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Original Article

Cyclophosphamide-Induced Depression of the Antioxidant Defense Mechanisms of the Lung

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Pages 153-165 | Received 02 Jun 1984, Published online: 02 Jul 2009

Keep up to date with the latest research on this topic with citation updates for this article.

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Mohammad Shokrzadeh, Amirhossein Ahmadi, Aroona Chabra, Farshad Naghshvar, Fatemeh Salehi, Emran Habibi & Hamed Haghi-Aminjan. (2014) An ethanol extract of Origanum vulgare attenuates cyclophosphamide-induced pulmonary injury and oxidative lung damage in mice. Pharmaceutical Biology 52:10, pages 1229-1236.
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Nora A. Ashry, Nariman M. Gameil & Ghada M. Suddek. (2013) Modulation of cyclophosphamide-induced early lung injury by allicin. Pharmaceutical Biology 51:6, pages 806-811.
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S. Pravansha, B. S. Thippeswamy & V. P. Veerapur. (2012) Immunomodulatory and antioxidant effect of Leptadenia reticulata leaf extract in rodents: possible modulation of cell and humoral immune response. Immunopharmacology and Immunotoxicology 34:6, pages 1010-1019.
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Arunabh Bhattacharya, Richard A. Lawrence, Aparna Krishnan, Khaliquz Zaman, Dongxu Sun & Gabriel Fernandes. (2003) Effect of Dietary n-3 and n-6 Oils with and without Food Restriction on Activity of Antioxidant Enzymes and Lipid Peroxidation in Livers of Cyclophosphamide Treated Autoimmune-Prone NZB/W Female Mice. Journal of the American College of Nutrition 22:5, pages 388-399.
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Articles from other publishers (31)

El M Shkal Karema, Azab Azab Elsayed, Attia Ahmed M, El-Banna Sabah G & Yahya Rabia AM. (2020) Zinc oxide nanoparticles attenuate the oxidative damage and disturbance in antioxidant defense system induced by cyclophosphamide in male albino rats. Insights in Biology and Medicine 4:1, pages 001-008.
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Sultan A. M. Saghir, Sulaiman A. Alharbi, Maged A. Al-Garadi, Naif Al-Gabri, Hagar Y. Rady, Nouran K. Olama, Mahfoudh A. M. Abdulghani, Amir M. Al Hroob, Amer A. Almaiman, May Bin-Jumah, Ayman M. Mahmoud & Medhat Taha. (2020) Curcumin Prevents Cyclophosphamide-Induced Lung Injury in Rats by Suppressing Oxidative Stress and Apoptosis. Processes 8:2, pages 127.
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Thalita Basso Scandolara, Bruno Ricardo Pires, Rodrigo Kern, Vanessa Jacob Victorino & Carolina Panis. 2019. Oxidative Stress in Heart Diseases. Oxidative Stress in Heart Diseases 39 57 .
Emran Habibi, Mohammad Shokrzadeh, Amirhossein Ahmadi, Aroona Chabra, Farshad Naghshvar, Hamed Haghi-Aminjan & Fatemeh Salehi. (2018) Pulmonoprotective Action of Zataria multiflora Ethanolic Extract on Cyclophosphamide-Induced Oxidative Lung Toxicity in Mice. Chinese Journal of Integrative Medicine.
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T.G. Fonseca, M. Auguste, F. Ribeiro, C. Cardoso, N.C. Mestre, D.M.S. Abessa & M.J. Bebianno. (2018) Environmental relevant levels of the cytotoxic drug cyclophosphamide produce harmful effects in the polychaete Nereis diversicolor. Science of The Total Environment 636, pages 798-809.
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Joseph Gbenga Omole, Oladele Abiodun Ayoka, Quadri Kunle Alabi, Modinat Adebukola Adefisayo, Muritala Abiola Asafa, Babalola Olusegun Olubunmi & Benson Akinloye Fadeyi. (2018) Protective Effect of Kolaviron on Cyclophosphamide-Induced Cardiac Toxicity in Rats. Journal of Evidence-Based Integrative Medicine 23, pages 215658721875764.
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Qing Lu, Miles Mundy, Eboni Chambers, Thilo Lange, Julie Newton, Diana Borgas, Hongwei Yao, Gaurav Choudhary, Rajshekhar Basak, Mahogany Oldham & Sharon Rounds. (2017) Alda-1 Protects Against Acrolein-Induced Acute Lung Injury and Endothelial Barrier Dysfunction. American Journal of Respiratory Cell and Molecular Biology 57:6, pages 662-673.
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David K. Madtes. 2016. Murray and Nadel's Textbook of Respiratory Medicine. Murray and Nadel's Textbook of Respiratory Medicine 1612 1623.e8 .
Ghada M. Suddek, Nora A. Ashry & Nariman M. Gameil. (2012) Thymoquinone attenuates cyclophosphamide-induced pulmonary injury in rats. Inflammopharmacology 21:6, pages 427-435.
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C.N. Okwuosa, P.U.O. Achukwu .N.C. Azubike .A.I.E. Abah .. (2012) Protective Effect of the Leaf Extracts of Combretum racemosum P. Beauv (Combretaceae) on Cyclophospahamide Induced Pancytopaenia and Liver Injury in Male Rats. Research Journal of Pharmacology 6:2, pages 30-34.
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Kamel Rouissi, Bechr Hamrita, Soumaya Kouidi, Yosra Messai, Bassem Jaouadi, Khaled Hamden, Imen Medimegh, Slah Ouerhani, Mohamed Cherif & Amel Benammar Elgaaied. (2011) In Vivo Prevention of Bladder Urotoxicity. International Journal of Toxicology 30:4, pages 419-427.
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Rodney J. Folz & Maria Cirino-Marcano. 2010. Murray and Nadel's Textbook of Respiratory Medicine. Murray and Nadel's Textbook of Respiratory Medicine 1950 1962 .
Valentina Todorova, Doug Vanderpool, Sarah Blossom, Emmanuel Nwokedi, Leah Hennings, Robert Mrak & V. Suzanne Klimberg. (2009) Oral glutamine protects against cyclophosphamide-induced cardiotoxicity in experimental rats through increase of cardiac glutathione. Nutrition 25:7-8, pages 812-817.
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Qiu Hua Zhang, Chun Fu Wu, Jing Yu Yang, Yan Hua Mu, Xiao Xue Chen & Yu Qing Zhao. (2009) Reduction of cyclophosphamide-induced DNA damage and apoptosis effects of ginsenoside Rb1 on mouse bone marrow cells and peripheral blood leukocytes. Environmental Toxicology and Pharmacology 27:3, pages 384-389.
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Qiu Hua Zhang, Chun Fu Wu, Lian Duan & Jing Yu Yang. (2007) Protective effects of ginsenoside Rg3 against cyclophosphamide-induced DNA damage and cell apoptosis in mice. Archives of Toxicology 82:2, pages 117-123.
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Qiu Hua Zhang, Chun Fu Wu, Lian Duan & Jing Yu Yang. (2008) Protective effects of total saponins from stem and leaf of Panax ginseng against cyclophosphamide-induced genotoxicity and apoptosis in mouse bone marrow cells and peripheral lymphocyte cells. Food and Chemical Toxicology 46:1, pages 293-302.
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Johnny Amer, Lola Weiss, Shoshana Reich, Michael Y. Shapira, Shimon Slavin & Eitan Fibach. (2007) The oxidative status of blood cells in a murine model of graft-versus-host disease. Annals of Hematology 86:10, pages 753-758.
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K. Bhatia, M. Kaur, F. Atif, M. Ali, H. Rehman, S. Rahman & S. Raisuddin. (2006) Aqueous extract of Trigonella foenum-graecum L. ameliorates additive urotoxicity of buthionine sulfoximine and cyclophosphamide in mice. Food and Chemical Toxicology 44:10, pages 1744-1750.
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Deborah D. Kennedy, Elena J. Ladas, Susan R. Rheingold, Jeffrey Blumberg & Kara M. Kelly. (2005) Antioxidant status decreases in children with acute lymphoblastic leukemia during the first six months of chemotherapy treatment. Pediatric Blood & Cancer 44:4, pages 378-385.
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Sarah G Lopez & Ulrike Luderer. (2004) Effects of cyclophosphamide and buthionine sulfoximine on ovarian glutathione and apoptosis. Free Radical Biology and Medicine 36:11, pages 1366-1377.
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Karan S. Bhalla & Rodney J. Folz. (2002) Idiopathic Pneumonia Syndrome after Syngeneic Bone Marrow Transplant in Mice. American Journal of Respiratory and Critical Care Medicine 166:12, pages 1579-1589.
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Amir M. AbushamaaThomas A. Sporn & Rodney J. Folz. (2002) Oxidative stress and inflammation contribute to lung toxicity after a common breast cancer chemotherapy regimen. American Journal of Physiology-Lung Cellular and Molecular Physiology 283:2, pages L336-L345.
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Michael E. Colvin & Judy N. Quong. 2002. 29 46 .
Thomas R. Ziegler, Angela Panoskaltsus-Mortari, Li H. Gu, Carolyn R. Jonas, Catherine L. Farrell, David L. Lacey, Dean P. Jones & Bruce R. Blazar. (2001) REGULATION OF GLUTATHIONE REDOX STATUS IN LUNG AND LIVER BY CONDITIONING REGIMENS AND KERATINOCYTE GROWTH FACTOR IN MURINE ALLOGENEIC BONE MARROW TRANSPLANTATION1. Transplantation 72:8, pages 1354-1362.
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R Bhagat, TA Sporn, GD Long & RJ Folz. (2001) Amiodarone and cyclophosphamide: potential for enhanced lung toxicity. Bone Marrow Transplantation 27:10, pages 1109-1111.
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Mariola Sulkowska, Stanislaw Sulkowski, Elżbieta Skrzydlewska & Ryszard Farbiszewski. (1998) Cyclophosphamide-induced generation of reactive oxygen species.Comparison with morphological changes in type II alveolar epithelial cells and lung capillaries. Experimental and Toxicologic Pathology 50:3, pages 209-220.
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Narayanan Venkatesan & Gowri Chandrakasan. (1995) Modulation of cyclophosphamide-induced early lung injury by curcumin, an anti-inflammatory antioxidant. Molecular and Cellular Biochemistry 142:1, pages 79-87.
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J.M. PATEL. 1993. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells. Metabolic Activation and Toxicity of Chemical Agents to Lung Tissue and Cells 239 254 .
Sadzuka Yasuyuki & Takino Yoshio. (1992) Effect of seasonal variation on lipid peroxide level and glutathione peroxidase activity in the mouse before and after adriamycin administration. Toxicology Letters 61:1, pages 49-56.
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J.M. Patel. (1990) Metabolism and pulmonary toxicity of cyclophosphamide. Pharmacology & Therapeutics 47:1, pages 137-146.
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Jawaharlal M. Patel. (1987) Stimulation of cyclophosphamide-induced pulmonary microsomal lipid peroxidation by oxygen. Toxicology 45:1, pages 79-91.
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