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Xenobiotica
the fate of foreign compounds in biological systems
Volume 23, 1993 - Issue 7
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Original Article

Metabolic fate and disposition of 1,1,1,2-tetrafluoroethane (HFC134a) in rat following a single exposure by inhalation

M. K. Ellis Investigative Toxicology Section, ZENECA Central Toxicology Laboratory, Alderley Park, Nr Macclesfield, SK10 4TJ, UK
,
L. A. Gowans Investigative Toxicology Section, ZENECA Central Toxicology Laboratory, Alderley Park, Nr Macclesfield, SK10 4TJ, UK
,
T. Green Investigative Toxicology Section, ZENECA Central Toxicology Laboratory, Alderley Park, Nr Macclesfield, SK10 4TJ, UK
&
R. J. N. Tanner Glaxo Group Research Ltd, Park Road, Ware, SG12 0DP, UK
Pages 719-729 | Received 17 Nov 1992, Accepted 08 May 1993, Published online: 23 Apr 2010

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George M. Rusch. (2018) The development of environmentally acceptable fluorocarbons. Critical Reviews in Toxicology 48:8, pages 615-665.
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AbigailE. Mitchell, KulbirS. Bakshi, CaroleA. Kimmel, GermaineM. Buck, MaureenH. Feuston, PaulM. D. Foster, J.M. Friedman, JosephF. Holson, ClaudeL. Hughes, JohnA. Moore, BernardA. Schwetz, AnthonyR. Scialli, WilliamJ. Scott, CharlesV. Vorhees & BarryR. Zirkin. (2004) Evaluating Chemical and other Agent Exosures for Reproductive and Developmental Toxicity. Journal of Toxicology and Environmental Health, Part A 67:15-16, pages 1159-1314.
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S. Dimitrov, V. Kamenska, J.D. Walker, W. Windle, R. Purdy, M. Lewis & O. Mekenyan. (2004) Predicting the biodegradation products of perfluorinated chemicals using CATABOL. SAR and QSAR in Environmental Research 15:1, pages 69-82.
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Articles from other publishers (17)

Santhosh Kumar, G. Subraya Bhat & K. Mahalinga Bhat. (2012) Development in techniques for gingival depigmentation – An update. Indian Journal of Dentistry 3:4, pages 213-221.
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George M. Rusch. 2003. Patty's Toxicology. Patty's Toxicology 359 427 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 252 266 .
. 2002. The MAK‐Collection for Occupational Health and Safety. The MAK‐Collection for Occupational Health and Safety 1 15 .
Fatih Arikan & Ali Gürkan. (2007) Cryosurgical treatment of gingival melanin pigmentation with tetrafluoroethane. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 103:4, pages 452-457.
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Sara Gunnare, Lena Ernstgård, Bengt Sjögren & Gunnar Johanson. (2006) Toxicokinetics of 1,1,1,2-tetrafluoroethane (HFC-134a) in male volunteers after experimental exposure. Toxicology Letters 167:1, pages 54-65.
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William J. Brock, George M. Rusch & Henry J. Trochimowicz. (2003) Cardiac sensitization: methodology and interpretation in risk assessment. Regulatory Toxicology and Pharmacology 38:1, pages 78-90.
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George M. Rusch. 2001. Patty's Toxicology. Patty's Toxicology.
George M. Rusch. 2003. Patty's Toxicology. Patty's Toxicology.
Glenn D Ritchie, Edward C Kimmel, Larry E Bowen, James E Reboulet & John RossiIIIIII. (2001) Acute Neurobehavioral Effects in Rats from Exposure to HFC 134a or CFC 12. NeuroToxicology 22:2, pages 233-248.
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H.H. Emmen, E.M.G. Hoogendijk, W.A.A. Klöpping-Ketelaars, H. Muijser, E. Duistermaat, J.C. Ravensberg, D.J. Alexander, D. Borkhataria, G.M. Rusch & B. Schmit. (2000) Human Safety and Pharmacokinetics of the CFC Alternative Propellants HFC 134a (1,1,1,2-Tetrafluoroethane) and HFC 227 (1,1,1,2,3,3,3-Heptafluoropropane) Following Whole-Body Exposure. Regulatory Toxicology and Pharmacology 32:1, pages 22-35.
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William J. Brock, David P. Kelly, Susan M. Munley, Karin S. Bentley, Kathy M. McGown & Rudolph Valentine. (2016) Inhalation Toxicity and Genotoxicity of Hydrofluorocarbon (HFC)-236fa and HFC-236ea. International Journal of Toxicology 19:2, pages 69-83.
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Lester Harrison. 1997. Metered Dose Inhaler Technology. Metered Dose Inhaler Technology 187 228 .
Martin K Ellis, Jacky L Naylor, Michael A Collins & Trevor Green. (2016) Metabolism and disposition of difluoromethane (HFC32) in the mouse. Human & Experimental Toxicology 15:7, pages 592-596.
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Katherine M. Cooper, Shaw F. Chang & Lester I. Harrison. (1995) Determination of the chlorofluorocarbon substitute 1,1,1,2-tetrafluoroethane (HFA-134a) in human and animal blood using gas chromatography with headspace analysis. Journal of Chromatography B: Biomedical Sciences and Applications 667:1, pages 85-93.
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Victor W. Pike, Richard J. N. Tanner, Franklin I. Aigbirhio, Christopher A. J. Freemantle, Stephen L. Waters, Brian C. Page, Christopher G. Rhodes, Per Olsson, G. Pietro Ventresca & Terry Jones. 1995. PET for Drug Development and Evaluation. PET for Drug Development and Evaluation 341 352 .
S.Y. Monté, I. Ismail, D.N. Mallett, C. Matthews & R.J.N. Tanner. (1994) The minimal metabolism of inhaled 1,1,1,2-tetrafluoroethane to trifluoroacetic acid in man as determined by high sensitivity 19F nuclear magnetic resonance spectroscopy of urine samples. Journal of Pharmaceutical and Biomedical Analysis 12:12, pages 1489-1493.
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