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Xenobiotica
the fate of foreign compounds in biological systems
Volume 24, 1994 - Issue 12
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Original Article

P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer

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Pages 1151-1175 | Received 12 May 1994, Published online: 27 Aug 2009

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Han Li, Yu-Guang Wang, Zeng-Chun Ma, Gao Yun-Hang, Song Ling, Chen Teng-Fei, Zhang Guang-Ping & Yue Gao. (2021) A high-throughput cell-based gaussia luciferase reporter assay for measurement of CYP1A1, CYP2B6, and CYP3A4 induction. Xenobiotica 51:7, pages 752-763.
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Imran Ullah, Yeongji Kim, Malgum Lim, Keon Bong Oh, Seongsoo Hwang, Yurianna Shin, Youngim Kim, Gi-Sun Im, Tai-Young Hur & Sun A Ock. (2017) In vitro 3-D culture demonstrates incompetence in improving maintenance ability of primary hepatocytes. Animal Cells and Systems 21:5, pages 332-340.
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Varsha Dhamankar, Mahfoud Assem & Maureen D. Donovan. (2015) Gene expression and immunochemical localization of major cytochrome P450 drug-metabolizing enzymes in bovine nasal olfactory and respiratory mucosa. Inhalation Toxicology 27:14, pages 767-777.
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María José Gómez-Lechón, José V Castell & María Teresa Donato. (2008) An update on metabolism studies using human hepatocytes in primary culture. Expert Opinion on Drug Metabolism & Toxicology 4:7, pages 837-854.
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David D. Stranz, Shichang Miao, Scott Campbell, George Maydwell & Sean Ekins. (2008) Combined Computational Metabolite Prediction and Automated Structure-Based Analysis of Mass Spectrometric Data. Toxicology Mechanisms and Methods 18:2-3, pages 243-250.
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Y. Uno, T. Kumano, G. Kito, R. Nagata, T. Kamataki & H. Fujino. (2007) CYP2C76-mediated species difference in drug metabolism: A comparison of pitavastatin metabolism between monkeys and humans. Xenobiotica 37:1, pages 30-43.
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Marcella Martignoni, Geny M M Groothuis & Ruben de Kanter. (2006) Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opinion on Drug Metabolism & Toxicology 2:6, pages 875-894.
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I. Gut, I. Ojima, R. Vaclavikova, P. Simek, S. Horsky, I. Linhart, P. Soucek, E. Kondrova, L. V. Kuznetsova & J. Chen. (2006) Metabolism of new-generation taxanes in human, pig, minipig and rat liver microsomes. Xenobiotica 36:9, pages 772-792.
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Sean Ekins, Sergey Andreyev, Andy Ryabov, Eugene Kirillov, Eugene A Rakhmatulin, Andrej Bugrim & Tatiana Nikolskaya. (2005) Computational prediction of human drug metabolism. Expert Opinion on Drug Metabolism & Toxicology 1:2, pages 303-324.
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Y. NISHIBE, M. WAKABAYASHI, T. HARAUCHI & K. OHNO. (1998) Characterization of cytochrome P450 (CYP3A12) induction by rifampicin in dog liver. Xenobiotica 28:6, pages 549-557.
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S. Krusekopf, U. Kleeburg, A. G. Hildebrandt & K. Ruckpaul. (1997) Effects of benzimidazole derivatives on cytochrome P450 1A1 expression in a human hepatoma cell line. Xenobiotica 27:1, pages 1-9.
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A. P. BERESFORD*W. J. ELLIS, J. AYRTON, M. A. JOHNSON & D. F. V. LEWIS. (1997) Cytochrome P4501A(CYP1A) induction in rat and man by the benzodioxino derivative, fluparoxan. Xenobiotica 27:2, pages 159-173.
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D. A. SMITH. (1997) Pharmacokinetics and pharmacodynamics in toxicology. Xenobiotica 27:5, pages 513-525.
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A. NAKAMURA*T. HIROTA, A. MORINO, T. SHIMADA & T. UEMATSU. (1997) N-oxidation of irsogladine by the CYP2C subfamily in the rat, dog, monkey and man. Xenobiotica 27:10, pages 995-1003.
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T. Niwa, H. Kaneko, Y. Naritomi, A. Togawa, T. Shiraga, K. Iwasaki, Z. Tozuka & T. Hata. (1995) Species and sex differences of testosterone and nifedipine oxidation in liver microsomes of rat, dog and monkey. Xenobiotica 25:10, pages 1041-1049.
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H. Hanioka, M. Hamamura, K. Kakino, H. Ogata, H. Jinno, A. Takahashi, T. Nishimura & M. Ando. (1995) Dog liver microsomal P450 enzyme-mediated toluene biotransformation. Xenobiotica 25:11, pages 1207-1217.
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