Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 4
142
Views
129
CrossRef citations to date
0
Altmetric
Original Article

Disposition in male volunteers of a subanaesthetic intravenous dose of an oil in water emulsion of 14C-propofol

, , , , &
Pages 429-440 | Received 15 Apr 1987, Accepted 13 Nov 1987, Published online: 30 Sep 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (15)

Shu-Feng Zhou, Jun-Ping Liu & Balram Chowbay. (2009) Polymorphism of human cytochrome P450 enzymes and its clinical impact. Drug Metabolism Reviews 41:2, pages 89-295.
Read now
Sarah J. Roffey, R. Scott Obach, Jenny I. Gedge & Dennis A. Smith. (2007) What is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs. Drug Metabolism Reviews 39:1, pages 17-43.
Read now
Howard Smith & Khallad El-Mohtar. (2006) Propofol Infusion and the Potential Use of Propofol Patient-Controlled Sedation (PCS) in Terminally 111 Patients. Journal Of Cancer Pain & Symptom Palliation 2:1, pages 33-40.
Read now
D. MCKILLOP, M. J. WILD, C. J. BUTTERS & C. SIMCOCK. (1998) Effects of propofol on human hepatic microsomal cytochrome P450 activities. Xenobiotica 28:9, pages 845-853.
Read now
J. Guitton, T. Burronfosse, M. Sanchez & M. Désage. (1997) Quantitation of Propofol Metabolite, 2,6-Diisopropyl-1,4-quinol, by Gas Chromatography-Mass Spectrometry. Analytical Letters 30:7, pages 1369-1378.
Read now
H. A. Tillmann Hein, C. Tracy Suit, Linda K. Douning, Samuel P. Marynick, J. Michael Putman, Lilly Zhang & Michael A. E. Ramsay. (1997) Anesthesiology Effect of Intravenous Sedation on the Outcome of Transvaginal Oocyte Retrieval: A Comparative Study of Propofol- and Methohexital-Based Techniques. Baylor University Medical Center Proceedings 10:2, pages 71-73.
Read now
AndrzejL. Dawidowicz & Anna Fijałkowska. (1996) Possibilities of Propofol Analysis in Various Blood Components by Means of HPLC. Journal of Liquid Chromatography & Related Technologies 19:9, pages 1423-1435.
Read now
J. R. Sneyd, P. J. Simons & B. Wright. (1994) Use of proton nmr spectroscopy to measure propofol metabolites in the urine of the female Caucasian patient. Xenobiotica 24:10, pages 1021-1028.
Read now
P. J. Simons, I. D. Cockshott, J. B. Glen, E. A. Gordon, S. Knott & R. J. Ruane. (1992) Disposition and pharmacology of propofol glucuronide administered intravenously to animals. Xenobiotica 22:11, pages 1267-1273.
Read now
P. A. Gray, G. R. Park, I. D. Cockshott, E. J. Douglas, B. Shuker & P. J. Simons. (1992) Propofol metabolism in man during the anhepatic and reperfusion phases of liver transplantation. Xenobiotica 22:1, pages 105-114.
Read now
I. D. Cockshott, E. J. Douglas, G. F. Plummer & P. J. Simons. (1992) The pharmacokinetics of propofol in laboratory animals. Xenobiotica 22:3, pages 369-375.
Read now
P. J. Simons, I. D. Cockshott, E. J. Douglas, E. A. Gordon, S. Knott & R. J. Ruane. (1991) Distribution in female rats of an anaesthetic intravenous dose of 14C-propofol. Xenobiotica 21:10, pages 1325-1335.
Read now
P. J. Simons, I. D. Cockshott, E. J. Douglas, E. A. Gordon, S. Knott & R. J. Ruane. (1991) Species differences in blood profiles, metabolism and excretion of 14C-propofol after intravenous dosing to rat, dog and rabbit. Xenobiotica 21:10, pages 1243-1256.
Read now
T. Yoshimura, S. Tanaka, H. Sakurai, Y. Nagai, K. Yamada, S. Katayama, S. Abe & I. Yamatsu. (1991) Metabolism and excretion of a new 5-lipoxygenase inhibitor in rats, guinea-pigs, beagles and rhesus monkeys. Xenobiotica 21:5, pages 627-634.
Read now
L. E. Mather, D. G. Selby, W. B. Runciman & C. F. McLean. (1989) Propofol: Assay and regional mass balance in the sheep. Xenobiotica 19:11, pages 1337-1347.
Read now

Articles from other publishers (114)

Jiaxuan Wen, Chen Liu, Xueying Ding, Zimeng Tian, Wenyu Jiang, Xiuhong Wei & Xin Liu. (2023) Efficacy and safety of ciprofol (HSK3486) for procedural sedation and anesthesia induction in surgical patients: A systematic review and meta-analysis. Heliyon 9:12, pages e22634.
Crossref
Dandan Yang, Yin Hu, Zourong Ruan, Bo Jiang, Haiying Wang, Yichao Xu, Mengyue Hu, Min Yan & Honggang Lou. (2023) Drug‐drug interaction of ciprofol injectable emulsion with mefenamic acid capsules in healthy subjects. British Journal of Clinical Pharmacology 89:10, pages 3165-3174.
Crossref
Karel Allegaert, Mohammad Yaseen Abbasi, Robin Michelet & Olusola Olafuyi. (2022) The Impact of Low Cardiac Output on Propofol Pharmacokinetics across Age Groups—An Investigation Using Physiologically Based Pharmacokinetic Modelling. Pharmaceutics 14:9, pages 1957.
Crossref
A. Ram Doo, Min Jong Ki, Seong Ok Park, Jun Ho Lee & Seonghoon Ko. (2022) Influence of body fatness on propofol requirements for loss of consciousness in target-controlled infusion: A STROBE-compliant study. Medicine 101:35, pages e30179.
Crossref
Akira Kuriyama. (2022) Green urine due to propofol. Postgraduate Medical Journal 98:1157, pages 230-230.
Crossref
Xiaojiao Li, Deming Yang, Qianqian Li, Hong Wang, Meng Wang, Pangke Yan, Nan Wu, Fangqiong Li, Shiping Ma, Yanhua Ding, Jingrui Liu & Hushan Wang. (2021) Safety, Pharmacokinetics, and Pharmacodynamics of a Single Bolus of the γ-aminobutyric Acid (GABA) Receptor Potentiator HSK3486 in Healthy Chinese Elderly and Non-elderly. Frontiers in Pharmacology 12.
Crossref
Gavin J. Kilpatrick. (2021) Remimazolam: Non-Clinical and Clinical Profile of a New Sedative/Anesthetic Agent. Frontiers in Pharmacology 12.
Crossref
Yicong Bian, Hua Zhang, Sheng Ma, Yongyi Jiao, Pangke Yan, Xiao Liu, Shiping Ma, Yating Xiong, Zheming Gu, Zhenwen Yu, Chenrong Huang & Liyan Miao. (2020) Mass balance, pharmacokinetics and pharmacodynamics of intravenous HSK3486, a novel anaesthetic, administered to healthy subjects. British Journal of Clinical Pharmacology 87:1, pages 93-105.
Crossref
Haiman Xu, Min Chen, Fangjun Yu, Tianpeng Zhang & Baojian Wu. (2020) Circadian Clock Component Rev-erb α Regulates Diurnal Rhythm of UDP-Glucuronosyltransferase 1a9 and Drug Glucuronidation in Mice . Drug Metabolism and Disposition 48:8, pages 681-689.
Crossref
Marko M. Sahinovic, Michel M. R. F. Struys & Anthony R. Absalom. (2018) Clinical Pharmacokinetics and Pharmacodynamics of Propofol. Clinical Pharmacokinetics 57:12, pages 1539-1558.
Crossref
Robin Michelet, Jan Van Bocxlaer, Karel Allegaert & An Vermeulen. (2018) The use of PBPK modeling across the pediatric age range using propofol as a case. Journal of Pharmacokinetics and Pharmacodynamics 45:6, pages 765-785.
Crossref
A. Maas, D. Lohr, C. Maier & B. Madea. (2018) Propofol – Abhängigkeitspotenzial und forensische RelevanzPropofol—dependence potential and forensic relevance. Rechtsmedizin 28:5, pages 453-467.
Crossref
Surender Rajasekaran, Mark Pressler, Jessica Parker, Alex Scales, Nicholas Andersen, Anthony Olivero, John Ballard & Robert McGough. (2018) Quantifying and Trending the Thermal Signal as an Index of Perfusion in Patients Sedated with Propofol. Healthcare 6:3, pages 87.
Crossref
Alexandra Maas, Christoph Maier, Stefanie Iwersen-Bergmann, Jennifer L. Pilgrim, Matthew Di Rago, Burkhard Madea & Cornelius Hess. (2018) Propofol and propofol glucuronide concentrations in hair following medical propofol administration and in forensic death cases. Forensic Toxicology 36:2, pages 270-279.
Crossref
Ricardo Jorge Dinis-Oliveira. (2018) Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects. BioMed Research International 2018, pages 1-16.
Crossref
Alexandra Maas, Christoph Maier, Stefanie Iwersen-Bergmann, Burkhard Madea & Cornelius Hess. (2017) Simultaneous extraction of propofol and propofol glucuronide from hair followed by validated LC–MS/MS analyses. Journal of Pharmaceutical and Biomedical Analysis 146, pages 236-243.
Crossref
Alexandra Maas, Christoph Maier, Beate Michel-Lauter, Sebastian Broecker, Burkhard Madea & Cornelius Hess. (2017) Verification of propofol sulfate as a further human propofol metabolite using LC-ESI-QQQ-MS and LC-ESI-QTOF-MS analysis. Drug Metabolism and Personalized Therapy 32:1, pages 67-72.
Crossref
Alexandra Maas, Christoph Maier, Beate Michel-Lauter, Burkhard Madea & Cornelius Hess. (2016) 1,2-Dimethylimidazole-4-sulfonyl chloride (DMISC), a novel derivatization strategy for the analysis of propofol by LC-ESI-MS/MS. Analytical and Bioanalytical Chemistry 409:6, pages 1547-1554.
Crossref
Andreas Eisenried, Andreas Wehrfritz, Harald Ihmsen, Jürgen Schüttler & Christian Jeleazcov. (2016) Determination of total and unbound propofol in patients during intensive care sedation by ultrafiltration and LC–MS/MS. Journal of Pharmaceutical and Biomedical Analysis 126, pages 148-155.
Crossref
Jae-Hwan Kwak, Hye Kyung Kim, Sanggil Choe, Sangwhan In & Jae Sung Pyo. (2016) Determination of propofol glucuronide from hair sample by using mixed mode anion exchange cartridge and liquid chromatography tandem mass spectrometry. Journal of Chromatography B 1015-1016, pages 209-213.
Crossref
Janat Tumukunde, Dlamini Diana Lomangisi, Ocen Davidson, Andrew Kintu, Ejoku Joseph & Arthur Kwizera. (2015) Effects of propofol versus thiopental on Apgar scores in newborns and peri-operative outcomes of women undergoing emergency cesarean section: a randomized clinical trial. BMC Anesthesiology 15:1.
Crossref
Vidya Chidambaran, Andrew Costandi & Ajay D’Mello. (2015) Propofol: A Review of its Role in Pediatric Anesthesia and Sedation. CNS Drugs 29:7, pages 543-563.
Crossref
Qing-Quan Lian, Pei-Pei Pan, Jun-Wei Li, Han Lin, Guo-Xin Hu, Ming-Zhang Zuo & Jian-Ping Cai. (2015) Impact of CYP2C9 Polymorphism Found in the Chinese Population on the Metabolism of Propofol <i>in Vitro</i>. Biological & Pharmaceutical Bulletin Biological and Pharmaceutical Bulletin 38:4, pages 531-535.
Crossref
Yu-Ting Tai, Yi-Ling Lin, Chia-Chen Chang, Yih-Giun Cherng, Ming-Jaw Don & Ruei-Ming Chen. (2015) Ring-Oxidative Biotransformation and Drug Interactions of Propofol in the Livers of Rats. BioMed Research International 2015, pages 1-11.
Crossref
Martin Regensburger, Hagen B. Huttner, Arnd Doerfler, Stefan Schwab & Dimitre Staykov. (2014) Propofol-related urine discoloration in a patient with fatal atypical intracerebral hemorrhage treated with hypothermia. SpringerPlus 3:1.
Crossref
Philipp Fruhmann, Philipp Skrinjar, Julia Weber, Hannes Mikula, Benedikt Warth, Michael Sulyok, Rudolf Krska, Gerhard Adam, Erwin Rosenberg, Christian Hametner & Johannes Fröhlich. (2014) Sulfation of deoxynivalenol, its acetylated derivatives, and T2-toxin. Tetrahedron 70:34, pages 5260-5266.
Crossref
GENTARO GOTO, YOKO HORI, MASASHI ISHIKAWA, SHUNSUKE TANAKA & ATSUHIRO SAKAMOTO. (2014) Changes in the gene expression levels of microRNAs in the rat hippocampus by sevoflurane and propofol anesthesia. Molecular Medicine Reports 9:5, pages 1715-1722.
Crossref
Rowan A. Stringer, Gareth Williams, Franck Picard, Bindi Sohal, Olivier Kretz, Jeff McKenna & Joel A. Krauser. (2014) Application of a Deuterium Replacement Strategy to Modulate the Pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a Novel CRF 1 Antagonist . Drug Metabolism and Disposition 42:5, pages 954-962.
Crossref
R. Scott Obach. 2014. Handbook of Metabolic Pathways of Xenobiotics. Handbook of Metabolic Pathways of Xenobiotics 1 41 .
David P. Martin & Joseph D. Tobias. 2014. Pediatric Critical Care Medicine. Pediatric Critical Care Medicine 11 29 .
Eva Choong, Irena Loryan, Marja Lindqvist, Åsa Nordling, Samira el Bouazzaoui, Ron H. van Schaik, Inger Johansson, Jan Jakobsson & Magnus Ingelman-Sundberg. (2013) Sex Difference in Formation of Propofol Metabolites: A Replication Study. Basic & Clinical Pharmacology & Toxicology 113:2, pages 126-131.
Crossref
Katherine L. Gill, Michael Gertz, J. Brian Houston & Aleksandra Galetin. (2013) Application of a Physiologically Based Pharmacokinetic Model to Assess Propofol Hepatic and Renal Glucuronidation in Isolation: Utility of In Vitro and In Vivo Data. Drug Metabolism and Disposition 41:4, pages 744-753.
Crossref
Muhammad Akbar & Masoud Agah. (2013) A Microfabricated Propofol Trap for Breath-Based Anesthesia Depth Monitoring. Journal of Microelectromechanical Systems 22:2, pages 443-451.
Crossref
Jung-Sam LeeHyun-Soo JangByeong-Jae Park. (2013) Green discoloration of urine after propofol infusion. Korean Journal of Anesthesiology 65:2, pages 177.
Crossref
Tomoyuki Tajima, Keiko Hirakawa, Hiroshi Kawaguchi & Atsuhiro Sakamoto. (2012) Proton nuclear magnetic resonance and pattern recognition analysis of liver extracts from rats under different anesthetics. BMC Medical Imaging 12:1.
Crossref
Derek J. Roberts, Babar Haroon & Richard I. Hall. (2012) Sedation for Critically Ill or Injured Adults in the Intensive Care Unit. Drugs 72:14, pages 1881-1916.
Crossref
Irena Loryan, Marja Lindqvist, Inger Johansson, Masahiro Hiratsuka, Ilse van der Heiden, Ron HN van Schaik, Jan Jakobsson & Magnus Ingelman-Sundberg. (2011) Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia. European Journal of Clinical Pharmacology 68:4, pages 397-406.
Crossref
Sara Asimus & Michael Ashton. (2009) Artemisinin–a possible CYP2B6 probe substrate?. Biopharmaceutics & Drug Disposition 30:5, pages 265-275.
Crossref
Young Chul LeeJong Nam LeeJun Seok BaeYoung Chul Park. (2009) Green urine in a patient who received a continuous infusion of propofol - A case report -. Korean Journal of Anesthesiology 56:3, pages 325.
Crossref
Keiko Nakazato, Yuko Yoshida, Ken Takemori, Katsuya Kobayashi & Atsuhiro Sakamoto. (2009) Expressions of genes encoding drug-metabolizing enzymes are altered after sevoflurane, isoflurane, propofol or dexmedetomidine anesthesia. Biomedical Research 30:1, pages 17-24.
Crossref
Joseph F. Foss & Marco A. Maurtua. 2009. Pharmacology and Therapeutics. Pharmacology and Therapeutics 873 882 .
Thomas K.H. Chang. 2010. Handbook of Drug-Nutrient Interactions. Handbook of Drug-Nutrient Interactions 85 117 .
K. Allegaert, J. Vancraeynest, M. Rayyan, J. de Hoon, V. Cossey, G. Naulaers & R. Verbesselt. (2008) Urinary propofol metabolites in early life after single intravenous bolus. British Journal of Anaesthesia 101:6, pages 827-831.
Crossref
K. Takata, T. Kurita, Y. Morishima, K. Morita, M. Uraoka & S. Sato. (2008) Do the kidneys contribute to propofol elimination?. British Journal of Anaesthesia 101:5, pages 648-652.
Crossref
Michael G. Fitzsimons, Keith H. Baker, Edward Lowenstein & Warren M. Zapol. (2008) Random Drug Testing to Reduce the Incidence of Addiction in Anesthesia Residents: Preliminary Results from One Program. Anesthesia & Analgesia 107:2, pages 630-635.
Crossref
Hiroko Takahashi, Yoshihiro Maruo, Asami Mori, Masaru Iwai, Hiroshi Sato & Yoshihiro Takeuchi. (2008) Effect of D256N and Y483D on Propofol Glucuronidation by Human Uridine 5′-diphosphate Glucuronosyltransferase (UGT1A9). Basic & Clinical Pharmacology & Toxicology 103:2, pages 131-136.
Crossref
C. Bleeker, T. Vree, A. Lagerwerf & E. Willems-van Bree. (2008) Recovery and long-term renal excretion of propofol, its glucuronide, and two di-isopropylquinol glucuronides after propofol infusion during surgery. British Journal of Anaesthesia 101:2, pages 207-212.
Crossref
Andrew Rowland, Kathleen M. Knights, Peter I. Mackenzie & John O. Miners. (2008) The “Albumin Effect” and Drug Glucuronidation: Bovine Serum Albumin and Fatty Acid-Free Human Serum Albumin Enhance the Glucuronidation of UDP-Glucuronosyltransferase (UGT) 1A9 Substrates but Not UGT1A1 and UGT1A6 Activities. Drug Metabolism and Disposition 36:6, pages 1056-1062.
Crossref
Joo Hyun YouHo-Kyung SongDae Chul JeongKeon Hee RyuYun Sun Chin. (2008) The Inhibitory Effect of Propofol on Splenocytes Proliferations to Lipopolysaccharide in BALB/c Mice: Based on the Measurement of BrdU Incorporation in vitro . Korean Journal of Anesthesiology 54:1, pages 74.
Crossref
Marek A. Mirski & Mitzi K. Hemstreet. (2007) Critical care sedation for neuroscience patients. Journal of the Neurological Sciences 261:1-2, pages 16-34.
Crossref
Elena F. Kranioti, Anna Mavroforou, Panagiotis Mylonakis & Manolis Michalodimitrakis. (2007) Lethal self administration of propofol (Diprivan). Forensic Science International 167:1, pages 56-58.
Crossref
Daisuke Takizawa, Eri Takizawa, Sohtaro Miyoshi, Fuminori Kawahara & Haruhiko Hiraoka. (2006) The Increase in Total and Unbound Propofol Concentrations During Accidental Hemorrhagic Shock in Patients Undergoing Liver Transplantation. Anesthesia & Analgesia 103:5, pages 1339-1340.
Crossref
Eri Takizawa, Daisuke Takizawa, Haruhiko Hiraoka, Shigeru Saito & Fumio Goto. (2006) Disposition and pharmacodynamics of propofol during isovolaemic haemorrhage followed by crystalloid resuscitation in humans. British Journal of Clinical Pharmacology 61:3, pages 256-261.
Crossref
Daisuke Takizawa, Haruhiko Hiraoka, Eri Sato, Toshio Aso, Chizu Aso, Fumio Kunimoto & Fumio Goto. (2006) The effect of gynecologic laparoscopy on propofol concentrations administered by the target-controlled infusion system. Journal of Anesthesia 20:1, pages 57-59.
Crossref
Haruhiko Hiraoka, Koujirou Yamamoto, Soutarou Miyoshi, Toshihiro Morita, Katsunori Nakamura, Yuuji Kadoi, Fumio Kunimoto & Ryuya Horiuchi. (2005) Kidneys contribute to the extrahepatic clearance of propofol in humans, but not lungs and brain. British Journal of Clinical Pharmacology 60:2, pages 176-182.
Crossref
J. Wu, S. M. Zhu, H. L. He, X. C. Weng, S. Q. Huang & Y. Z. Chen. (2005) Plasma propofol concentrations during orthotopic liver transplantation. Acta Anaesthesiologica Scandinavica 49:6, pages 804-810.
Crossref
RUEI-MING CHEN, GONG-JHE WU, HWA-CHIA CHANG, JUE-TAI CHEN, TZENG-FU CHEN, YI-LING LIN & TA-LIANG CHEN. (2005) 2,6-Diisopropylphenol Protects Osteoblasts from Oxidative Stress-Induced Apoptosis through Suppression of Caspase-3 Activation. Annals of the New York Academy of Sciences 1042:1, pages 448-459.
Crossref
GONG-JHE WU, YU-TING TAI, TA-LIANG CHEN, LI-LING LIN, YUNE-FANG UENG & RUEI-MING CHEN. (2005) Propofol Specifically Inhibits Mitochondrial Membrane Potential but Not Complex I NADH Dehydrogenase Activity, Thus Reducing Cellular ATP Biosynthesis and Migration of Macrophages. Annals of the New York Academy of Sciences 1042:1, pages 168-176.
Crossref
Daisuke Takizawa, Koichi Nishikawa, Eri Sato, Haruhiko Hiraoka, Koujirou Yamamoto, Shigeru Saito, Ryuya Horiuchi & Fumio Goto. (2005) A dopamine infusion decreases propofol concentration during epidural blockade under general anesthesiaUne perfusion de dopamine diminue la concentration de propofol pendant le bloc péridural sous anesthésie générale. Canadian Journal of Anesthesia/Journal canadien d'anesthésie 52:5, pages 463-466.
Crossref
J. Schmidt, W. Hering & S. Albrecht. (2005) Total intravenöse Anästhesie mit Propofol und RemifentanilTotal intravenous anesthesia with propofol and remifentanil. Der Anaesthesist 54:1, pages 17-28.
Crossref
Einosuke Tanaka, Yui Takano, Shinichi Inomata, Hidenori Toyooka & Katsuya Honda. (2004) Premedication medicines do not cause drug metabolic interaction with propofol using human liver microsomes in vitro. European Journal of Clinical Pharmacology 60:8, pages 565-568.
Crossref
Guoming Xie, Roger N. Gunn, Alain Dagher, Thierry Daloze, Gilles Plourde, Steven B. Backman, Mirko Diksic & Pierre Fiset. (2003) PET quantification of muscarinic cholinergic receptors with [N‐ 11 C‐methyl]‐benztropine and application to studies of propofol‐induced unconsciousness in healthy human volunteers . Synapse 51:2, pages 91-101.
Crossref
Thomas K. H. Chang. 2004. Handbook of Drug-Nutrient Interactions. Handbook of Drug-Nutrient Interactions 43 67 .
Kate McKeage & Caroline M Perry. (2003) Propofol. CNS Drugs 17:4, pages 235-272.
Crossref
Makiko Shimizu, Yoshiaki Matsumoto, Masahiro Tatsuno & Masamichi Fukuoka. (2003) Glucuronidation of Propofol and Its Analogs by Human and Rat Liver Microsomes.. Biological and Pharmaceutical Bulletin 26:2, pages 216-219.
Crossref
J. Helfenbein, C. Lartigue, E. Noirault, E. Azim, J. Legailliard, M. J. Galmier & J. C. Madelmont. (2002) Isotopic Effect Study of Propofol Deuteration on the Metabolism, Activity, and Toxicity of the Anesthetic. Journal of Medicinal Chemistry 45:26, pages 5806-5808.
Crossref
Sam Boase & John O. Miners. (2002) In vitro–in vivo correlations for drugs eliminated by glucuronidation: Investigations with the model substrate zidovudine . British Journal of Clinical Pharmacology 54:5, pages 493-503.
Crossref
Andrzej L. Dawidowicz, Rafał Kalityński, Jerzy Trocewicz, Andrzej Nestorowicz, Anna Fijałkowska & Katarzyna Trela‐Stachurska. (2002) Investigation of propofol renal elimination by HPLC using supported liquid membrane procedure for sample preparation. Biomedical Chromatography 16:7, pages 455-458.
Crossref
P. Favetta, C.-S. Degoute, J.-P. Perdrix, C. Dufresne, R. Boulieu & J. Guitton. (2002) Propofol metabolites in man following propofol induction and maintenance. British Journal of Anaesthesia 88:5, pages 653-658.
Crossref
Hang Chang, Shih-Ying Tsai, Yi Chang, Ta-Liang Chen & Ruei-Ming Chen. (2002) Therapeutic concentrations of propofol protects mouse macrophages from nitric oxide-induced cell death and apoptosisDes concentrations thérapeutiques de propofol protègent les macrophages de souris de la mort cellulaire et de l’apoptose induites par l’oxyde nitrique. Canadian Journal of Anesthesia/Journal canadien d'anesthésie 49:5, pages 477-480.
Crossref
M. G. Soars, B. Burchell & R. J. Riley. (2002) In Vitro Analysis of Human Drug Glucuronidation and Prediction of in Vivo Metabolic Clearance. Journal of Pharmacology and Experimental Therapeutics 301:1, pages 382-390.
Crossref
Paul E. Marik & Gary P. Zaloga. (2002) Therapeutic sedation: Has its time come? *. Critical Care Medicine 30:4, pages 949-952.
Crossref
Cornelius Jungheinrich, Roland Scharpf, Manfred Wargenau, Carmen Dilger & Frank Bepperling. (2002) Pharmacokinetics of the Generic Formulation Propofol 1% Fresenius in Comparison with the Original Formulation (Disoprivan?? 1%). Clinical Drug Investigation 22:7, pages 417-427.
Crossref
Takahiro Murai, Fujiko Tsuruta, Toshio Terao, Toshihiko Ikeda & Haruo Iwabuchi. (2002) Formation of a Structurally Novel, Serial Diglucuronide of 4-Hydroxybiphenyl by Further Glucuronidation of a Monoglucuronide in Dog Liver Microsomes. Drug Metabolism and Pharmacokinetics 17:5, pages 457-466.
Crossref
B.M.Q. Weaver, G.E. Staddon & W.W. Mapleson. (2001) Tissue/blood and tissue/water partition coefficients for propofol in sheep † ‡. British Journal of Anaesthesia 86:5, pages 693-703.
Crossref
P. Favetta, C. Dufresne, M. D�sage, O. Pa�ss�, J. P. Perdrix, R. Boulieu & J. Guitton. (2000) Detection of new propofol metabolites in human urine using gas chromatography/mass spectrometry and liquid chromatography/mass spectrometry techniques. Rapid Communications in Mass Spectrometry 14:20, pages 1932-1936.
Crossref
Christy McCowan & Paul Marik. (2000) Refractory delirium tremens treated with propofol: A case series. Critical Care Medicine 28:6, pages 1781-1784.
Crossref
P Favetta, J Guitton, C.S Degoute, L Van Daele & R Boulieu. (2000) High-performance liquid chromatographic assay to detect hydroxylate and conjugate metabolites of propofol in human urine. Journal of Chromatography B: Biomedical Sciences and Applications 742:1, pages 25-35.
Crossref
P. L. De Riu, G. De Riu, C. Testa, M. Mulas, M. A. Caria, S. Mameli & O. Mameli. (2000) Disposition of propofol between red blood cells, plasma, brain and cerebrospinal fluid in rabbits. European Journal of Anaesthesiology 17:1, pages 18-22.
Crossref
P. L. Riu, G. Riu, C. Testa, M. Mulas, M. A. Caria, S. Mameli & O. Mameli. (2000) Disposition of propofol between red blood cells, plasma, brain and cerebrospinal fluid in rabbits. European Journal of Anaesthesiology 17:1, pages 18-22.
Crossref
Ken Yamamoto, Tsunehisa Tsubokawa, Toshihiro Yagi, Shuichi Ishizuka, Shigeo Ohmura & Tsutomu Kobayashi. (1999) The influence of hypoxia and hyperoxia on the kinetics of propofol emulsion. Canadian Journal of Anesthesia/Journal canadien d'anesthésie 46:12, pages 1150-1155.
Crossref
Elise M Weerts, Nancy A Ator & Roland R Griffiths. (1999) Comparison of the intravenous reinforcing effects of propofol and methohexital in baboons. Drug and Alcohol Dependence 57:1, pages 51-60.
Crossref
Charles E. Short & Antonello Bufalari. (1999) Propofol Anesthesia. Veterinary Clinics of North America: Small Animal Practice 29:3, pages 747-778.
Crossref
T.B. Vree, A.J. Lagerwerf, C.P. Bleeker & P.M.R.M. de Grood. (1999) Direct high-performance liquid chromatography determination of propofol and its metabolite quinol with their glucuronide conjugates and preliminary pharmacokinetics in plasma and urine of man. Journal of Chromatography B: Biomedical Sciences and Applications 721:2, pages 217-228.
Crossref
Tsunehisa Tsubokawa, Ken Yamamoto & Tsutomu Kobayashi. (1998) Propofol Clearance and Distribution Volume Increase in Patients with Hyperthyroidism. Anesthesia & Analgesia 87:1, pages 195-199.
Crossref
Tsunehisa Tsubokawa, Ken Yamamoto & Tsutomu Kobayashi. (1998) Propofol Clearance and Distribution Volume Increase in Patients with Hyperthyroidism. Anesthesia & Analgesia 87:1, pages 195-199.
Crossref
Lindsey R Douglas, J.Burton Douglass, Jens Otto Sieck & Phillip J Smith. (1998) Oral management of the patient with end-stage liver disease and the liver transplant patient. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 86:1, pages 55-64.
Crossref
Gerard J. Mulder. (1998) 5 Glucuronidation and anaesthesia. Baillière's Clinical Anaesthesiology 12:2, pages 229-245.
Crossref
Paul A. Dickinson & Glyn Taylor. (1998) Route dependent pulmonary first-pass metabolism of a series of biphenylacetic acid esters in rats. European Journal of Pharmaceutical Sciences 6:1, pages 11-18.
Crossref
Akira Masuda, Takehisa Asahi, Midori Sakamaki, Katsuhito Nakamaru, Koki Hirota & Yusuke Ito. (1997) Uric Acid Excretion Increases During Propofol Anesthesia. Anesthesia & Analgesia 85:1, pages 144-148.
Crossref
Akira Masuda, Takehisa Asahi, Midori Sakamaki, Katsuhito Nakamaru, Koki Hirota & Yusuke Ito. (1997) Uric Acid Excretion Increases During Propofol Anesthesia. Anesthesia & Analgesia 85:1, pages 144-148.
Crossref
Gabriela R. Lauretti, Claudia R. Lauretti & Argemiro Lauretti-Filho. (1997) Propofol decreases ocular pressure in outpatients undergoing trabeculectomy. Journal of Clinical Anesthesia 9:4, pages 289-292.
Crossref
Per Westrin. (1996) 6 Intravenous and inhalational anaesthetic agents. Baillière's Clinical Anaesthesiology 10:4, pages 687-715.
Crossref
J. E. Larsson & G. Wahlström. (2008) Age‐dependent development of acute tolerance to propofol and its distribution in a pharmacokinetic compartment‐independent rat model. Acta Anaesthesiologica Scandinavica 40:6, pages 734-740.
Crossref
Marek A. Mirski, Birgitt Muffelman, John A. Ulatowski & Daniel F. Hanley. (1995) Sedation for the critically ill neurologic patient. Critical Care Medicine 23:12, pages 2038-2053.
Crossref
Chantal Le Guellec, Bruno Lacarelle, Pierre-Henri Villard, Huguette Point, Jacques Catalin & Alain Durand. (1995) Glucuronidation of Propofol in Microsomal Fractions from Various Tissues and Species Including Humans. Anesthesia & Analgesia 81:4, pages 855-861.
Crossref
Chantal Le Guellec, Bruno Lacarelle, Pierre-Henri Villard, Huguette Point, Jacques Catalin & Alain Durand. (1995) Glucuronidation of Propofol in Microsomal Fractions from Various Tissues and Species Including Humans. Anesthesia & Analgesia 81:4, pages 855-861.
Crossref
Juliana Barr & Andrew Donner. (1995) Optimal Intravenous Dosing Strategies for Sedatives and Analgesics in the Intensive Care Unit. Critical Care Clinics 11:4, pages 827-847.
Crossref
Joseph Mirenda & Gregory Broyles. (1995) Propofol as Used for Sedation in the ICU. Chest 108:2, pages 539-548.
Crossref
J. M. Eddleston, B. J. Pollard, J. F. Blades & B. Doran. (1995) The use of propofol for sedation of critically ill patients undergoing haemodiafiltration. Intensive Care Medicine 21:4, pages 342-347.
Crossref
M.W.B. Hartmannsgruber, H. Schulte-Steinberg, P. Conzen & A. Doenicke. (1995) 4 New intravenous induction agents. Baillière's Clinical Anaesthesiology 9:1, pages 51-66.
Crossref
Carol A. Moote. (1994) ANESTHESIA FOR RENAL TRANSPLANTATION. Anesthesiology Clinics of North America 12:4, pages 691-715.
Crossref
T.C. Chao, D.S.T. Lo, P.P.S. Chui & T.H. Koh. (1994) The first fatal 2,6-di-isopropylphenol (propofol) poisoning in Singapore: a case report. Forensic Science International 66:1, pages 1-7.
Crossref
D. J. Clarke & B. Burchell. 1994. Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity. Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity 3 43 .
J. REID & A. M. NOLAN. (2008) Pharmacokinetics of propofol in dogs premedicated with acepromazine and maintained with halothane and nitrous oxide. Journal of Veterinary Pharmacology and Therapeutics 16:4, pages 501-505.
Crossref
A. M. NOLAN, J. REID & S. GRANT. (2008) The effects of halothane and nitrous oxide on the pharmacokinetics of propofol in dogs. Journal of Veterinary Pharmacology and Therapeutics 16:3, pages 335-342.
Crossref
Norman R. Searle & Philippe Sahab. (1993) Propofol in patients with cardiac disease. Canadian Journal of Anaesthesia 40:8, pages 730-747.
Crossref
Paul M.H.J. Roekaerts, Frank J.P.M. Huygen & Simon de Lange. (1993) Infusion of propofol versus midazolam for sedation in the intensive care unit following coronary artery surgery. Journal of Cardiothoracic and Vascular Anesthesia 7:2, pages 142-147.
Crossref
Richard A. Kraut. (1992) Propofol. Oral and Maxillofacial Surgery Clinics of North America 4:4, pages 825-830.
Crossref
Robert J. Deegan. (1992) Propofol: A Review of the Pharmacology and Applications of an Intravenous Anesthetic Agent. The American Journal of the Medical Sciences 304:1, pages 45-49.
Crossref
E. Gepts & F. Camu. (1991) Pharmacokinetics of intravenous induction agents. Baillière's Clinical Anaesthesiology 5:3, pages 513-542.
Crossref
John O. Miners & Peter I. Mackenzie. (1991) Drug glucuronidation in humans. Pharmacology & Therapeutics 51:3, pages 347-369.
Crossref
DJ Morgan, GA Campbell & DP Crankshaw. (2012) Pharmacokinetics of propofol when given by intravenous infusion.. British Journal of Clinical Pharmacology 30:1, pages 144-148.
Crossref
Mark A. Skues & Cedric Prys-Roberts. (1989) The pharmacology of propofol. Journal of Clinical Anesthesia 1:5, pages 387-400.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.