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Xenobiotica
the fate of foreign compounds in biological systems
Volume 18, 1988 - Issue 9
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Original Article

Metabolism of 2,6-Dichlorobenzonitrile, 2,6-Dichlorothiobenzamide in Rodents and Goats

J. E. Bakke Metabolism and Radiation Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Fargo, ND, 58105, USA
,
G. L. Larsen Metabolism and Radiation Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Fargo, ND, 58105, USA
,
C. Struble Metabolism and Radiation Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Fargo, ND, 58105, USA
,
V. J. Feil Metabolism and Radiation Research Laboratory, Agricultural Research Service, U.S. Department of Agriculture, Fargo, ND, 58105, USA
,
I. Brandt The Swedish University of Agricultural Sciences, Department of Pharmacology and Toxicology Upsalla Biomedical Center, Box 573, S-75123, Uppsala, Sweden
&
E. B. Brittebo The Swedish University of Agricultural Sciences, Department of Pharmacology and Toxicology Upsalla Biomedical Center, Box 573, S-75123, Uppsala, Sweden
Pages 1063-1075 | Received 22 Dec 1987, Accepted 01 May 1988, Published online: 30 Sep 2009

Citations (23)

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Patrick E. Hanna & M. W. Anders. (2019) The mercapturic acid pathway. Critical Reviews in Toxicology 49:10, pages 819-929.
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J. E. Bakke, G. L. Larsen & K. L. Davison. (1994) Effect of AT-125 on the metabolism of propachlor and the glutathione conjugates of propachlor and bromobenzene in rat. Xenobiotica 24:9, pages 909-919.
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J. E. Bakke, D. J. Mulford, J. K. Huwe, V. J. Feil & K. L. Davison. (1993) Glutathione-mediated methylthio-turnover and sex differences in the metabolism of pentachlorothioanisole by rat. Xenobiotica 23:8, pages 949-960.
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Ronald T. H. van Welie, Rob G. J. M. van Dijck, Nico P. E. Vermeulen & Nico J. van Sittert. (1992) Mercapturic Acids, Protein Adducts, and DNA Adducts as Biomarkers of Electrophilic Chemicals. Critical Reviews in Toxicology 22:5-6, pages 271-306.
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Alan R. Dahl & William M. Hadley. (1991) Nasal Cavity Enzymes Involved in Xenobiotic Metabolism: Effects on the Toxicity of Inhalants. Critical Reviews in Toxicology 21:5, pages 345-372.
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J. E. Bakke. (1990) Biochemical and Physiological Dispositions of Glutathione Conjugates. Drug Metabolism Reviews 22:6-8, pages 637-647.
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J. E. Bakke, K. L. Davison & G. L. Larsen. (1990) Evidence for the absence of cysteine S-conjugate N-acetyltransferase activity in the metabolism of propachlor, naphthalene, and dichlobanil in calves. Xenobiotica 20:8, pages 801-807.
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J. E. Bakke & K. L. Davison. (1988) Metabolism of Naphthalene in Roosters. Xenobiotica 18:9, pages 1057-1062.
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Articles from other publishers (15)

Viktoria Vedin, Burton Slotnick & Anna Berghard. (2004) Zonal ablation of the olfactory sensory neuroepithelium of the mouse: effects on odorant detection. European Journal of Neuroscience 20:7, pages 1858-1864.
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Elena PirasAnna FranzénEstíbaliz L. FernándezUlrika Bergström, Françoise Raffalli-MathieuMatti LangEva B. Brittebo. (2016) Cell-specific Expression of CYP2A5 in the Mouse Respiratory Tract: Effects of Olfactory Toxicants. Journal of Histochemistry & Cytochemistry 51:11, pages 1545-1555.
Crossref
. 2001. Metabolic Maps. Metabolic Maps 288 295 .
E.B. Brittebo & I. Brandt. (1997) Cell- and tissue-specific metabolic activation of chemicals as determined by autoradiography: in vitro—in vivo correlations. Toxicology in Vitro 11:5, pages 417-426.
Crossref
Eva B Brittebo. (1997) Metabolism-dependent activation and toxicity of chemicals in nasal glands. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 380:1-2, pages 61-75.
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Anne Hillenweck, Jean-Pierre Cravedi, Laurent Debrauwer, James C. KilleenJr.Jr., Myron BlissJr.Jr. & Denis E. Corpet. (1997) Chlorothalonil Biotransformation by Gastrointestinal Microflora:In VitroComparative Approach in Rat, Dog, and Human. Pesticide Biochemistry and Physiology 58:1, pages 34-48.
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Catarina Eriksson & Eva B. Brittebo. (1995) Effects of the herbicide chlorthiamid on the olfactory mucosa. Toxicology Letters 76:3, pages 203-208.
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Catalina Eriksson & Eva B. Brittebo. (1995) Metabolic activation of the olfactory toxicant, dichlobenil, in rat olfactory microsomes: comparative studies with p-nitrophenol. Chemico-Biological Interactions 94:3, pages 183-196.
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Catalina Eriksson & Eva B. Brittebo. (1995) Dichlobenil in the fetal and neonatal mouse olfactory mucosa. Toxicology 96:2, pages 93-104.
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Bohdan Markus & Chul‐Hoon Kwon. (1994) In Vitro Metabolism of Aromatic Nitriles. Journal of Pharmaceutical Sciences 83:12, pages 1729-1734.
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C. Eriksson, I. Brandt & E. Brittebo. (1992) Tissue-binding and toxicity of compounds structurally related to the herbicide dichlobenil in the mouse olfactory mucosa. Food and Chemical Toxicology 30:10, pages 871-877.
Crossref
Eva B. Brittebo, Catarina Eriksson & Ingvar Brandt. (1992) Effects of glutathione-modulating agents on the covalent binding and toxicity of dichlobenil in the mouse olfactory mucosa. Toxicology and Applied Pharmacology 114:1, pages 31-40.
Crossref
I. Brandt, C. Eriksson & E.B. Brittebo. (1991) Tissue specific toxicity and metabolic activation of 2,6-dichlorobenzonitrile and 2,6-dichlorothiobenzamide in the olfactory nasal mucosa. Chemosphere 23:11-12, pages 1803-1809.
Crossref
Catarina Eriksson & Eva B. Brittebo. (1991) Metabolic activation of the herbicide dichlobenil in the olfactory mucosa of mice and rats. Chemico-Biological Interactions 79:2, pages 165-177.
Crossref
I. Brandt, E.B. Brittebo, V.J. Feil & J.E. Bakke. (1990) Irreversible binding and toxicity of the herbicide dichlobenil (2,6-dichlorobenzonitrile) in the olfactory mucosa of mice. Toxicology and Applied Pharmacology 103:3, pages 491-501.
Crossref

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