant Origin. Chinese Drugs of Plant Origin 337 349 .
JOSEPH P. BROWN. 1988. Role of the Gut Flora in Toxicity and Cancer. Role of the Gut Flora in Toxicity and Cancer 109 144 .
WOLFGANG BARZ & KLAUS-MICHAEL WELTRING. 1985. Biosynthesis and Biodegradation of Wood Components. Biosynthesis and Biodegradation of Wood Components 607 666 .
Luc P. Balant & Maurice Wermeille. (1984) METABOLISM AND PHARMACOKINETICS OF HYDROXYETHYLATED RUTOSIDES IN ANIMALS AND MAN. Drug Metabolism and Drug Interactions 5:1, pages 1-24.
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S. Brown & L. A. Griffiths. (1983) New metabolites of the naturally-occurring mutagen, quercetin, the pro-mutagen, rutin and of taxifolin. Experientia 39:2, pages 198-200.
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